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Q9UPN3 (MACF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Alternative name(s):
620 kDa actin-binding protein
Short name=ABP620
Actin cross-linking family protein 7
Macrophin-1
Trabeculin-alpha
Gene names
Name:MACF1
Synonyms:ABP620, ACF7, KIAA0465, KIAA1251
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length7388 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells By similarity. Ref.9 Ref.16

Subunit structure

Isoform 2 interacts with MAPRE1, CLASP1, CLASP2, AXIN1 and LRP6 By similarity. Isoform 2 is found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B By similarity. Isoform 2 interacts with GOLGA4. Ref.9

Subcellular location

Isoform 2: Cytoplasmcytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projectionruffle membrane. Note: The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules By similarity. Localizes to the tips of microtubules. APC controls its localization to the cell membrane which is critical for its function in microtubule stabilization. Ref.9 Ref.10 Ref.16

Isoform 1: Cytoplasm. Golgi apparatus. Note: Localizes to the tips of microtubules. Ref.9 Ref.10 Ref.16

Tissue specificity

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in cell lines NCI-H460, A-549 and HaCaT. Isoform 4 is expressed in heart, lung, pituitary and placenta, not found in brain, kidney, liver, pancreas or skeletal muscle. Ref.3 Ref.10

Domain

The C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding By similarity.

Post-translational modification

Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation By similarity.

Sequence similarities

Belongs to the plakin or cytolinker family.

Contains 1 actin-binding domain.

Contains 2 CH (calponin-homology) domains.

Contains 2 EF-hand domains.

Contains 1 GAR domain.

Contains 24 LRR (leucine-rich) repeats.

Contains 11 plectin repeats.

Contains 1 SH3 domain.

Contains 17 spectrin repeats.

Sequence caution

The sequence BAA83821.1 differs from that shown. Reason: Frameshift at positions 575 and 594.

The sequence CAH70156.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAH73668.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI16417.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI21814.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentCell membrane
Cell projection
Cytoplasm
Cytoskeleton
Golgi apparatus
Membrane
Microtubule
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainLeucine-rich repeat
Repeat
SH3 domain
   LigandActin-binding
Calcium
Metal-binding
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processATP catabolic process

Inferred from sequence or structural similarity. Source: GOC

Golgi to plasma membrane protein transport

Inferred from direct assay Ref.9. Source: UniProtKB

Wnt signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cell cycle arrest

Inferred from electronic annotation. Source: InterPro

cellular component movement

Inferred from electronic annotation. Source: Ensembl

establishment or maintenance of cell polarity

Inferred from electronic annotation. Source: Ensembl

mesoderm formation

Inferred from electronic annotation. Source: Ensembl

positive regulation of Wnt signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

posttranslational protein targeting to membrane

Inferred from electronic annotation. Source: Ensembl

regulation of epithelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of focal adhesion assembly

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of microtubule-based process

Inferred from mutant phenotype Ref.16. Source: UniProtKB

wound healing

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentGolgi apparatus

Inferred from direct assay Ref.9Ref.10. Source: UniProtKB

actin cytoskeleton

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay Ref.2Ref.9Ref.10. Source: UniProtKB

cytoskeleton

Non-traceable author statement Ref.1. Source: UniProtKB

microtubule

Inferred from direct assay Ref.10. Source: UniProtKB

plasma membrane

Inferred from direct assay Ref.16. Source: UniProtKB

ruffle membrane

Inferred from direct assay Ref.16. Source: UniProtKB

   Molecular_functionATPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

actin binding

Inferred from direct assay Ref.2. Source: UniProtKB

actin filament binding

Non-traceable author statement Ref.1Ref.2. Source: UniProtKB

calcium ion binding

Inferred from electronic annotation. Source: InterPro

poly(A) RNA binding

Inferred from direct assay PubMed 22681889. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 11443112Ref.9. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DISC1Q9NRI55EBI-522925,EBI-529989

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UPN3-1)

Also known as: Macf1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UPN3-2)

Also known as: Macf1a;

The sequence of this isoform differs from the canonical sequence as follows:
     1543-3609: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL
Isoform 3 (identifier: Q9UPN3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MSSSDEETLS...DPAERAVVRV → MFPVLWAGIP...CTSASRVAVI
     1543-3609: Missing.
     4410-4430: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL
Isoform 5 (identifier: Q9UPN3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1543-3609: Missing.
     4410-4430: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9UPN3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1565: Missing.
     5497-5497: K → KALEEDIENH...VLHRQHADHL
     7150-7150: R → RFFLGNQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 73887388Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
PRO_0000073449

Regions

Domain1 – 295295Actin-binding
Domain78 – 181104CH 1
Repeat148 – 17124LRR 1
Domain194 – 295102CH 2
Repeat240 – 26425LRR 2
Repeat377 – 39923LRR 3
Repeat441 – 46424LRR 4
Domain871 – 92353SH3
Repeat1050 – 107324LRR 5
Repeat1128 – 115427LRR 6
Repeat1187 – 121024LRR 7
Repeat1257 – 128226LRR 8
Repeat1577 – 162145Plectin 1
Repeat1654 – 169643Plectin 2
Repeat1769 – 180941Plectin 3
Repeat1811 – 184838Plectin 4
Repeat1855 – 188632Plectin 5
Repeat2290 – 233243Plectin 6
Repeat2367 – 241044Plectin 7
Repeat2411 – 243727Plectin 8
Repeat2501 – 254343Plectin 9
Repeat2581 – 261232Plectin 10
Repeat2686 – 273045Plectin 11
Repeat3239 – 326224LRR 9
Repeat3264 – 328320LRR 10
Repeat3646 – 366924LRR 11
Repeat3696 – 372025LRR 12
Repeat3883 – 395775Spectrin 1
Repeat3936 – 395823LRR 13
Repeat4000 – 4108109Spectrin 2
Repeat4125 – 415026LRR 14
Repeat4261 – 428727LRR 15
Repeat4466 – 4574109Spectrin 3
Repeat4511 – 453424LRR 16
Repeat4601 – 462424LRR 17
Repeat4769 – 479224LRR 18
Repeat4800 – 4904105Spectrin 4
Repeat4909 – 5012104Spectrin 5
Repeat5051 – 507626LRR 19
Repeat5172 – 519423LRR 20
Repeat5236 – 5341106Spectrin 6
Repeat5281 – 530424LRR 21
Repeat5348 – 5450103Spectrin 7
Repeat5455 – 5557103Spectrin 8
Repeat5695 – 571925LRR 22
Repeat5783 – 5885103Spectrin 9
Repeat5804 – 582825LRR 23
Repeat6005 – 6110106Spectrin 10
Repeat6115 – 6219105Spectrin 11
Repeat6225 – 6328104Spectrin 12
Repeat6333 – 6439107Spectrin 13
Repeat6443 – 6547105Spectrin 14
Repeat6496 – 651924LRR 24
Repeat6552 – 6658107Spectrin 15
Repeat6665 – 6766102Spectrin 16
Repeat6771 – 6874104Spectrin 17
Domain7041 – 707636EF-hand 1
Domain7077 – 711236EF-hand 2
Domain7117 – 718973GAR
Calcium binding7054 – 7065121 Potential
Calcium binding7090 – 7101122 Potential
Region7117 – 7388272C-terminal tail By similarity
Region7313 – 7328164 X 4 AA tandem repeats of [GS]-S-R-[AR]
Compositional bias698 – 7036Poly-Glu
Compositional bias1122 – 11276Poly-Ser
Compositional bias1414 – 14174Poly-Glu
Compositional bias1986 – 19894Poly-Leu
Compositional bias7222 – 7351130Ser-rich

Amino acid modifications

Modified residue2801Phosphoserine Ref.17 Ref.19
Modified residue13761Phosphoserine Ref.12 Ref.14 Ref.17 Ref.19
Modified residue31221Phosphoserine By similarity
Modified residue39271Phosphoserine Ref.12 Ref.17 Ref.19
Modified residue44951Phosphoserine Ref.12
Modified residue44961Phosphoserine Ref.12 Ref.19
Modified residue45211Phosphoserine Ref.11 Ref.14 Ref.17 Ref.19
Modified residue49621Phosphoserine Ref.19
Modified residue62101N6-acetyllysine Ref.15
Modified residue69671Phosphoserine Ref.12
Modified residue72541Phosphothreonine Ref.12
Modified residue72921Phosphoserine Ref.12
Modified residue73301Phosphoserine Ref.12 Ref.14
Modified residue73331Phosphoserine By similarity

Natural variations

Alternative sequence1 – 15651565Missing in isoform 4.
VSP_043626
Alternative sequence1 – 7272MSSSD…AVVRV → MFPVLWAGIPGRDVGSLQPL PPGFKQFCTSASRVAVI in isoform 3.
VSP_041390
Alternative sequence1543 – 36092067Missing in isoform 2, isoform 3 and isoform 5.
VSP_041391
Alternative sequence4410 – 443021Missing in isoform 3 and isoform 5.
VSP_041392
Alternative sequence54971K → KALEEDIENHATDVHQAVKI GQSLSSLTSPAEQGVLSEKI DSLQARYSEIQDRCCRKAAL LDQALSNARLFGEDEVEVLN WLAEVEDKLSSVFVKDFKQD VLHRQHADHL in isoform 2, isoform 3 and isoform 4.
VSP_041393
Alternative sequence71501R → RFFLGNQ in isoform 4.
VSP_043627
Natural variant3021E → V in a breast cancer sample; somatic mutation. Ref.20
VAR_035451
Natural variant43571M → V. Ref.2
Corresponds to variant rs2296172 [ dbSNP | Ensembl ].
VAR_048625
Natural variant62011K → R.
Corresponds to variant rs682351 [ dbSNP | Ensembl ].
VAR_048626
Natural variant63081A → T.
Corresponds to variant rs587404 [ dbSNP | Ensembl ].
VAR_048627
Natural variant64621E → Q in a breast cancer sample; somatic mutation. Ref.20
VAR_035452
Natural variant66281S → T. Ref.2 Ref.3
Corresponds to variant rs668556 [ dbSNP | Ensembl ].
VAR_048628
Natural variant67521T → I.
Corresponds to variant rs2296174 [ dbSNP | Ensembl ].
VAR_048629
Natural variant68551I → V.
Corresponds to variant rs12068423 [ dbSNP | Ensembl ].
VAR_048630
Natural variant70931G → E in a breast cancer sample; somatic mutation. Ref.20
VAR_065256

Experimental info

Sequence conflict1295 – 12962TA → LP in AAL39000. Ref.4
Sequence conflict14871T → A in BAA83821. Ref.1
Sequence conflict14871T → A in AAL39000. Ref.4
Sequence conflict32771P → S in AAL38997. Ref.3
Sequence conflict40301V → A in BAA83821. Ref.1
Sequence conflict41191E → D in BAA83821. Ref.1
Sequence conflict41501E → K in AAF06360. Ref.2
Sequence conflict43881C → Y in BAA83821. Ref.1
Sequence conflict4411 – 44177SILPSVG → EYRLFKI in BAA86565. Ref.5
Sequence conflict45901R → Q in BAA83821. Ref.1
Sequence conflict67911Missing in AAF06360. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Macf1b) [UniParc].

Last modified June 28, 2011. Version 4.
Checksum: B044DC183C048416

FASTA7,388838,308
        10         20         30         40         50         60 
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS 

        70         80         90        100        110        120 
VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS 

       130        140        150        160        170        180 
GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ VKLVNIRNDD ITDGNPKLTL GLIWTIILHF 

       190        200        210        220        230        240 
QISDIYISGE SGDMSAKEKL LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL 

       250        260        270        280        290        300 
VDMERVQIQS NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 

       310        320        330        340        350        360 
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK ALYNQYIHFK 

       370        380        390        400        410        420 
ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND VEEEWGKLII EMLEREKSLR 

       430        440        450        460        470        480 
PAVERLELLL QIANKIQNGA LNCEEKLTLA KNTLQADAAH LESGQPVQCE SDVIMYIQEC 

       490        500        510        520        530        540 
EGLIRQLQVD LQILRDENYY QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP 

       550        560        570        580        590        600 
STLTTTHLKA EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ 

       610        620        630        640        650        660 
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF HTSYAETLGK 

       670        680        690        700        710        720 
LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE EEELAYDWSD NNSNISAKRN 

       730        740        750        760        770        780 
YFSELTMELE EKQDVFRSLQ DTAELLSLEN HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ 

       790        800        810        820        830        840 
HVKENTAYFQ FFSDARELES FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ 

       850        860        870        880        890        900 
SKSSVASLVG RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR 

       910        920        930        940        950        960 
TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL HVNTKSLISW 

       970        980        990       1000       1010       1020 
NYLRKDLDLV QTWNLEKLRS SAPGECHQIM KNLQAHYEDF LQDSRDSVLF SVADRLRLEE 

      1030       1040       1050       1060       1070       1080 
EVEACKARFQ HLMKSMENED KEETVAKMYI SELKNIRLRL EEYEQRVVKR IQSLASSRTD 

      1090       1100       1110       1120       1130       1140 
RDAWQDNALR IAEQEHTQED LQQLRSDLDA VSMKCDSFLH QSPSSSSVPT LRSELNLLVE 

      1150       1160       1170       1180       1190       1200 
KMDHVYGLST VYLNKLKTVD VIVRSIQDAE LLVKGYEIKL SQEEVVLADL SALEAHWSTL 

      1210       1220       1230       1240       1250       1260 
RHWLSDVKDK NSVFSVLDEE IAKAKVVAEQ MSRLTPERNL DLERYQEKGS QLQERWHRVI 

      1270       1280       1290       1300       1310       1320 
AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM MKPGQAEDSR VLSEQLSQQT 

      1330       1340       1350       1360       1370       1380 
ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY ELQLMTYKAF VESQQKSPGK RRRMLSSSDA 

      1390       1400       1410       1420       1430       1440 
ITQEFMDLRT RYTALVTLTT QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST 

      1450       1460       1470       1480       1490       1500 
LARNTQGKAT SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS 

      1510       1520       1530       1540       1550       1560 
EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKECRAVAG VIDLGTVEIF 

      1570       1580       1590       1600       1610       1620 
PIFKAMQKGL LDQDTGLVLL ESQVIMSGLI APETGENLSL EEGIARNLIN PQMYQQLREL 

      1630       1640       1650       1660       1670       1680 
QDALALISRL TESRGPLSVV EAIEKRIISE TVGLKILEAH LATGGFSLSP SENCINLEEA 

      1690       1700       1710       1720       1730       1740 
FHQGLISAWL HSVLESYLRT SKNLIDPNTA EKIGLLDLMQ RCIVHQESGF KLLPVKQLAG 

      1750       1760       1770       1780       1790       1800 
GMVSLKSGRK VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI 

      1810       1820       1830       1840       1850       1860 
DQDMACAILI RQLQTGGIID TVTGQRLTID EAVSNDLVAA KIALVILESL WSFMGLLWPE 

      1870       1880       1890       1900       1910       1920 
SGEILPITDA LEQGIVSTEL AHKILSNRQH IKALFLPATT EILSWKKAIE SGILDRDLAN 

      1930       1940       1950       1960       1970       1980 
NLKSICIPDV MPHMQLADSA EQNINPGAAV LPCSKSHPKA TASQSENLLF QLMTHSYINV 

      1990       2000       2010       2020       2030       2040 
QNGQRLLLLD KELMETLTSR DEYQTSPPKV VEIGHQRQKT PEGLQESANV KISGTFSSGW 

      2050       2060       2070       2080       2090       2100 
TVRLPEFQFS SQNKEYPDRE DCTTEKGKKT TVETEDSSVE NPEQDLFVEQ KERNPNIDAL 

      2110       2120       2130       2140       2150       2160 
KVINKVKLEV QRQLIGTQRE DQTAVSVREN ASRGHLLTIP PAEAEGVPLV VDKDVFSVET 

      2170       2180       2190       2200       2210       2220 
PKKEHQPLRN TSFTCQNEQA HTLETEYIHD ETGGSHIKPQ SKKLQVQVKK TLGIKLELKS 

      2230       2240       2250       2260       2270       2280 
ETDGNVHPLD KKEMLKKTFL AKDDHKESQE AQNIAGGSMM MSEKTDEEDS GREIFLSCSH 

      2290       2300       2310       2320       2330       2340 
PLELLEEATL NVLSAQLLDG GIFHEQTGQK LLLNEAISRG IVPSHTAVKL MEKLNMFQGF 

      2350       2360       2370       2380       2390       2400 
FDSQTCESLT TEEVINEGLM DEKLLHNVLM ADKAISGVLD PRTQTLCSVK DAVTVGLLDK 

      2410       2420       2430       2440       2450       2460 
ETATRILERQ VVTGGIIDLK RGKKVSVTLA STLGLVDVAD QPELINLEKA SKGRDAEKTV 

      2470       2480       2490       2500       2510       2520 
RERLISLQME TTGLIDPDSK APLTVVQSID RGLLEREEAV RLLTKQVVDG GIIHHISGMR 

      2530       2540       2550       2560       2570       2580 
LSVDNAFRHG LIGEDLAEKL KRVENLNIHQ IFNPETKENI SLPKAIKLDL ITSDLKREIQ 

      2590       2600       2610       2620       2630       2640 
EVQAFTGNFV DLISGQRLTL AEAKKEGLLT NEAVLSPGMM HGIVDPENCR IVPYSELVKK 

      2650       2660       2670       2680       2690       2700 
CKIDIESGQR YLEVIPFSDI KDGVSDKVLT LSQAIQLGKV DFASTLKVLE AQANTGGIID 

      2710       2720       2730       2740       2750       2760 
TATGKRLTLA SALEEKLVDE NMVRIIASHQ VLNGGIVDIF SDQRVTLVEA IEKRLISPEL 

      2770       2780       2790       2800       2810       2820 
ANMIQIDSSE FSDHRAQIEK QEGIEVCALQ NEFLGKDMLI ACNQTAEMSC NKVEESERLF 

      2830       2840       2850       2860       2870       2880 
QVENQSAQEK VKVRVSDGEQ AKKSREISLK EFGCKDQRKP RMSSDAKEFI SIINPHNLKG 

      2890       2900       2910       2920       2930       2940 
KSLGQVSLTH PYSECDFKLK EVARNNMGND TNEEQEKAVT KIEIISHMKQ STSCLDSEEI 

      2950       2960       2970       2980       2990       3000 
RENQGEVILE VQETYCETSG KLPSEQVLQQ PMNARVKSKR EKREVIVEES IRTCKPAFLS 

      3010       3020       3030       3040       3050       3060 
EEKLYQETAI RDEHDSHIKS QPREMTSSEK GKEADTEMGF SITFKIEESS SQVVPQGISV 

      3070       3080       3090       3100       3110       3120 
KHLDALTLFS SKQANEGKVN NLSLCLTLKP EENLSREIAC GAQSEPFPCM TPRPEGLHYQ 

      3130       3140       3150       3160       3170       3180 
ESDGKAQVTG PSQISKTDKS FQGTTRQETN YQDSWVTSKT KETKHQISSS NECKEKSYQE 

      3190       3200       3210       3220       3230       3240 
VSFDPARGLK LEEITVSRPD SKEVRYLEFS DRKDLHHQGS KSDDKLCGTL KSEIATQELT 

      3250       3260       3270       3280       3290       3300 
GEKFLEMANP NVAGLEAGSI EDIVTQRGSR VLGSFLPEKL FKGVSQKENT GQQNAIISPT 

      3310       3320       3330       3340       3350       3360 
VLETSEEKTV SLTVCSAVKT EKTPQEKLRE SPGSEQTPFM TAPEGKGNGG VNPEPFRATQ 

      3370       3380       3390       3400       3410       3420 
NVFTRQLCLE HDEKLVSYLS LLRNIEMRTK QIQPLELNLA ELQDLLCQAK VLERELKDLT 

      3430       3440       3450       3460       3470       3480 
TLVSQELECV NQIIISQPQE VPAQLLKALE KDAKNLQKSL SSVSDTWNSR LLHFQNAVEI 

