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Q9UPQ3

- AGAP1_HUMAN

UniProt

Q9UPQ3 - AGAP1_HUMAN

Protein

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

Gene

AGAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 4 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.1 Publication

    Enzyme regulationi

    GAP activity stimulated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and, to a lesser extent, by phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidic acid potentiates PIP2 stimulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 858GTPSequence Analysis
    Nucleotide bindingi122 – 1265GTPSequence Analysis
    Nucleotide bindingi178 – 1814GTPSequence Analysis
    Zinc fingeri624 – 64724C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. phospholipid binding Source: FlyBase
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. regulation of ARF GTPase activity Source: InterPro
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    Short name:
    AGAP-1
    Alternative name(s):
    Centaurin-gamma-2
    Short name:
    Cnt-g2
    GTP-binding and GTPase-activating protein 1
    Short name:
    GGAP1
    Gene namesi
    Name:AGAP1
    Synonyms:CENTG2, KIAA1099
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:16922. AGAP1.

    Subcellular locationi

    Cytoplasm 2 Publications
    Note: Associates with the endocytic compartment.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi647 – 6471C → S: Loss of GAP activity. 1 Publication
    Mutagenesisi652 – 6521R → K: Loss of GAP activity. No effect on AP-3-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA26412.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1PRO_0000074218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei836 – 8361Phosphothreonine2 Publications

    Post-translational modificationi

    Phosphorylated on tyrosines.2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPQ3.
    PaxDbiQ9UPQ3.
    PRIDEiQ9UPQ3.

    PTM databases

    PhosphoSiteiQ9UPQ3.

    Expressioni

    Tissue specificityi

    Widely expressed.4 Publications

    Gene expression databases

    ArrayExpressiQ9UPQ3.
    BgeeiQ9UPQ3.
    CleanExiHS_AGAP1.
    GenevestigatoriQ9UPQ3.

    Organism-specific databases

    HPAiHPA051405.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with several subunits of the AP-3 protein complex: AP3M1, AP3S1 and AP3S2. Interacts with GUCY1A3 and GUCY1B3.2 Publications

    Protein-protein interaction databases

    BioGridi125550. 4 interactions.
    IntActiQ9UPQ3. 3 interactions.
    MINTiMINT-6783717.
    STRINGi9606.ENSP00000307634.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPQ3.
    SMRiQ9UPQ3. Positions 70-233, 344-422, 530-592, 612-854.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini346 – 588243PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini609 – 729121Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati768 – 79730ANK 1Add
    BLAST
    Repeati801 – 83030ANK 2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 276211Small GTPase-likeAdd
    BLAST

    Domaini

    The PH domain mediates AP-3 binding.

    Sequence similaritiesi

    Belongs to the centaurin gamma-like family.Curated
    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri624 – 64724C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000007233.
    HOVERGENiHBG054045.
    KOiK12491.
    OMAiEVENNIS.
    OrthoDBiEOG72VH5V.
    PhylomeDBiQ9UPQ3.
    TreeFamiTF317762.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    3.40.50.300. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF08477. Miro. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPQ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNYQQQLANS AAIRAEIQRF ESVHPNIYSI YELLERVEEP VLQNQIREHV    50
    IAIEDAFVNS QEWTLSRSVP ELKVGIVGNL ASGKSALVHR YLTGTYVQEE 100
    SPEGGRFKKE IVVDGQSYLL LIRDEGGPPE AQFAMWVDAV IFVFSLEDEI 150
    SFQTVYHYYS RMANYRNTSE IPLVLVGTQD AISSANPRVI DDARARKLSN 200
    DLKRCTYYET CATYGLNVER VFQDVAQKIV ATRKKQQLSI GPCKSLPNSP 250
    SHSSVCSAQV SAVHISQTSN GGGSLSDYSS SVPSTPSTSQ KELRIDVPPT 300
    ANTPTPVRKQ SKRRSNLFTS RKGSDPDKEK KGLESRADSI GSGRAIPIKQ 350
    GMLLKRSGKS LNKEWKKKYV TLCDNGVLTY HPSLHDYMQN VHGKEIDLLR 400
    TTVKVPGKRP PRATSACAPI SSPKTNGLSK DMSSLHISPN SGNVTSASGS 450
    QMASGISLVS FNSRPDGMHQ RSYSVSSADQ WSEATVIANS AISSDTGLGD 500
    SVCSSPSISS TTSPKLDPPP SPHANRKKHR RKKSTSNFKA DGLSGTAEEQ 550
    EENFEFIIVS LTGQTWHFEA TTYEERDAWV QAIESQILAS LQSCESSKNK 600
    SRLTSQSEAM ALQSIRNMRG NSHCVDCETQ NPNWASLNLG ALMCIECSGI 650
    HRNLGTHLSR VRSLDLDDWP VELIKVMSSI GNELANSVWE ESSQGRTKPS 700
    VDSTREEKER WIRAKYEQKL FLAPLPCTEL SLGQHLLRAT ADEDLRTAIL 750
    LLAHGSRDEV NETCGEGDGR TALHLACRKG NVVLAQLLIW YGVDVTARDA 800
    HGNTALAYAR QASSQECIDV LLQYGCPDER FVLMATPNLS RRNNNRNNSS 850
    GRVPTII 857
    Length:857
    Mass (Da):94,470
    Last modified:November 13, 2007 - v4
    Checksum:iBBFDB8DA0ECD55E8
    GO
    Isoform 2 (identifier: Q9UPQ3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         442-494: Missing.

