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Protein

Zinc finger protein PLAGL2

Gene

PLAGL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Shows weak transcriptional activatory activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 92C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 120C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri127 – 149C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126003-MONOMER.
SIGNORiQ9UPG8.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein PLAGL2
Alternative name(s):
Pleiomorphic adenoma-like protein 2
Gene namesi
Name:PLAGL2
Synonyms:KIAA0198
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9047. PLAGL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5326.
OpenTargetsiENSG00000126003.
PharmGKBiPA33380.

Polymorphism and mutation databases

BioMutaiPLAGL2.
DMDMi14548188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472231 – 496Zinc finger protein PLAGL2Add BLAST496

Proteomic databases

EPDiQ9UPG8.
MaxQBiQ9UPG8.
PaxDbiQ9UPG8.
PeptideAtlasiQ9UPG8.
PRIDEiQ9UPG8.

PTM databases

iPTMnetiQ9UPG8.
PhosphoSitePlusiQ9UPG8.

Expressioni

Gene expression databases

BgeeiENSG00000126003.
CleanExiHS_PLAGL2.
GenevisibleiQ9UPG8. HS.

Organism-specific databases

HPAiHPA005900.

Interactioni

Protein-protein interaction databases

BioGridi111342. 4 interactors.
IntActiQ9UPG8. 5 interactors.
STRINGi9606.ENSP00000246229.

Structurei

3D structure databases

ProteinModelPortaliQ9UPG8.
SMRiQ9UPG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri68 – 92C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri98 – 120C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri127 – 149C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri156 – 178C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 242C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiQ9UPG8.
KOiK19486.
OMAiEMESFLM.
OrthoDBiEOG091G061O.
PhylomeDBiQ9UPG8.
TreeFamiTF332024.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS
60 70 80 90 100
NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC
110 120 130 140 150
MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA
160 170 180 190 200
ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF
210 220 230 240 250
YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK
260 270 280 290 300
TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA
310 320 330 340 350
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL
360 370 380 390 400
PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP
410 420 430 440 450
ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL
460 470 480 490
TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
Length:496
Mass (Da):54,584
Last modified:May 1, 2000 - v1
Checksum:i20F5E7A28EF60603
GO

Sequence cautioni

The sequence BAA12113 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006005 mRNA. Translation: AAC34252.1.
D83784 mRNA. Translation: BAA12113.1. Different initiation.
AK292450 mRNA. Translation: BAF85139.1.
AL121897 Genomic DNA. Translation: CAC16423.1.
CH471077 Genomic DNA. Translation: EAW76386.1.
CH471077 Genomic DNA. Translation: EAW76387.1.
BC023655 mRNA. Translation: AAH23655.1.
CCDSiCCDS13197.1.
RefSeqiNP_002648.1. NM_002657.3.
XP_005260493.1. XM_005260436.3.
XP_011527165.1. XM_011528863.2.
XP_011527166.1. XM_011528864.2.
UniGeneiHs.154104.

Genome annotation databases

EnsembliENST00000246229; ENSP00000246229; ENSG00000126003.
GeneIDi5326.
KEGGihsa:5326.
UCSCiuc002wxn.3. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006005 mRNA. Translation: AAC34252.1.
D83784 mRNA. Translation: BAA12113.1. Different initiation.
AK292450 mRNA. Translation: BAF85139.1.
AL121897 Genomic DNA. Translation: CAC16423.1.
CH471077 Genomic DNA. Translation: EAW76386.1.
CH471077 Genomic DNA. Translation: EAW76387.1.
BC023655 mRNA. Translation: AAH23655.1.
CCDSiCCDS13197.1.
RefSeqiNP_002648.1. NM_002657.3.
XP_005260493.1. XM_005260436.3.
XP_011527165.1. XM_011528863.2.
XP_011527166.1. XM_011528864.2.
UniGeneiHs.154104.

3D structure databases

ProteinModelPortaliQ9UPG8.
SMRiQ9UPG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111342. 4 interactors.
IntActiQ9UPG8. 5 interactors.
STRINGi9606.ENSP00000246229.

PTM databases

iPTMnetiQ9UPG8.
PhosphoSitePlusiQ9UPG8.

Polymorphism and mutation databases

BioMutaiPLAGL2.
DMDMi14548188.

Proteomic databases

EPDiQ9UPG8.
MaxQBiQ9UPG8.
PaxDbiQ9UPG8.
PeptideAtlasiQ9UPG8.
PRIDEiQ9UPG8.

Protocols and materials databases

DNASUi5326.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246229; ENSP00000246229; ENSG00000126003.
GeneIDi5326.
KEGGihsa:5326.
UCSCiuc002wxn.3. human.

Organism-specific databases

CTDi5326.
DisGeNETi5326.
GeneCardsiPLAGL2.
HGNCiHGNC:9047. PLAGL2.
HPAiHPA005900.
MIMi604866. gene.
neXtProtiNX_Q9UPG8.
OpenTargetsiENSG00000126003.
PharmGKBiPA33380.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013640.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiQ9UPG8.
KOiK19486.
OMAiEMESFLM.
OrthoDBiEOG091G061O.
PhylomeDBiQ9UPG8.
TreeFamiTF332024.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126003-MONOMER.
SIGNORiQ9UPG8.

Miscellaneous databases

GeneWikiiPLAGL2.
GenomeRNAii5326.
PROiQ9UPG8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126003.
CleanExiHS_PLAGL2.
GenevisibleiQ9UPG8. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLAL2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPG8
Secondary accession number(s): A8K8T5, E1P5M3, Q92584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.