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Q9UPQ4

- TRI35_HUMAN

UniProt

Q9UPQ4 - TRI35_HUMAN

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Protein

Tripartite motif-containing protein 35

Gene
TRIM35, HLS5, KIAA1098
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role as a tumor suppressor. Implicated in the cell death mechanism By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 6141RING-typeAdd
BLAST
Zinc fingeri96 – 13742B box-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB
  2. innate immune response Source: UniProt
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of mitotic cell cycle Source: UniProtKB
  5. negative regulation of viral release from host cell Source: UniProt
  6. positive regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 35
Alternative name(s):
Hemopoietic lineage switch protein 5
Gene namesi
Name:TRIM35
Synonyms:HLS5, KIAA1098
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:16285. TRIM35.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Tripartite motif-containing protein 35PRO_0000056250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei4 – 41Phosphoserine1 Publication
Modified residuei8 – 81Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9UPQ4.
PRIDEiQ9UPQ4.

PTM databases

PhosphoSiteiQ9UPQ4.

Expressioni

Gene expression databases

ArrayExpressiQ9UPQ4.
BgeeiQ9UPQ4.
CleanExiHS_TRIM35.
GenevestigatoriQ9UPQ4.

Organism-specific databases

HPAiHPA019647.

Interactioni

Protein-protein interaction databases

BioGridi116716. 13 interactions.
IntActiQ9UPQ4. 9 interactions.
STRINGi9606.ENSP00000301924.

Structurei

3D structure databases

ProteinModelPortaliQ9UPQ4.
SMRiQ9UPQ4. Positions 15-61, 302-483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini284 – 487204B30.2/SPRYAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili210 – 25142 Reviewed predictionAdd
BLAST

Domaini

The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity By similarity.

Sequence similaritiesi

Belongs to the TRIM/RBCC family.
Contains 1 B30.2/SPRY domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG285726.
HOGENOMiHOG000124586.
HOVERGENiHBG098569.
InParanoidiQ9UPQ4.
KOiK12012.
OMAiCWEVQVA.
OrthoDBiEOG74BJRP.
PhylomeDBiQ9UPQ4.
TreeFamiTF334286.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE    50
VQVSPTCPVC KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV 100
CRLHRGQLSL FCLEDKELLC CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN 150
MEHALREKAK AFWAMRRSYE AIAKHNQVEA AWLEGRIRQE FDKLREFLRV 200
EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER LQMEMKEDDV 250
SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE 300
SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV 350
FSQGSHAWEV ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC 400
RTQGVEGDHC VTSDPATSPL VLAIPRRLRV ELECEEGELS FYDAERHCHL 450
YTFHARFGEV RPYFYLGGAR GAGPPEPLRI CPLHISVKEE LDG 493
Length:493
Mass (Da):56,540
Last modified:December 7, 2004 - v2
Checksum:iBFB7E5BFD3AD7E2D
GO
Isoform 2 (identifier: Q9UPQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-206: AKCRNMEHAL...FLRVEEQAIL → VRSLIAEERR...QGLLGHAALL

Note: No experimental confirmation available.

Show »
Length:493
Mass (Da):55,914
Checksum:i2DB3305B868B67F8
GO

Sequence cautioni

The sequence BAA83050.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 20661AKCRN…EQAIL → VRSLIAEERRNFLPTHQWIV TKTRLQTSSPNLQSRRQGQV QEHGACTAGEGQGLLGHAAL L in isoform 2. VSP_012061Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492463 mRNA. Translation: AAO85480.1.
AB029021 mRNA. Translation: BAA83050.1. Different initiation.
BC018337 mRNA. Translation: AAH18337.1.
BC069226 mRNA. Translation: AAH69226.1.
CCDSiCCDS6056.2. [Q9UPQ4-1]
RefSeqiNP_741983.2. NM_171982.3. [Q9UPQ4-1]
UniGeneiHs.104223.

Genome annotation databases

EnsembliENST00000305364; ENSP00000301924; ENSG00000104228. [Q9UPQ4-1]
GeneIDi23087.
KEGGihsa:23087.
UCSCiuc003xfl.1. human. [Q9UPQ4-1]

Polymorphism databases

DMDMi56404980.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF492463 mRNA. Translation: AAO85480.1 .
AB029021 mRNA. Translation: BAA83050.1 . Different initiation.
BC018337 mRNA. Translation: AAH18337.1 .
BC069226 mRNA. Translation: AAH69226.1 .
CCDSi CCDS6056.2. [Q9UPQ4-1 ]
RefSeqi NP_741983.2. NM_171982.3. [Q9UPQ4-1 ]
UniGenei Hs.104223.

3D structure databases

ProteinModelPortali Q9UPQ4.
SMRi Q9UPQ4. Positions 15-61, 302-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116716. 13 interactions.
IntActi Q9UPQ4. 9 interactions.
STRINGi 9606.ENSP00000301924.

PTM databases

PhosphoSitei Q9UPQ4.

Polymorphism databases

DMDMi 56404980.

Proteomic databases

PaxDbi Q9UPQ4.
PRIDEi Q9UPQ4.

Protocols and materials databases

DNASUi 23087.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305364 ; ENSP00000301924 ; ENSG00000104228 . [Q9UPQ4-1 ]
GeneIDi 23087.
KEGGi hsa:23087.
UCSCi uc003xfl.1. human. [Q9UPQ4-1 ]

Organism-specific databases

CTDi 23087.
GeneCardsi GC08M027142.
HGNCi HGNC:16285. TRIM35.
HPAi HPA019647.
neXtProti NX_Q9UPQ4.
PharmGKBi PA38115.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG285726.
HOGENOMi HOG000124586.
HOVERGENi HBG098569.
InParanoidi Q9UPQ4.
KOi K12012.
OMAi CWEVQVA.
OrthoDBi EOG74BJRP.
PhylomeDBi Q9UPQ4.
TreeFami TF334286.

Miscellaneous databases

GenomeRNAii 23087.
NextBioi 44229.
PROi Q9UPQ4.

Gene expression databases

ArrayExpressi Q9UPQ4.
Bgeei Q9UPQ4.
CleanExi HS_TRIM35.
Genevestigatori Q9UPQ4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor."
    Lalonde J.-P., Lim R., Ingley E., Tilbrook P.A., Thompson M.J., McCulloch R., Beaumont J.G., Wicking C., Eyre H.J., Sutherland G.R., Howe K., Solomon E., Williams J.H., Klinken S.P.
    J. Biol. Chem. 279:8181-8189(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Lung.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-8, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTRI35_HUMAN
AccessioniPrimary (citable) accession number: Q9UPQ4
Secondary accession number(s): Q86XQ0, Q8WVA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi