Q9UPE1 (SRPK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SRSF protein kinase 3
EC=2.7.11.1

Alternative name(s):
Muscle-specific serine kinase 1
Short name=MSSK-1
Serine/arginine-rich protein-specific kinase 3
Short name=SR-protein-specific kinase 3
Serine/threonine-protein kinase 23

Gene names

Name:	SRPK3
Synonyms:	MSSK1, STK23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	Exclusively expressed in skeletal and heart muscle. Ref.6
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW muscle tissue development Inferred from sequence or structural similarity. Source: UniProtKB skeletal muscle tissue development Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Non-traceable author statement. Source: UniProtKB protein serine/threonine kinase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UPE1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UPE1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     259-259: Missing.
     318-350: Missing.

Isoform 3 (identifier: Q9UPE1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.
     318-350: Missing.

Isoform 4 (identifier: Q9UPE1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	SRSF protein kinase 3		PRO_0000086709
Regions
	Domain	79 – 565	487	Protein kinase
	Nucleotide binding	85 – 93	9	ATP By similarity
	Compositional bias	17 – 21	5	Poly-Ser
Sites
	Active site	212	1	Proton acceptor By similarity
	Binding site	108	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 42	42	Missing in isoform 2.		VSP_040939
	Alternative sequence	259	1	Missing in isoform 2, isoform 3 and isoform 4.		VSP_040940
	Alternative sequence	318 – 350	33	Missing in isoform 2 and isoform 3.		VSP_040941
	Natural variant	101	1	R → C. Ref.8 Corresponds to variant rs55910507 [ dbSNP | Ensembl ].		VAR_041119
	Natural variant	114	1	G → E. Ref.8 Corresponds to variant rs35865042 [ dbSNP | Ensembl ].		VAR_041120
	Natural variant	233	1	E → K. Ref.8 Corresponds to variant rs34497419 [ dbSNP | Ensembl ].		VAR_041121

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 2. Checksum: 754A9F3759ADEE82	FASTA	567	62,014
	10 20 30 40 50 60 MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS DDEEQEDPKD 70 80 90 100 110 120 YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ RKRFVALKVV KSAGHYTETA 130 140 150 160 170 180 VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY 190 200 210 220 230 240 QGLPVPCVKS IVRQVLHGLD YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA 250 260 270 280 290 300 GAPPPSRSIV STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ 310 320 330 340 350 360 AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT SGFSGSLFSP 370 380 390 400 410 420 ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA DKIKIKIADL GNACWVHKHF 430 440 450 460 470 480 TEDIQTRQYR AVEVLIGAEY GPPADIWSTA CMAFELATGD YLFEPHSGED YSRDEDHIAH 490 500 510 520 530 540 IVELLGDIPP AFALSGRYSR EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA 550 560 FLLPMMEYIP EKRASAADCL QHPWLNP
	Isoform 2 [UniParc]. Checksum: B6B39C04D670CC1D	FASTA	491	55,327
	10 20 30 40 50 60 MLQGLLGSDD EEQEDPKDYC KGGYHPVKIG DVFNGRYHVV RKLGWGHFST VWLCWDIQRK 70 80 90 100 110 120 RFVALKVVKS AGHYTETAVD EIKLLKCVRD SDPSDPKRET IVQLIDDFRI SGVNGVHVCM 130 140 150 160 170 180 VLEVLGHQLL KWIIKSNYQG LPVPCVKSIV RQVLHGLDYL HTKCKIIHTD IKPENILLCV 190 200 210 220 230 240 GDAYIRRLAA EATEWQQAGA PPPSRSIVST APQEVLTGKL SKNKRKKMRR KRKQQKRLLE 250 260 270 280 290 300 ERLRDLQRLE AMEAATQAED SGLRLDGGSG STSSSGFSGS LFSPASCSIL SGSSNQRETG 310 320 330 340 350 360 GLLSPSTPFG ASNLLVNPLE PQNADKIKIK IADLGNACWV HKHFTEDIQT RQYRAVEVLI 370 380 390 400 410 420 GAEYGPPADI WSTACMAFEL ATGDYLFEPH SGEDYSRDED HIAHIVELLG DIPPAFALSG 430 440 450 460 470 480 RYSREFFNRR GELRHIHNLK HWGLYEVLME KYEWPLEQAT QFSAFLLPMM EYIPEKRASA 490 ADCLQHPWLN P
	Isoform 3 [UniParc]. Checksum: 2CA221A4373B9054	FASTA	533	58,997
	10 20 30 40 50 60 MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS DDEEQEDPKD 70 80 90 100 110 120 YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ RKRFVALKVV KSAGHYTETA 130 140 150 160 170 180 VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY 190 200 210 220 230 240 QGLPVPCVKS IVRQVLHGLD YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA 250 260 270 280 290 300 GAPPPSRSIV STAPQEVLTG KLSKNKRKKM RRKRKQQKRL LEERLRDLQR LEAMEAATQA 310 320 330 340 350 360 EDSGLRLDGG SGSTSSSGFS GSLFSPASCS ILSGSSNQRE TGGLLSPSTP FGASNLLVNP 370 380 390 400 410 420 LEPQNADKIK IKIADLGNAC WVHKHFTEDI QTRQYRAVEV LIGAEYGPPA DIWSTACMAF 430 440 450 460 470 480 ELATGDYLFE PHSGEDYSRD EDHIAHIVEL LGDIPPAFAL SGRYSREFFN RRGELRHIHN 490 500 510 520 530 LKHWGLYEVL MEKYEWPLEQ ATQFSAFLLP MMEYIPEKRA SAADCLQHPW LNP
	Isoform 4 [UniParc]. Checksum: 078F3D5A99FDF014	FASTA	566	61,886
	10 20 30 40 50 60 MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS DDEEQEDPKD 70 80 90 100 110 120 YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ RKRFVALKVV KSAGHYTETA 130 140 150 160 170 180 VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY 190 200 210 220 230 240 QGLPVPCVKS IVRQVLHGLD YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA 250 260 270 280 290 300 GAPPPSRSIV STAPQEVLTG KLSKNKRKKM RRKRKQQKRL LEERLRDLQR LEAMEAATQA 310 320 330 340 350 360 EDSGLRLDGG SGSTSSSGCH PGGARAGPSP ASSSPAPGGG RSLSAGSQTS GFSGSLFSPA 370 380 390 400 410 420 SCSILSGSSN QRETGGLLSP STPFGASNLL VNPLEPQNAD KIKIKIADLG NACWVHKHFT 430 440 450 460 470 480 EDIQTRQYRA VEVLIGAEYG PPADIWSTAC MAFELATGDY LFEPHSGEDY SRDEDHIAHI 490 500 510 520 530 540 VELLGDIPPA FALSGRYSRE FFNRRGELRH IHNLKHWGLY EVLMEKYEWP LEQATQFSAF 550 560 LLPMMEYIPE KRASAADCLQ HPWLNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of a new human serine kinase gene located in human Xq28." Brenner V., Rosenthal A., Platzer M. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3). Tissue: Skeletal muscle.
[2]	Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain.
[6]	"Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes." Grunau C., Hindermann W., Rosenthal A. Hum. Mol. Genet. 9:2651-2663(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Serine-arginine protein kinases: a small protein kinase family with a large cellular presence." Giannakouros T., Nikolakaki E., Mylonis I., Georgatsou E. FEBS J. 278:570-586(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW ON FUNCTION.
[8]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-101; GLU-114 AND LYS-233.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF027406 mRNA. Translation: AAD01848.1. U82808 mRNA. Translation: AAD00539.1. DQ099381 mRNA. Translation: AAZ13757.1. AK301749 mRNA. Translation: BAG63211.1. U52111 Genomic DNA. No translation available. BC092416 mRNA. Translation: AAH92416.1. BC117124 mRNA. Translation: AAI17125.1.
IPI	IPI00010067. IPI00921386. IPI00936551. IPI00946650.
RefSeq	NP_001164231.1. NM_001170760.1. NP_001164232.1. NM_001170761.1. NP_055185.2. NM_014370.3.
UniGene	Hs.104865.
3D structure databases
ProteinModelPortal	Q9UPE1.
SMR	Q9UPE1. Positions 66-261, 350-566.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UPE1. 2 interactions.
PTM databases
PhosphoSite	Q9UPE1.
Polymorphism databases
DMDM	13124568.
Proteomic databases
PaxDb	Q9UPE1.
PRIDE	Q9UPE1.
Protocols and materials databases
DNASU	26576.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370101; ENSP00000359119; ENSG00000184343. ENST00000370104; ENSP00000359122; ENSG00000184343. ENST00000393786; ENSP00000377376; ENSG00000184343. ENST00000593665; ENSP00000471760; ENSG00000268444. ENST00000596666; ENSP00000470146; ENSG00000268444. ENST00000598944; ENSP00000471780; ENSG00000268444.
GeneID	26576.
KEGG	hsa:26576.
UCSC	uc004fil.3. human. uc004fim.3. human. uc004fin.3. human. uc010nul.3. human.
Organism-specific databases
CTD	26576.
GeneCards	GC0XP153041.
HGNC	HGNC:11402. SRPK3.
HPA	HPA042489.
neXtProt	NX_Q9UPE1.
PharmGKB	PA162404805.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000171558.
HOVERGEN	HBG108512.
KO	K08832.
Enzyme and pathway databases
BRENDA	2.7.11.1. 2681.
Gene expression databases
ArrayExpress	Q9UPE1.
Bgee	Q9UPE1.
CleanEx	HS_SRPK3.
Genevestigator	Q9UPE1.
GermOnline	ENSG00000184343. Homo sapiens.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 2 hits. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9UPE1.
ChEMBL	CHEMBL5415.
GenomeRNAi	26576.
NextBio	48918.

Entry information

Entry name

SRPK3_HUMAN

Accession

Primary (citable) accession number: Q9UPE1
Secondary accession number(s): Q13583 , Q4F970, Q562F5, Q9UM62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.