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Protein

LIM and calponin homology domains-containing protein 1

Gene

LIMCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and calponin homology domains-containing protein 1
Gene namesi
Name:LIMCH1
Synonyms:KIAA1102
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29191. LIMCH1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393957.

Polymorphism and mutation databases

BioMutaiLIMCH1.
DMDMi296439483.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10831083LIM and calponin homology domains-containing protein 1PRO_0000293619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei177 – 1771PhosphoserineBy similarity
Modified residuei192 – 1921PhosphoserineCombined sources
Modified residuei201 – 2011PhosphoserineCombined sources
Modified residuei204 – 2041PhosphoserineCombined sources
Modified residuei207 – 2071PhosphoserineCombined sources
Modified residuei215 – 2151PhosphothreonineCombined sources
Modified residuei217 – 2171PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineCombined sources
Modified residuei233 – 2331PhosphoserineCombined sources
Modified residuei297 – 2971PhosphoserineCombined sources
Modified residuei303 – 3031PhosphoserineCombined sources
Modified residuei313 – 3131PhosphotyrosineBy similarity
Modified residuei377 – 3771PhosphoserineCombined sources
Modified residuei402 – 4021PhosphothreonineCombined sources
Modified residuei471 – 4711PhosphoserineCombined sources
Modified residuei472 – 4721PhosphothreonineBy similarity
Modified residuei516 – 5161PhosphoserineCombined sources
Modified residuei518 – 5181PhosphoserineCombined sources
Modified residuei523 – 5231PhosphoserineCombined sources
Modified residuei529 – 5291PhosphothreonineCombined sources
Modified residuei537 – 5371PhosphothreonineCombined sources
Modified residuei601 – 6011PhosphoserineCombined sources
Modified residuei670 – 6701PhosphoserineCombined sources
Modified residuei681 – 6811PhosphoserineCombined sources
Modified residuei718 – 7181PhosphoserineCombined sources
Modified residuei724 – 7241PhosphothreonineCombined sources
Modified residuei750 – 7501PhosphoserineBy similarity
Modified residuei756 – 7561PhosphoserineBy similarity
Modified residuei875 – 8751PhosphoserineCombined sources
Modified residuei900 – 9001PhosphothreonineBy similarity
Modified residuei966 – 9661PhosphoserineCombined sources
Modified residuei973 – 9731PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPQ0.
MaxQBiQ9UPQ0.
PaxDbiQ9UPQ0.
PeptideAtlasiQ9UPQ0.
PRIDEiQ9UPQ0.

PTM databases

iPTMnetiQ9UPQ0.

Expressioni

Gene expression databases

BgeeiQ9UPQ0.
CleanExiHS_LIMCH1.
ExpressionAtlasiQ9UPQ0. baseline and differential.
GenevisibleiQ9UPQ0. HS.

Organism-specific databases

HPAiHPA004184.
HPA063840.

Interactioni

Protein-protein interaction databases

BioGridi116645. 39 interactions.
IntActiQ9UPQ0. 21 interactions.
MINTiMINT-4724874.
STRINGi9606.ENSP00000316891.

Structurei

3D structure databases

ProteinModelPortaliQ9UPQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 125105CHPROSITE-ProRule annotationAdd
BLAST
Domaini1011 – 107767LIM zinc-bindingPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili348 – 43992Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi771 – 82656Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the LIMCH1 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 LIM zinc-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

eggNOGiENOG410INGA. Eukaryota.
ENOG410XQB9. LUCA.
GeneTreeiENSGT00530000063559.
HOVERGENiHBG108087.
InParanoidiQ9UPQ0.
OrthoDBiEOG79SDWD.
PhylomeDBiQ9UPQ0.
TreeFamiTF332155.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR001715. CH-domain.
IPR031865. DUF4757.
IPR029980. LIMCH1.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF3. PTHR15551:SF3. 1 hit.
PfamiPF00307. CH. 1 hit.
PF15949. DUF4757. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACPALGLEA LQPLQPEPPP EPAFSEAQKW IEQVTGRSFG DKDFRTGLEN
60 70 80 90 100
GILLCELLNA IKPGLVKKIN RLPTPIAGLD NIILFLRGCK ELGLKESQLF
110 120 130 140 150
DPSDLQDTSN RVTVKSLDYS RKLKNVLVTI YWLGKAANSC TSYSGTTLNL
160 170 180 190 200
KEFEGLLAQM RKDTDDIESP KRSIRDSGYI DCWDSERSDS LSPPRHGRDD
210 220 230 240 250
SFDSLDSFGS RSRQTPSPDV VLRGSSDGRG SDSESDLPHR KLPDVKKDDM
260 270 280 290 300
SARRTSHGEP KSAVPFNQYL PNKSNQTAYV PAPLRKKKAE REEYRKSWST
310 320 330 340 350
ATSPLGGERP FRYGPRTPVS DDAESTSMFD MRCEEEAAVQ PHSRARQEQL
360 370 380 390 400
QLINNQLREE DDKWQDDLAR WKSRRRSVSQ DLIKKEEERK KMEKLLAGED
410 420 430 440 450
GTSERRKSIK TYREIVQEKE RRERELHEAY KNARSQEEAE GILQQYIERF
460 470 480 490 500
TISEAVLERL EMPKILERSH STEPNLSSFL NDPNPMKYLR QQSLPPPKFT
510 520 530 540 550
ATVETTIARA SVLDTSMSAG SGSPSKTVTP KAVPMLTPKP YSQPKNSQDV
560 570 580 590 600
LKTFKVDGKV SVNGETVHRE EEKERECPTV APAHSLTKSQ MFEGVARVHG
610 620 630 640 650
SPLELKQDNG SIEINIKKPN SVPQELAATT EKTEPNSQED KNDGGKSRKG
660 670 680 690 700
NIELASSEPQ HFTTTVTRCS PTVAFVEFPS SPQLKNDVSE EKDQKKPENE
710 720 730 740 750
MSGKVELVLS QKVVKPKSPE PEATLTFPFL DKMPEANQLH LPNLNSQVDS
760 770 780 790 800
PSSEKSPVMT PQFKFWAWDP EEERRRQEKW QQEQERLLQE RYQKEQDKLK
810 820 830 840 850
EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD QLSTSSSMTE
860 870 880 890 900
GSGTMNKIDL GNCQDEKQDR RWKKSFQGDD SDLLLKTRES DRLEEKGSLT
910 920 930 940 950
EGALAHSGNP VSKGVHEDHQ LDTEAGAPHC GTNPQLAQDP SQNQQTSNPT
960 970 980 990 1000
HSSEDVKPKT LPLDKSINHQ IESPSERRKK SPREHFQAGP FSPCSPTPPG
1010 1020 1030 1040 1050
QSPNRSISGK KLCSSCGLPL GKGAAMIIET LNLYFHIQCF RCGICKGQLG
1060 1070 1080
DAVSGTDVRI RNGLLNCNDC YMRSRSAGQP TTL
Length:1,083
Mass (Da):121,867
Last modified:May 18, 2010 - v4
Checksum:i19C8BA192EDBDC6B
GO
Isoform 2 (identifier: Q9UPQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     980-1005: Missing.

Show »
Length:1,057
Mass (Da):119,078
Checksum:i0941CE1DC5A787A8
GO
Isoform 3 (identifier: Q9UPQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     311-311: F → FSFPETIEEE...SSKGLPMKDQ
     762-762: Missing.

Note: No experimental confirmation available.
Show »
Length:1,467
Mass (Da):164,440
Checksum:i0D87F5D5CC068B60
GO
Isoform 4 (identifier: Q9UPQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:1,069
Mass (Da):120,496
Checksum:iDFE247E4E66028D9
GO
Isoform 5 (identifier: Q9UPQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:910
Mass (Da):103,010
Checksum:i569E37A38F29AB9A
GO
Isoform 6 (identifier: Q9UPQ0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     762-762: Missing.
     980-1005: Missing.

Show »
Length:902
Mass (Da):102,022
Checksum:i7584455BA8EAEC5D
GO
Isoform 7 (identifier: Q9UPQ0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     288-297: KAEREEYRKS → NADTMRRSVR
     298-1083: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,551
Checksum:i7829A68BD11C1097
GO
Isoform 8 (identifier: Q9UPQ0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:897
Mass (Da):101,464
Checksum:iE6A5FF8C3D53D2F9
GO
Isoform 9 (identifier: Q9UPQ0-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     313-324: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:890
Mass (Da):100,734
Checksum:iD0F8D08238E15CDD
GO
Isoform 10 (identifier: Q9UPQ0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-762: Missing.
     980-1005: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):118,950
Checksum:i69BBB44235180481
GO

Sequence cautioni

The sequence BAA83054.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171E → G in CAI56749 (PubMed:17974005).Curated
Sequence conflicti142 – 1421S → P in CR936664 (PubMed:17974005).Curated
Sequence conflicti207 – 2071S → F in CAI56749 (PubMed:17974005).Curated
Sequence conflicti409 – 4091I → T in CR936664 (PubMed:17974005).Curated
Sequence conflicti537 – 5371T → I in CAH18063 (PubMed:17974005).Curated
Sequence conflicti611 – 6111S → G in CAD38604 (PubMed:17974005).Curated
Sequence conflicti622 – 6221V → I in CR936664 (PubMed:17974005).Curated
Sequence conflicti706 – 7061E → G in CAI56754 (PubMed:17974005).Curated
Sequence conflicti750 – 7501S → P in CAD38604 (PubMed:17974005).Curated
Sequence conflicti867 – 8671K → N in CAH18063 (PubMed:17974005).Curated
Sequence conflicti1053 – 10531V → A in CAD38604 (PubMed:17974005).Curated
Sequence conflicti1059 – 10591R → G in CAI45946 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti759 – 7591M → T.3 Publications
Corresponds to variant rs11734372 [ dbSNP | Ensembl ].
VAR_033105

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 159159Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsVSP_026541Add
BLAST
Alternative sequencei1 – 154154Missing in isoform 6 and isoform 9. 1 PublicationVSP_026542Add
BLAST
Alternative sequencei155 – 1617GLLAQMR → MDSERQV in isoform 6 and isoform 9. 1 PublicationVSP_026543
Alternative sequencei288 – 29710KAEREEYRKS → NADTMRRSVR in isoform 7. 1 PublicationVSP_026544
Alternative sequencei298 – 1083786Missing in isoform 7. 1 PublicationVSP_026545Add
BLAST
Alternative sequencei311 – 3111F → FSFPETIEEEGSEVGSAGED NPAGQMNPGWKPSDGGCELP DGSGKEHPSSDGAVVAPAPK SEEKDAAEIQKRERLEQAGI KVMPAAQRFASQKQLSEEKE AIRDIVLRKENSFLTHQHGN DSEAEGEVVCRLPDLEKDDF AARRARMNQTKPMVPLNQLL YGPYPKKGAEKSDGSKQLSK GISKKRSLEYKRNQGHTEEV KLIVTCNMRAQESEPVEGGL RKVPDLHKDDLAQQRIQGSL APHREPPSFITLSNITEADL ETWERLKVSEKARDGDVQHI CASEPSPEIKAETAIRDDFA NRKARASKKASSPRQKFVHF GPVTELDQQKWKRLSIGKAG PREDEEEVICHGSKIQMDSV SPVSAATSSLKGHQIFNRQN DCRTMNCGRGDYCRRASWLA PVPESQEEWVCSLGECPRGT EEVTSKQLPQDGKEETESAP RDSERLSKAERSEDSSQPLV CPLASECEASGTEEKLEKMT APAWSGSGLKGQRKLDDSRK DDMMARRTGMSLRHTGSNPN QFLPVPFAKQQDVEESSKGL PMKDQ in isoform 3. 1 PublicationVSP_026546
Alternative sequencei313 – 32412Missing in isoform 4, isoform 5 and isoform 9. 1 PublicationVSP_026547Add
BLAST
Alternative sequencei747 – 7471Q → QESPGTASVPLRVQNSWRRS QFFSQS in isoform 4 and isoform 5. 1 PublicationVSP_026548
Alternative sequencei762 – 7621Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_026549
Alternative sequencei980 – 100526Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 PublicationsVSP_026550Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029025 mRNA. Translation: BAA83054.2. Different initiation.
AL831962 mRNA. Translation: CAD38604.1.
BX537916 mRNA. Translation: CAD97899.1.
CR749205 mRNA. Translation: CAH18063.1.
CR933645 mRNA. Translation: CAI45946.1.
CR936601 mRNA. Translation: CAI56749.1.
CR936610 mRNA. Translation: CAI56754.1.
CR936664 mRNA. No translation available.
AC095043 Genomic DNA. No translation available.
AC105389 Genomic DNA. No translation available.
AC108050 Genomic DNA. No translation available.
AC121159 Genomic DNA. No translation available.
AC124009 Genomic DNA. No translation available.
BC023546 mRNA. Translation: AAH23546.1.
BC029735 mRNA. Translation: AAH29735.1.
BC095394 mRNA. Translation: AAH95394.1.
CCDSiCCDS33977.1. [Q9UPQ0-1]
CCDS47047.1. [Q9UPQ0-6]
CCDS54763.1. [Q9UPQ0-2]
CCDS54764.1. [Q9UPQ0-10]
CCDS54765.1. [Q9UPQ0-9]
CCDS75119.1. [Q9UPQ0-4]
CCDS75121.1. [Q9UPQ0-5]
RefSeqiNP_001106188.1. NM_001112717.2. [Q9UPQ0-2]
NP_001106189.1. NM_001112718.2. [Q9UPQ0-10]
NP_001106190.1. NM_001112719.2. [Q9UPQ0-6]
NP_001106191.1. NM_001112720.2. [Q9UPQ0-9]
NP_001276051.1. NM_001289122.1. [Q9UPQ0-4]
NP_001276053.1. NM_001289124.1. [Q9UPQ0-5]
NP_055803.2. NM_014988.3. [Q9UPQ0-1]
UniGeneiHs.335163.

Genome annotation databases

EnsembliENST00000313860; ENSP00000316891; ENSG00000064042. [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042. [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042. [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042. [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042. [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042. [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042. [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042. [Q9UPQ0-5]
GeneIDi22998.
KEGGihsa:22998.
UCSCiuc003gvu.6. human. [Q9UPQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029025 mRNA. Translation: BAA83054.2. Different initiation.
AL831962 mRNA. Translation: CAD38604.1.
BX537916 mRNA. Translation: CAD97899.1.
CR749205 mRNA. Translation: CAH18063.1.
CR933645 mRNA. Translation: CAI45946.1.
CR936601 mRNA. Translation: CAI56749.1.
CR936610 mRNA. Translation: CAI56754.1.
CR936664 mRNA. No translation available.
AC095043 Genomic DNA. No translation available.
AC105389 Genomic DNA. No translation available.
AC108050 Genomic DNA. No translation available.
AC121159 Genomic DNA. No translation available.
AC124009 Genomic DNA. No translation available.
BC023546 mRNA. Translation: AAH23546.1.
BC029735 mRNA. Translation: AAH29735.1.
BC095394 mRNA. Translation: AAH95394.1.
CCDSiCCDS33977.1. [Q9UPQ0-1]
CCDS47047.1. [Q9UPQ0-6]
CCDS54763.1. [Q9UPQ0-2]
CCDS54764.1. [Q9UPQ0-10]
CCDS54765.1. [Q9UPQ0-9]
CCDS75119.1. [Q9UPQ0-4]
CCDS75121.1. [Q9UPQ0-5]
RefSeqiNP_001106188.1. NM_001112717.2. [Q9UPQ0-2]
NP_001106189.1. NM_001112718.2. [Q9UPQ0-10]
NP_001106190.1. NM_001112719.2. [Q9UPQ0-6]
NP_001106191.1. NM_001112720.2. [Q9UPQ0-9]
NP_001276051.1. NM_001289122.1. [Q9UPQ0-4]
NP_001276053.1. NM_001289124.1. [Q9UPQ0-5]
NP_055803.2. NM_014988.3. [Q9UPQ0-1]
UniGeneiHs.335163.

3D structure databases

ProteinModelPortaliQ9UPQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116645. 39 interactions.
IntActiQ9UPQ0. 21 interactions.
MINTiMINT-4724874.
STRINGi9606.ENSP00000316891.

PTM databases

iPTMnetiQ9UPQ0.

Polymorphism and mutation databases

BioMutaiLIMCH1.
DMDMi296439483.

Proteomic databases

EPDiQ9UPQ0.
MaxQBiQ9UPQ0.
PaxDbiQ9UPQ0.
PeptideAtlasiQ9UPQ0.
PRIDEiQ9UPQ0.

Protocols and materials databases

DNASUi22998.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313860; ENSP00000316891; ENSG00000064042. [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042. [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042. [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042. [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042. [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042. [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042. [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042. [Q9UPQ0-5]
GeneIDi22998.
KEGGihsa:22998.
UCSCiuc003gvu.6. human. [Q9UPQ0-1]

Organism-specific databases

CTDi22998.
GeneCardsiLIMCH1.
H-InvDBHIX0004177.
HIX0120158.
HGNCiHGNC:29191. LIMCH1.
HPAiHPA004184.
HPA063840.
neXtProtiNX_Q9UPQ0.
PharmGKBiPA162393957.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INGA. Eukaryota.
ENOG410XQB9. LUCA.
GeneTreeiENSGT00530000063559.
HOVERGENiHBG108087.
InParanoidiQ9UPQ0.
OrthoDBiEOG79SDWD.
PhylomeDBiQ9UPQ0.
TreeFamiTF332155.

Miscellaneous databases

ChiTaRSiLIMCH1. human.
GeneWikiiLIMCH1.
GenomeRNAii22998.
PROiQ9UPQ0.

Gene expression databases

BgeeiQ9UPQ0.
CleanExiHS_LIMCH1.
ExpressionAtlasiQ9UPQ0. baseline and differential.
GenevisibleiQ9UPQ0. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
2.10.110.10. 1 hit.
InterProiIPR001997. Calponin/LIMCH1.
IPR001715. CH-domain.
IPR031865. DUF4757.
IPR029980. LIMCH1.
IPR003096. SM22_calponin.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR15551:SF3. PTHR15551:SF3. 1 hit.
PfamiPF00307. CH. 1 hit.
PF15949. DUF4757. 1 hit.
PF00412. LIM. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
SM00132. LIM. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00478. LIM_DOMAIN_1. 1 hit.
PS50023. LIM_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-759.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4; 5; 6; 9 AND 10), VARIANT THR-759.
    Tissue: Endometrial adenocarcinoma, Fetal kidney, Retina, Salivary gland and Skeletal muscle.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 7 AND 8), VARIANT THR-759.
    Tissue: Brain, Muscle and Ovary.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-201 AND SER-718, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-718, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192; THR-215; SER-217; SER-231; SER-233; SER-377; SER-471; SER-516; THR-529; SER-718; SER-875 AND SER-973, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217; SER-233; SER-377; SER-516; SER-523; THR-537; SER-601; SER-718; THR-724; SER-875 AND SER-973, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-215; SER-217 AND SER-718, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; SER-192; SER-201; SER-204; SER-207; THR-215; SER-217; SER-231; SER-233; SER-297; SER-303; SER-377; THR-402; SER-471; SER-518; SER-523; SER-670; SER-681; SER-718; SER-875; SER-966 AND SER-973, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLIMC1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPQ0
Secondary accession number(s): A8MXC3
, E9PHM7, Q503B5, Q5CZB1, Q5CZB6, Q5H9S8, Q68E07, Q6PJ44, Q7Z3G5, Q8N3S9, Q8N6M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.