      3490       3500       3510       3520       3530       3540 
EKTKVLNQHT QLEGRLQDLR AWVGNKNLIL NSKGSNSEID VDSLNLCLQQ YEDLKQPMAE 

      3550       3560       3570       3580       3590       3600 
RKAQLDALAF DIQFFISEHA QDLSPQQNRQ MLRLLNELQR SFQDILEQTA AQVDALQGHL 

      3610       3620       3630       3640       3650       3660 
QQMEQEALVK TLQKQQNTCH QQLEDLCSWV GQAERALAGH QGRTTQQDLS ALQKNQSDLK 

      3670       3680       3690       3700       3710       3720 
DLQDDIQNRA TSFATVVKDI EGFMEENQTK LSPRELTALR EKLHQAKEQY EALQEETRVA 

      3730       3740       3750       3760       3770       3780 
QKELEEAVTS ALQQETEKSK AAKELAENKK KIDALLDWVT SVGSSGGQLL TNLPGMEQLS 

      3790       3800       3810       3820       3830       3840 
GASLEKGALD TTDGYMGVNQ APEKLDKQCE MMKARHQELL SQQQNFILAT QSAQAFLDQH 

      3850       3860       3870       3880       3890       3900 
GHNLTPEEQQ MLQQKLGELK EQYSTSLAQS EAELKQVQTL QDELQKFLQD HKEFESWLER 

      3910       3920       3930       3940       3950       3960 
SEKELENMHK GGSSPETLPS LLKRQGSFSE DVISHKGDLR FVTISGQKVL DMENSFKEGK 

      3970       3980       3990       4000       4010       4020 
EPSEIGNLVK DKLKDATERY TALHSKCTRL GSHLNMLLGQ YHQFQNSADS LQAWMQACEA 

      4030       4040       4050       4060       4070       4080 
NVEKLLSDTV ASDPGVLQEQ LATTKQLQEE LAEHQVPVEK LQKVARDIME IEGEPAPDHR 

      4090       4100       4110       4120       4130       4140 
HVQETTDSIL SHFQSLSYSL AERSSLLQKA IAQSQSVQES LESLLQSIGE VEQNLEGKQV 

      4150       4160       4170       4180       4190       4200 
SSLSSGVIQE ALATNMKLKQ DIARQKSSLE ATREMVTRFM ETADSTTAAV LQGKLAEVSQ 

      4210       4220       4230       4240       4250       4260 
RFEQLCLQQQ EKESSLKKLL PQAEMFEHLS GKLQQFMENK SRMLASGNQP DQDITHFFQQ 

      4270       4280       4290       4300       4310       4320 
IQELNLEMED QQENLDTLEH LVTELSSCGF ALDLCQHQDR VQNLRKDFTE LQKTVKEREK 

      4330       4340       4350       4360       4370       4380 
DASSCQEQLD EFRKLVRTFQ KWLKETEGSI PPTETSMSAK ELEKQIEHLK SLLDDWASKG 

      4390       4400       4410       4420       4430       4440 
TLVEEINCKG TSLENLIMEI TAPDSQGKTG SILPSVGSSV GSVNGYHTCK DLTEIQCDMS 

      4450       4460       4470       4480       4490       4500 
DVNLKYEKLG GVLHERQESL QAILNRMEEV HKEANSVLQW LESKEEVLKS MDAMSSPTKT 

      4510       4520       4530       4540       4550       4560 
ETVKAQAESN KAFLAELEQN SPKIQKVKEA LAGLLVTYPN SQEAENWKKI QEELNSRWER 

      4570       4580       4590       4600       4610       4620 
ATEVTVARQR QLEESASHLA CFQAAESQLR PWLMEKELMM GVLGPLSIDP NMLNAQKQQV 

      4630       4640       4650       4660       4670       4680 
QFMLKEFEAR RQQHEQLNEA AQGILTGPGD VSLSTSQVQK ELQSINQKWV ELTDKLNSRS 

      4690       4700       4710       4720       4730       4740 
SQIDQAIVKS TQYQELLQDL SEKVRAVGQR LSVQSAISTQ PEAVKQQLEE TSEIRSDLEQ 

      4750       4760       4770       4780       4790       4800 
LDHEVKEAQT LCDELSVLIG EQYLKDELKK RLETVALPLQ GLEDLAADRI NRLQAALAST 

      4810       4820       4830       4840       4850       4860 
QQFQQMFDEL RTWLDDKQSQ QAKNCPISAK LERLQSQLQE NEEFQKSLNQ HSGSYEVIVA 

      4870       4880       4890       4900       4910       4920 
EGESLLLSVP PGEEKRTLQN QLVELKNHWE ELSKKTADRQ SRLKDCMQKA QKYQWHVEDL 

      4930       4940       4950       4960       4970       4980 
VPWIEDCKAK MSELRVTLDP VQLESSLLRS KAMLNEVEKR RSLLEILNSA ADILINSSEA 

      4990       5000       5010       5020       5030       5040 
DEDGIRDEKA GINQNMDAVT EELQAKTGSL EEMTQRLREF QESFKNIEKK VEGAKHQLEI 

      5050       5060       5070       5080       5090       5100 
FDALGSQACS NKNLEKLRAQ QEVLQALEPQ VDYLRNFTQG LVEDAPDGSD ASQLLHQAEV 

      5110       5120       5130       5140       5150       5160 
AQQEFLEVKQ RVNSGCVMME NKLEGIGQFH CRVREMFSQL ADLDDELDGM GAIGRDTDSL 

      5170       5180       5190       5200       5210       5220 
QSQIEDVRLF LNKIHVLKLD IEASEAECRH MLEEEGTLDL LGLKRELEAL NKQCGKLTER 

      5230       5240       5250       5260       5270       5280 
GKARQEQLEL TLGRVEDFYR KLKGLNDATT AAEEAEALQW VVGTEVEIIN QQLADFKMFQ 

      5290       5300       5310       5320       5330       5340 
KEQVDPLQMK LQQVNGLGQG LIQSAGKDCD VQGLEHDMEE INARWNTLNK KVAQRIAQLQ 

      5350       5360       5370       5380       5390       5400 
EALLHCGKFQ DALEPLLSWL ADTEELIANQ KPPSAEYKVV KAQIQEQKLL QRLLDDRKAT 

      5410       5420       5430       5440       5450       5460 
VDMLQAEGGR IAQSAELADR EKITGQLESL ESRWTELLSK AAARQKQLED ILVLAKQFHE 

      5470       5480       5490       5500       5510       5520 
TAEPISDFLS VTEKKLANSE PVGTQTAKIQ QQIIRHKALN EEIVNRKKNV DQAIKNGQAL 

      5530       5540       5550       5560       5570       5580 
LKQTTGEEVL LIQEKLDGIK TRYADITVTS SKALRTLEQA RQLATKFQST YEELTGWLRE 

      5590       5600       5610       5620       5630       5640 
VEEELATSGG QSPTGEQIPQ FQQRQKELKK EVMEHRLVLD TVNEVSRALL ELVPWRAREG 

      5650       5660       5670       5680       5690       5700 
LDKLVSDANE QYKLVSDTIG QRVDEIDAAI QRSQQYEQAA DAELAWVAET KRKLMALGPI 

      5710       5720       5730       5740       5750       5760 
RLEQDQTTAQ LQVQKAFSID IIRHKDSMDE LFSHRSEIFG TCGEEQKTVL QEKTESLIQQ 

      5770       5780       5790       5800       5810       5820 
YEAISLLNSE RYARLERAQV LVNQFWETYE ELSPWIEETR ALIAQLPSPA IDHEQLRQQQ 

      5830       5840       5850       5860       5870       5880 
EEMRQLRESI AEHKPHIDKL LKIGPQLKEL NPEEGEMVEE KYQKAENMYA QIKEEVRQRA 

      5890       5900       5910       5920       5930       5940 
LALDEAVSQS TQITEFHDKI EPMLETLENL SSRLRMPPLI PAEVDKIREC ISDNKSATVE 

      5950       5960       5970       5980       5990       6000 
LEKLQPSFEA LKRRGEELIG RSQGADKDLA AKEIQDKLDQ MVFFWEDIKA RAEEREIKFL 

      6010       6020       6030       6040       6050       6060 
DVLELAEKFW YDMAALLTTI KDTQDIVHDL ESPGIDPSII KQQVEAAETI KEETDGLHEE 

      6070       6080       6090       6100       6110       6120 
LEFIRILGAD LIFACGETEK PEVRKSIDEM NNAWENLNKT WKERLEKLED AMQAAVQYQD 

      6130       6140       6150       6160       6170       6180 
TLQAMFDWLD NTVIKLCTMP PVGTDLNTVK DQLNEMKEFK VEVYQQQIEM EKLNHQGELM 

      6190       6200       6210       6220       6230       6240 
LKKATDETDR DIIREPLTEL KHLWENLGEK IAHRQHKLEG ALLALGQFQH ALEELMSWLT 

      6250       6260       6270       6280       6290       6300 
HTEELLDAQR PISGDPKVIE VELAKHHVLK NDVLAHQATV ETVNKAGNEL LESSAGDDAS 

      6310       6320       6330       6340       6350       6360 
SLRSRLEAMN QCWESVLQKT EEREQQLQST LQQAQGFHSE IEDFLLELTR MESQLSASKP 

      6370       6380       6390       6400       6410       6420 
TGGLPETARE QLDTHMELYS QLKAKEETYN QLLDKGRLML LSRDDSGSGS KTEQSVALLE 

      6430       6440       6450       6460       6470       6480 
QKWHVVSSKM EERKSKLEEA LNLATEFQNS LQEFINWLTL AEQSLNIASP PSLILNTVLS 

      6490       6500       6510       6520       6530       6540 
QIEEHKVFAN EVNAHRDQII ELDQTGNQLK FLSQKQDVVL IKNLLVSVQS RWEKVVQRSI 

      6550       6560       6570       6580       6590       6600 
ERGRSLDDAR KRAKQFHEAW KKLIDWLEDA ESHLDSELEI SNDPDKIKLQ LSKHKEFQKT 

      6610       6620       6630       6640       6650       6660 
LGGKQPVYDT TIRTGRALKE KTLLPEDSQK LDNFLGEVRD KWDTVCGKSV ERQHKLEEAL 

      6670       6680       6690       6700       6710       6720 
LFSGQFMDAL QALVDWLYKV EPQLAEDQPV HGDLDLVMNL MDAHKVFQKE LGKRTGTVQV 

      6730       6740       6750       6760       6770       6780 
LKRSGRELIE NSRDDTTWVK GQLQELSTRW DTVCKLSVSK QSRLEQALKQ AEVFRDTVHM 

      6790       6800       6810       6820       6830       6840 
LLEWLSEAEQ TLRFRGALPD DTEALQSLID THKEFMKKVE EKRVDVNSAV AMGEVILAVC 

      6850       6860       6870       6880       6890       6900 
HPDCITTIKH WITIIRARFE EVLTWAKQHQ QRLETALSEL VANAELLEEL LAWIQWAETT 

      6910       6920       6930       6940       6950       6960 
LIQRDQEPIP QNIDRVKALI AEHQTFMEEM TRKQPDVDRV TKTYKRKNIE PTHAPFIEKS 

      6970       6980       6990       7000       7010       7020 
RSGGRKSLSQ PTPPPMPILS QSEAKNPRIN QLSARWQQVW LLALERQRKL NDALDRLEEL 

      7030       7040       7050       7060       7070       7080 
KEFANFDFDV WRKKYMRWMN HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI LASKFPTTKL 

      7090       7100       7110       7120       7130       7140 
EMTAVADIFD RDGDGYIDYY EFVAALHPNK DAYRPTTDAD KIEDEVTRQV AQCKCAKRFQ 

      7150       7160       7170       7180       7190       7200 
VEQIGENKYR FGDSQQLRLV RILRSTVMVR VGGGWMALDE FLVKNDPCRA RGRTNIELRE 

      7210       7220       7230       7240       7250       7260 
KFILPEGASQ GMTPFRSRGR RSKPSSRAAS PTRSSSSASQ SNHSCTSMPS SPATPASGTK 

      7270       7280       7290       7300       7310       7320 
VIPSSGSKLK RPTPTFHSSR TSLAGDTSNS SSPASTGAKT NRADPKKSAS RPGSRAGSRA 

      7330       7340       7350       7360       7370       7380 
GSRASSRRGS DASDFDLLET QSACSDTSES SAAGGQGNSR RGLNKPSKIP TMSKKTTTAS 


PRTPGPKR 

« Hide

Isoform 2 (Macf1a) [UniParc].

Checksum: 4C0CB72BDFBF9777
Show »

FASTA5,430620,418
Isoform 3 [UniParc].

Checksum: 503537231A91ABDA
Show »

FASTA5,374614,153
Isoform 5 [UniParc].

Checksum: E5364BDE41CBB545
Show »

FASTA5,300606,164
Isoform 4 [UniParc].

Checksum: 360611C48946A058
Show »

FASTA5,938670,137

References

« Hide 'large scale' references
[1]"Molecular cloning of macrophin, a human homologue of Drosophila kakapo with a close structural similarity to plectin and dystrophin."
Okuda T., Matsuda S., Nakatsugawa S., Ichigotani Y., Iwahashi N., Takahashi M., Ishigaki T., Hamaguchi M.
Biochem. Biophys. Res. Commun. 264:568-574(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Molecular cloning and characterization of human trabeculin-alpha, a giant protein defining a new family of actin-binding proteins."
Sun Y., Zhang J., Kraeft S.-K., Auclair D., Chang M.-S., Liu Y., Sutherland R., Salgia R., Griffin J.D., Ferland L.H., Chen L.B.
J. Biol. Chem. 274:33522-33530(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANTS VAL-4357 AND THR-6628.
[3]"MACF1 gene structure: a hybrid of plectin and dystrophin."
Gong T.-W.L., Besirli C.G., Lomax M.I.
Mamm. Genome 12:852-861(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 182-6770 (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE SPECIFICITY, VARIANT THR-6628.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 868-4417 (ISOFORM 2).
Tissue: Brain.
[6]"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 868-7388 (ISOFORM 5).
Tissue: Brain.
[7]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[8]Ohara O.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[9]"Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery."
Kakinuma T., Ichikawa H., Tsukada Y., Nakamura T., Toh B.H.
Exp. Cell Res. 298:388-398(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GOLGA4.
[10]"Microtubule actin crosslinking factor 1b: a novel plakin that localizes to the Golgi complex."
Lin C.-M., Chen H.-J., Leung C.L., Parry D.A.D., Liem R.K.H.
J. Cell Sci. 118:3727-3738(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF ISOFORM 1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[11]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1376; SER-3927; SER-4495; SER-4496; SER-6967; THR-7254; SER-7292 AND SER-7330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1376; SER-4521 AND SER-7330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."
Zaoui K., Benseddik K., Daou P., Salaun D., Badache A.
Proc. Natl. Acad. Sci. U.S.A. 107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[17]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-1376; SER-3927 AND SER-4521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[18]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-1376; SER-3927; SER-4496; SER-4521 AND SER-4962, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-302; GLN-6462 AND GLU-7093.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB029290 mRNA. Translation: BAA83821.1. Frameshift.
AF141968 mRNA. Translation: AAF06360.1.
AF317696 mRNA. Translation: AAL09459.1.
AF325341 expand/collapse EMBL AC list , AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA. Translation: AAL38997.1.
AF325341 expand/collapse EMBL AC list , AF325330, AF325331, AF325332, AF325333, AF325334, AF325335, AF325336, AF325339, AF325340 Genomic DNA. Translation: AAL39000.1.
AL442071 expand/collapse EMBL AC list , AL137853, AL355477, AL365277 Genomic DNA. Translation: CAH73668.1. Sequence problems.
AL442071, AL137853, AL365277 Genomic DNA. Translation: CAH73671.1.
AL137853 expand/collapse EMBL AC list , AL355477, AL365277, AL442071 Genomic DNA. Translation: CAI21814.1. Sequence problems.
AL137853, AL365277, AL442071 Genomic DNA. Translation: CAI21816.1.
AL365277 expand/collapse EMBL AC list , AL137853, AL355477, AL442071 Genomic DNA. Translation: CAI16417.1. Sequence problems.
AL365277, AL137853, AL442071 Genomic DNA. Translation: CAI16422.1.
AL355477 expand/collapse EMBL AC list , AL137853, AL365277, AL442071 Genomic DNA. Translation: CAH70156.1. Sequence problems.
AL356055 Genomic DNA. No translation available.
AB033077 mRNA. Translation: BAA86565.1.
AB007934 mRNA. Translation: BAA32310.3.
CCDSCCDS435.1. [Q9UPN3-2]
PIRT00079.
RefSeqNP_036222.3. NM_012090.5. [Q9UPN3-2]
UniGeneHs.472475.
Hs.692278.

3D structure databases

ProteinModelPortalQ9UPN3.
SMRQ9UPN3. Positions 69-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117048. 36 interactions.
DIPDIP-50616N.
IntActQ9UPN3. 26 interactions.
MINTMINT-1195815.
STRING9606.ENSP00000289893.

PTM databases

PhosphoSiteQ9UPN3.

Polymorphism databases

DMDM338817989.

Proteomic databases

MaxQBQ9UPN3.
PaxDbQ9UPN3.
PRIDEQ9UPN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289893; ENSP00000289893; ENSG00000127603. [Q9UPN3-5]
ENST00000361689; ENSP00000354573; ENSG00000127603. [Q9UPN3-2]
ENST00000372915; ENSP00000362006; ENSG00000127603. [Q9UPN3-1]
ENST00000545844; ENSP00000439537; ENSG00000127603. [Q9UPN3-2]
GeneID23499.
KEGGhsa:23499.
UCSCuc001cda.1. human. [Q9UPN3-3]
uc021olt.1. human. [Q9UPN3-2]
uc031pmd.1. human. [Q9UPN3-5]

Organism-specific databases

CTD23499.
GeneCardsGC01P039546.
HGNCHGNC:13664. MACF1.
HPAHPA013713.
MIM608271. gene.
neXtProtNX_Q9UPN3.
PharmGKBPA30518.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000049054.
HOVERGENHBG031127.
PhylomeDBQ9UPN3.
TreeFamTF335163.

Enzyme and pathway databases

SignaLinkQ9UPN3.

Gene expression databases

ArrayExpressQ9UPN3.
BgeeQ9UPN3.
CleanExHS_MACF1.
GenevestigatorQ9UPN3.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
1.10.418.10. 2 hits.
3.30.920.20. 1 hit.
3.90.1290.10. 5 hits.
InterProIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR003108. GAS2_dom.
IPR028408. Macf1.
IPR001101. Plectin_repeat.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERPTHR11915:SF37. PTHR11915:SF37. 1 hit.
PfamPF00307. CH. 2 hits.
PF13499. EF-hand_7. 1 hit.
PF02187. GAS2. 1 hit.
PF00681. Plectin. 11 hits.
PF00435. Spectrin. 17 hits.
[Graphical view]
SMARTSM00033. CH. 2 hits.
SM00054. EFh. 2 hits.
SM00243. GAS2. 1 hit.
SM00250. PLEC. 20 hits.
SM00150. SPEC. 33 hits.
[Graphical view]
SUPFAMSSF143575. SSF143575. 1 hit.
SSF47576. SSF47576. 1 hit.
SSF75399. SSF75399. 6 hits.
PROSITEPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51460. GAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMACF1. human.
GeneWikiMACF1.
GenomeRNAi23499.
NextBio45871.
PROQ9UPN3.
SOURCESearch...

Entry information

Entry nameMACF1_HUMAN
AccessionPrimary (citable) accession number: Q9UPN3
Secondary accession number(s): B1ALC5 expand/collapse secondary AC list , E9PJT0, O75053, Q5VW20, Q8WXY1, Q8WXY2, Q96PK2, Q9H540, Q9UKP0, Q9ULG9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 142 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM