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Q9UPE1

- SRPK3_HUMAN

UniProt

Q9UPE1 - SRPK3_HUMAN

Protein

SRSF protein kinase 3

Gene

SRPK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (03 May 2011)
      Previous versions | rss
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    Functioni

    Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei108 – 1081ATPPROSITE-ProRule annotation
    Active sitei212 – 2121Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi85 – 939ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. muscle tissue development Source: UniProtKB
    3. skeletal muscle tissue development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Differentiation, Myogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    SignaLinkiQ9UPE1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SRSF protein kinase 3 (EC:2.7.11.1)
    Alternative name(s):
    Muscle-specific serine kinase 1
    Short name:
    MSSK-1
    Serine/arginine-rich protein-specific kinase 3
    Short name:
    SR-protein-specific kinase 3
    Serine/threonine-protein kinase 23
    Gene namesi
    Name:SRPK3
    Synonyms:MSSK1, STK23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11402. SRPK3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162404805.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567SRSF protein kinase 3PRO_0000086709Add
    BLAST

    Proteomic databases

    MaxQBiQ9UPE1.
    PaxDbiQ9UPE1.
    PRIDEiQ9UPE1.

    PTM databases

    PhosphoSiteiQ9UPE1.

    Expressioni

    Tissue specificityi

    Exclusively expressed in skeletal and heart muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9UPE1.
    BgeeiQ9UPE1.
    CleanExiHS_SRPK3.
    GenevestigatoriQ9UPE1.

    Organism-specific databases

    HPAiHPA042489.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SRPK1Q96SB42EBI-6381269,EBI-539478

    Protein-protein interaction databases

    BioGridi117745. 61 interactions.
    IntActiQ9UPE1. 56 interactions.
    STRINGi9606.ENSP00000359119.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPE1.
    SMRiQ9UPE1. Positions 66-261, 350-566.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 565487Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 215Poly-Ser

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000171558.
    HOVERGENiHBG108512.
    KOiK08832.
    TreeFamiTF105334.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 2 hits.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UPE1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS    50
    DDEEQEDPKD YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ 100
    RKRFVALKVV KSAGHYTETA VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF 150
    RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY QGLPVPCVKS IVRQVLHGLD 200
    YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA GAPPPSRSIV 250
    STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ 300
    AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT 350
    SGFSGSLFSP ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA 400
    DKIKIKIADL GNACWVHKHF TEDIQTRQYR AVEVLIGAEY GPPADIWSTA 450
    CMAFELATGD YLFEPHSGED YSRDEDHIAH IVELLGDIPP AFALSGRYSR 500
    EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA FLLPMMEYIP 550
    EKRASAADCL QHPWLNP 567
    Length:567
    Mass (Da):62,014
    Last modified:May 3, 2011 - v2
    Checksum:i754A9F3759ADEE82
    GO
    Isoform 2 (identifier: Q9UPE1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-42: Missing.
         259-259: Missing.
         318-350: Missing.

    Show »
    Length:491
    Mass (Da):55,327
    Checksum:iB6B39C04D670CC1D
    GO
    Isoform 3 (identifier: Q9UPE1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-259: Missing.
         318-350: Missing.

    Show »
    Length:533
    Mass (Da):58,997
    Checksum:i2CA221A4373B9054
    GO
    Isoform 4 (identifier: Q9UPE1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         259-259: Missing.

    Show »
    Length:566
    Mass (Da):61,886
    Checksum:i078F3D5A99FDF014
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti101 – 1011R → C.1 Publication
    Corresponds to variant rs55910507 [ dbSNP | Ensembl ].
    VAR_041119
    Natural varianti114 – 1141G → E.1 Publication
    Corresponds to variant rs35865042 [ dbSNP | Ensembl ].
    VAR_041120
    Natural varianti233 – 2331E → K.1 Publication
    Corresponds to variant rs34497419 [ dbSNP | Ensembl ].
    VAR_041121

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_040939Add
    BLAST
    Alternative sequencei259 – 2591Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_040940
    Alternative sequencei318 – 35033Missing in isoform 2 and isoform 3. 1 PublicationVSP_040941Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027406 mRNA. Translation: AAD01848.1.
    U82808 mRNA. Translation: AAD00539.1.
    DQ099381 mRNA. Translation: AAZ13757.1.
    AK301749 mRNA. Translation: BAG63211.1.
    U52111 Genomic DNA. No translation available.
    BC092416 mRNA. Translation: AAH92416.1.
    BC117124 mRNA. Translation: AAI17125.1.
    CCDSiCCDS35441.1. [Q9UPE1-1]
    CCDS55537.1. [Q9UPE1-3]
    CCDS55538.1. [Q9UPE1-4]
    RefSeqiNP_001164231.1. NM_001170760.1. [Q9UPE1-4]
    NP_001164232.1. NM_001170761.1. [Q9UPE1-3]
    NP_055185.2. NM_014370.3. [Q9UPE1-1]
    UniGeneiHs.104865.

    Genome annotation databases

    EnsembliENST00000370101; ENSP00000359119; ENSG00000184343. [Q9UPE1-1]
    ENST00000370104; ENSP00000359122; ENSG00000184343. [Q9UPE1-4]
    ENST00000393786; ENSP00000377376; ENSG00000184343. [Q9UPE1-3]
    GeneIDi26576.
    KEGGihsa:26576.
    UCSCiuc004fil.3. human. [Q9UPE1-1]
    uc004fim.3. human. [Q9UPE1-3]
    uc004fin.3. human. [Q9UPE1-4]
    uc010nul.3. human. [Q9UPE1-2]

    Polymorphism databases

    DMDMi332278151.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027406 mRNA. Translation: AAD01848.1 .
    U82808 mRNA. Translation: AAD00539.1 .
    DQ099381 mRNA. Translation: AAZ13757.1 .
    AK301749 mRNA. Translation: BAG63211.1 .
    U52111 Genomic DNA. No translation available.
    BC092416 mRNA. Translation: AAH92416.1 .
    BC117124 mRNA. Translation: AAI17125.1 .
    CCDSi CCDS35441.1. [Q9UPE1-1 ]
    CCDS55537.1. [Q9UPE1-3 ]
    CCDS55538.1. [Q9UPE1-4 ]
    RefSeqi NP_001164231.1. NM_001170760.1. [Q9UPE1-4 ]
    NP_001164232.1. NM_001170761.1. [Q9UPE1-3 ]
    NP_055185.2. NM_014370.3. [Q9UPE1-1 ]
    UniGenei Hs.104865.

    3D structure databases

    ProteinModelPortali Q9UPE1.
    SMRi Q9UPE1. Positions 66-261, 350-566.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117745. 61 interactions.
    IntActi Q9UPE1. 56 interactions.
    STRINGi 9606.ENSP00000359119.

    Chemistry

    BindingDBi Q9UPE1.
    ChEMBLi CHEMBL5415.
    GuidetoPHARMACOLOGYi 2210.

    PTM databases

    PhosphoSitei Q9UPE1.

    Polymorphism databases

    DMDMi 332278151.

    Proteomic databases

    MaxQBi Q9UPE1.
    PaxDbi Q9UPE1.
    PRIDEi Q9UPE1.

    Protocols and materials databases

    DNASUi 26576.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370101 ; ENSP00000359119 ; ENSG00000184343 . [Q9UPE1-1 ]
    ENST00000370104 ; ENSP00000359122 ; ENSG00000184343 . [Q9UPE1-4 ]
    ENST00000393786 ; ENSP00000377376 ; ENSG00000184343 . [Q9UPE1-3 ]
    GeneIDi 26576.
    KEGGi hsa:26576.
    UCSCi uc004fil.3. human. [Q9UPE1-1 ]
    uc004fim.3. human. [Q9UPE1-3 ]
    uc004fin.3. human. [Q9UPE1-4 ]
    uc010nul.3. human. [Q9UPE1-2 ]

    Organism-specific databases

    CTDi 26576.
    GeneCardsi GC0XP153041.
    HGNCi HGNC:11402. SRPK3.
    HPAi HPA042489.
    neXtProti NX_Q9UPE1.
    PharmGKBi PA162404805.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000171558.
    HOVERGENi HBG108512.
    KOi K08832.
    TreeFami TF105334.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    SignaLinki Q9UPE1.

    Miscellaneous databases

    GenomeRNAii 26576.
    NextBioi 48918.
    PROi Q9UPE1.

    Gene expression databases

    ArrayExpressi Q9UPE1.
    Bgeei Q9UPE1.
    CleanExi HS_SRPK3.
    Genevestigatori Q9UPE1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a new human serine kinase gene located in human Xq28."
      Brenner V., Rosenthal A., Platzer M.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
      Tissue: Skeletal muscle.
    2. Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Brain.
    6. "Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes."
      Grunau C., Hindermann W., Rosenthal A.
      Hum. Mol. Genet. 9:2651-2663(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Serine-arginine protein kinases: a small protein kinase family with a large cellular presence."
      Giannakouros T., Nikolakaki E., Mylonis I., Georgatsou E.
      FEBS J. 278:570-586(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    8. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-101; GLU-114 AND LYS-233.

    Entry informationi

    Entry nameiSRPK3_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPE1
    Secondary accession number(s): Q13583
    , Q4F970, Q562F5, Q9UM62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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