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Q9UPC5 (GPR34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 34
Gene names
Name:GPR34
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Broadly expressed.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Probable G-protein coupled receptor 34
PRO_0000069559

Regions

Topological domain1 – 6161Extracellular Potential
Transmembrane62 – 8221Helical; Name=1; Potential
Topological domain83 – 886Cytoplasmic Potential
Transmembrane89 – 10921Helical; Name=2; Potential
Topological domain110 – 12819Extracellular Potential
Transmembrane129 – 14921Helical; Name=3; Potential
Topological domain150 – 17122Cytoplasmic Potential
Transmembrane172 – 19221Helical; Name=4; Potential
Topological domain193 – 21624Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 26932Cytoplasmic Potential
Transmembrane270 – 29021Helical; Name=6; Potential
Topological domain291 – 31020Extracellular Potential
Transmembrane311 – 33121Helical; Name=7; Potential
Topological domain332 – 38150Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Disulfide bond127 ↔ 204 By similarity

Experimental info

Sequence conflict1811L → V in AAD50531. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UPC5 [UniParc].

Last modified January 24, 2001. Version 2.
Checksum: 491FC016E5624379

FASTA38143,860
        10         20         30         40         50         60 
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS 

        70         80         90        100        110        120 
YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW 

       130        140        150        160        170        180 
TLGVILCKVV GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM 

       190        200        210        220        230        240 
LALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK 

       250        260        270        280        290        300 
IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 

       310        320        330        340        350        360 
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK 

       370        380 
PGYSLHDTSV AVKIQSSSKS T 

« Hide

References

« Hide 'large scale' references
[1]"A novel subgroup of class I G-protein-coupled receptors."
Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T.
Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Discovery of three novel orphan G-protein-coupled receptors."
Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H.Q., Nowak T., Im D.-S., Lynch K.R., George S.R., O'Dowd B.F.
Genomics 56:12-21(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1."
Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A., Pusch C.M.
Hum. Genet. 107:89-91(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF039686 mRNA. Translation: AAD50531.1.
AF118670 Genomic DNA. Translation: AAD17248.1.
AK027780 mRNA. Translation: BAB55362.1.
BC020678 mRNA. Translation: AAH20678.1.
RefSeqNP_001091048.1. NM_001097579.1.
NP_005291.1. NM_005300.3.
XP_005272654.1. XM_005272597.1.
UniGeneHs.495989.

3D structure databases

ProteinModelPortalQ9UPC5.
SMRQ9UPC5. Positions 50-342.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9UPC5. 1 interaction.
STRING9606.ENSP00000367378.

Chemistry

GuidetoPHARMACOLOGY101.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9UPC5.

Polymorphism databases

DMDM12643337.

Proteomic databases

PaxDbQ9UPC5.
PRIDEQ9UPC5.

Protocols and materials databases

DNASU2857.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378138; ENSP00000367378; ENSG00000171659.
ENST00000378142; ENSP00000367384; ENSG00000171659.
GeneID2857.
KEGGhsa:2857.
UCSCuc004dfp.4. human.

Organism-specific databases

CTD2857.
GeneCardsGC0XP041548.
HGNCHGNC:4490. GPR34.
HPACAB025490.
HPA010668.
MIM300241. gene.
neXtProtNX_Q9UPC5.
PharmGKBPA28878.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145214.
HOGENOMHOG000039982.
HOVERGENHBG063715.
InParanoidQ9UPC5.
KOK08383.
OMAYHAFRFV.
OrthoDBEOG7NGQCP.
PhylomeDBQ9UPC5.
TreeFamTF330969.

Gene expression databases

ArrayExpressQ9UPC5.
BgeeQ9UPC5.
CleanExHS_GPR34.
GenevestigatorQ9UPC5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2857.
NextBio11267.
PROQ9UPC5.
SOURCESearch...

Entry information

Entry nameGPR34_HUMAN
AccessionPrimary (citable) accession number: Q9UPC5
Secondary accession number(s): O95853
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries