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Q9UPN3

- MACF1_HUMAN

UniProt

Q9UPN3 - MACF1_HUMAN

Protein

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 4 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi7054 – 7065121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi7090 – 7101122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. actin filament binding Source: UniProtKB
    3. ATPase activity Source: UniProtKB
    4. calcium ion binding Source: InterPro
    5. poly(A) RNA binding Source: UniProtKB
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. cell cycle arrest Source: InterPro
    3. cellular component movement Source: Ensembl
    4. establishment or maintenance of cell polarity Source: Ensembl
    5. Golgi to plasma membrane protein transport Source: UniProtKB
    6. mesoderm formation Source: Ensembl
    7. positive regulation of Wnt signaling pathway Source: UniProtKB
    8. posttranslational protein targeting to membrane Source: Ensembl
    9. regulation of epithelial cell migration Source: UniProtKB
    10. regulation of focal adhesion assembly Source: UniProtKB
    11. regulation of microtubule-based process Source: UniProtKB
    12. Wnt signaling pathway Source: UniProtKB-KW
    13. wound healing Source: UniProtKB

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Enzyme and pathway databases

    SignaLinkiQ9UPN3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
    Alternative name(s):
    620 kDa actin-binding protein
    Short name:
    ABP620
    Actin cross-linking family protein 7
    Macrophin-1
    Trabeculin-alpha
    Gene namesi
    Name:MACF1
    Synonyms:ABP620, ACF7, KIAA0465, KIAA1251
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13664. MACF1.

    Subcellular locationi

    Isoform 2 : Cytoplasmcytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projectionruffle membrane
    Note: The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules By similarity. Localizes to the tips of microtubules. APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization.By similarity
    Isoform 1 : Cytoplasm. Golgi apparatus
    Note: Localizes to the tips of microtubules.

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: UniProtKB
    4. Golgi apparatus Source: UniProtKB
    5. microtubule Source: UniProtKB
    6. plasma membrane Source: UniProtKB
    7. ruffle membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30518.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 73887388Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5PRO_0000073449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei280 – 2801Phosphoserine2 Publications
    Modified residuei1376 – 13761Phosphoserine4 Publications
    Modified residuei3122 – 31221PhosphoserineBy similarity
    Modified residuei3927 – 39271Phosphoserine3 Publications
    Modified residuei4495 – 44951Phosphoserine1 Publication
    Modified residuei4496 – 44961Phosphoserine2 Publications
    Modified residuei4521 – 45211Phosphoserine4 Publications
    Modified residuei4962 – 49621Phosphoserine1 Publication
    Modified residuei6210 – 62101N6-acetyllysine1 Publication
    Modified residuei6967 – 69671Phosphoserine1 Publication
    Modified residuei7254 – 72541Phosphothreonine1 Publication
    Modified residuei7292 – 72921Phosphoserine1 Publication
    Modified residuei7330 – 73301Phosphoserine2 Publications
    Modified residuei7333 – 73331PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UPN3.
    PaxDbiQ9UPN3.
    PRIDEiQ9UPN3.

    PTM databases

    PhosphoSiteiQ9UPN3.

    Expressioni

    Tissue specificityi

    Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4 is expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle.2 Publications

    Gene expression databases

    ArrayExpressiQ9UPN3.
    BgeeiQ9UPN3.
    CleanExiHS_MACF1.
    GenevestigatoriQ9UPN3.

    Organism-specific databases

    HPAiHPA013713.

    Interactioni

    Subunit structurei

    Isoform 2 interacts with MAPRE1, CLASP1, CLASP2, AXIN1 and LRP6 By similarity. Isoform 2 is found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B By similarity. Isoform 2 interacts with GOLGA4.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DISC1Q9NRI55EBI-522925,EBI-529989

    Protein-protein interaction databases

    BioGridi117048. 36 interactions.
    DIPiDIP-50616N.
    IntActiQ9UPN3. 26 interactions.
    MINTiMINT-1195815.
    STRINGi9606.ENSP00000289893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPN3.
    SMRiQ9UPN3. Positions 69-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 295295Actin-bindingAdd
    BLAST
    Domaini78 – 181104CH 1PROSITE-ProRule annotationAdd
    BLAST
    Repeati148 – 17124LRR 1Add
    BLAST
    Domaini194 – 295102CH 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati240 – 26425LRR 2Add
    BLAST
    Repeati377 – 39923LRR 3Add
    BLAST
    Repeati441 – 46424LRR 4Add
    BLAST
    Domaini871 – 92353SH3Add
    BLAST
    Repeati1050 – 107324LRR 5Add
    BLAST
    Repeati1128 – 115427LRR 6Add
    BLAST
    Repeati1187 – 121024LRR 7Add
    BLAST
    Repeati1257 – 128226LRR 8Add
    BLAST
    Repeati1577 – 162145Plectin 1Add
    BLAST
    Repeati1654 – 169643Plectin 2Add
    BLAST
    Repeati1769 – 180941Plectin 3Add
    BLAST
    Repeati1811 – 184838Plectin 4Add
    BLAST
    Repeati1855 – 188632Plectin 5Add
    BLAST
    Repeati2290 – 233243Plectin 6Add
    BLAST
    Repeati2367 – 241044Plectin 7Add
    BLAST
    Repeati2411 – 243727Plectin 8Add
    BLAST
    Repeati2501 – 254343Plectin 9Add
    BLAST
    Repeati2581 – 261232Plectin 10Add
    BLAST
    Repeati2686 – 273045Plectin 11Add
    BLAST
    Repeati3239 – 326224LRR 9Add
    BLAST
    Repeati3264 – 328320LRR 10Add
    BLAST
    Repeati3646 – 366924LRR 11Add
    BLAST
    Repeati3696 – 372025LRR 12Add
    BLAST
    Repeati3883 – 395775Spectrin 1Add
    BLAST
    Repeati3936 – 395823LRR 13Add
    BLAST
    Repeati4000 – 4108109Spectrin 2Add
    BLAST
    Repeati4125 – 415026LRR 14Add
    BLAST
    Repeati4261 – 428727LRR 15Add
    BLAST
    Repeati4466 – 4574109Spectrin 3Add
    BLAST
    Repeati4511 – 453424LRR 16Add
    BLAST
    Repeati4601 – 462424LRR 17Add
    BLAST
    Repeati4769 – 479224LRR 18Add
    BLAST
    Repeati4800 – 4904105Spectrin 4Add
    BLAST
    Repeati4909 – 5012104Spectrin 5Add
    BLAST
    Repeati5051 – 507626LRR 19Add
    BLAST
    Repeati5172 – 519423LRR 20Add
    BLAST
    Repeati5236 – 5341106Spectrin 6Add
    BLAST
    Repeati5281 – 530424LRR 21Add
    BLAST
    Repeati5348 – 5450103Spectrin 7Add
    BLAST
    Repeati5455 – 5557103Spectrin 8Add
    BLAST
    Repeati5695 – 571925LRR 22Add
    BLAST
    Repeati5783 – 5885103Spectrin 9Add
    BLAST
    Repeati5804 – 582825LRR 23Add
    BLAST
    Repeati6005 – 6110106Spectrin 10Add
    BLAST
    Repeati6115 – 6219105Spectrin 11Add
    BLAST
    Repeati6225 – 6328104Spectrin 12Add
    BLAST
    Repeati6333 – 6439107Spectrin 13Add
    BLAST
    Repeati6443 – 6547105Spectrin 14Add
    BLAST
    Repeati6496 – 651924LRR 24Add
    BLAST
    Repeati6552 – 6658107Spectrin 15Add
    BLAST
    Repeati6665 – 6766102Spectrin 16Add
    BLAST
    Repeati6771 – 6874104Spectrin 17Add
    BLAST
    Domaini7041 – 707636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini7077 – 711236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini7117 – 718973GARPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7117 – 7388272C-terminal tailBy similarityAdd
    BLAST
    Regioni7313 – 7328164 X 4 AA tandem repeats of [GS]-S-R-[AR]Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi698 – 7036Poly-Glu
    Compositional biasi1122 – 11276Poly-Ser
    Compositional biasi1414 – 14174Poly-Glu
    Compositional biasi1986 – 19894Poly-Leu
    Compositional biasi7222 – 7351130Ser-richAdd
    BLAST

    Domaini

    The C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding.By similarity

    Sequence similaritiesi

    Belongs to the plakin or cytolinker family.Curated
    Contains 1 actin-binding domain.Curated
    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 GAR domain.PROSITE-ProRule annotation
    Contains 24 LRR (leucine-rich) repeats.Curated
    Contains 11 plectin repeats.Curated
    Contains 1 SH3 domain.Curated
    Contains 17 spectrin repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000049054.
    HOVERGENiHBG031127.
    PhylomeDBiQ9UPN3.
    TreeFamiTF335163.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.418.10. 2 hits.
    3.30.920.20. 1 hit.
    3.90.1290.10. 5 hits.
    InterProiIPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR003108. GAS2_dom.
    IPR028408. Macf1.
    IPR001101. Plectin_repeat.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view]
    PANTHERiPTHR11915:SF37. PTHR11915:SF37. 1 hit.
    PfamiPF00307. CH. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    PF02187. GAS2. 1 hit.
    PF00681. Plectin. 11 hits.
    PF00435. Spectrin. 17 hits.
    [Graphical view]
    SMARTiSM00033. CH. 2 hits.
    SM00054. EFh. 2 hits.
    SM00243. GAS2. 1 hit.
    SM00250. PLEC. 20 hits.
    SM00150. SPEC. 33 hits.
    [Graphical view]
    SUPFAMiSSF143575. SSF143575. 1 hit.
    SSF47576. SSF47576. 1 hit.
    SSF75399. SSF75399. 6 hits.
    PROSITEiPS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS51460. GAR. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPN3-1) [UniParc]FASTAAdd to Basket

    Also known as: Macf1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH     50
    EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN 100
    DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ 150
    VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL 200
    LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS 250
    NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 300
    PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK 350
    ALYNQYIHFK ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND 400
    VEEEWGKLII EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA 450
    KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDENYY 500
    QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP STLTTTHLKA 550
    EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ 600
    MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF 650
    HTSYAETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE 700
    EEELAYDWSD NNSNISAKRN YFSELTMELE EKQDVFRSLQ DTAELLSLEN 750
    HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENTAYFQ FFSDARELES 800
    FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG 850
    RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR 900
    TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL 950
    HVNTKSLISW NYLRKDLDLV QTWNLEKLRS SAPGECHQIM KNLQAHYEDF 1000
    LQDSRDSVLF SVADRLRLEE EVEACKARFQ HLMKSMENED KEETVAKMYI 1050
    SELKNIRLRL EEYEQRVVKR IQSLASSRTD RDAWQDNALR IAEQEHTQED 1100
    LQQLRSDLDA VSMKCDSFLH QSPSSSSVPT LRSELNLLVE KMDHVYGLST 1150
    VYLNKLKTVD VIVRSIQDAE LLVKGYEIKL SQEEVVLADL SALEAHWSTL 1200
    RHWLSDVKDK NSVFSVLDEE IAKAKVVAEQ MSRLTPERNL DLERYQEKGS 1250
    QLQERWHRVI AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM 1300
    MKPGQAEDSR VLSEQLSQQT ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY 1350
    ELQLMTYKAF VESQQKSPGK RRRMLSSSDA ITQEFMDLRT RYTALVTLTT 1400
    QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST LARNTQGKAT 1450
    SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS 1500
    EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKECRAVAG 1550
    VIDLGTVEIF PIFKAMQKGL LDQDTGLVLL ESQVIMSGLI APETGENLSL 1600
    EEGIARNLIN PQMYQQLREL QDALALISRL TESRGPLSVV EAIEKRIISE 1650
    TVGLKILEAH LATGGFSLSP SENCINLEEA FHQGLISAWL HSVLESYLRT 1700
    SKNLIDPNTA EKIGLLDLMQ RCIVHQESGF KLLPVKQLAG GMVSLKSGRK 1750
    VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI 1800
    DQDMACAILI RQLQTGGIID TVTGQRLTID EAVSNDLVAA KIALVILESL 1850
    WSFMGLLWPE SGEILPITDA LEQGIVSTEL AHKILSNRQH IKALFLPATT 1900
    EILSWKKAIE SGILDRDLAN NLKSICIPDV MPHMQLADSA EQNINPGAAV 1950
    LPCSKSHPKA TASQSENLLF QLMTHSYINV QNGQRLLLLD KELMETLTSR 2000
    DEYQTSPPKV VEIGHQRQKT PEGLQESANV KISGTFSSGW TVRLPEFQFS 2050
    SQNKEYPDRE DCTTEKGKKT TVETEDSSVE NPEQDLFVEQ KERNPNIDAL 2100
    KVINKVKLEV QRQLIGTQRE DQTAVSVREN ASRGHLLTIP PAEAEGVPLV 2150
    VDKDVFSVET PKKEHQPLRN TSFTCQNEQA HTLETEYIHD ETGGSHIKPQ 2200
    SKKLQVQVKK TLGIKLELKS ETDGNVHPLD KKEMLKKTFL AKDDHKESQE 2250
    AQNIAGGSMM MSEKTDEEDS GREIFLSCSH PLELLEEATL NVLSAQLLDG 2300
    GIFHEQTGQK LLLNEAISRG IVPSHTAVKL MEKLNMFQGF FDSQTCESLT 2350
    TEEVINEGLM DEKLLHNVLM ADKAISGVLD PRTQTLCSVK DAVTVGLLDK 2400
    ETATRILERQ VVTGGIIDLK RGKKVSVTLA STLGLVDVAD QPELINLEKA 2450
