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UniProtKB - Q9UPP5 (K1107_HUMAN)

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Protein

Uncharacterized protein KIAA1107

Gene

KIAA1107

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1107
Gene namesi
Name:KIAA1107
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29192. KIAA1107.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671620.

Polymorphism and mutation databases

BioMutaiKIAA1107.
DMDMi172045554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206771 – 1409Uncharacterized protein KIAA1107Add BLAST1409

Proteomic databases

EPDiQ9UPP5.
PaxDbiQ9UPP5.
PeptideAtlasiQ9UPP5.
PRIDEiQ9UPP5.

PTM databases

iPTMnetiQ9UPP5.
PhosphoSitePlusiQ9UPP5.

Expressioni

Gene expression databases

CleanExiHS_KIAA1107.

Organism-specific databases

HPAiHPA024216.
HPA027327.

Interactioni

Protein-protein interaction databases

BioGridi116883. 22 interactors.
IntActiQ9UPP5. 23 interactors.
MINTiMINT-7554975.

Structurei

3D structure databases

SMRiQ9UPP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFU8. Eukaryota.
ENOG4111MST. LUCA.
HOGENOMiHOG000168280.
HOVERGENiHBG108026.
InParanoidiQ9UPP5.
PhylomeDBiQ9UPP5.

Family and domain databases

InterProiView protein in InterPro
IPR027907. DUF4596.
PfamiView protein in Pfam
PF15363. DUF4596. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPP5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESDRLIISL PRVKWTEAAL TMASQLQEKC IAFIVDNFSK IIQSENFALL 
        60         70         80         90        100
LQSQAMSSTA DLLDTILKAI EENITTENSC SLLMALDTLL NSDSTKEMGF 
       110        120        130        140        150
TCKIQALRDK LWIFLVQSFY AVRHTESWKL MSTDDQQKIQ AAAFDKGDDR 
       160        170        180        190        200
RLGKKPIFSS SQQRKQVSDS GDIKIKSWRG NNKKECWSYL STNKKMKSDG 
       210        220        230        240        250
LGASGHSSST NRNSINKTLK QDDVKEKDGT KIASKITKEL KTGGKNVSGK 
       260        270        280        290        300
PKTVTKSKTE NGDKARLENM SPRQVVERSA TAAAAATGQK NLLNGKGVRN 
       310        320        330        340        350
QEGQISGARP KVLTGNLNVQ AKAKPLKKAT GKDSPCLSIA GPSSRSTDSS 
       360        370        380        390        400
MEFSISTECL DEPKENGSTE EEKPSGHKLS FCDSPGQMMK NSVDSVKNST 
       410        420        430        440        450
VAIKSRPVSR VTNGTSNKKS IHEQDTNVNN SVLKKVSGKG CSEPVPQAIL 
       460        470        480        490        500
KKRGTSNGCT AAQQRTKSTP SNLTKTQGSQ GESPNSVKSS VSSRQSDENV 
       510        520        530        540        550
AKLDHNTTTE KQAPKRKMVK QVHTALPKVN AKIVAMPKNL NQSKKGETLN 
       560        570        580        590        600
NKDSKQKMPP GQVISKTQPS SQRPLKHETS TVQKSMFHDV RDNNNKDSVS 
       610        620        630        640        650
EQKPHKPLIN LASEISDAEA LQSSCRPDPQ KPLNDQEKEK LALECQNISK 
       660        670        680        690        700
LDKSLKHELE SKQICLDKSE TKFPNHKETD DCDAANICCH SVGSDNVNSK 
       710        720        730        740        750
FYSTTALKYM VSNPNENSLN SNPVCDLDST SAGQIHLISD RENQVGRKDT 
       760        770        780        790        800
NKQSSIKCVE DVSLCNPERT NGTLNSAQED KKSKVPVEGL TIPSKLSDES 
       810        820        830        840        850
AMDEDKHATA DSDVSSKCFS GQLSEKNSPK NMETSESPES HETPETPFVG 
       860        870        880        890        900
HWNLSTGVLH QRESPESDTG SATTSSDDIK PRSEDYDAGG SQDDDGSNDR 
       910        920        930        940        950
GISKCGTMLC HDFLGRSSSD TSTPEELKIY DSNLRIEVKM KKQSNNDLFQ 
       960        970        980        990       1000
VNSTSDDEIP RKRPEIWSRS AIVHSREREN IPRGSVQFAQ EIDQVSSSAD 
      1010       1020       1030       1040       1050
ETEDERSEAE NVAENFSISN PAPQQFQGII NLAFEDATEN ECREFSANKK 
      1060       1070       1080       1090       1100
FKRSVLLSVD ECEELGSDEG EVHTPFQASV DSFSPSDVFD GISHEHHGRT 
      1110       1120       1130       1140       1150
CYSRFSRESE DNILECKQNK GNSVCKNEST VLDLSSIDSS RKNKQSVSAT 
      1160       1170       1180       1190       1200
EKKNTIDVLS SRSRQLLRED KKVNNGSNVE NDIQQRSKFL DSDVKSQERP 
      1210       1220       1230       1240       1250
CHLDLHQREP NSDIPKNSST KSLDSFRSQV LPQEGPVKES HSTTTEKANI 
      1260       1270       1280       1290       1300
ALSAGDIDDC DTLAQTRMYD HRPSKTLSPI YEMDVIEAFE QKVESETHVT 
      1310       1320       1330       1340       1350
DMDFEDDQHF AKQDWTLLKQ LLSEQDSNLD VTNSVPEDLS LAQYLINQTL 
      1360       1370       1380       1390       1400
LLARDSSKPQ GITHIDTLNR WSELTSPLDS SASITMASFS SEDCSPQGEW 

TILELETQH
Length:1,409
Mass (Da):155,681
Last modified:February 26, 2008 - v2
Checksum:i6CC150E2EDE1861B
GO
Isoform 2 (identifier: Q9UPP5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1256-1259: DIDD → NVQK
     1260-1409: Missing.

Note: No experimental confirmation available.
Show »
Length:1,259
Mass (Da):138,601
Checksum:i10E0393711C281DF
GO

Sequence cautioni

The sequence AAC28132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1016F → L in AAH37317 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060300422H → R. Corresponds to variant dbSNP:rs2128647Ensembl.1
Natural variantiVAR_060301442S → I. Corresponds to variant dbSNP:rs12084085Ensembl.1
Natural variantiVAR_060302522V → L. Corresponds to variant dbSNP:rs7552286Ensembl.1
Natural variantiVAR_060303602Q → R. Corresponds to variant dbSNP:rs11166332Ensembl.1
Natural variantiVAR_060304681D → G. Corresponds to variant dbSNP:rs7523466Ensembl.1
Natural variantiVAR_060305715N → Y. Corresponds to variant dbSNP:rs7523552Ensembl.1
Natural variantiVAR_060306826K → E. Corresponds to variant dbSNP:rs3738439Ensembl.1
Natural variantiVAR_060307945N → S. Corresponds to variant dbSNP:rs560389Ensembl.1
Natural variantiVAR_0603081048N → T. Corresponds to variant dbSNP:rs565156Ensembl.1
Natural variantiVAR_0603091083F → V. Corresponds to variant dbSNP:rs17578364Ensembl.1
Natural variantiVAR_0603101158V → I. Corresponds to variant dbSNP:rs566576Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317371256 – 1259DIDD → NVQK in isoform 2. 1 Publication4
Alternative sequenceiVSP_0317381260 – 1409Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104836 Genomic DNA. No translation available.
AF017090 mRNA. Translation: AAC28132.1. Different initiation.
AB029030 mRNA. Translation: BAA83059.1.
BC037317 mRNA. Translation: AAH37317.2.
RefSeqiNP_056052.3. NM_015237.3.
UniGeneiHs.21554.

Genome annotation databases

EnsembliENST00000409154; ENSP00000386957; ENSG00000069712.
GeneIDi23285.
KEGGihsa:23285.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK1107_HUMAN
AccessioniPrimary (citable) accession number: Q9UPP5
Secondary accession number(s): O14767, Q8N3X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations