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Protein

Inactive phospholipase C-like protein 2

Gene

PLCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipase C-like protein 2
Short name:
PLC-L(2)
Short name:
PLC-L2
Short name:
Phospholipase C-L2
Alternative name(s):
Phospholipase C-epsilon-2
Short name:
PLC-epsilon-2
Gene namesi
Name:PLCL2
Synonyms:KIAA1092, PLCE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:9064. PLCL2.

Subcellular locationi

  • Cytoplasm

  • Note: Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23228.
OpenTargetsiENSG00000154822.
PharmGKBiPA33395.

Polymorphism and mutation databases

BioMutaiPLCL2.
DMDMi148880116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002888512 – 1127Inactive phospholipase C-like protein 2Add BLAST1126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei584PhosphothreonineCombined sources1
Modified residuei1113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UPR0.
PaxDbiQ9UPR0.
PeptideAtlasiQ9UPR0.
PRIDEiQ9UPR0.

PTM databases

iPTMnetiQ9UPR0.
PhosphoSitePlusiQ9UPR0.

Expressioni

Gene expression databases

BgeeiENSG00000154822.
CleanExiHS_PLCL2.
ExpressionAtlasiQ9UPR0. baseline and differential.
GenevisibleiQ9UPR0. HS.

Organism-specific databases

HPAiHPA047616.

Interactioni

GO - Molecular functioni

  • GABA receptor binding Source: MGI

Protein-protein interaction databases

BioGridi116833. 6 interactors.
IntActiQ9UPR0. 2 interactors.
MINTiMINT-1198933.
STRINGi9606.ENSP00000409637.

Structurei

3D structure databases

ProteinModelPortaliQ9UPR0.
SMRiQ9UPR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini141 – 251PHPROSITE-ProRule annotationAdd BLAST111
Domaini426 – 570PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini618 – 734PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini741 – 846C2PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 65Gly-richAdd BLAST61

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000006871.
HOVERGENiHBG108265.
InParanoidiQ9UPR0.
KOiK15370.
OMAiPNNVPVK.
OrthoDBiEOG091G00S7.
PhylomeDBiQ9UPR0.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR028383. PLCL2.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF84. PTHR10336:SF84. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF16457. PH_12. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD
60 70 80 90 100
SGGVSNGDCS LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG
110 120 130 140 150
LPRRSSIIKD GTKQKRERKK TVSFSSMPTE KKISSASDCI NSMVEGSELK
160 170 180 190 200
KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD SEKAKIDIKS IKEVRTGKNT
210 220 230 240 250
DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN IWVTGLRYLI
260 270 280 290 300
SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN
310 320 330 340 350
PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ
360 370 380 390 400
FSSNKEFLDT KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL
410 420 430 440 450
SIDGFTNYLM SPDCYIFDPE HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF
460 470 480 490 500
RGPSDITGYI RALKMGCRSV ELDVWDGPDN EPVIYTGHTM TSQIVFRSVI
510 520 530 540 550
DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG DKLYTTSPNV
560 570 580 590 600
EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN
610 620 630 640 650
MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE
660 670 680 690 700
VLASKYANEN PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV
710 720 730 740 750
AMNFQTPGLM MDLNIGWFRQ NGNCGYVLRP AIMREEVSFF SANTKDSVPG
760 770 780 790 800
VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD PYVYVEIHGI PADCAEQRTK
810 820 830 840 850
TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE FIGQYTIPFE
860 870 880 890 900
CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK
910 920 930 940 950
KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL
960 970 980 990 1000
SSVANLMQCM LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI
1010 1020 1030 1040 1050
VTTYDMMIQS LKALIENADA VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE
1060 1070 1080 1090 1100
RKLQKAVESF TWNITILKGQ ADLLKYAKNE TLENLKQIHF AAVSCGLNKP
1110 1120
GTENADVQKP RRSLEVIPEK ANDETGE
Length:1,127
Mass (Da):125,866
Last modified:May 29, 2007 - v2
Checksum:iF75F774DAE18EC5F
GO
Isoform 2 (identifier: Q9UPR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     1069-1086: GQADLLKYAKNETLENLK → IRKTGRRSIFVPQTPIMV
     1087-1127: Missing.

