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Protein

Uncharacterized protein KIAA1107

Gene

KIAA1107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1107
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29192. KIAA1107.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671620.

Polymorphism and mutation databases

BioMutaiKIAA1107.
DMDMi172045554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206771 – 1409Uncharacterized protein KIAA1107Add BLAST1409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei891PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UPP5.
PeptideAtlasiQ9UPP5.
PRIDEiQ9UPP5.

PTM databases

iPTMnetiQ9UPP5.
PhosphoSitePlusiQ9UPP5.

Expressioni

Gene expression databases

BgeeiENSG00000069712.
CleanExiHS_KIAA1107.

Organism-specific databases

HPAiHPA024216.
HPA027327.

Interactioni

Protein-protein interaction databases

BioGridi116883. 22 interactors.
IntActiQ9UPP5. 23 interactors.
MINTiMINT-7554975.
STRINGi9606.ENSP00000359404.

Structurei

3D structure databases

ProteinModelPortaliQ9UPP5.
SMRiQ9UPP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFU8. Eukaryota.
ENOG4111MST. LUCA.
HOGENOMiHOG000168280.
HOVERGENiHBG108026.
InParanoidiQ9UPP5.
PhylomeDBiQ9UPP5.

Family and domain databases

InterProiIPR027907. DUF4596.
[Graphical view]
PfamiPF15363. DUF4596. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESDRLIISL PRVKWTEAAL TMASQLQEKC IAFIVDNFSK IIQSENFALL
60 70 80 90 100
LQSQAMSSTA DLLDTILKAI EENITTENSC SLLMALDTLL NSDSTKEMGF
110 120 130 140 150
TCKIQALRDK LWIFLVQSFY AVRHTESWKL MSTDDQQKIQ AAAFDKGDDR
160 170 180 190 200
RLGKKPIFSS SQQRKQVSDS GDIKIKSWRG NNKKECWSYL STNKKMKSDG
210 220 230 240 250
LGASGHSSST NRNSINKTLK QDDVKEKDGT KIASKITKEL KTGGKNVSGK
260 270 280 290 300
PKTVTKSKTE NGDKARLENM SPRQVVERSA TAAAAATGQK NLLNGKGVRN
310 320 330 340 350
QEGQISGARP KVLTGNLNVQ AKAKPLKKAT GKDSPCLSIA GPSSRSTDSS
360 370 380 390 400
MEFSISTECL DEPKENGSTE EEKPSGHKLS FCDSPGQMMK NSVDSVKNST
410 420 430 440 450
VAIKSRPVSR VTNGTSNKKS IHEQDTNVNN SVLKKVSGKG CSEPVPQAIL
460 470 480 490 500
KKRGTSNGCT AAQQRTKSTP SNLTKTQGSQ GESPNSVKSS VSSRQSDENV
510 520 530 540 550
AKLDHNTTTE KQAPKRKMVK QVHTALPKVN AKIVAMPKNL NQSKKGETLN
560 570 580 590 600
NKDSKQKMPP GQVISKTQPS SQRPLKHETS TVQKSMFHDV RDNNNKDSVS
610 620 630 640 650
EQKPHKPLIN LASEISDAEA LQSSCRPDPQ KPLNDQEKEK LALECQNISK
660 670 680 690 700
LDKSLKHELE SKQICLDKSE TKFPNHKETD DCDAANICCH SVGSDNVNSK
710 720 730 740 750
FYSTTALKYM VSNPNENSLN SNPVCDLDST SAGQIHLISD RENQVGRKDT
760 770 780 790 800
NKQSSIKCVE DVSLCNPERT NGTLNSAQED KKSKVPVEGL TIPSKLSDES
810 820 830 840 850
AMDEDKHATA DSDVSSKCFS GQLSEKNSPK NMETSESPES HETPETPFVG
860 870 880 890 900
HWNLSTGVLH QRESPESDTG SATTSSDDIK PRSEDYDAGG SQDDDGSNDR
910 920 930 940 950
GISKCGTMLC HDFLGRSSSD TSTPEELKIY DSNLRIEVKM KKQSNNDLFQ
960 970 980 990 1000
VNSTSDDEIP RKRPEIWSRS AIVHSREREN IPRGSVQFAQ EIDQVSSSAD
1010 1020 1030 1040 1050
ETEDERSEAE NVAENFSISN PAPQQFQGII NLAFEDATEN ECREFSANKK
1060 1070 1080 1090 1100
FKRSVLLSVD ECEELGSDEG EVHTPFQASV DSFSPSDVFD GISHEHHGRT
1110 1120 1130 1140 1150
CYSRFSRESE DNILECKQNK GNSVCKNEST VLDLSSIDSS RKNKQSVSAT
1160 1170 1180 1190 1200
EKKNTIDVLS SRSRQLLRED KKVNNGSNVE NDIQQRSKFL DSDVKSQERP
1210 1220 1230 1240 1250
CHLDLHQREP NSDIPKNSST KSLDSFRSQV LPQEGPVKES HSTTTEKANI
1260 1270 1280 1290 1300
ALSAGDIDDC DTLAQTRMYD HRPSKTLSPI YEMDVIEAFE QKVESETHVT
1310 1320 1330 1340 1350
DMDFEDDQHF AKQDWTLLKQ LLSEQDSNLD VTNSVPEDLS LAQYLINQTL
1360 1370 1380 1390 1400
LLARDSSKPQ GITHIDTLNR WSELTSPLDS SASITMASFS SEDCSPQGEW

TILELETQH
Length:1,409
Mass (Da):155,681
Last modified:February 26, 2008 - v2
Checksum:i6CC150E2EDE1861B
GO
Isoform 2 (identifier: Q9UPP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1259: DIDD → NVQK
     1260-1409: Missing.

Note: No experimental confirmation available.
Show »
Length:1,259
Mass (Da):138,601
Checksum:i10E0393711C281DF
GO

Sequence cautioni

The sequence AAC28132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1016F → L in AAH37317 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060300422H → R.Corresponds to variant rs2128647dbSNPEnsembl.1
Natural variantiVAR_060301442S → I.Corresponds to variant rs12084085dbSNPEnsembl.1
Natural variantiVAR_060302522V → L.Corresponds to variant rs7552286dbSNPEnsembl.1
Natural variantiVAR_060303602Q → R.Corresponds to variant rs11166332dbSNPEnsembl.1
Natural variantiVAR_060304681D → G.Corresponds to variant rs7523466dbSNPEnsembl.1
Natural variantiVAR_060305715N → Y.Corresponds to variant rs7523552dbSNPEnsembl.1
Natural variantiVAR_060306826K → E.Corresponds to variant rs3738439dbSNPEnsembl.1
Natural variantiVAR_060307945N → S.Corresponds to variant rs560389dbSNPEnsembl.1
Natural variantiVAR_0603081048N → T.Corresponds to variant rs565156dbSNPEnsembl.1
Natural variantiVAR_0603091083F → V.Corresponds to variant rs17578364dbSNPEnsembl.1
Natural variantiVAR_0603101158V → I.Corresponds to variant rs566576dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317371256 – 1259DIDD → NVQK in isoform 2. 1 Publication4
Alternative sequenceiVSP_0317381260 – 1409Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA. No translation available.
AF017090 mRNA. Translation: AAC28132.1. Different initiation.
AB029030 mRNA. Translation: BAA83059.1.
BC037317 mRNA. Translation: AAH37317.2.
RefSeqiNP_056052.3. NM_015237.3.
UniGeneiHs.21554.

Genome annotation databases

EnsembliENST00000409154; ENSP00000386957; ENSG00000069712.
GeneIDi23285.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA. No translation available.
AF017090 mRNA. Translation: AAC28132.1. Different initiation.
AB029030 mRNA. Translation: BAA83059.1.
BC037317 mRNA. Translation: AAH37317.2.
RefSeqiNP_056052.3. NM_015237.3.
UniGeneiHs.21554.

3D structure databases

ProteinModelPortaliQ9UPP5.
SMRiQ9UPP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116883. 22 interactors.
IntActiQ9UPP5. 23 interactors.
MINTiMINT-7554975.
STRINGi9606.ENSP00000359404.

PTM databases

iPTMnetiQ9UPP5.
PhosphoSitePlusiQ9UPP5.

Polymorphism and mutation databases

BioMutaiKIAA1107.
DMDMi172045554.

Proteomic databases

PaxDbiQ9UPP5.
PeptideAtlasiQ9UPP5.
PRIDEiQ9UPP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409154; ENSP00000386957; ENSG00000069712.
GeneIDi23285.

Organism-specific databases

CTDi23285.
GeneCardsiKIAA1107.
HGNCiHGNC:29192. KIAA1107.
HPAiHPA024216.
HPA027327.
neXtProtiNX_Q9UPP5.
PharmGKBiPA142671620.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFU8. Eukaryota.
ENOG4111MST. LUCA.
HOGENOMiHOG000168280.
HOVERGENiHBG108026.
InParanoidiQ9UPP5.
PhylomeDBiQ9UPP5.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069712-MONOMER.

Miscellaneous databases

GenomeRNAii23285.
PROiQ9UPP5.

Gene expression databases

BgeeiENSG00000069712.
CleanExiHS_KIAA1107.

Family and domain databases

InterProiIPR027907. DUF4596.
[Graphical view]
PfamiPF15363. DUF4596. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1107_HUMAN
AccessioniPrimary (citable) accession number: Q9UPP5
Secondary accession number(s): O14767, Q8N3X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.