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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 1

Gene

PPP6R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

GO - Molecular functioni

  • protein phosphatase binding Source: MGI
  • Rho GTPase binding Source: UniProtKB

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 1
Alternative name(s):
SAPS domain family member 1
Gene namesi
Name:PPP6R1
Synonyms:KIAA1115, PP6R1, SAPS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105063.18
HGNCiHGNC:29195 PPP6R1
MIMi610875 gene
neXtProtiNX_Q9UPN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105063
PharmGKBiPA165394108

Polymorphism and mutation databases

BioMutaiPPP6R1
DMDMi261260102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000460961 – 881Serine/threonine-protein phosphatase 6 regulatory subunit 1Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei524PhosphothreonineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei726PhosphoserineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei846PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPN7
MaxQBiQ9UPN7
PaxDbiQ9UPN7
PeptideAtlasiQ9UPN7
PRIDEiQ9UPN7

PTM databases

iPTMnetiQ9UPN7
PhosphoSitePlusiQ9UPN7

Miscellaneous databases

PMAP-CutDBiQ9UPN7

Expressioni

Tissue specificityi

Ubiquitous with higher expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000105063
CleanExiHS_SAPS1
ExpressionAtlasiQ9UPN7 baseline and differential
GenevisibleiQ9UPN7 HS

Organism-specific databases

HPAiHPA043989
HPA063681

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein phosphatase binding Source: MGI
  • Rho GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116537, 66 interactors
CORUMiQ9UPN7
DIPiDIP-27589N
IntActiQ9UPN7, 58 interactors
MINTiQ9UPN7
STRINGi9606.ENSP00000414202

Structurei

3D structure databases

ProteinModelPortaliQ9UPN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 403Interaction with PPP6CAdd BLAST394

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi624 – 685Glu-richAdd BLAST62
Compositional biasi624 – 631Poly-Glu8
Compositional biasi671 – 685Poly-GluAdd BLAST15
Compositional biasi697 – 878Pro-richAdd BLAST182

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiQ9UPN7
KOiK15499
OMAiCFHQLLL
OrthoDBiEOG091G0893
PhylomeDBiQ9UPN7
TreeFamiTF313227

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 5 hits

Sequencei

Sequence statusi: Complete.

Q9UPN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWKFDLHTS SHLDTLLERE DLSLPELLDE EDVLQECKVV NRKLLDFLLQ
60 70 80 90 100
PPHLQAMVAW VTQEPPDSGE ERLRYKYPSV ACEILTSDVP QINDALGADE
110 120 130 140 150
SLLNRLYGFL QSTGSLNPLL ASFFSKVMGI LINRKTDQLV SFLRKKDDFV
160 170 180 190 200
DLLLQHIGTS AIMDLLLRLL TCVERPQLRQ DVVNWLNEEK IVQRLIEQIH
210 220 230 240 250
PSKDENQHSN ASQSLCDIIR LSREQMIQVQ DSPEPDQLLA TLEKQETIEQ
260 270 280 290 300
LLSNMFEGEQ SQSVIVSGIQ VLLTLLEPRR PRSESVTVNS FFSSVDGQLE
310 320 330 340 350
LLAQGALEST VSSVGALHAL RPRLSCFHQL LLEPPKLEPL QMTWGMLAPP
360 370 380 390 400
LGNTRLHVVK LLASALSAND AALTHELLAL DVPNTMLDLF FHYVFNNFLH
410 420 430 440 450
AQVEGCVSTM LSLGPPPDSS PETPIQNPVV KHLLQQCRLV ERILTSWEEN
460 470 480 490 500
DRVQCAGGPR KGYMGHLTRV AGALVQNTEK GPNAEQLRQL LKELPSEQQE
510 520 530 540 550
QWEAFVSGPL AETNKKNMVD LVNTHHLHSS SDDEDDRLKE FNFPEEAVLQ
560 570 580 590 600
QAFMDFQMQR MTSAFIDHFG FNDEEFGEQE ESVNAPFDKT ANITFSLNAD
610 620 630 640 650
DENPNANLLE ICYKDRIQQF DDDEEEEDEE EAQGSGESDG EDGAWQGSQL
660 670 680 690 700
ARGARLGQPP GVRSGGSTDS EDEEEEDEEE EEDEEGIGCA ARGGATPLSY
710 720 730 740 750
PSPGPQPPGP SWTATFDPVP TDAPTSPRVS GEEELHTGPP APQGPLSVPQ
760 770 780 790 800
GLPTQSLASP PARDALQLRS QDPTPPSAPQ EATEGSKVTE PSAPCQALVS
810 820 830 840 850
IGDLQATFHG IRSAPSSSDS ATRDPSTSVP ASGAHQPPQT TEGEKSPEPL
860 870 880
GLPQSQSAQA LTPPPIPNGS APEGPASPGS Q
Length:881
Mass (Da):96,724
Last modified:October 13, 2009 - v5
Checksum:i36DDA2E945ED599A
GO

Sequence cautioni

The sequence BAA83067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029038 mRNA Translation: BAA83067.3 Different initiation.
BC002799 mRNA Translation: AAH02799.2
BC068014 mRNA Translation: AAH68014.1
BC094753 mRNA Translation: AAH94753.2
CCDSiCCDS46186.1
RefSeqiNP_055746.3, NM_014931.3
UniGeneiHs.515610

Genome annotation databases

EnsembliENST00000412770; ENSP00000414202; ENSG00000105063
ENST00000587283; ENSP00000467521; ENSG00000105063
GeneIDi22870
KEGGihsa:22870
UCSCiuc002qjw.5 human

Similar proteinsi

Entry informationi

Entry nameiPP6R1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPN7
Secondary accession number(s): Q2M2H3
, Q504V2, Q6NVJ6, Q9BU97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 13, 2009
Last modified: April 25, 2018
This is version 149 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health