Q9UPC5 (GPR34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 34

Gene names

Name:

GPR34

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Broadly expressed.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro G-protein coupled receptor activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	Probable G-protein coupled receptor 34		PRO_0000069559
Regions
	Topological domain	1 – 61	61	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Name=1; Potential
	Topological domain	83 – 88	6	Cytoplasmic Potential
	Transmembrane	89 – 109	21	Helical; Name=2; Potential
	Topological domain	110 – 128	19	Extracellular Potential
	Transmembrane	129 – 149	21	Helical; Name=3; Potential
	Topological domain	150 – 171	22	Cytoplasmic Potential
	Transmembrane	172 – 192	21	Helical; Name=4; Potential
	Topological domain	193 – 216	24	Extracellular Potential
	Transmembrane	217 – 237	21	Helical; Name=5; Potential
	Topological domain	238 – 269	32	Cytoplasmic Potential
	Transmembrane	270 – 290	21	Helical; Name=6; Potential
	Topological domain	291 – 310	20	Extracellular Potential
	Transmembrane	311 – 331	21	Helical; Name=7; Potential
	Topological domain	332 – 381	50	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	42	1	N-linked (GlcNAc...) Potential
	Glycosylation	200	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Disulfide bond	127 ↔ 204		By similarity
Experimental info
	Sequence conflict	181	1	L → V in AAD50531. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9UPC5 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: 491FC016E5624379	FASTA	381	43,860
	10 20 30 40 50 60 MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS 70 80 90 100 110 120 YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW 130 140 150 160 170 180 TLGVILCKVV GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM 190 200 210 220 230 240 LALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK 250 260 270 280 290 300 IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 310 320 330 340 350 360 WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK 370 380 PGYSLHDTSV AVKIQSSSKS T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel subgroup of class I G-protein-coupled receptors." Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T. Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Discovery of three novel orphan G-protein-coupled receptors." Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H.Q., Nowak T., Im D.-S., Lynch K.R., George S.R., O'Dowd B.F. Genomics 56:12-21(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1." Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A., Pusch C.M. Hum. Genet. 107:89-91(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF039686 mRNA. Translation: AAD50531.1. AF118670 Genomic DNA. Translation: AAD17248.1. AK027780 mRNA. Translation: BAB55362.1. BC020678 mRNA. Translation: AAH20678.1.
IPI	IPI00010051.
RefSeq	NP_001091048.1. NM_001097579.1. NP_005291.1. NM_005300.3.
UniGene	Hs.495989.
3D structure databases
ProteinModelPortal	Q9UPC5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UPC5. 1 interaction.
STRING	9606.ENSP00000367378.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9UPC5.
Polymorphism databases
DMDM	12643337.
Proteomic databases
PaxDb	Q9UPC5.
PRIDE	Q9UPC5.
Protocols and materials databases
DNASU	2857.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378138; ENSP00000367378; ENSG00000171659. ENST00000378142; ENSP00000367384; ENSG00000171659.
GeneID	2857.
KEGG	hsa:2857.
UCSC	uc004dfp.4. human.
Organism-specific databases
CTD	2857.
GeneCards	GC0XP041548.
HGNC	HGNC:4490. GPR34.
HPA	CAB025490. HPA010668.
MIM	300241. gene.
neXtProt	NX_Q9UPC5.
PharmGKB	PA28878.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145214.
HOGENOM	HOG000039982.
HOVERGEN	HBG063715.
InParanoid	Q9UPC5.
KO	K08383.
OMA	YHAFRFV.
OrthoDB	EOG4X3H1F.
PhylomeDB	Q9UPC5.
Gene expression databases
ArrayExpress	Q9UPC5.
Bgee	Q9UPC5.
CleanEx	HS_GPR34.
Genevestigator	Q9UPC5.
GermOnline	ENSG00000171659. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2857.
NextBio	11267.
SOURCE	Search...

Entry information

Entry name

GPR34_HUMAN

Accession

Primary (citable) accession number: Q9UPC5
Secondary accession number(s): O95853

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 24, 2001
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.