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Protein

Zinc finger protein PLAGL2

Gene

PLAGL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows weak transcriptional activatory activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 92C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 120C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri127 – 149C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9UPG8

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein PLAGL2
Alternative name(s):
Pleiomorphic adenoma-like protein 2
Gene namesi
Name:PLAGL2
Synonyms:KIAA0198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000126003.6
HGNCiHGNC:9047 PLAGL2
MIMi604866 gene
neXtProtiNX_Q9UPG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5326
OpenTargetsiENSG00000126003
PharmGKBiPA33380

Polymorphism and mutation databases

BioMutaiPLAGL2
DMDMi14548188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472231 – 496Zinc finger protein PLAGL2Add BLAST496

Proteomic databases

EPDiQ9UPG8
MaxQBiQ9UPG8
PaxDbiQ9UPG8
PeptideAtlasiQ9UPG8
PRIDEiQ9UPG8

PTM databases

iPTMnetiQ9UPG8
PhosphoSitePlusiQ9UPG8

Expressioni

Gene expression databases

BgeeiENSG00000126003
CleanExiHS_PLAGL2
GenevisibleiQ9UPG8 HS

Organism-specific databases

HPAiHPA005900

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM83AQ86UY54EBI-2876622,EBI-1384254

Protein-protein interaction databases

BioGridi1113424 interactors.
IntActiQ9UPG8 35 interactors.
STRINGi9606.ENSP00000246229

Structurei

3D structure databases

ProteinModelPortaliQ9UPG8
SMRiQ9UPG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 92C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 120C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri127 – 149C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000013640
HOGENOMiHOG000294191
HOVERGENiHBG053608
InParanoidiQ9UPG8
KOiK19486
OMAiEMESFLM
OrthoDBiEOG091G061O
PhylomeDBiQ9UPG8
TreeFamiTF332024

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q9UPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS
60 70 80 90 100
NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC
110 120 130 140 150
MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA
160 170 180 190 200
ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF
210 220 230 240 250
YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK
260 270 280 290 300
TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA
310 320 330 340 350
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL
360 370 380 390 400
PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP
410 420 430 440 450
ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL
460 470 480 490
TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
Length:496
Mass (Da):54,584
Last modified:May 1, 2000 - v1
Checksum:i20F5E7A28EF60603
GO

Sequence cautioni

The sequence BAA12113 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006005 mRNA Translation: AAC34252.1
D83784 mRNA Translation: BAA12113.1 Different initiation.
AK292450 mRNA Translation: BAF85139.1
AL121897 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76386.1
CH471077 Genomic DNA Translation: EAW76387.1
BC023655 mRNA Translation: AAH23655.1
CCDSiCCDS13197.1
RefSeqiNP_002648.1, NM_002657.3
XP_005260493.1, XM_005260436.3
XP_011527165.1, XM_011528863.2
XP_011527166.1, XM_011528864.2
UniGeneiHs.154104

Genome annotation databases

EnsembliENST00000246229; ENSP00000246229; ENSG00000126003
GeneIDi5326
KEGGihsa:5326
UCSCiuc002wxn.3 human

Similar proteinsi

Entry informationi

Entry nameiPLAL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPG8
Secondary accession number(s): A8K8T5, E1P5M3, Q92584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome