ID PLAL2_HUMAN Reviewed; 496 AA. AC Q9UPG8; A8K8T5; E1P5M3; Q92584; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 191. DE RecName: Full=Zinc finger protein PLAGL2; DE AltName: Full=Pleiomorphic adenoma-like protein 2; GN Name=PLAGL2; Synonyms=KIAA0198; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Fetal kidney; RX PubMed=9722527; DOI=10.1074/jbc.273.36.23026; RA Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.; RT "Transcriptional activation capacity of the novel PLAG family of zinc RT finger proteins."; RL J. Biol. Chem. 273:23026-23032(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Bone marrow; RX PubMed=8724849; DOI=10.1093/dnares/3.1.17; RA Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.; RT "Prediction of the coding sequences of unidentified human genes. V. The RT coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of RT cDNA clones from human cell line KG-1."; RL DNA Res. 3:17-24(1996). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=B-cell; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Shows weak transcriptional activatory activity. CC -!- INTERACTION: CC Q9UPG8; X5D778: ANKRD11; NbExp=3; IntAct=EBI-2876622, EBI-17183751; CC Q9UPG8; Q03989: ARID5A; NbExp=3; IntAct=EBI-2876622, EBI-948603; CC Q9UPG8; O75934: BCAS2; NbExp=3; IntAct=EBI-2876622, EBI-1050106; CC Q9UPG8; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-2876622, EBI-744545; CC Q9UPG8; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-2876622, EBI-744556; CC Q9UPG8; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-2876622, EBI-11962928; CC Q9UPG8; Q6P158: DHX57; NbExp=3; IntAct=EBI-2876622, EBI-1051531; CC Q9UPG8; Q92997: DVL3; NbExp=3; IntAct=EBI-2876622, EBI-739789; CC Q9UPG8; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-2876622, EBI-7225287; CC Q9UPG8; Q86UY5: FAM83A; NbExp=5; IntAct=EBI-2876622, EBI-1384254; CC Q9UPG8; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-2876622, EBI-6658203; CC Q9UPG8; P55040: GEM; NbExp=3; IntAct=EBI-2876622, EBI-744104; CC Q9UPG8; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-2876622, EBI-748515; CC Q9UPG8; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-2876622, EBI-11959863; CC Q9UPG8; P13807: GYS1; NbExp=3; IntAct=EBI-2876622, EBI-740553; CC Q9UPG8; Q9C086: INO80B; NbExp=3; IntAct=EBI-2876622, EBI-715611; CC Q9UPG8; Q9BZI1: IRX2; NbExp=3; IntAct=EBI-2876622, EBI-12166369; CC Q9UPG8; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2876622, EBI-2556193; CC Q9UPG8; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-2876622, EBI-77889; CC Q9UPG8; P28482: MAPK1; NbExp=3; IntAct=EBI-2876622, EBI-959949; CC Q9UPG8; Q8NDC4: MORN4; NbExp=3; IntAct=EBI-2876622, EBI-10269566; CC Q9UPG8; O43482: OIP5; NbExp=3; IntAct=EBI-2876622, EBI-536879; CC Q9UPG8; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-2876622, EBI-10225049; CC Q9UPG8; P55771: PAX9; NbExp=5; IntAct=EBI-2876622, EBI-12111000; CC Q9UPG8; B7ZLY0: PHC2; NbExp=3; IntAct=EBI-2876622, EBI-14568740; CC Q9UPG8; Q13526: PIN1; NbExp=3; IntAct=EBI-2876622, EBI-714158; CC Q9UPG8; P0CG20: PRR35; NbExp=3; IntAct=EBI-2876622, EBI-11986293; CC Q9UPG8; O94955: RHOBTB3; NbExp=3; IntAct=EBI-2876622, EBI-2367123; CC Q9UPG8; Q0D2K3: RIPPLY1; NbExp=5; IntAct=EBI-2876622, EBI-10226430; CC Q9UPG8; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-2876622, EBI-14067109; CC Q9UPG8; P49903: SEPHS1; NbExp=3; IntAct=EBI-2876622, EBI-714091; CC Q9UPG8; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-2876622, EBI-358489; CC Q9UPG8; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-2876622, EBI-8644516; CC Q9UPG8; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-2876622, EBI-750487; CC Q9UPG8; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-2876622, EBI-3650647; CC Q9UPG8; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-2876622, EBI-725997; CC Q9UPG8; Q14119: VEZF1; NbExp=3; IntAct=EBI-2876622, EBI-11980193; CC Q9UPG8; P62699: YPEL5; NbExp=3; IntAct=EBI-2876622, EBI-11721624; CC Q9UPG8; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-2876622, EBI-10273713; CC Q9UPG8; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-2876622, EBI-745520; CC Q9UPG8; Q96EJ4; NbExp=3; IntAct=EBI-2876622, EBI-750454; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA12113.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and CC Haematology; CC URL="https://atlasgeneticsoncology.org/gene/41738/PLAGL2"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF006005; AAC34252.1; -; mRNA. DR EMBL; D83784; BAA12113.1; ALT_INIT; mRNA. DR EMBL; AK292450; BAF85139.1; -; mRNA. DR EMBL; AL121897; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471077; EAW76386.1; -; Genomic_DNA. DR EMBL; CH471077; EAW76387.1; -; Genomic_DNA. DR EMBL; BC023655; AAH23655.1; -; mRNA. DR CCDS; CCDS13197.1; -. DR RefSeq; NP_002648.1; NM_002657.3. DR RefSeq; XP_005260493.1; XM_005260436.3. DR RefSeq; XP_011527165.1; XM_011528863.2. DR RefSeq; XP_011527166.1; XM_011528864.2. DR AlphaFoldDB; Q9UPG8; -. DR SMR; Q9UPG8; -. DR BioGRID; 111342; 57. DR IntAct; Q9UPG8; 48. DR STRING; 9606.ENSP00000246229; -. DR iPTMnet; Q9UPG8; -. DR PhosphoSitePlus; Q9UPG8; -. DR BioMuta; PLAGL2; -. DR DMDM; 14548188; -. DR EPD; Q9UPG8; -. DR jPOST; Q9UPG8; -. DR MassIVE; Q9UPG8; -. DR MaxQB; Q9UPG8; -. DR PaxDb; 9606-ENSP00000246229; -. DR PeptideAtlas; Q9UPG8; -. DR ProteomicsDB; 85371; -. DR Antibodypedia; 1784; 127 antibodies from 25 providers. DR DNASU; 5326; -. DR Ensembl; ENST00000246229.5; ENSP00000246229.4; ENSG00000126003.7. DR GeneID; 5326; -. DR KEGG; hsa:5326; -. DR MANE-Select; ENST00000246229.5; ENSP00000246229.4; NM_002657.3; NP_002648.1. DR UCSC; uc002wxn.3; human. DR AGR; HGNC:9047; -. DR CTD; 5326; -. DR DisGeNET; 5326; -. DR GeneCards; PLAGL2; -. DR HGNC; HGNC:9047; PLAGL2. DR HPA; ENSG00000126003; Tissue enhanced (bone). DR MIM; 604866; gene. DR neXtProt; NX_Q9UPG8; -. DR OpenTargets; ENSG00000126003; -. DR PharmGKB; PA33380; -. DR VEuPathDB; HostDB:ENSG00000126003; -. DR eggNOG; KOG1721; Eukaryota. DR GeneTree; ENSGT00940000160566; -. DR HOGENOM; CLU_002678_66_1_1; -. DR InParanoid; Q9UPG8; -. DR OMA; DMMGGKS; -. DR OrthoDB; 2971215at2759; -. DR PhylomeDB; Q9UPG8; -. DR TreeFam; TF332024; -. DR PathwayCommons; Q9UPG8; -. DR SignaLink; Q9UPG8; -. DR SIGNOR; Q9UPG8; -. DR BioGRID-ORCS; 5326; 45 hits in 1186 CRISPR screens. DR ChiTaRS; PLAGL2; human. DR GeneWiki; PLAGL2; -. DR GenomeRNAi; 5326; -. DR Pharos; Q9UPG8; Tbio. DR PRO; PR:Q9UPG8; -. DR Proteomes; UP000005640; Chromosome 20. DR RNAct; Q9UPG8; Protein. DR Bgee; ENSG00000126003; Expressed in sperm and 138 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI. DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:0034378; P:chylomicron assembly; IEA:Ensembl. DR GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl. DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl. DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR24408; ZINC FINGER PROTEIN; 1. DR PANTHER; PTHR24408:SF20; ZINC FINGER PROTEIN PLAGL2; 1. DR Pfam; PF00096; zf-C2H2; 3. DR Pfam; PF13912; zf-C2H2_6; 1. DR SMART; SM00355; ZnF_C2H2; 6. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6. DR Genevisible; Q9UPG8; HS. PE 1: Evidence at protein level; KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..496 FT /note="Zinc finger protein PLAGL2" FT /id="PRO_0000047223" FT ZN_FING 68..92 FT /note="C2H2-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 98..120 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 127..149 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 156..178 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 191..213 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 219..242 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" SQ SEQUENCE 496 AA; 54584 MW; 20F5E7A28EF60603 CRC64; MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ //