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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 1

Gene

PPP6R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

GO - Molecular functioni

  • protein phosphatase binding Source: MGI

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 1
Alternative name(s):
SAPS domain family member 1
Gene namesi
Name:PPP6R1
Synonyms:KIAA1115, PP6R1, SAPS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29195. PPP6R1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394108.

Polymorphism and mutation databases

BioMutaiPPP6R1.
DMDMi261260102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Serine/threonine-protein phosphatase 6 regulatory subunit 1PRO_0000046096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei232 – 2321PhosphoserineBy similarity
Modified residuei524 – 5241PhosphothreonineCombined sources
Modified residuei529 – 5291PhosphoserineCombined sources
Modified residuei530 – 5301PhosphoserineCombined sources
Modified residuei531 – 5311PhosphoserineCombined sources
Modified residuei635 – 6351PhosphoserineCombined sources
Modified residuei638 – 6381PhosphoserineCombined sources
Modified residuei702 – 7021PhosphoserineCombined sources
Modified residuei726 – 7261PhosphoserineCombined sources
Modified residuei759 – 7591PhosphoserineCombined sources
Modified residuei846 – 8461PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPN7.
MaxQBiQ9UPN7.
PaxDbiQ9UPN7.
PeptideAtlasiQ9UPN7.
PRIDEiQ9UPN7.

PTM databases

iPTMnetiQ9UPN7.
PhosphoSiteiQ9UPN7.

Miscellaneous databases

PMAP-CutDBQ9UPN7.

Expressioni

Tissue specificityi

Ubiquitous with higher expression in testis.1 Publication

Gene expression databases

BgeeiENSG00000105063.
CleanExiHS_SAPS1.
ExpressionAtlasiQ9UPN7. baseline and differential.
GenevisibleiQ9UPN7. HS.

Organism-specific databases

HPAiHPA043989.
HPA063681.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ANKRD28O1508410EBI-359745,EBI-359567
ANKRD44Q8N8A24EBI-359745,EBI-1245329
ANKRD52Q8NB464EBI-359745,EBI-1996119
NFKBIEO002212EBI-359745,EBI-355098
PPP6CO0074311EBI-359745,EBI-359751

GO - Molecular functioni

  • protein phosphatase binding Source: MGI

Protein-protein interaction databases

BioGridi116537. 62 interactions.
DIPiDIP-27589N.
IntActiQ9UPN7. 47 interactions.
MINTiMINT-1154650.
STRINGi9606.ENSP00000414202.

Structurei

3D structure databases

ProteinModelPortaliQ9UPN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 403394Interaction with PPP6CAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi624 – 68562Glu-richAdd
BLAST
Compositional biasi624 – 6318Poly-Glu
Compositional biasi671 – 68515Poly-GluAdd
BLAST
Compositional biasi697 – 878182Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiQ9UPN7.
KOiK15499.
OMAiCFHQLLL.
OrthoDBiEOG091G0893.
PhylomeDBiQ9UPN7.
TreeFamiTF313227.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequencei

Sequence statusi: Complete.

Q9UPN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWKFDLHTS SHLDTLLERE DLSLPELLDE EDVLQECKVV NRKLLDFLLQ
60 70 80 90 100
PPHLQAMVAW VTQEPPDSGE ERLRYKYPSV ACEILTSDVP QINDALGADE
110 120 130 140 150
SLLNRLYGFL QSTGSLNPLL ASFFSKVMGI LINRKTDQLV SFLRKKDDFV
160 170 180 190 200
DLLLQHIGTS AIMDLLLRLL TCVERPQLRQ DVVNWLNEEK IVQRLIEQIH
210 220 230 240 250
PSKDENQHSN ASQSLCDIIR LSREQMIQVQ DSPEPDQLLA TLEKQETIEQ
260 270 280 290 300
LLSNMFEGEQ SQSVIVSGIQ VLLTLLEPRR PRSESVTVNS FFSSVDGQLE
310 320 330 340 350
LLAQGALEST VSSVGALHAL RPRLSCFHQL LLEPPKLEPL QMTWGMLAPP
360 370 380 390 400
LGNTRLHVVK LLASALSAND AALTHELLAL DVPNTMLDLF FHYVFNNFLH
410 420 430 440 450
AQVEGCVSTM LSLGPPPDSS PETPIQNPVV KHLLQQCRLV ERILTSWEEN
460 470 480 490 500
DRVQCAGGPR KGYMGHLTRV AGALVQNTEK GPNAEQLRQL LKELPSEQQE
510 520 530 540 550
QWEAFVSGPL AETNKKNMVD LVNTHHLHSS SDDEDDRLKE FNFPEEAVLQ
560 570 580 590 600
QAFMDFQMQR MTSAFIDHFG FNDEEFGEQE ESVNAPFDKT ANITFSLNAD
610 620 630 640 650
DENPNANLLE ICYKDRIQQF DDDEEEEDEE EAQGSGESDG EDGAWQGSQL
660 670 680 690 700
ARGARLGQPP GVRSGGSTDS EDEEEEDEEE EEDEEGIGCA ARGGATPLSY
710 720 730 740 750
PSPGPQPPGP SWTATFDPVP TDAPTSPRVS GEEELHTGPP APQGPLSVPQ
760 770 780 790 800
GLPTQSLASP PARDALQLRS QDPTPPSAPQ EATEGSKVTE PSAPCQALVS
810 820 830 840 850
IGDLQATFHG IRSAPSSSDS ATRDPSTSVP ASGAHQPPQT TEGEKSPEPL
860 870 880
GLPQSQSAQA LTPPPIPNGS APEGPASPGS Q
Length:881
Mass (Da):96,724
Last modified:October 13, 2009 - v5
Checksum:i36DDA2E945ED599A
GO

Sequence cautioni

The sequence BAA83067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029038 mRNA. Translation: BAA83067.3. Different initiation.
BC002799 mRNA. Translation: AAH02799.2.
BC068014 mRNA. Translation: AAH68014.1.
BC094753 mRNA. Translation: AAH94753.2.
CCDSiCCDS46186.1.
RefSeqiNP_055746.3. NM_014931.3.
UniGeneiHs.515610.

Genome annotation databases

EnsembliENST00000412770; ENSP00000414202; ENSG00000105063.
ENST00000587283; ENSP00000467521; ENSG00000105063.
GeneIDi22870.
KEGGihsa:22870.
UCSCiuc002qjw.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029038 mRNA. Translation: BAA83067.3. Different initiation.
BC002799 mRNA. Translation: AAH02799.2.
BC068014 mRNA. Translation: AAH68014.1.
BC094753 mRNA. Translation: AAH94753.2.
CCDSiCCDS46186.1.
RefSeqiNP_055746.3. NM_014931.3.
UniGeneiHs.515610.

3D structure databases

ProteinModelPortaliQ9UPN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116537. 62 interactions.
DIPiDIP-27589N.
IntActiQ9UPN7. 47 interactions.
MINTiMINT-1154650.
STRINGi9606.ENSP00000414202.

PTM databases

iPTMnetiQ9UPN7.
PhosphoSiteiQ9UPN7.

Polymorphism and mutation databases

BioMutaiPPP6R1.
DMDMi261260102.

Proteomic databases

EPDiQ9UPN7.
MaxQBiQ9UPN7.
PaxDbiQ9UPN7.
PeptideAtlasiQ9UPN7.
PRIDEiQ9UPN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412770; ENSP00000414202; ENSG00000105063.
ENST00000587283; ENSP00000467521; ENSG00000105063.
GeneIDi22870.
KEGGihsa:22870.
UCSCiuc002qjw.5. human.

Organism-specific databases

CTDi22870.
GeneCardsiPPP6R1.
HGNCiHGNC:29195. PPP6R1.
HPAiHPA043989.
HPA063681.
MIMi610875. gene.
neXtProtiNX_Q9UPN7.
PharmGKBiPA165394108.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2073. Eukaryota.
ENOG410XRM1. LUCA.
GeneTreeiENSGT00390000009899.
HOVERGENiHBG069733.
InParanoidiQ9UPN7.
KOiK15499.
OMAiCFHQLLL.
OrthoDBiEOG091G0893.
PhylomeDBiQ9UPN7.
TreeFamiTF313227.

Enzyme and pathway databases

ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

ChiTaRSiPPP6R1. human.
GenomeRNAii22870.
PMAP-CutDBQ9UPN7.
PROiQ9UPN7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105063.
CleanExiHS_SAPS1.
ExpressionAtlasiQ9UPN7. baseline and differential.
GenevisibleiQ9UPN7. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007587. SAPS.
[Graphical view]
PANTHERiPTHR12634. PTHR12634. 1 hit.
PfamiPF04499. SAPS. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPP6R1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPN7
Secondary accession number(s): Q2M2H3
, Q504V2, Q6NVJ6, Q9BU97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 139 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.