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Protein

SRSF protein kinase 3

Gene

SRPK3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108ATPPROSITE-ProRule annotation1
Active sitei212Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 93ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Myogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
SignaLinkiQ9UPE1

Names & Taxonomyi

Protein namesi
Recommended name:
SRSF protein kinase 3 (EC:2.7.11.1)
Alternative name(s):
Muscle-specific serine kinase 1
Short name:
MSSK-1
Serine/arginine-rich protein-specific kinase 3
Short name:
SR-protein-specific kinase 3
Serine/threonine-protein kinase 23
Gene namesi
Name:SRPK3
Synonyms:MSSK1, STK23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000184343.10
HGNCiHGNC:11402 SRPK3
MIMi301002 gene
neXtProtiNX_Q9UPE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi26576
OpenTargetsiENSG00000184343
PharmGKBiPA162404805

Chemistry databases

ChEMBLiCHEMBL5415
GuidetoPHARMACOLOGYi2210

Polymorphism and mutation databases

BioMutaiSRPK3
DMDMi332278151

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867091 – 567SRSF protein kinase 3Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9UPE1
PeptideAtlasiQ9UPE1
PRIDEiQ9UPE1
ProteomicsDBi85367
85368 [Q9UPE1-2]
85369 [Q9UPE1-3]
85370 [Q9UPE1-4]

PTM databases

iPTMnetiQ9UPE1
PhosphoSitePlusiQ9UPE1

Expressioni

Tissue specificityi

Exclusively expressed in skeletal and heart muscle.1 Publication

Gene expression databases

BgeeiENSG00000184343
CleanExiHS_SRPK3
ExpressionAtlasiQ9UPE1 baseline and differential
GenevisibleiQ9UPE1 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SRPK1Q96SB42EBI-6381269,EBI-539478

Protein-protein interaction databases

BioGridi117745, 60 interactors
IntActiQ9UPE1, 57 interactors
STRINGi9606.ENSP00000359119

Chemistry databases

BindingDBiQ9UPE1

Structurei

3D structure databases

ProteinModelPortaliQ9UPE1
SMRiQ9UPE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 565Protein kinasePROSITE-ProRule annotationAdd BLAST487

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 21Poly-Ser5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1290 Eukaryota
ENOG410XRBH LUCA
GeneTreeiENSGT00530000063566
HOGENOMiHOG000171558
HOVERGENiHBG108512
InParanoidiQ9UPE1
KOiK08832
TreeFamiTF105334

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPE1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS
60 70 80 90 100
DDEEQEDPKD YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ
110 120 130 140 150
RKRFVALKVV KSAGHYTETA VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF
160 170 180 190 200
RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY QGLPVPCVKS IVRQVLHGLD
210 220 230 240 250
YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA GAPPPSRSIV
260 270 280 290 300
STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ
310 320 330 340 350
AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT
360 370 380 390 400
SGFSGSLFSP ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA
410 420 430 440 450
DKIKIKIADL GNACWVHKHF TEDIQTRQYR AVEVLIGAEY GPPADIWSTA
460 470 480 490 500
CMAFELATGD YLFEPHSGED YSRDEDHIAH IVELLGDIPP AFALSGRYSR
510 520 530 540 550
EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA FLLPMMEYIP
560
EKRASAADCL QHPWLNP
Length:567
Mass (Da):62,014
Last modified:May 3, 2011 - v2
Checksum:i754A9F3759ADEE82
GO
Isoform 2 (identifier: Q9UPE1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     259-259: Missing.
     318-350: Missing.

Show »
Length:491
Mass (Da):55,327
Checksum:iB6B39C04D670CC1D
GO
Isoform 3 (identifier: Q9UPE1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.
     318-350: Missing.

Show »
Length:533
Mass (Da):58,997
Checksum:i2CA221A4373B9054
GO
Isoform 4 (identifier: Q9UPE1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.

Show »
Length:566
Mass (Da):61,886
Checksum:i078F3D5A99FDF014
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041119101R → C1 PublicationCorresponds to variant dbSNP:rs55910507Ensembl.1
Natural variantiVAR_041120114G → E1 PublicationCorresponds to variant dbSNP:rs35865042Ensembl.1
Natural variantiVAR_041121233E → K1 PublicationCorresponds to variant dbSNP:rs34497419Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0409391 – 42Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_040940259Missing in isoform 2, isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_040941318 – 350Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027406 mRNA Translation: AAD01848.1
U82808 mRNA Translation: AAD00539.1
DQ099381 mRNA Translation: AAZ13757.1
AK301749 mRNA Translation: BAG63211.1
U52111 Genomic DNA No translation available.
BC092416 mRNA Translation: AAH92416.1
BC117124 mRNA Translation: AAI17125.1
CCDSiCCDS35441.1 [Q9UPE1-1]
CCDS55537.1 [Q9UPE1-3]
CCDS55538.1 [Q9UPE1-4]
RefSeqiNP_001164231.1, NM_001170760.1 [Q9UPE1-4]
NP_001164232.1, NM_001170761.1 [Q9UPE1-3]
NP_055185.2, NM_014370.3 [Q9UPE1-1]
UniGeneiHs.104865

Genome annotation databases

EnsembliENST00000370101; ENSP00000359119; ENSG00000184343 [Q9UPE1-1]
ENST00000370104; ENSP00000359122; ENSG00000184343 [Q9UPE1-4]
ENST00000393786; ENSP00000377376; ENSG00000184343 [Q9UPE1-3]
GeneIDi26576
KEGGihsa:26576
UCSCiuc004fil.4 human [Q9UPE1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSRPK3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPE1
Secondary accession number(s): Q13583
, Q4F970, Q562F5, Q9UM62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 3, 2011
Last modified: June 20, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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