    Show »
    Length:804
    Mass (Da):89,066
    Checksum:i6014F37974C24A52
    GO
    Isoform 3 (identifier: Q9UPQ3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         352-405: MLLKRSGKSL...IDLLRTTVKV → LPFFVLALTA...SAQLSGAMMN
         406-857: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:405
    Mass (Da):44,512
    Checksum:i0B179759420981A9
    GO

    Sequence cautioni

    The sequence AAH60814.1 differs from that shown. Reason: A 4-nucleotides insertion of unknown origin disrupts the reading frame.
    The sequence BAA83051.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAA91862.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti288 – 2881T → I in AAK56506. (PubMed:12640130)Curated
    Sequence conflicti288 – 2881T → I in AAL04172. 1 PublicationCurated
    Sequence conflicti288 – 2881T → I in BAA83051. (PubMed:10470851)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821S → G in an autistic patient. 1 Publication
    VAR_026446
    Natural varianti148 – 1481D → G.1 Publication
    Corresponds to variant rs17855721 [ dbSNP | Ensembl ].
    VAR_026447
    Natural varianti522 – 5221P → L.
    Corresponds to variant rs17840725 [ dbSNP | Ensembl ].
    VAR_048331
    Natural varianti671 – 6711V → I.5 Publications
    Corresponds to variant rs2034648 [ dbSNP | Ensembl ].
    VAR_026448
    Natural varianti798 – 7981R → G in an autistic patient. 1 Publication
    VAR_026449
    Natural varianti829 – 8291E → K.
    Corresponds to variant rs15718 [ dbSNP | Ensembl ].
    VAR_019550
    Natural varianti854 – 8541P → T in a family with an autistic patient. 1 Publication
    VAR_026450

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei352 – 40554MLLKR…TTVKV → LPFFVLALTASTYLRPAGAR ARQSSPWPGPRGGQTSPHCA EGPQSAQLSGAMMN in isoform 3. 1 PublicationVSP_011181Add
    BLAST
    Alternative sequencei406 – 857452Missing in isoform 3. 1 PublicationVSP_011182Add
    BLAST
    Alternative sequencei442 – 49453Missing in isoform 2. 3 PublicationsVSP_011183Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033765 mRNA. Translation: AAK56506.1.
    AF413078 mRNA. Translation: AAL04172.1.
    AB029022 mRNA. Translation: BAA83051.2. Different initiation.
    AC012305 Genomic DNA. No translation available.
    AC019047 Genomic DNA. No translation available.
    AC064874 Genomic DNA. No translation available.
    AC073989 Genomic DNA. No translation available.
    AC079400 Genomic DNA. No translation available.
    BC060814 mRNA. Translation: AAH60814.1. Sequence problems.
    BC140856 mRNA. Translation: AAI40857.1.
    AK001722 mRNA. Translation: BAA91862.1. Different initiation.
    CCDSiCCDS2514.1. [Q9UPQ3-2]
    CCDS33408.1. [Q9UPQ3-1]
    CCDS58756.1. [Q9UPQ3-3]
    RefSeqiNP_001032208.1. NM_001037131.2. [Q9UPQ3-1]
    NP_001231817.1. NM_001244888.1. [Q9UPQ3-3]
    NP_055729.2. NM_014914.4. [Q9UPQ3-2]
    UniGeneiHs.435039.

    Genome annotation databases

    EnsembliENST00000304032; ENSP00000307634; ENSG00000157985. [Q9UPQ3-1]
    ENST00000336665; ENSP00000338378; ENSG00000157985. [Q9UPQ3-2]
    ENST00000409457; ENSP00000387174; ENSG00000157985. [Q9UPQ3-3]
    GeneIDi116987.
    KEGGihsa:116987.
    UCSCiuc002vvs.3. human. [Q9UPQ3-1]
    uc002vvt.3. human. [Q9UPQ3-2]
    uc021vyp.1. human. [Q9UPQ3-3]

    Polymorphism databases

    DMDMi160332373.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033765 mRNA. Translation: AAK56506.1 .
    AF413078 mRNA. Translation: AAL04172.1 .
    AB029022 mRNA. Translation: BAA83051.2 . Different initiation.
    AC012305 Genomic DNA. No translation available.
    AC019047 Genomic DNA. No translation available.
    AC064874 Genomic DNA. No translation available.
    AC073989 Genomic DNA. No translation available.
    AC079400 Genomic DNA. No translation available.
    BC060814 mRNA. Translation: AAH60814.1 . Sequence problems.
    BC140856 mRNA. Translation: AAI40857.1 .
    AK001722 mRNA. Translation: BAA91862.1 . Different initiation.
    CCDSi CCDS2514.1. [Q9UPQ3-2 ]
    CCDS33408.1. [Q9UPQ3-1 ]
    CCDS58756.1. [Q9UPQ3-3 ]
    RefSeqi NP_001032208.1. NM_001037131.2. [Q9UPQ3-1 ]
    NP_001231817.1. NM_001244888.1. [Q9UPQ3-3 ]
    NP_055729.2. NM_014914.4. [Q9UPQ3-2 ]
    UniGenei Hs.435039.

    3D structure databases

    ProteinModelPortali Q9UPQ3.
    SMRi Q9UPQ3. Positions 70-233, 344-422, 530-592, 612-854.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125550. 4 interactions.
    IntActi Q9UPQ3. 3 interactions.
    MINTi MINT-6783717.
    STRINGi 9606.ENSP00000307634.

    PTM databases

    PhosphoSitei Q9UPQ3.

    Polymorphism databases

    DMDMi 160332373.

    Proteomic databases

    MaxQBi Q9UPQ3.
    PaxDbi Q9UPQ3.
    PRIDEi Q9UPQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304032 ; ENSP00000307634 ; ENSG00000157985 . [Q9UPQ3-1 ]
    ENST00000336665 ; ENSP00000338378 ; ENSG00000157985 . [Q9UPQ3-2 ]
    ENST00000409457 ; ENSP00000387174 ; ENSG00000157985 . [Q9UPQ3-3 ]
    GeneIDi 116987.
    KEGGi hsa:116987.
    UCSCi uc002vvs.3. human. [Q9UPQ3-1 ]
    uc002vvt.3. human. [Q9UPQ3-2 ]
    uc021vyp.1. human. [Q9UPQ3-3 ]

    Organism-specific databases

    CTDi 116987.
    GeneCardsi GC02P236402.
    HGNCi HGNC:16922. AGAP1.
    HPAi HPA051405.
    MIMi 608651. gene.
    neXtProti NX_Q9UPQ3.
    PharmGKBi PA26412.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000007233.
    HOVERGENi HBG054045.
    KOi K12491.
    OMAi EVENNIS.
    OrthoDBi EOG72VH5V.
    PhylomeDBi Q9UPQ3.
    TreeFami TF317762.

    Miscellaneous databases

    ChiTaRSi AGAP1. human.
    GeneWikii CENTG2.
    GenomeRNAii 116987.
    NextBioi 80074.
    PROi Q9UPQ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPQ3.
    Bgeei Q9UPQ3.
    CleanExi HS_AGAP1.
    Genevestigatori Q9UPQ3.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    2.30.29.30. 2 hits.
    3.40.50.300. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR013684. MIRO-like.
    IPR027417. P-loop_NTPase.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF08477. Miro. 1 hit.
    PF00169. PH. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 2 hits.
    SM00105. ArfGap. 1 hit.
    SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins."
      Xia C., Ma W., Stafford L.J., Liu C., Gong L., Martin J.F., Liu M.
      Mol. Cell. Biol. 23:2476-2488(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-671, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
      Tissue: Heart.
    2. "Kiaa1099 as a member (centaurin gamma2) of the centaurin ArfGAP protein family."
      Hong W.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ILE-671.
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-671.
      Tissue: Brain.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLY-148.
      Tissue: Placenta.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 429-857 (ISOFORM 1), VARIANT ILE-671.
      Tissue: Teratocarcinoma.
    7. "AGAP1, an endosome-associated, phosphoinositide-dependent ADP-ribosylation factor GTPase-activating protein that affects actin cytoskeleton."
      Nie Z., Stanley K.T., Stauffer S., Jacques K.M., Hirsch D.S., Takei J., Randazzo P.A.
      J. Biol. Chem. 277:48965-48975(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-647 AND ARG-652.
    8. "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1."
      Nie Z., Boehm M., Boja E.S., Vass W.C., Bonifacino J.S., Fales H.M., Randazzo P.A.
      Dev. Cell 5:513-521(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH THE AP-3 COMPLEX.
    9. "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase."
      Meurer S., Pioch S., Wagner K., Mueller-Esterl W., Gross S.
      J. Biol. Chem. 279:49346-49354(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH GUCY1A3 AND GUCY1B3.
    10. "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3."
      Nie Z., Fei J., Premont R.T., Randazzo P.A.
      J. Cell Sci. 118:3555-3566(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-836, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANTS GLY-82; ILE-671; GLY-798 AND THR-854.

    Entry informationi

    Entry nameiAGAP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPQ3
    Secondary accession number(s): B2RTX7
    , Q541S5, Q6P9D7, Q9NV93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 148 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3