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Q9UPG8

- PLAL2_HUMAN

UniProt

Q9UPG8 - PLAL2_HUMAN

Protein

Zinc finger protein PLAGL2

Gene

PLAGL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Shows weak transcriptional activatory activity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri68 – 9225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri98 – 12023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri127 – 14923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri191 – 21323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri219 – 24224C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. chylomicron assembly Source: RefGenome
    2. lipid metabolic process Source: Ensembl
    3. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    4. post-embryonic development Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein PLAGL2
    Alternative name(s):
    Pleiomorphic adenoma-like protein 2
    Gene namesi
    Name:PLAGL2
    Synonyms:KIAA0198
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:9047. PLAGL2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Zinc finger protein PLAGL2PRO_0000047223Add
    BLAST

    Proteomic databases

    MaxQBiQ9UPG8.
    PaxDbiQ9UPG8.
    PRIDEiQ9UPG8.

    PTM databases

    PhosphoSiteiQ9UPG8.

    Expressioni

    Gene expression databases

    BgeeiQ9UPG8.
    CleanExiHS_PLAGL2.
    GenevestigatoriQ9UPG8.

    Organism-specific databases

    HPAiHPA005900.

    Interactioni

    Protein-protein interaction databases

    BioGridi111342. 3 interactions.
    IntActiQ9UPG8. 1 interaction.
    STRINGi9606.ENSP00000246229.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPG8.
    SMRiQ9UPG8. Positions 41-278.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri68 – 9225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri98 – 12023C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri127 – 14923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri156 – 17823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri191 – 21323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri219 – 24224C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000294191.
    HOVERGENiHBG053608.
    InParanoidiQ9UPG8.
    OMAiTWPFAIS.
    OrthoDBiEOG71K62Q.
    PhylomeDBiQ9UPG8.
    TreeFamiTF332024.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UPG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS    50
    NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC 100
    MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA 150
    ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF 200
    YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK 250
    TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA 300
    HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL 350
    PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP 400
    ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL 450
    TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ 496
    Length:496
    Mass (Da):54,584
    Last modified:May 1, 2000 - v1
    Checksum:i20F5E7A28EF60603
    GO

    Sequence cautioni

    The sequence BAA12113.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006005 mRNA. Translation: AAC34252.1.
    D83784 mRNA. Translation: BAA12113.1. Different initiation.
    AK292450 mRNA. Translation: BAF85139.1.
    AL121897 Genomic DNA. Translation: CAC16423.1.
    CH471077 Genomic DNA. Translation: EAW76386.1.
    CH471077 Genomic DNA. Translation: EAW76387.1.
    BC023655 mRNA. Translation: AAH23655.1.
    CCDSiCCDS13197.1.
    RefSeqiNP_002648.1. NM_002657.3.
    XP_005260493.1. XM_005260436.1.
    UniGeneiHs.154104.

    Genome annotation databases

    EnsembliENST00000246229; ENSP00000246229; ENSG00000126003.
    GeneIDi5326.
    KEGGihsa:5326.
    UCSCiuc002wxn.2. human.

    Polymorphism databases

    DMDMi14548188.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006005 mRNA. Translation: AAC34252.1 .
    D83784 mRNA. Translation: BAA12113.1 . Different initiation.
    AK292450 mRNA. Translation: BAF85139.1 .
    AL121897 Genomic DNA. Translation: CAC16423.1 .
    CH471077 Genomic DNA. Translation: EAW76386.1 .
    CH471077 Genomic DNA. Translation: EAW76387.1 .
    BC023655 mRNA. Translation: AAH23655.1 .
    CCDSi CCDS13197.1.
    RefSeqi NP_002648.1. NM_002657.3.
    XP_005260493.1. XM_005260436.1.
    UniGenei Hs.154104.

    3D structure databases

    ProteinModelPortali Q9UPG8.
    SMRi Q9UPG8. Positions 41-278.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111342. 3 interactions.
    IntActi Q9UPG8. 1 interaction.
    STRINGi 9606.ENSP00000246229.

    PTM databases

    PhosphoSitei Q9UPG8.

    Polymorphism databases

    DMDMi 14548188.

    Proteomic databases

    MaxQBi Q9UPG8.
    PaxDbi Q9UPG8.
    PRIDEi Q9UPG8.

    Protocols and materials databases

    DNASUi 5326.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246229 ; ENSP00000246229 ; ENSG00000126003 .
    GeneIDi 5326.
    KEGGi hsa:5326.
    UCSCi uc002wxn.2. human.

    Organism-specific databases

    CTDi 5326.
    GeneCardsi GC20M030780.
    HGNCi HGNC:9047. PLAGL2.
    HPAi HPA005900.
    MIMi 604866. gene.
    neXtProti NX_Q9UPG8.
    PharmGKBi PA33380.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000294191.
    HOVERGENi HBG053608.
    InParanoidi Q9UPG8.
    OMAi TWPFAIS.
    OrthoDBi EOG71K62Q.
    PhylomeDBi Q9UPG8.
    TreeFami TF332024.

    Miscellaneous databases

    GeneWikii PLAGL2.
    GenomeRNAii 5326.
    NextBioi 20618.
    PROi Q9UPG8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UPG8.
    CleanExi HS_PLAGL2.
    Genevestigatori Q9UPG8.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
      Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.
      J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal kidney.
    2. "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.
      DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: B-cell.

    Entry informationi

    Entry nameiPLAL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPG8
    Secondary accession number(s): A8K8T5, E1P5M3, Q92584
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3