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Q9UPQ4

- TRI35_HUMAN

UniProt

Q9UPQ4 - TRI35_HUMAN

Protein

Tripartite motif-containing protein 35

Gene

TRIM35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    May play a role as a tumor suppressor. Implicated in the cell death mechanism By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri21 – 6141RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 13742B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. innate immune response Source: UniProt
    3. negative regulation of cell proliferation Source: Ensembl
    4. negative regulation of mitotic cell cycle Source: UniProtKB
    5. negative regulation of viral release from host cell Source: UniProt
    6. positive regulation of apoptotic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 35
    Alternative name(s):
    Hemopoietic lineage switch protein 5
    Gene namesi
    Name:TRIM35
    Synonyms:HLS5, KIAA1098
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:16285. TRIM35.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38115.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Tripartite motif-containing protein 35PRO_0000056250Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei4 – 41Phosphoserine1 Publication
    Modified residuei8 – 81Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ9UPQ4.
    PRIDEiQ9UPQ4.

    PTM databases

    PhosphoSiteiQ9UPQ4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9UPQ4.
    BgeeiQ9UPQ4.
    CleanExiHS_TRIM35.
    GenevestigatoriQ9UPQ4.

    Organism-specific databases

    HPAiHPA019647.

    Interactioni

    Protein-protein interaction databases

    BioGridi116716. 13 interactions.
    IntActiQ9UPQ4. 9 interactions.
    STRINGi9606.ENSP00000301924.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPQ4.
    SMRiQ9UPQ4. Positions 15-61, 302-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini284 – 487204B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili210 – 25142Sequence AnalysisAdd
    BLAST

    Domaini

    The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.By similarity

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri21 – 6141RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 13742B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG285726.
    HOGENOMiHOG000124586.
    HOVERGENiHBG098569.
    InParanoidiQ9UPQ4.
    KOiK12012.
    OMAiCWEVQVA.
    OrthoDBiEOG74BJRP.
    PhylomeDBiQ9UPQ4.
    TreeFamiTF334286.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPQ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE    50
    VQVSPTCPVC KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV 100
    CRLHRGQLSL FCLEDKELLC CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN 150
    MEHALREKAK AFWAMRRSYE AIAKHNQVEA AWLEGRIRQE FDKLREFLRV 200
    EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER LQMEMKEDDV 250
    SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE 300
    SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV 350
    FSQGSHAWEV ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC 400
    RTQGVEGDHC VTSDPATSPL VLAIPRRLRV ELECEEGELS FYDAERHCHL 450
    YTFHARFGEV RPYFYLGGAR GAGPPEPLRI CPLHISVKEE LDG 493
    Length:493
    Mass (Da):56,540
    Last modified:December 7, 2004 - v2
    Checksum:iBFB7E5BFD3AD7E2D
    GO
    Isoform 2 (identifier: Q9UPQ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         146-206: AKCRNMEHAL...FLRVEEQAIL → VRSLIAEERR...QGLLGHAALL

    Note: No experimental confirmation available.

    Show »
    Length:493
    Mass (Da):55,914
    Checksum:i2DB3305B868B67F8
    GO

    Sequence cautioni

    The sequence BAA83050.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei146 – 20661AKCRN…EQAIL → VRSLIAEERRNFLPTHQWIV TKTRLQTSSPNLQSRRQGQV QEHGACTAGEGQGLLGHAAL L in isoform 2. 1 PublicationVSP_012061Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492463 mRNA. Translation: AAO85480.1.
    AB029021 mRNA. Translation: BAA83050.1. Different initiation.
    BC018337 mRNA. Translation: AAH18337.1.
    BC069226 mRNA. Translation: AAH69226.1.
    CCDSiCCDS6056.2. [Q9UPQ4-1]
    RefSeqiNP_741983.2. NM_171982.3. [Q9UPQ4-1]
    UniGeneiHs.104223.

    Genome annotation databases

    EnsembliENST00000305364; ENSP00000301924; ENSG00000104228. [Q9UPQ4-1]
    GeneIDi23087.
    KEGGihsa:23087.
    UCSCiuc003xfl.1. human. [Q9UPQ4-1]

    Polymorphism databases

    DMDMi56404980.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF492463 mRNA. Translation: AAO85480.1 .
    AB029021 mRNA. Translation: BAA83050.1 . Different initiation.
    BC018337 mRNA. Translation: AAH18337.1 .
    BC069226 mRNA. Translation: AAH69226.1 .
    CCDSi CCDS6056.2. [Q9UPQ4-1 ]
    RefSeqi NP_741983.2. NM_171982.3. [Q9UPQ4-1 ]
    UniGenei Hs.104223.

    3D structure databases

    ProteinModelPortali Q9UPQ4.
    SMRi Q9UPQ4. Positions 15-61, 302-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116716. 13 interactions.
    IntActi Q9UPQ4. 9 interactions.
    STRINGi 9606.ENSP00000301924.

    PTM databases

    PhosphoSitei Q9UPQ4.

    Polymorphism databases

    DMDMi 56404980.

    Proteomic databases

    PaxDbi Q9UPQ4.
    PRIDEi Q9UPQ4.

    Protocols and materials databases

    DNASUi 23087.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305364 ; ENSP00000301924 ; ENSG00000104228 . [Q9UPQ4-1 ]
    GeneIDi 23087.
    KEGGi hsa:23087.
    UCSCi uc003xfl.1. human. [Q9UPQ4-1 ]

    Organism-specific databases

    CTDi 23087.
    GeneCardsi GC08M027142.
    HGNCi HGNC:16285. TRIM35.
    HPAi HPA019647.
    neXtProti NX_Q9UPQ4.
    PharmGKBi PA38115.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285726.
    HOGENOMi HOG000124586.
    HOVERGENi HBG098569.
    InParanoidi Q9UPQ4.
    KOi K12012.
    OMAi CWEVQVA.
    OrthoDBi EOG74BJRP.
    PhylomeDBi Q9UPQ4.
    TreeFami TF334286.

    Miscellaneous databases

    GenomeRNAii 23087.
    NextBioi 44229.
    PROi Q9UPQ4.

    Gene expression databases

    ArrayExpressi Q9UPQ4.
    Bgeei Q9UPQ4.
    CleanExi HS_TRIM35.
    Genevestigatori Q9UPQ4.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor."
      Lalonde J.-P., Lim R., Ingley E., Tilbrook P.A., Thompson M.J., McCulloch R., Beaumont J.G., Wicking C., Eyre H.J., Sutherland G.R., Howe K., Solomon E., Williams J.H., Klinken S.P.
      J. Biol. Chem. 279:8181-8189(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Lung.
    4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-8, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTRI35_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPQ4
    Secondary accession number(s): Q86XQ0, Q8WVA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3