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Protein

Probable G-protein coupled receptor 34

Gene

GPR34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 34
Gene namesi
Name:GPR34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4490. GPR34.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161ExtracellularSequence AnalysisAdd
BLAST
Transmembranei62 – 8221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini83 – 886CytoplasmicSequence Analysis
Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini110 – 12819ExtracellularSequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini150 – 17122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini193 – 21624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini238 – 26932CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini291 – 31020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38150CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28878.

Polymorphism and mutation databases

BioMutaiGPR34.
DMDMi12643337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Probable G-protein coupled receptor 34PRO_0000069559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 204PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UPC5.
PRIDEiQ9UPC5.

PTM databases

PhosphoSiteiQ9UPC5.

Expressioni

Tissue specificityi

Broadly expressed.

Gene expression databases

BgeeiQ9UPC5.
CleanExiHS_GPR34.
ExpressionAtlasiQ9UPC5. baseline and differential.
GenevisibleiQ9UPC5. HS.

Organism-specific databases

HPAiCAB025490.
HPA010668.

Interactioni

Protein-protein interaction databases

IntActiQ9UPC5. 1 interaction.
STRINGi9606.ENSP00000367378.

Structurei

3D structure databases

ProteinModelPortaliQ9UPC5.
SMRiQ9UPC5. Positions 44-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145214.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000039982.
HOVERGENiHBG063715.
InParanoidiQ9UPC5.
KOiK08383.
OMAiYHAFRFV.
OrthoDBiEOG7NGQCP.
PhylomeDBiQ9UPC5.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UPC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE
60 70 80 90 100
KLLSTVLTTS YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD
110 120 130 140 150
LLLIFCLPFR IMYHINQNKW TLGVILCKVV GTLFYMNMYI SIILLGFISL
160 170 180 190 200
DRYIKINRSI QQRKAITTKQ SIYVCCIVWM LALGGFLTMI ILTLKKGGHN
210 220 230 240 250
STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK IGKNLLRISK
260 270 280 290 300
RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
310 320 330 340 350
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP
360 370 380
SRSESTSEFK PGYSLHDTSV AVKIQSSSKS T
Length:381
Mass (Da):43,860
Last modified:January 24, 2001 - v2
Checksum:i491FC016E5624379
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811L → V in AAD50531 (PubMed:10395919).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039686 mRNA. Translation: AAD50531.1.
AF118670 Genomic DNA. Translation: AAD17248.1.
AK027780 mRNA. Translation: BAB55362.1.
BC020678 mRNA. Translation: AAH20678.1.
CCDSiCCDS14258.1.
RefSeqiNP_001091048.1. NM_001097579.1.
NP_005291.1. NM_005300.3.
XP_005272654.1. XM_005272597.2.
UniGeneiHs.495989.

Genome annotation databases

EnsembliENST00000378138; ENSP00000367378; ENSG00000171659.
ENST00000378142; ENSP00000367384; ENSG00000171659.
GeneIDi2857.
KEGGihsa:2857.
UCSCiuc004dfp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039686 mRNA. Translation: AAD50531.1.
AF118670 Genomic DNA. Translation: AAD17248.1.
AK027780 mRNA. Translation: BAB55362.1.
BC020678 mRNA. Translation: AAH20678.1.
CCDSiCCDS14258.1.
RefSeqiNP_001091048.1. NM_001097579.1.
NP_005291.1. NM_005300.3.
XP_005272654.1. XM_005272597.2.
UniGeneiHs.495989.

3D structure databases

ProteinModelPortaliQ9UPC5.
SMRiQ9UPC5. Positions 44-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UPC5. 1 interaction.
STRINGi9606.ENSP00000367378.

Chemistry

GuidetoPHARMACOLOGYi101.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9UPC5.

Polymorphism and mutation databases

BioMutaiGPR34.
DMDMi12643337.

Proteomic databases

PaxDbiQ9UPC5.
PRIDEiQ9UPC5.

Protocols and materials databases

DNASUi2857.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378138; ENSP00000367378; ENSG00000171659.
ENST00000378142; ENSP00000367384; ENSG00000171659.
GeneIDi2857.
KEGGihsa:2857.
UCSCiuc004dfp.4. human.

Organism-specific databases

CTDi2857.
GeneCardsiGC0XP041548.
HGNCiHGNC:4490. GPR34.
HPAiCAB025490.
HPA010668.
MIMi300241. gene.
neXtProtiNX_Q9UPC5.
PharmGKBiPA28878.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG145214.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000039982.
HOVERGENiHBG063715.
InParanoidiQ9UPC5.
KOiK08383.
OMAiYHAFRFV.
OrthoDBiEOG7NGQCP.
PhylomeDBiQ9UPC5.
TreeFamiTF330969.

Miscellaneous databases

GenomeRNAii2857.
NextBioi11267.
PROiQ9UPC5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UPC5.
CleanExiHS_GPR34.
ExpressionAtlasiQ9UPC5. baseline and differential.
GenevisibleiQ9UPC5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel subgroup of class I G-protein-coupled receptors."
    Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T.
    Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1."
    Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A., Pusch C.M.
    Hum. Genet. 107:89-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiGPR34_HUMAN
AccessioniPrimary (citable) accession number: Q9UPC5
Secondary accession number(s): O95853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: June 24, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.