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Q9UPG8

- PLAL2_HUMAN

UniProt

Q9UPG8 - PLAL2_HUMAN

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Protein

Zinc finger protein PLAGL2

Gene

PLAGL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Shows weak transcriptional activatory activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 9225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 14923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 21323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. chylomicron assembly Source: RefGenome
  2. lipid metabolic process Source: Ensembl
  3. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  4. post-embryonic development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein PLAGL2
Alternative name(s):
Pleiomorphic adenoma-like protein 2
Gene namesi
Name:PLAGL2
Synonyms:KIAA0198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:9047. PLAGL2.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Zinc finger protein PLAGL2PRO_0000047223Add
BLAST

Proteomic databases

MaxQBiQ9UPG8.
PaxDbiQ9UPG8.
PRIDEiQ9UPG8.

PTM databases

PhosphoSiteiQ9UPG8.

Expressioni

Gene expression databases

BgeeiQ9UPG8.
CleanExiHS_PLAGL2.
GenevestigatoriQ9UPG8.

Organism-specific databases

HPAiHPA005900.

Interactioni

Protein-protein interaction databases

BioGridi111342. 3 interactions.
IntActiQ9UPG8. 1 interaction.
STRINGi9606.ENSP00000246229.

Structurei

3D structure databases

ProteinModelPortaliQ9UPG8.
SMRiQ9UPG8. Positions 41-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri68 – 9225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri98 – 12023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 14923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri191 – 21323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri219 – 24224C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiQ9UPG8.
OMAiTWPFAIS.
OrthoDBiEOG71K62Q.
PhylomeDBiQ9UPG8.
TreeFamiTF332024.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UPG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS
60 70 80 90 100
NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC
110 120 130 140 150
MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA
160 170 180 190 200
ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF
210 220 230 240 250
YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK
260 270 280 290 300
TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA
310 320 330 340 350
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL
360 370 380 390 400
PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP
410 420 430 440 450
ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL
460 470 480 490
TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
Length:496
Mass (Da):54,584
Last modified:May 1, 2000 - v1
Checksum:i20F5E7A28EF60603
GO

Sequence cautioni

The sequence BAA12113.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006005 mRNA. Translation: AAC34252.1.
D83784 mRNA. Translation: BAA12113.1. Different initiation.
AK292450 mRNA. Translation: BAF85139.1.
AL121897 Genomic DNA. Translation: CAC16423.1.
CH471077 Genomic DNA. Translation: EAW76386.1.
CH471077 Genomic DNA. Translation: EAW76387.1.
BC023655 mRNA. Translation: AAH23655.1.
CCDSiCCDS13197.1.
RefSeqiNP_002648.1. NM_002657.3.
XP_005260493.1. XM_005260436.1.
UniGeneiHs.154104.

Genome annotation databases

EnsembliENST00000246229; ENSP00000246229; ENSG00000126003.
GeneIDi5326.
KEGGihsa:5326.
UCSCiuc002wxn.2. human.

Polymorphism databases

DMDMi14548188.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006005 mRNA. Translation: AAC34252.1 .
D83784 mRNA. Translation: BAA12113.1 . Different initiation.
AK292450 mRNA. Translation: BAF85139.1 .
AL121897 Genomic DNA. Translation: CAC16423.1 .
CH471077 Genomic DNA. Translation: EAW76386.1 .
CH471077 Genomic DNA. Translation: EAW76387.1 .
BC023655 mRNA. Translation: AAH23655.1 .
CCDSi CCDS13197.1.
RefSeqi NP_002648.1. NM_002657.3.
XP_005260493.1. XM_005260436.1.
UniGenei Hs.154104.

3D structure databases

ProteinModelPortali Q9UPG8.
SMRi Q9UPG8. Positions 41-245.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111342. 3 interactions.
IntActi Q9UPG8. 1 interaction.
STRINGi 9606.ENSP00000246229.

PTM databases

PhosphoSitei Q9UPG8.

Polymorphism databases

DMDMi 14548188.

Proteomic databases

MaxQBi Q9UPG8.
PaxDbi Q9UPG8.
PRIDEi Q9UPG8.

Protocols and materials databases

DNASUi 5326.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246229 ; ENSP00000246229 ; ENSG00000126003 .
GeneIDi 5326.
KEGGi hsa:5326.
UCSCi uc002wxn.2. human.

Organism-specific databases

CTDi 5326.
GeneCardsi GC20M030780.
HGNCi HGNC:9047. PLAGL2.
HPAi HPA005900.
MIMi 604866. gene.
neXtProti NX_Q9UPG8.
PharmGKBi PA33380.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00390000013640.
HOGENOMi HOG000294191.
HOVERGENi HBG053608.
InParanoidi Q9UPG8.
OMAi TWPFAIS.
OrthoDBi EOG71K62Q.
PhylomeDBi Q9UPG8.
TreeFami TF332024.

Miscellaneous databases

GeneWikii PLAGL2.
GenomeRNAii 5326.
NextBioi 20618.
PROi Q9UPG8.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPG8.
CleanExi HS_PLAGL2.
Genevestigatori Q9UPG8.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
    Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.
    J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal kidney.
  2. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
    DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.

Entry informationi

Entry nameiPLAL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPG8
Secondary accession number(s): A8K8T5, E1P5M3, Q92584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3