ID   TRI35_HUMAN    STANDARD;      PRT;   493 AA.
AC   Q9UPQ4; Q86XQ0; Q8WVA4;
DT   01-FEB-2005 (Rel. 46, Created)
DT   01-FEB-2005 (Rel. 46, Last sequence update)
DT   01-MAY-2005 (Rel. 47, Last annotation update)
DE   Tripartite motif protein 35 (Hemopoeitic lineage switch protein 5).
GN   Name=TRIM35; Synonyms=HLS5, KIAA1098;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC   TISSUE=Liver;
RX   PubMed=14662771; DOI=10.1074/jbc.M306751200;
RA   Lalonde J.-P., Lim R., Ingley E., Tilbrook P.A., Thompson M.J.,
RA   McCulloch R., Beaumont J.G., Wicking C., Eyre H.J., Sutherland G.R.,
RA   Howe K., Solomon E., Williams J.H., Klinken S.P.;
RT   "HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member
RT   isolated from a hemopoietic lineage switch, is a candidate tumor
RT   suppressor.";
RL   J. Biol. Chem. 279:8181-8189(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1).
RC   TISSUE=Brain;
RX   MEDLINE=99397452; PubMed=10470851;
RA   Kikuno R., Nagase T., Ishikawa K.-I., Hirosawa M., Miyajima N.,
RA   Tanaka A., Kotani H., Nomura N., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIV.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 6:197-205(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: May play a role as a tumor suppressor. Implicated in the
CC       cell death mechanism (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear. Found predominantly
CC       in cytoplasm with a granular distribution. Found in punctuate
CC       nuclear bodies (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UPQ4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UPQ4-2; Sequence=VSP_012061;
CC         Note=No experimental confirmation available;
CC   -!- DOMAIN: The RING finger domain and the coiled-coil region are
CC       required for the apoptosis-inducing activity (By similarity).
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC   -!- SIMILARITY: Contains 1 B box-type zinc finger.
CC   -!- SIMILARITY: Contains 1 B30.2-like domain.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
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DR   EMBL; AF492463; AAO85480.1; -.
DR   EMBL; AB029021; BAA83050.1; ALT_INIT.
DR   EMBL; BC018337; AAH18337.1; -.
DR   EMBL; BC069226; AAH69226.1; -.
DR   HSSP; Q99728; 1JM7.
DR   Ensembl; ENSG00000104228; Homo sapiens.
DR   Genew; HGNC:16285; TRIM35.
DR   InterPro; IPR001870; B302.
DR   InterPro; IPR003879; Butyrophylin.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_receptor.
DR   InterPro; IPR000315; Znf_Bbox.
DR   InterPro; IPR001841; Znf_ring.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   PRINTS; PR01406; BBOXZNFINGER.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
KW   Alternative splicing; Apoptosis; Coiled coil; Metal-binding;
KW   Nuclear protein; Zinc; Zinc-finger.
FT   ZN_FING      21     61       RING-type.
FT   ZN_FING      96    137       B box-type.
FT   DOMAIN      304    467       B30.2-like.
FT   DOMAIN      210    251       Coiled coil (Potential).
FT   VARSPLIC    146    206       AKCRNMEHALREKAKAFWAMRRSYEAIAKHNQVEAAWLEGR
FT                                IRQEFDKLREFLRVEEQAIL -> VRSLIAEERRNFLPTHQ
FT                                WIVTKTRLQTSSPNLQSRRQGQVQEHGACTAGEGQGLLGHA
FT                                ALL (in isoform 2).
FT                                /FTId=VSP_012061.
SQ   SEQUENCE   493 AA;  56540 MW;  BFB7E5BFD3AD7E2D CRC64;
     MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE VQVSPTCPVC
     KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV CRLHRGQLSL FCLEDKELLC
     CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN MEHALREKAK AFWAMRRSYE AIAKHNQVEA
     AWLEGRIRQE FDKLREFLRV EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER
     LQMEMKEDDV SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE
     SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV FSQGSHAWEV
     ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC RTQGVEGDHC VTSDPATSPL
     VLAIPRRLRV ELECEEGELS FYDAERHCHL YTFHARFGEV RPYFYLGGAR GAGPPEPLRI
     CPLHISVKEE LDG
//