    SKGRDAEKTV RERLISLQME TTGLIDPDSK APLTVVQSID RGLLEREEAV 2500
    RLLTKQVVDG GIIHHISGMR LSVDNAFRHG LIGEDLAEKL KRVENLNIHQ 2550
    IFNPETKENI SLPKAIKLDL ITSDLKREIQ EVQAFTGNFV DLISGQRLTL 2600
    AEAKKEGLLT NEAVLSPGMM HGIVDPENCR IVPYSELVKK CKIDIESGQR 2650
    YLEVIPFSDI KDGVSDKVLT LSQAIQLGKV DFASTLKVLE AQANTGGIID 2700
    TATGKRLTLA SALEEKLVDE NMVRIIASHQ VLNGGIVDIF SDQRVTLVEA 2750
    IEKRLISPEL ANMIQIDSSE FSDHRAQIEK QEGIEVCALQ NEFLGKDMLI 2800
    ACNQTAEMSC NKVEESERLF QVENQSAQEK VKVRVSDGEQ AKKSREISLK 2850
    EFGCKDQRKP RMSSDAKEFI SIINPHNLKG KSLGQVSLTH PYSECDFKLK 2900
    EVARNNMGND TNEEQEKAVT KIEIISHMKQ STSCLDSEEI RENQGEVILE 2950
    VQETYCETSG KLPSEQVLQQ PMNARVKSKR EKREVIVEES IRTCKPAFLS 3000
    EEKLYQETAI RDEHDSHIKS QPREMTSSEK GKEADTEMGF SITFKIEESS 3050
    SQVVPQGISV KHLDALTLFS SKQANEGKVN NLSLCLTLKP EENLSREIAC 3100
    GAQSEPFPCM TPRPEGLHYQ ESDGKAQVTG PSQISKTDKS FQGTTRQETN 3150
    YQDSWVTSKT KETKHQISSS NECKEKSYQE VSFDPARGLK LEEITVSRPD 3200
    SKEVRYLEFS DRKDLHHQGS KSDDKLCGTL KSEIATQELT GEKFLEMANP 3250
    NVAGLEAGSI EDIVTQRGSR VLGSFLPEKL FKGVSQKENT GQQNAIISPT 3300
    VLETSEEKTV SLTVCSAVKT EKTPQEKLRE SPGSEQTPFM TAPEGKGNGG 3350
    VNPEPFRATQ NVFTRQLCLE HDEKLVSYLS LLRNIEMRTK QIQPLELNLA 3400
    ELQDLLCQAK VLERELKDLT TLVSQELECV NQIIISQPQE VPAQLLKALE 3450
    KDAKNLQKSL SSVSDTWNSR LLHFQNAVEI EKTKVLNQHT QLEGRLQDLR 3500
    AWVGNKNLIL NSKGSNSEID VDSLNLCLQQ YEDLKQPMAE RKAQLDALAF 3550
    DIQFFISEHA QDLSPQQNRQ MLRLLNELQR SFQDILEQTA AQVDALQGHL 3600
    QQMEQEALVK TLQKQQNTCH QQLEDLCSWV GQAERALAGH QGRTTQQDLS 3650
    ALQKNQSDLK DLQDDIQNRA TSFATVVKDI EGFMEENQTK LSPRELTALR 3700
    EKLHQAKEQY EALQEETRVA QKELEEAVTS ALQQETEKSK AAKELAENKK 3750
    KIDALLDWVT SVGSSGGQLL TNLPGMEQLS GASLEKGALD TTDGYMGVNQ 3800
    APEKLDKQCE MMKARHQELL SQQQNFILAT QSAQAFLDQH GHNLTPEEQQ 3850
    MLQQKLGELK EQYSTSLAQS EAELKQVQTL QDELQKFLQD HKEFESWLER 3900
    SEKELENMHK GGSSPETLPS LLKRQGSFSE DVISHKGDLR FVTISGQKVL 3950
    DMENSFKEGK EPSEIGNLVK DKLKDATERY TALHSKCTRL GSHLNMLLGQ 4000
    YHQFQNSADS LQAWMQACEA NVEKLLSDTV ASDPGVLQEQ LATTKQLQEE 4050
    LAEHQVPVEK LQKVARDIME IEGEPAPDHR HVQETTDSIL SHFQSLSYSL 4100
    AERSSLLQKA IAQSQSVQES LESLLQSIGE VEQNLEGKQV SSLSSGVIQE 4150
    ALATNMKLKQ DIARQKSSLE ATREMVTRFM ETADSTTAAV LQGKLAEVSQ 4200
    RFEQLCLQQQ EKESSLKKLL PQAEMFEHLS GKLQQFMENK SRMLASGNQP 4250
    DQDITHFFQQ IQELNLEMED QQENLDTLEH LVTELSSCGF ALDLCQHQDR 4300
    VQNLRKDFTE LQKTVKEREK DASSCQEQLD EFRKLVRTFQ KWLKETEGSI 4350
    PPTETSMSAK ELEKQIEHLK SLLDDWASKG TLVEEINCKG TSLENLIMEI 4400
    TAPDSQGKTG SILPSVGSSV GSVNGYHTCK DLTEIQCDMS DVNLKYEKLG 4450
    GVLHERQESL QAILNRMEEV HKEANSVLQW LESKEEVLKS MDAMSSPTKT 4500
    ETVKAQAESN KAFLAELEQN SPKIQKVKEA LAGLLVTYPN SQEAENWKKI 4550
    QEELNSRWER ATEVTVARQR QLEESASHLA CFQAAESQLR PWLMEKELMM 4600
    GVLGPLSIDP NMLNAQKQQV QFMLKEFEAR RQQHEQLNEA AQGILTGPGD 4650
    VSLSTSQVQK ELQSINQKWV ELTDKLNSRS SQIDQAIVKS TQYQELLQDL 4700
    SEKVRAVGQR LSVQSAISTQ PEAVKQQLEE TSEIRSDLEQ LDHEVKEAQT 4750
    LCDELSVLIG EQYLKDELKK RLETVALPLQ GLEDLAADRI NRLQAALAST 4800
    QQFQQMFDEL RTWLDDKQSQ QAKNCPISAK LERLQSQLQE NEEFQKSLNQ 4850
    HSGSYEVIVA EGESLLLSVP PGEEKRTLQN QLVELKNHWE ELSKKTADRQ 4900
    SRLKDCMQKA QKYQWHVEDL VPWIEDCKAK MSELRVTLDP VQLESSLLRS 4950
    KAMLNEVEKR RSLLEILNSA ADILINSSEA DEDGIRDEKA GINQNMDAVT 5000
    EELQAKTGSL EEMTQRLREF QESFKNIEKK VEGAKHQLEI FDALGSQACS 5050
    NKNLEKLRAQ QEVLQALEPQ VDYLRNFTQG LVEDAPDGSD ASQLLHQAEV 5100
    AQQEFLEVKQ RVNSGCVMME NKLEGIGQFH CRVREMFSQL ADLDDELDGM 5150
    GAIGRDTDSL QSQIEDVRLF LNKIHVLKLD IEASEAECRH MLEEEGTLDL 5200
    LGLKRELEAL NKQCGKLTER GKARQEQLEL TLGRVEDFYR KLKGLNDATT 5250
    AAEEAEALQW VVGTEVEIIN QQLADFKMFQ KEQVDPLQMK LQQVNGLGQG 5300
    LIQSAGKDCD VQGLEHDMEE INARWNTLNK KVAQRIAQLQ EALLHCGKFQ 5350
    DALEPLLSWL ADTEELIANQ KPPSAEYKVV KAQIQEQKLL QRLLDDRKAT 5400
    VDMLQAEGGR IAQSAELADR EKITGQLESL ESRWTELLSK AAARQKQLED 5450
    ILVLAKQFHE TAEPISDFLS VTEKKLANSE PVGTQTAKIQ QQIIRHKALN 5500
    EEIVNRKKNV DQAIKNGQAL LKQTTGEEVL LIQEKLDGIK TRYADITVTS 5550
    SKALRTLEQA RQLATKFQST YEELTGWLRE VEEELATSGG QSPTGEQIPQ 5600
    FQQRQKELKK EVMEHRLVLD TVNEVSRALL ELVPWRAREG LDKLVSDANE 5650
    QYKLVSDTIG QRVDEIDAAI QRSQQYEQAA DAELAWVAET KRKLMALGPI 5700
    RLEQDQTTAQ LQVQKAFSID IIRHKDSMDE LFSHRSEIFG TCGEEQKTVL 5750
    QEKTESLIQQ YEAISLLNSE RYARLERAQV LVNQFWETYE ELSPWIEETR 5800
    ALIAQLPSPA IDHEQLRQQQ EEMRQLRESI AEHKPHIDKL LKIGPQLKEL 5850
    NPEEGEMVEE KYQKAENMYA QIKEEVRQRA LALDEAVSQS TQITEFHDKI 5900
    EPMLETLENL SSRLRMPPLI PAEVDKIREC ISDNKSATVE LEKLQPSFEA 5950
    LKRRGEELIG RSQGADKDLA AKEIQDKLDQ MVFFWEDIKA RAEEREIKFL 6000
    DVLELAEKFW YDMAALLTTI KDTQDIVHDL ESPGIDPSII KQQVEAAETI 6050
    KEETDGLHEE LEFIRILGAD LIFACGETEK PEVRKSIDEM NNAWENLNKT 6100
    WKERLEKLED AMQAAVQYQD TLQAMFDWLD NTVIKLCTMP PVGTDLNTVK 6150
    DQLNEMKEFK VEVYQQQIEM EKLNHQGELM LKKATDETDR DIIREPLTEL 6200
    KHLWENLGEK IAHRQHKLEG ALLALGQFQH ALEELMSWLT HTEELLDAQR 6250
    PISGDPKVIE VELAKHHVLK NDVLAHQATV ETVNKAGNEL LESSAGDDAS 6300
    SLRSRLEAMN QCWESVLQKT EEREQQLQST LQQAQGFHSE IEDFLLELTR 6350
    MESQLSASKP TGGLPETARE QLDTHMELYS QLKAKEETYN QLLDKGRLML 6400
    LSRDDSGSGS KTEQSVALLE QKWHVVSSKM EERKSKLEEA LNLATEFQNS 6450
    LQEFINWLTL AEQSLNIASP PSLILNTVLS QIEEHKVFAN EVNAHRDQII 6500
    ELDQTGNQLK FLSQKQDVVL IKNLLVSVQS RWEKVVQRSI ERGRSLDDAR 6550
    KRAKQFHEAW KKLIDWLEDA ESHLDSELEI SNDPDKIKLQ LSKHKEFQKT 6600
    LGGKQPVYDT TIRTGRALKE KTLLPEDSQK LDNFLGEVRD KWDTVCGKSV 6650
    ERQHKLEEAL LFSGQFMDAL QALVDWLYKV EPQLAEDQPV HGDLDLVMNL 6700
    MDAHKVFQKE LGKRTGTVQV LKRSGRELIE NSRDDTTWVK GQLQELSTRW 6750
    DTVCKLSVSK QSRLEQALKQ AEVFRDTVHM LLEWLSEAEQ TLRFRGALPD 6800
    DTEALQSLID THKEFMKKVE EKRVDVNSAV AMGEVILAVC HPDCITTIKH 6850
    WITIIRARFE EVLTWAKQHQ QRLETALSEL VANAELLEEL LAWIQWAETT 6900
    LIQRDQEPIP QNIDRVKALI AEHQTFMEEM TRKQPDVDRV TKTYKRKNIE 6950
    PTHAPFIEKS RSGGRKSLSQ PTPPPMPILS QSEAKNPRIN QLSARWQQVW 7000
    LLALERQRKL NDALDRLEEL KEFANFDFDV WRKKYMRWMN HKKSRVMDFF 7050
    RRIDKDQDGK ITRQEFIDGI LASKFPTTKL EMTAVADIFD RDGDGYIDYY 7100
    EFVAALHPNK DAYRPTTDAD KIEDEVTRQV AQCKCAKRFQ VEQIGENKYR 7150
    FGDSQQLRLV RILRSTVMVR VGGGWMALDE FLVKNDPCRA RGRTNIELRE 7200
    KFILPEGASQ GMTPFRSRGR RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS 7250
    SPATPASGTK VIPSSGSKLK RPTPTFHSSR TSLAGDTSNS SSPASTGAKT 7300
    NRADPKKSAS RPGSRAGSRA GSRASSRRGS DASDFDLLET QSACSDTSES 7350
    SAAGGQGNSR RGLNKPSKIP TMSKKTTTAS PRTPGPKR 7388
    Length:7,388
    Mass (Da):838,308
    Last modified:June 28, 2011 - v4
    Checksum:iB044DC183C048416
    GO
    Isoform 2 (identifier: Q9UPN3-2) [UniParc]FASTAAdd to Basket

    Also known as: Macf1a

    The sequence of this isoform differs from the canonical sequence as follows:
         1543-3609: Missing.
         5497-5497: K → KALEEDIENH...VLHRQHADHL

    Show »
    Length:5,430
    Mass (Da):620,418
    Checksum:i4C0CB72BDFBF9777
    GO
    Isoform 3 (identifier: Q9UPN3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-72: MSSSDEETLS...DPAERAVVRV → MFPVLWAGIP...CTSASRVAVI
         1543-3609: Missing.
         4410-4430: Missing.
         5497-5497: K → KALEEDIENH...VLHRQHADHL

    Show »
    Length:5,374
    Mass (Da):614,153
    Checksum:i503537231A91ABDA
    GO
    Isoform 5 (identifier: Q9UPN3-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1543-3609: Missing.
         4410-4430: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:5,300
    Mass (Da):606,164
    Checksum:iE5364BDE41CBB545
    GO
    Isoform 4 (identifier: Q9UPN3-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1565: Missing.
         5497-5497: K → KALEEDIENH...VLHRQHADHL
         7150-7150: R → RFFLGNQ

    Show »
    Length:5,938
    Mass (Da):670,137
    Checksum:i360611C48946A058
    GO

    Sequence cautioni

    The sequence BAA83821.1 differs from that shown. Reason: Frameshift at positions 575 and 594.
    The sequence CAH70156.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAH73668.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI16417.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21814.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1295 – 12962TA → LP in AAL39000. (PubMed:16710414)Curated
    Sequence conflicti1487 – 14871T → A in BAA83821. (PubMed:10529403)Curated
    Sequence conflicti1487 – 14871T → A in AAL39000. (PubMed:16710414)Curated
    Sequence conflicti3277 – 32771P → S in AAL38997. (PubMed:11845288)Curated
    Sequence conflicti4030 – 40301V → A in BAA83821. (PubMed:10529403)Curated
    Sequence conflicti4119 – 41191E → D in BAA83821. (PubMed:10529403)Curated
    Sequence conflicti4150 – 41501E → K in AAF06360. (PubMed:10559237)Curated
    Sequence conflicti4388 – 43881C → Y in BAA83821. (PubMed:10529403)Curated
    Sequence conflicti4411 – 44177SILPSVG → EYRLFKI in BAA86565. (PubMed:10574462)Curated
    Sequence conflicti4590 – 45901R → Q in BAA83821. (PubMed:10529403)Curated
    Sequence conflicti6791 – 67911Missing in AAF06360. (PubMed:10559237)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti302 – 3021E → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035451
    Natural varianti4357 – 43571M → V.1 Publication
    Corresponds to variant rs2296172 [ dbSNP | Ensembl ].
    VAR_048625
    Natural varianti6201 – 62011K → R.
    Corresponds to variant rs682351 [ dbSNP | Ensembl ].
    VAR_048626
    Natural varianti6308 – 63081A → T.
    Corresponds to variant rs587404 [ dbSNP | Ensembl ].
    VAR_048627
    Natural varianti6462 – 64621E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035452
    Natural varianti6628 – 66281S → T.2 Publications
    Corresponds to variant rs668556 [ dbSNP | Ensembl ].
    VAR_048628
    Natural varianti6752 – 67521T → I.
    Corresponds to variant rs2296174 [ dbSNP | Ensembl ].
    VAR_048629
    Natural varianti6855 – 68551I → V.
    Corresponds to variant rs12068423 [ dbSNP | Ensembl ].
    VAR_048630
    Natural varianti7093 – 70931G → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_065256

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 15651565Missing in isoform 4. 1 PublicationVSP_043626Add
    BLAST
    Alternative sequencei1 – 7272MSSSD…AVVRV → MFPVLWAGIPGRDVGSLQPL PPGFKQFCTSASRVAVI in isoform 3. 1 PublicationVSP_041390Add
    BLAST
    Alternative sequencei1543 – 36092067Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsVSP_041391Add
    BLAST
    Alternative sequencei4410 – 443021Missing in isoform 3 and isoform 5. 2 PublicationsVSP_041392Add
    BLAST
    Alternative sequencei5497 – 54971K → KALEEDIENHATDVHQAVKI GQSLSSLTSPAEQGVLSEKI DSLQARYSEIQDRCCRKAAL LDQALSNARLFGEDEVEVLN WLAEVEDKLSSVFVKDFKQD VLHRQHADHL in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_041393
    Alternative sequencei7150 – 71501R → RFFLGNQ in isoform 4. 1 PublicationVSP_043627

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029290 mRNA. Translation: BAA83821.1. Frameshift.
    AF141968 mRNA. Translation: AAF06360.1.
    AF317696 mRNA. Translation: AAL09459.1.
    AF325341
    , AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA. Translation: AAL38997.1.
    AF325341
    , AF325330, AF325331, AF325332, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA. Translation: AAL39000.1.
    AL442071
    , AL137853, AL355477, AL365277 Genomic DNA. Translation: CAH73668.1. Sequence problems.
    AL442071, AL137853, AL365277 Genomic DNA. Translation: CAH73671.1.
    AL137853
    , AL355477, AL365277, AL442071 Genomic DNA. Translation: CAI21814.1. Sequence problems.
    AL137853, AL365277, AL442071 Genomic DNA. Translation: CAI21816.1.
    AL365277
    , AL137853, AL355477, AL442071 Genomic DNA. Translation: CAI16417.1. Sequence problems.
    AL365277, AL137853, AL442071 Genomic DNA. Translation: CAI16422.1.
    AL355477
    , AL137853, AL365277, AL442071 Genomic DNA. Translation: CAH70156.1. Sequence problems.
    AL356055 Genomic DNA. No translation available.
    AB033077 mRNA. Translation: BAA86565.1.
    AB007934 mRNA. Translation: BAA32310.3.
    CCDSiCCDS435.1. [Q9UPN3-2]
    PIRiT00079.
    RefSeqiNP_036222.3. NM_012090.5. [Q9UPN3-2]
    UniGeneiHs.472475.
    Hs.692278.

    Genome annotation databases

    EnsembliENST00000289893; ENSP00000289893; ENSG00000127603. [Q9UPN3-5]
    ENST00000361689; ENSP00000354573; ENSG00000127603. [Q9UPN3-2]
    ENST00000372915; ENSP00000362006; ENSG00000127603. [Q9UPN3-1]
    GeneIDi23499.
    KEGGihsa:23499.
    UCSCiuc001cda.1. human. [Q9UPN3-3]
    uc021olt.1. human. [Q9UPN3-2]
    uc031pmd.1. human. [Q9UPN3-5]

    Polymorphism databases

    DMDMi338817989.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB029290 mRNA. Translation: BAA83821.1 . Frameshift.
    AF141968 mRNA. Translation: AAF06360.1 .
    AF317696 mRNA. Translation: AAL09459.1 .
    AF325341
    , AF325333 , AF325334 , AF325335 , AF325336 , AF325339 , AF325340 Genomic DNA. Translation: AAL38997.1 .
    AF325341
    , AF325330 , AF325331 , AF325332 , AF325333 , AF325334 , AF325335 , AF325336 , AF325339 , AF325340 Genomic DNA. Translation: AAL39000.1 .
    AL442071
    , AL137853 , AL355477 , AL365277 Genomic DNA. Translation: CAH73668.1 . Sequence problems.
    AL442071 , AL137853 , AL365277 Genomic DNA. Translation: CAH73671.1 .
    AL137853
    , AL355477 , AL365277 , AL442071 Genomic DNA. Translation: CAI21814.1 . Sequence problems.
    AL137853 , AL365277 , AL442071 Genomic DNA. Translation: CAI21816.1 .
    AL365277
    , AL137853 , AL355477 , AL442071 Genomic DNA. Translation: CAI16417.1 . Sequence problems.
    AL365277 , AL137853 , AL442071 Genomic DNA. Translation: CAI16422.1 .
    AL355477
    , AL137853 , AL365277 , AL442071 Genomic DNA. Translation: CAH70156.1 . Sequence problems.
    AL356055 Genomic DNA. No translation available.
    AB033077 mRNA. Translation: BAA86565.1 .
    AB007934 mRNA. Translation: BAA32310.3 .
    CCDSi CCDS435.1. [Q9UPN3-2 ]
    PIRi T00079.
    RefSeqi NP_036222.3. NM_012090.5. [Q9UPN3-2 ]
    UniGenei Hs.472475.
    Hs.692278.

    3D structure databases

    ProteinModelPortali Q9UPN3.
    SMRi Q9UPN3. Positions 69-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117048. 36 interactions.
    DIPi DIP-50616N.
    IntActi Q9UPN3. 26 interactions.
    MINTi MINT-1195815.
    STRINGi 9606.ENSP00000289893.

    PTM databases

    PhosphoSitei Q9UPN3.

    Polymorphism databases

    DMDMi 338817989.

    Proteomic databases

    MaxQBi Q9UPN3.
    PaxDbi Q9UPN3.
    PRIDEi Q9UPN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289893 ; ENSP00000289893 ; ENSG00000127603 . [Q9UPN3-5 ]
    ENST00000361689 ; ENSP00000354573 ; ENSG00000127603 . [Q9UPN3-2 ]
    ENST00000372915 ; ENSP00000362006 ; ENSG00000127603 . [Q9UPN3-1 ]
    GeneIDi 23499.
    KEGGi hsa:23499.
    UCSCi uc001cda.1. human. [Q9UPN3-3 ]
    uc021olt.1. human. [Q9UPN3-2 ]
    uc031pmd.1. human. [Q9UPN3-5 ]

    Organism-specific databases

    CTDi 23499.
    GeneCardsi GC01P039546.
    HGNCi HGNC:13664. MACF1.
    HPAi HPA013713.
    MIMi 608271. gene.
    neXtProti NX_Q9UPN3.
    PharmGKBi PA30518.
    HUGEi Search...
    Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000049054.
    HOVERGENi HBG031127.
    PhylomeDBi Q9UPN3.
    TreeFami TF335163.

    Enzyme and pathway databases

    SignaLinki Q9UPN3.

    Miscellaneous databases

    ChiTaRSi MACF1. human.
    GeneWikii MACF1.
    GenomeRNAii 23499.
    NextBioi 45871.
    PROi Q9UPN3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPN3.
    Bgeei Q9UPN3.
    CleanExi HS_MACF1.
    Genevestigatori Q9UPN3.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.418.10. 2 hits.
    3.30.920.20. 1 hit.
    3.90.1290.10. 5 hits.
    InterProi IPR001589. Actinin_actin-bd_CS.
    IPR001715. CH-domain.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR003108. GAS2_dom.
    IPR028408. Macf1.
    IPR001101. Plectin_repeat.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view ]
    PANTHERi PTHR11915:SF37. PTHR11915:SF37. 1 hit.
    Pfami PF00307. CH. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    PF02187. GAS2. 1 hit.
    PF00681. Plectin. 11 hits.
    PF00435. Spectrin. 17 hits.
    [Graphical view ]
    SMARTi SM00033. CH. 2 hits.
    SM00054. EFh. 2 hits.
    SM00243. GAS2. 1 hit.
    SM00250. PLEC. 20 hits.
    SM00150. SPEC. 33 hits.
    [Graphical view ]
    SUPFAMi SSF143575. SSF143575. 1 hit.
    SSF47576. SSF47576. 1 hit.
    SSF75399. SSF75399. 6 hits.
    PROSITEi PS00019. ACTININ_1. 1 hit.
    PS00020. ACTININ_2. 1 hit.
    PS50021. CH. 2 hits.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS51460. GAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin."
      Okuda T., Matsuda S., Nakatsugawa S., Ichigotani Y., Iwahashi N., Takahashi M., Ishigaki T., Hamaguchi M.
      Biochem. Biophys. Res. Commun. 264:568-574(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins."
      Sun Y., Zhang J., Kraeft S.-K., Auclair D., Chang M.-S., Liu Y., Sutherland R., Salgia R., Griffin J.D., Ferland L.H., Chen L.B.
      J. Biol. Chem. 274:33522-33530(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS VAL-4357 AND THR-6628.
    3. "MACF1 gene structure: a hybrid of plectin and dystrophin."
      Gong T.-W.L., Besirli C.G., Lomax M.I.
      Mamm. Genome 12:852-861(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-6770 (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANT THR-6628.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 868-4417 (ISOFORM 2).
      Tissue: Brain.
    6. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
      DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 868-7388 (ISOFORM 5).
      Tissue: Brain.
    7. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    8. Ohara O.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    9. "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."
      Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H.
      Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GOLGA4.
    10. "Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex."
      Lin C.-M., Chen H.-J., Leung C.L., Parry D.A.D., Liem R.K.H.
      J. Cell Sci. 118:3727-3738(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF ISOFORM 1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1376; SER-3927; SER-4495; SER-4496; SER-6967; THR-7254; SER-7292 AND SER-7330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1376; SER-4521 AND SER-7330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."
      Zaoui K., Benseddik K., Daou P., Salaun D., Badache A.
      Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-1376; SER-3927 AND SER-4521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-1376; SER-3927; SER-4496; SER-4521 AND SER-4962, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-302; GLN-6462 AND GLU-7093.

    Entry informationi

    Entry nameiMACF1_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPN3
    Secondary accession number(s): B1ALC5
    , E9PJT0, O75053, Q5VW20, Q8WXY1, Q8WXY2, Q96PK2, Q9H540, Q9UKP0, Q9ULG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 143 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3