Note: No experimental confirmation available.
Show »
Length:960
Mass (Da):109,221
Checksum:iDD532227D68B5986
GO
Isoform 3 (identifier: Q9UPR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:1,001
Mass (Da):113,602
Checksum:i7208D87B3EA88134
GO

Sequence cautioni

The sequence BAA83044 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14606 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032507211Q → R.1 PublicationCorresponds to variant rs17853614dbSNPEnsembl.1
Natural variantiVAR_032508635V → M.1 PublicationCorresponds to variant rs17857109dbSNPEnsembl.1
Natural variantiVAR_032509742A → V.1 PublicationCorresponds to variant rs17857110dbSNPEnsembl.1
Natural variantiVAR_032510809P → H.1 PublicationCorresponds to variant rs17853612dbSNPEnsembl.1
Natural variantiVAR_032511890H → R.1 PublicationCorresponds to variant rs17853613dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257901 – 126Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST126
Alternative sequenceiVSP_0257911069 – 1086GQADL…LENLK → IRKTGRRSIFVPQTPIMV in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0257921087 – 1127Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029015 mRNA. Translation: BAA83044.1. Different initiation.
AK023546 mRNA. Translation: BAB14606.1. Different initiation.
AK291419 mRNA. Translation: BAF84108.1.
BC036392 mRNA. Translation: AAH36392.1.
AL117515 mRNA. Translation: CAB55974.1.
CCDSiCCDS33713.1. [Q9UPR0-3]
CCDS74911.1. [Q9UPR0-1]
PIRiT17284.
RefSeqiNP_001137854.1. NM_001144382.1. [Q9UPR0-1]
NP_055999.2. NM_015184.5. [Q9UPR0-3]
XP_016861511.1. XM_017006022.1. [Q9UPR0-1]
XP_016861512.1. XM_017006023.1. [Q9UPR0-1]
XP_016861513.1. XM_017006024.1. [Q9UPR0-1]
XP_016861514.1. XM_017006025.1. [Q9UPR0-3]
UniGeneiHs.202010.
Hs.741267.

Genome annotation databases

EnsembliENST00000432376; ENSP00000412836; ENSG00000154822. [Q9UPR0-3]
ENST00000615277; ENSP00000478458; ENSG00000154822. [Q9UPR0-1]
GeneIDi23228.
KEGGihsa:23228.
UCSCiuc011awd.3. human. [Q9UPR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029015 mRNA. Translation: BAA83044.1. Different initiation.
AK023546 mRNA. Translation: BAB14606.1. Different initiation.
AK291419 mRNA. Translation: BAF84108.1.
BC036392 mRNA. Translation: AAH36392.1.
AL117515 mRNA. Translation: CAB55974.1.
CCDSiCCDS33713.1. [Q9UPR0-3]
CCDS74911.1. [Q9UPR0-1]
PIRiT17284.
RefSeqiNP_001137854.1. NM_001144382.1. [Q9UPR0-1]
NP_055999.2. NM_015184.5. [Q9UPR0-3]
XP_016861511.1. XM_017006022.1. [Q9UPR0-1]
XP_016861512.1. XM_017006023.1. [Q9UPR0-1]
XP_016861513.1. XM_017006024.1. [Q9UPR0-1]
XP_016861514.1. XM_017006025.1. [Q9UPR0-3]
UniGeneiHs.202010.
Hs.741267.

3D structure databases

ProteinModelPortaliQ9UPR0.
SMRiQ9UPR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116833. 6 interactors.
IntActiQ9UPR0. 2 interactors.
MINTiMINT-1198933.
STRINGi9606.ENSP00000409637.

PTM databases

iPTMnetiQ9UPR0.
PhosphoSitePlusiQ9UPR0.

Polymorphism and mutation databases

BioMutaiPLCL2.
DMDMi148880116.

Proteomic databases

EPDiQ9UPR0.
PaxDbiQ9UPR0.
PeptideAtlasiQ9UPR0.
PRIDEiQ9UPR0.

Protocols and materials databases

DNASUi23228.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432376; ENSP00000412836; ENSG00000154822. [Q9UPR0-3]
ENST00000615277; ENSP00000478458; ENSG00000154822. [Q9UPR0-1]
GeneIDi23228.
KEGGihsa:23228.
UCSCiuc011awd.3. human. [Q9UPR0-1]

Organism-specific databases

CTDi23228.
DisGeNETi23228.
GeneCardsiPLCL2.
HGNCiHGNC:9064. PLCL2.
HPAiHPA047616.
MIMi614276. gene.
neXtProtiNX_Q9UPR0.
OpenTargetsiENSG00000154822.
PharmGKBiPA33395.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000006871.
HOVERGENiHBG108265.
InParanoidiQ9UPR0.
KOiK15370.
OMAiPNNVPVK.
OrthoDBiEOG091G00S7.
PhylomeDBiQ9UPR0.
TreeFamiTF313216.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000154822-MONOMER.

Miscellaneous databases

ChiTaRSiPLCL2. human.
GenomeRNAii23228.
PROiQ9UPR0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154822.
CleanExiHS_PLCL2.
ExpressionAtlasiQ9UPR0. baseline and differential.
GenevisibleiQ9UPR0. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR028383. PLCL2.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF84. PTHR10336:SF84. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF16457. PH_12. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPR0
Secondary accession number(s): A8K5V4
, Q8N498, Q9H8L0, Q9UFP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.