Q9UPQ9 (TNR6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trinucleotide repeat-containing gene 6B protein

Gene names

Name:	TNRC6B
Synonyms:	KIAA1093

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1833 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Ref.7 Ref.10 Ref.11 Ref.16
Subunit structure	Interacts with EIF2C1/AGO1, EIF2C2/AGO2, EIF2C3/AGO3 and EIF2C4/AGO4. Interacts with CNOT1; the interaction mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Ref.7 Ref.8 Ref.10 Ref.11 Ref.12 Ref.16 Ref.17
Subcellular location	Cytoplasm › P-body. Note: Mammalian P-bodies are also known as GW bodies (GWBs). Ref.7 Ref.10
Sequence similarities	Belongs to the GW182 family. Contains 1 RRM (RNA recognition motif) domain.
Sequence caution	The sequence BAA83045.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	RNA-mediated gene silencing Translation regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Traceable author statement. Source: Reactome epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome gene expression Traceable author statement. Source: Reactome gene silencing by RNA Inferred from mutant phenotype PubMed 19716330. Source: UniProtKB innate immune response Traceable author statement. Source: Reactome neurotrophin TRK receptor signaling pathway Traceable author statement. Source: Reactome phosphatidylinositol-mediated signaling Traceable author statement. Source: Reactome positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Inferred from mutant phenotype PubMed 19716330. Source: UniProtKB positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Inferred from mutant phenotype PubMed 19716330. Source: UniProtKB regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic mRNA processing body Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNOT1	A5YKK6	4	EBI-947158,EBI-1222758
PAN3	Q58A45	4	EBI-947158,EBI-2513054

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UPQ9-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UPQ9-1)

The sequence of this isoform differs from the canonical sequence as follows:
     936-989: VWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDTGASTTGWGNTPANAPNAMKPN → D
     1138-1194: Missing.

Isoform 3 (identifier: Q9UPQ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MR → MQTNEGEVSEESSSKVEQEDFVMEGHGKTPPPGEESKQ
     153-935: Missing.
     1138-1194: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1833	1833	Trinucleotide repeat-containing gene 6B protein		PRO_0000072605
Regions
	Domain	1648 – 1720	73	RRM
	Region	1 – 994	994	Interaction with argonaute proteins
	Region	1218 – 1723	506	Silencing domain; interaction with CNOT1 and PAN3
	Region	1472 – 1490	19	PABPC1-interacting motif-2 (PAM2)
	Coiled coil	1 – 39	39	Potential
	Compositional bias	825 – 880	56	Pro-rich
	Compositional bias	1150 – 1220	71	Gln-rich
Amino acid modifications
	Modified residue	879	1	Phosphoserine Ref.18
	Modified residue	1816	1	Phosphoserine Ref.9 Ref.13 Ref.14
	Modified residue	1832	1	Phosphoserine Ref.14
Natural variations
	Alternative sequence	1 – 2	2	MR → MQTNEGEVSEESSSKVEQED FVMEGHGKTPPPGEESKQ in isoform 3.		VSP_037290
	Alternative sequence	153 – 935	783	Missing in isoform 3.		VSP_037291
	Alternative sequence	936 – 989	54	VWSKS…AMKPN → D in isoform 2.		VSP_037292
	Alternative sequence	1138 – 1194	57	Missing in isoform 2 and isoform 3.		VSP_037293
	Natural variant	517	1	S → C. Corresponds to variant rs17001767 [ dbSNP | Ensembl ].		VAR_051452
Experimental info
	Sequence conflict	1321	1	Missing in BAA83045. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 5, 2009. Version 4. Checksum: E982B786C97C75D0	FASTA	1,833	194,002
	10 20 30 40 50 60 MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP 70 80 90 100 110 120 SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG 130 140 150 160 170 180 GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS 190 200 210 220 230 240 PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG 250 260 270 280 290 300 KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS 310 320 330 340 350 360 NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS 370 380 390 400 410 420 GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG 430 440 450 460 470 480 SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST 490 500 510 520 530 540 GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN 550 560 570 580 590 600 QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC 610 620 630 640 650 660 QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT 670 680 690 700 710 720 KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS 730 740 750 760 770 780 SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI 790 800 810 820 830 840 GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW 850 860 870 880 890 900 GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN 910 920 930 940 950 960 SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASVWSKS TPPAPDNGTS AWGEPNESSP 970 980 990 1000 1010 1020 GWGEMDDTGA STTGWGNTPA NAPNAMKPNS KSMQDGWGES DGPVTGARHP SWEEEEDGGV 1030 1040 1050 1060 1070 1080 WNTTGSQGSA SSHNSASWGQ GGKKQMKCSL KGGNNDSWMN PLAKQFSNMG LLSQTEDNPS 1090 1100 1110 1120 1130 1140 SKMDLSVGSL SDKKFDVDKR AMNLGDFNDI MRKDRSGFRP PNSKDMGTTD SGPYFEKLTL 1150 1160 1170 1180 1190 1200 PFSNQDGCLG DEAPCSPFSP SPSYKLSPSG STLPNVSLGA IGTGLNPQNF AARQGGSHGL 1210 1220 1230 1240 1250 1260 FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL SPGLFNVGPQ 1270 1280 1290 1300 1310 1320 LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE QQLARMVSAL 1330 1340 1350 1360 1370 1380 QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG YGSGFSSGGM 1390 1400 1410 1420 1430 1440 DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG GSPYNQFDII 1450 1460 1470 1480 1490 1500 PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ NIDPESDPYV 1510 1520 1530 1540 1550 1560 TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN SFTNVHSTSA 1570 1580 1590 1600 1610 1620 KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP SSPWSSTAPR 1630 1640 1650 1660 1670 1680 SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ HGPLLTFHLN 1690 1700 1710 1720 1730 1740 LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA QPPTPAATPS 1750 1760 1770 1780 1790 1800 APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA SLWGPPNYSS 1810 1820 1830 SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
	Isoform 2 [UniParc]. Checksum: 80AFD934D6D02FC6	FASTA	1,723	182,815
	10 20 30 40 50 60 MREKEQEREE QLMEDKKRKK EDKKKKEATQ KVTEQKTKVP EVTKPSLSQP TAASPIGSSP 70 80 90 100 110 120 SPPVNGGNNA KRVAVPNGQP PSAARYMPRE VPPRFRCQQD HKVLLKRGQP PPPSCMLLGG 130 140 150 160 170 180 GAGPPPCTAP GANPNNAQVT GALLQSESGT APDSTLGGAA ASNYANSTWG SGASSNNGTS 190 200 210 220 230 240 PNPIHIWDKV IVDGSDMEEW PCIASKDTES SSENTTDNNS ASNPGSEKST LPGSTTSNKG 250 260 270 280 290 300 KGSQCQSASS GNECNLGVWK SDPKAKSVQS SNSTTENNNG LGNWRNVSGQ DRIGPGSGFS 310 320 330 340 350 360 NFNPNSNPSA WPALVQEGTS RKGALETDNS NSSAQVSTVG QTSREQQSKM ENAGVNFVVS 370 380 390 400 410 420 GREQAQIHNT DGPKNGNTNS LNLSSPNPME NKGMPFGMGL GNTSRSTDAP SQSTGDRKTG 430 440 450 460 470 480 SVGSWGAARG PSGTDTVSGQ SNSGNNGNNG KEREDSWKGA SVQKSTGSKN DSWDNNNRST 490 500 510 520 530 540 GGSWNFGPQD SNDNKWGEGN KMTSGVSQGE WKQPTGSDEL KIGEWSGPNQ PNSSTGAWDN 550 560 570 580 590 600 QKGHPLPENQ GNAQAPCWGR SSSSTGSEVG GQSTGSNHKA GSSDSHNSGR RSYRPTHPDC 610 620 630 640 650 660 QAVLQTLLSR TDLDPRVLSN TGWGQTQIKQ DTVWDIEEVP RPEGKSDKGT EGWESAATQT 670 680 690 700 710 720 KNSGGWGDAP SQSNQMKSGW GELSASTEWK DPKNTGGWND YKNNNSSNWG GGRPDEKTPS 730 740 750 760 770 780 SWNENPSKDQ GWGGGRQPNQ GWSSGKNGWG EEVDQTKNSN WESSASKPVS GWGEGGQNEI 790 800 810 820 830 840 GTWGNGGNAS LASKGGWEDC KRSPAWNETG RQPNSWNKQH QQQQPPQQPP PPQPEASGSW 850 860 870 880 890 900 GGPPPPPPGN VRPSNSSWSS GPQPATPKDE EPSGWEEPSP QSISRKMDID DGTSAWGDPN 910 920 930 940 950 960 SYNYKNVNLW DKNSQGGPAP REPNLPTPMT SKSASDSKSM QDGWGESDGP VTGARHPSWE 970 980 990 1000 1010 1020 EEEDGGVWNT TGSQGSASSH NSASWGQGGK KQMKCSLKGG NNDSWMNPLA KQFSNMGLLS 1030 1040 1050 1060 1070 1080 QTEDNPSSKM DLSVGSLSDK KFDVDKRAMN LGDFNDIMRK DRSGFRPPNS KDMGTTDSGP 1090 1100 1110 1120 1130 1140 YFEKGGSHGL FGNSTAQSRG LHTPVQPLNS SPSLRAQVPP QFISPQVSAS MLKQFPNSGL 1150 1160 1170 1180 1190 1200 SPGLFNVGPQ LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQLLQNQRK ISQAVRQQQE 1210 1220 1230 1240 1250 1260 QQLARMVSAL QQQQQQQQRQ PGMKHSPSHP VGPKPHLDNM VPNALNVGLP DLQTKGPIPG 1270 1280 1290 1300 1310 1320 YGSGFSSGGM DYGMVGGKEA GTESRFKQWT SMMEGLPSVA TQEANMHKNG AIVAPGKTRG 1330 1340 1350 1360 1370 1380 GSPYNQFDII PGDTLGGHTG PAGDSWLPAK SPPTNKIGSK SSNASWPPEF QPGVPWKGIQ 1390 1400 1410 1420 1430 1440 NIDPESDPYV TPGSVLGGTA TSPIVDTDHQ LLRDNTTGSN SSLNTSLPSP GAWPYSASDN 1450 1460 1470 1480 1490 1500 SFTNVHSTSA KFPDYKSTWS PDPIGHNPTH LSNKMWKNHI SSRNTTPLPR PPPGLTNPKP 1510 1520 1530 1540 1550 1560 SSPWSSTAPR SVRGWGTQDS RLASASTWSD GGSVRPSYWL VLHNLTPQID GSTLRTICMQ 1570 1580 1590 1600 1610 1620 HGPLLTFHLN LTQGTALIRY STKQEAAKAQ TALHMCVLGN TTILAEFATD DEVSRFLAQA 1630 1640 1650 1660 1670 1680 QPPTPAATPS APAAGWQSLE TGQNQSDPVG PALNLFGGST GLGQWSSSAG GSSGADLAGA 1690 1700 1710 1720 SLWGPPNYSS SLWGVPTVED PHRMGSPAPL LPGDLLGGGS DSI
	Isoform 3 [UniParc]. Checksum: 4CF58AF70B8973B3	FASTA	1,029	109,345
	10 20 30 40 50 60 MQTNEGEVSE ESSSKVEQED FVMEGHGKTP PPGEESKQEK EQEREEQLME DKKRKKEDKK 70 80 90 100 110 120 KKEATQKVTE QKTKVPEVTK PSLSQPTAAS PIGSSPSPPV NGGNNAKRVA VPNGQPPSAA 130 140 150 160 170 180 RYMPREVPPR FRCQQDHKVL LKRGQPPPPS CMLLGGGAGP PPCTAPGANP NNAQVTGALL 190 200 210 220 230 240 QSESGTAPVW SKSTPPAPDN GTSAWGEPNE SSPGWGEMDD TGASTTGWGN TPANAPNAMK 250 260 270 280 290 300 PNSKSMQDGW GESDGPVTGA RHPSWEEEED GGVWNTTGSQ GSASSHNSAS WGQGGKKQMK 310 320 330 340 350 360 CSLKGGNNDS WMNPLAKQFS NMGLLSQTED NPSSKMDLSV GSLSDKKFDV DKRAMNLGDF 370 380 390 400 410 420 NDIMRKDRSG FRPPNSKDMG TTDSGPYFEK GGSHGLFGNS TAQSRGLHTP VQPLNSSPSL 430 440 450 460 470 480 RAQVPPQFIS PQVSASMLKQ FPNSGLSPGL FNVGPQLSPQ QIAMLSQLPQ IPQFQLACQL 490 500 510 520 530 540 LLQQQQQQQL LQNQRKISQA VRQQQEQQLA RMVSALQQQQ QQQQRQPGMK HSPSHPVGPK 550 560 570 580 590 600 PHLDNMVPNA LNVGLPDLQT KGPIPGYGSG FSSGGMDYGM VGGKEAGTES RFKQWTSMME 610 620 630 640 650 660 GLPSVATQEA NMHKNGAIVA PGKTRGGSPY NQFDIIPGDT LGGHTGPAGD SWLPAKSPPT 670 680 690 700 710 720 NKIGSKSSNA SWPPEFQPGV PWKGIQNIDP ESDPYVTPGS VLGGTATSPI VDTDHQLLRD 730 740 750 760 770 780 NTTGSNSSLN TSLPSPGAWP YSASDNSFTN VHSTSAKFPD YKSTWSPDPI GHNPTHLSNK 790 800 810 820 830 840 MWKNHISSRN TTPLPRPPPG LTNPKPSSPW SSTAPRSVRG WGTQDSRLAS ASTWSDGGSV 850 860 870 880 890 900 RPSYWLVLHN LTPQIDGSTL RTICMQHGPL LTFHLNLTQG TALIRYSTKQ EAAKAQTALH 910 920 930 940 950 960 MCVLGNTTIL AEFATDDEVS RFLAQAQPPT PAATPSAPAA GWQSLETGQN QSDPVGPALN 970 980 990 1000 1010 1020 LFGGSTGLGQ WSSSAGGSSG ADLAGASLWG PPNYSSSLWG VPTVEDPHRM GSPAPLLPGD LLGGGSDSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[4]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[7]	"Identification of novel argonaute-associated proteins." Meister G., Landthaler M., Peters L., Chen P.Y., Urlaub H., Luehrmann R., Tuschl T. Curr. Biol. 15:2149-2155(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH EIF2C1 AND EIF2C2, SUBCELLULAR LOCATION.
[8]	"Prolyl 4-hydroxylation regulates Argonaute 2 stability." Qi H.H., Ongusaha P.P., Myllyharju J., Cheng D., Pakkanen O., Shi Y., Lee S.W., Peng J., Shi Y. Nature 455:421-424(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH EIF2C1; EIF2C2; EIF2C3 AND EIF2C4.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1816, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs." Weinmann L., Hoeck J., Ivacevic T., Ohrt T., Muetze J., Schwille P., Kremmer E., Benes V., Urlaub H., Meister G. Cell 136:496-507(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH EIF2C3 AND EIF2C4, SUBCELLULAR LOCATION.
[11]	"Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression." Zipprich J.T., Bhattacharyya S., Mathys H., Filipowicz W. RNA 15:781-793(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH EIF2C2.
[12]	"The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins." Lazzaretti D., Tournier I., Izaurralde E. RNA 15:1059-1066(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EIF2C1; EIF2C2; EIF2C3 AND EIF2C4.
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1816, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1816 AND SER-1832, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets." Braun J.E., Huntzinger E., Fauser M., Izaurralde E. Mol. Cell 44:120-133(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CNOT1 AND PAN3.
[17]	"miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT." Fabian M.R., Cieplak M.K., Frank F., Morita M., Green J., Srikumar T., Nagar B., Yamamoto T., Raught B., Duchaine T.F., Sonenberg N. Nat. Struct. Mol. Biol. 18:1211-1217(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CNOT1.
[18]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-879, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB029016 mRNA. Translation: BAA83045.2. Different initiation. AK294519 mRNA. Translation: BAG57731.1. Z93783, AL022238, AL031589 Genomic DNA. Translation: CAQ07207.1. Z93783, AL022238, AL031589 Genomic DNA. Translation: CAQ07209.1. AL031589, AL022238, Z93783 Genomic DNA. Translation: CAQ08008.1. AL031589, AL022238, Z93783 Genomic DNA. Translation: CAQ08010.1. AL022238, AL031589, Z93783 Genomic DNA. Translation: CAQ08927.1. AL022238, AL031589, Z93783 Genomic DNA. Translation: CAQ08932.1. CH471095 Genomic DNA. Translation: EAW60367.1. BC028626 mRNA. Translation: AAH28626.1.
IPI	IPI00152296. IPI00873067. IPI00940033.
RefSeq	NP_001020014.1. NM_001024843.1. NP_001155973.1. NM_001162501.1. NP_055903.2. NM_015088.2.
UniGene	Hs.372082.
3D structure databases
ProteinModelPortal	Q9UPQ9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29624N. DIP-44174N.
IntAct	Q9UPQ9. 26 interactions.
MINT	MINT-2822586.
STRING	9606.ENSP00000338371.
PTM databases
PhosphoSite	Q9UPQ9.
Polymorphism databases
DMDM	229904901.
Proteomic databases
PaxDb	Q9UPQ9.
PRIDE	Q9UPQ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301923; ENSP00000306759; ENSG00000100354. ENST00000335727; ENSP00000338371; ENSG00000100354. ENST00000402203; ENSP00000384795; ENSG00000100354. ENST00000454349; ENSP00000401946; ENSG00000100354.
GeneID	23112.
KEGG	hsa:23112.
UCSC	uc003aym.3. human. uc003ayn.4. human. uc003ayo.3. human.
Organism-specific databases
CTD	23112.
GeneCards	GC22P040440.
HGNC	HGNC:29190. TNRC6B.
HPA	HPA003180.
MIM	610740. gene.
neXtProt	NX_Q9UPQ9.
PharmGKB	PA134992981.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260411.
HOGENOM	HOG000049171.
HOVERGEN	HBG062594.
OMA	NETGRQP.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9UPQ9.
Bgee	Q9UPQ9.
CleanEx	HS_TNRC6B.
Genevestigator	Q9UPQ9.
GermOnline	ENSG00000100354. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.330. 2 hits.
InterPro	IPR019486. Argonaute_hook_dom. IPR026804. GW182_fam. IPR012677. Nucleotide-bd_a/b_plait. IPR009060. UBA-like. [Graphical view]
PANTHER	PTHR31070. PTHR31070. 1 hit.
Pfam	PF10427. Ago_hook. 1 hit. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit.
PROSITE	PS50102. RRM. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TNRC6B. human.
GenomeRNAi	23112.
NextBio	44311.
SOURCE	Search...

Entry information

Entry name

TNR6B_HUMAN

Accession

Primary (citable) accession number: Q9UPQ9
Secondary accession number(s): B0QY73 , B0QY78, B4DGC0, Q5TH52, Q8TBX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	May 5, 2009
Last modified:	May 29, 2013
This is version 103 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.