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Q9UPE1

- SRPK3_HUMAN

UniProt

Q9UPE1 - SRPK3_HUMAN

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Protein
SRSF protein kinase 3
Gene
SRPK3, MSSK1, STK23
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei108 – 1081ATP By similarity
Active sitei212 – 2121Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi85 – 939ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. muscle tissue development Source: UniProtKB
  3. skeletal muscle tissue development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Differentiation, Myogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiQ9UPE1.

Names & Taxonomyi

Protein namesi
Recommended name:
SRSF protein kinase 3 (EC:2.7.11.1)
Alternative name(s):
Muscle-specific serine kinase 1
Short name:
MSSK-1
Serine/arginine-rich protein-specific kinase 3
Short name:
SR-protein-specific kinase 3
Serine/threonine-protein kinase 23
Gene namesi
Name:SRPK3
Synonyms:MSSK1, STK23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11402. SRPK3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162404805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567SRSF protein kinase 3
PRO_0000086709Add
BLAST

Proteomic databases

MaxQBiQ9UPE1.
PaxDbiQ9UPE1.
PRIDEiQ9UPE1.

PTM databases

PhosphoSiteiQ9UPE1.

Expressioni

Tissue specificityi

Exclusively expressed in skeletal and heart muscle.1 Publication

Gene expression databases

ArrayExpressiQ9UPE1.
BgeeiQ9UPE1.
CleanExiHS_SRPK3.
GenevestigatoriQ9UPE1.

Organism-specific databases

HPAiHPA042489.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SRPK1Q96SB42EBI-6381269,EBI-539478

Protein-protein interaction databases

BioGridi117745. 61 interactions.
IntActiQ9UPE1. 56 interactions.
STRINGi9606.ENSP00000359119.

Structurei

3D structure databases

ProteinModelPortaliQ9UPE1.
SMRiQ9UPE1. Positions 66-261, 350-566.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 565487Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 215Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000171558.
HOVERGENiHBG108512.
KOiK08832.
TreeFamiTF105334.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UPE1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS    50
DDEEQEDPKD YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ 100
RKRFVALKVV KSAGHYTETA VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF 150
RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY QGLPVPCVKS IVRQVLHGLD 200
YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA GAPPPSRSIV 250
STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ 300
AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT 350
SGFSGSLFSP ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA 400
DKIKIKIADL GNACWVHKHF TEDIQTRQYR AVEVLIGAEY GPPADIWSTA 450
CMAFELATGD YLFEPHSGED YSRDEDHIAH IVELLGDIPP AFALSGRYSR 500
EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA FLLPMMEYIP 550
EKRASAADCL QHPWLNP 567
Length:567
Mass (Da):62,014
Last modified:May 3, 2011 - v2
Checksum:i754A9F3759ADEE82
GO
Isoform 2 (identifier: Q9UPE1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     259-259: Missing.
     318-350: Missing.

Show »
Length:491
Mass (Da):55,327
Checksum:iB6B39C04D670CC1D
GO
Isoform 3 (identifier: Q9UPE1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.
     318-350: Missing.

Show »
Length:533
Mass (Da):58,997
Checksum:i2CA221A4373B9054
GO
Isoform 4 (identifier: Q9UPE1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-259: Missing.

Show »
Length:566
Mass (Da):61,886
Checksum:i078F3D5A99FDF014
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti101 – 1011R → C.1 Publication
Corresponds to variant rs55910507 [ dbSNP | Ensembl ].
VAR_041119
Natural varianti114 – 1141G → E.1 Publication
Corresponds to variant rs35865042 [ dbSNP | Ensembl ].
VAR_041120
Natural varianti233 – 2331E → K.1 Publication
Corresponds to variant rs34497419 [ dbSNP | Ensembl ].
VAR_041121

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2.
VSP_040939Add
BLAST
Alternative sequencei259 – 2591Missing in isoform 2, isoform 3 and isoform 4.
VSP_040940
Alternative sequencei318 – 35033Missing in isoform 2 and isoform 3.
VSP_040941Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027406 mRNA. Translation: AAD01848.1.
U82808 mRNA. Translation: AAD00539.1.
DQ099381 mRNA. Translation: AAZ13757.1.
AK301749 mRNA. Translation: BAG63211.1.
U52111 Genomic DNA. No translation available.
BC092416 mRNA. Translation: AAH92416.1.
BC117124 mRNA. Translation: AAI17125.1.
CCDSiCCDS35441.1. [Q9UPE1-1]
CCDS55537.1. [Q9UPE1-3]
CCDS55538.1. [Q9UPE1-4]
RefSeqiNP_001164231.1. NM_001170760.1. [Q9UPE1-4]
NP_001164232.1. NM_001170761.1. [Q9UPE1-3]
NP_055185.2. NM_014370.3. [Q9UPE1-1]
UniGeneiHs.104865.

Genome annotation databases

EnsembliENST00000370101; ENSP00000359119; ENSG00000184343. [Q9UPE1-1]
ENST00000370104; ENSP00000359122; ENSG00000184343. [Q9UPE1-4]
ENST00000393786; ENSP00000377376; ENSG00000184343. [Q9UPE1-3]
ENST00000593665; ENSP00000471760; ENSG00000268444. [Q9UPE1-4]
ENST00000596666; ENSP00000470146; ENSG00000268444. [Q9UPE1-3]
ENST00000598944; ENSP00000471780; ENSG00000268444. [Q9UPE1-1]
GeneIDi26576.
KEGGihsa:26576.
UCSCiuc004fil.3. human. [Q9UPE1-1]
uc004fim.3. human. [Q9UPE1-3]
uc004fin.3. human. [Q9UPE1-4]
uc010nul.3. human. [Q9UPE1-2]

Polymorphism databases

DMDMi332278151.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027406 mRNA. Translation: AAD01848.1 .
U82808 mRNA. Translation: AAD00539.1 .
DQ099381 mRNA. Translation: AAZ13757.1 .
AK301749 mRNA. Translation: BAG63211.1 .
U52111 Genomic DNA. No translation available.
BC092416 mRNA. Translation: AAH92416.1 .
BC117124 mRNA. Translation: AAI17125.1 .
CCDSi CCDS35441.1. [Q9UPE1-1 ]
CCDS55537.1. [Q9UPE1-3 ]
CCDS55538.1. [Q9UPE1-4 ]
RefSeqi NP_001164231.1. NM_001170760.1. [Q9UPE1-4 ]
NP_001164232.1. NM_001170761.1. [Q9UPE1-3 ]
NP_055185.2. NM_014370.3. [Q9UPE1-1 ]
UniGenei Hs.104865.

3D structure databases

ProteinModelPortali Q9UPE1.
SMRi Q9UPE1. Positions 66-261, 350-566.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117745. 61 interactions.
IntActi Q9UPE1. 56 interactions.
STRINGi 9606.ENSP00000359119.

Chemistry

BindingDBi Q9UPE1.
ChEMBLi CHEMBL5415.
GuidetoPHARMACOLOGYi 2210.

PTM databases

PhosphoSitei Q9UPE1.

Polymorphism databases

DMDMi 332278151.

Proteomic databases

MaxQBi Q9UPE1.
PaxDbi Q9UPE1.
PRIDEi Q9UPE1.

Protocols and materials databases

DNASUi 26576.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370101 ; ENSP00000359119 ; ENSG00000184343 . [Q9UPE1-1 ]
ENST00000370104 ; ENSP00000359122 ; ENSG00000184343 . [Q9UPE1-4 ]
ENST00000393786 ; ENSP00000377376 ; ENSG00000184343 . [Q9UPE1-3 ]
ENST00000593665 ; ENSP00000471760 ; ENSG00000268444 . [Q9UPE1-4 ]
ENST00000596666 ; ENSP00000470146 ; ENSG00000268444 . [Q9UPE1-3 ]
ENST00000598944 ; ENSP00000471780 ; ENSG00000268444 . [Q9UPE1-1 ]
GeneIDi 26576.
KEGGi hsa:26576.
UCSCi uc004fil.3. human. [Q9UPE1-1 ]
uc004fim.3. human. [Q9UPE1-3 ]
uc004fin.3. human. [Q9UPE1-4 ]
uc010nul.3. human. [Q9UPE1-2 ]

Organism-specific databases

CTDi 26576.
GeneCardsi GC0XP153041.
HGNCi HGNC:11402. SRPK3.
HPAi HPA042489.
neXtProti NX_Q9UPE1.
PharmGKBi PA162404805.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000171558.
HOVERGENi HBG108512.
KOi K08832.
TreeFami TF105334.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
SignaLinki Q9UPE1.

Miscellaneous databases

GenomeRNAii 26576.
NextBioi 48918.
PROi Q9UPE1.

Gene expression databases

ArrayExpressi Q9UPE1.
Bgeei Q9UPE1.
CleanExi HS_SRPK3.
Genevestigatori Q9UPE1.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 2 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a new human serine kinase gene located in human Xq28."
    Brenner V., Rosenthal A., Platzer M.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    Tissue: Skeletal muscle.
  2. Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Brain.
  6. "Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes."
    Grunau C., Hindermann W., Rosenthal A.
    Hum. Mol. Genet. 9:2651-2663(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Serine-arginine protein kinases: a small protein kinase family with a large cellular presence."
    Giannakouros T., Nikolakaki E., Mylonis I., Georgatsou E.
    FEBS J. 278:570-586(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  8. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-101; GLU-114 AND LYS-233.

Entry informationi

Entry nameiSRPK3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPE1
Secondary accession number(s): Q13583
, Q4F970, Q562F5, Q9UM62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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