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Q9UPC5

- GPR34_HUMAN

UniProt

Q9UPC5 - GPR34_HUMAN

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Protein

Probable G-protein coupled receptor 34

Gene

GPR34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 34
Gene namesi
Name:GPR34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4490. GPR34.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Probable G-protein coupled receptor 34PRO_0000069559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 204PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UPC5.
PRIDEiQ9UPC5.

PTM databases

PhosphoSiteiQ9UPC5.

Expressioni

Tissue specificityi

Broadly expressed.

Gene expression databases

BgeeiQ9UPC5.
CleanExiHS_GPR34.
ExpressionAtlasiQ9UPC5. baseline and differential.
GenevestigatoriQ9UPC5.

Organism-specific databases

HPAiCAB025490.
HPA010668.

Interactioni

Protein-protein interaction databases

IntActiQ9UPC5. 1 interaction.
STRINGi9606.ENSP00000367378.

Structurei

3D structure databases

ProteinModelPortaliQ9UPC5.
SMRiQ9UPC5. Positions 44-342.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6161ExtracellularSequence AnalysisAdd
BLAST
Topological domaini83 – 886CytoplasmicSequence Analysis
Topological domaini110 – 12819ExtracellularSequence AnalysisAdd
BLAST
Topological domaini150 – 17122CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini193 – 21624ExtracellularSequence AnalysisAdd
BLAST
Topological domaini238 – 26932CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini291 – 31020ExtracellularSequence AnalysisAdd
BLAST
Topological domaini332 – 38150CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei62 – 8221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145214.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000039982.
HOVERGENiHBG063715.
InParanoidiQ9UPC5.
KOiK08383.
OMAiYHAFRFV.
OrthoDBiEOG7NGQCP.
PhylomeDBiQ9UPC5.
TreeFamiTF330969.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UPC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE
60 70 80 90 100
KLLSTVLTTS YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD
110 120 130 140 150
LLLIFCLPFR IMYHINQNKW TLGVILCKVV GTLFYMNMYI SIILLGFISL
160 170 180 190 200
DRYIKINRSI QQRKAITTKQ SIYVCCIVWM LALGGFLTMI ILTLKKGGHN
210 220 230 240 250
STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK IGKNLLRISK
260 270 280 290 300
RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
310 320 330 340 350
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP
360 370 380
SRSESTSEFK PGYSLHDTSV AVKIQSSSKS T
Length:381
Mass (Da):43,860
Last modified:January 24, 2001 - v2
Checksum:i491FC016E5624379
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811L → V in AAD50531. (PubMed:10395919)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039686 mRNA. Translation: AAD50531.1.
AF118670 Genomic DNA. Translation: AAD17248.1.
AK027780 mRNA. Translation: BAB55362.1.
BC020678 mRNA. Translation: AAH20678.1.
CCDSiCCDS14258.1.
RefSeqiNP_001091048.1. NM_001097579.1.
NP_005291.1. NM_005300.3.
XP_005272654.1. XM_005272597.1.
UniGeneiHs.495989.

Genome annotation databases

EnsembliENST00000378138; ENSP00000367378; ENSG00000171659.
ENST00000378142; ENSP00000367384; ENSG00000171659.
GeneIDi2857.
KEGGihsa:2857.
UCSCiuc004dfp.4. human.

Polymorphism databases

DMDMi12643337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039686 mRNA. Translation: AAD50531.1 .
AF118670 Genomic DNA. Translation: AAD17248.1 .
AK027780 mRNA. Translation: BAB55362.1 .
BC020678 mRNA. Translation: AAH20678.1 .
CCDSi CCDS14258.1.
RefSeqi NP_001091048.1. NM_001097579.1.
NP_005291.1. NM_005300.3.
XP_005272654.1. XM_005272597.1.
UniGenei Hs.495989.

3D structure databases

ProteinModelPortali Q9UPC5.
SMRi Q9UPC5. Positions 44-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9UPC5. 1 interaction.
STRINGi 9606.ENSP00000367378.

Chemistry

GuidetoPHARMACOLOGYi 101.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9UPC5.

Polymorphism databases

DMDMi 12643337.

Proteomic databases

PaxDbi Q9UPC5.
PRIDEi Q9UPC5.

Protocols and materials databases

DNASUi 2857.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378138 ; ENSP00000367378 ; ENSG00000171659 .
ENST00000378142 ; ENSP00000367384 ; ENSG00000171659 .
GeneIDi 2857.
KEGGi hsa:2857.
UCSCi uc004dfp.4. human.

Organism-specific databases

CTDi 2857.
GeneCardsi GC0XP041548.
HGNCi HGNC:4490. GPR34.
HPAi CAB025490.
HPA010668.
MIMi 300241. gene.
neXtProti NX_Q9UPC5.
PharmGKBi PA28878.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145214.
GeneTreei ENSGT00640000091213.
HOGENOMi HOG000039982.
HOVERGENi HBG063715.
InParanoidi Q9UPC5.
KOi K08383.
OMAi YHAFRFV.
OrthoDBi EOG7NGQCP.
PhylomeDBi Q9UPC5.
TreeFami TF330969.

Miscellaneous databases

GenomeRNAii 2857.
NextBioi 11267.
PROi Q9UPC5.
SOURCEi Search...

Gene expression databases

Bgeei Q9UPC5.
CleanExi HS_GPR34.
ExpressionAtlasi Q9UPC5. baseline and differential.
Genevestigatori Q9UPC5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel subgroup of class I G-protein-coupled receptors."
    Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T.
    Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1."
    Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A., Pusch C.M.
    Hum. Genet. 107:89-91(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiGPR34_HUMAN
AccessioniPrimary (citable) accession number: Q9UPC5
Secondary accession number(s): O95853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3