Reviewed,
UniProtKB/Swiss-Prot Q9UPG8 (PLAL2_HUMAN)
Last modified
January 19, 2010.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Zinc finger protein PLAGL2 Alternative name(s): Pleiomorphic adenoma-like protein 2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 496 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Shows weak transcriptional activatory activity. |
| Subcellular location | Nucleus Probable. |
| Sequence similarities | Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| Molecular function | Activator |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | transcription Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA nucleusInferred from direct assay. Source: HPA |
| Molecular function | transcription factor activity Ref.1 Traceable author statement. Source: ProtInc zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 496 | 496 | Zinc finger protein PLAGL2 | PRO_0000047223 | |||||
Regions | |||||||||
| Zinc finger | 68 – 92 | 25 | C2H2-type 1 | ||||||
| Zinc finger | 98 – 120 | 23 | C2H2-type 2 | ||||||
| Zinc finger | 127 – 149 | 23 | C2H2-type 3 | ||||||
| Zinc finger | 156 – 178 | 23 | C2H2-type 4 | ||||||
| Zinc finger | 191 – 213 | 23 | C2H2-type 5 | ||||||
| Zinc finger | 219 – 242 | 24 | C2H2-type 6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins." Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M. J. Biol. Chem. 273:23026-23032(1998) [PubMed: 9722527] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney. |
| [2] | "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [4] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF006005 mRNA. Translation: AAC34252.1. D83784 mRNA. Translation: BAA12113.1. Different initiation. AK292450 mRNA. Translation: BAF85139.1. AL121897 Genomic DNA. Translation: CAC16423.1. CH471077 Genomic DNA. Translation: EAW76386.1. BC023655 mRNA. Translation: AAH23655.1. |
| IPI | IPI00010085. |
| RefSeq | NP_002648.1. |
| UniGene | Hs.154104 |
3D structure databases | |
| SMR | Q9UPG8. Positions 39-215, 66-245. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UPG8. |
PTM databases | |
| PhosphoSite | Q9UPG8. |
Proteomic databases | |
| PRIDE | Q9UPG8. |
Genome annotation databases | |
| Ensembl | ENST00000246229; ENSP00000246229; ENSG00000126003; Homo sapiens. [Genome view] |
| GeneID | 5326. |
| KEGG | hsa:5326. |
| UCSC | uc002wxn.2. human. |
Organism-specific databases | |
| CTD | 5326. |
| GeneCards | GC20M030243. |
| HGNC | HGNC:9047. PLAGL2. |
| HPA | HPA005900. |
| MIM | 604866. gene. |
| PharmGKB | PA33380. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG14055. |
| HOGENOM | HBG717420. |
| HOVERGEN | Q9UPG8. |
| InParanoid | Q9UPG8. |
| OMA | TMPSTGM. |
| OrthoDB | EOG9S1WSM. |
| PhylomeDB | Q9UPG8. |
Gene expression databases | |
| ArrayExpress | Q9UPG8. |
| Bgee | Q9UPG8. |
| CleanEx | HS_PLAGL2. |
| Genevestigator | Q9UPG8. |
| GermOnline | ENSG00000126003. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit. |
| Pfam | PF00096. zf-C2H2. 1 hit. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 6 hits. [Graphical view] |
| PROSITE | PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 20618. |
| SOURCE | Search... |
Entry information
| Entry name | PLAL2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UPG8 Secondary accession number(s): A8K8T5, Q92584 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


