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Q9UPC5

- GPR34_HUMAN

UniProt

Q9UPC5 - GPR34_HUMAN

Protein

Probable G-protein coupled receptor 34

Gene

GPR34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 34
    Gene namesi
    Name:GPR34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4490. GPR34.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28878.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Probable G-protein coupled receptor 34PRO_0000069559Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 204PROSITE-ProRule annotation
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9UPC5.
    PRIDEiQ9UPC5.

    PTM databases

    PhosphoSiteiQ9UPC5.

    Expressioni

    Tissue specificityi

    Broadly expressed.

    Gene expression databases

    ArrayExpressiQ9UPC5.
    BgeeiQ9UPC5.
    CleanExiHS_GPR34.
    GenevestigatoriQ9UPC5.

    Organism-specific databases

    HPAiCAB025490.
    HPA010668.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9UPC5. 1 interaction.
    STRINGi9606.ENSP00000367378.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UPC5.
    SMRiQ9UPC5. Positions 50-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini83 – 886CytoplasmicSequence Analysis
    Topological domaini110 – 12819ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini150 – 17122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini193 – 21624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 26932CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini332 – 38150CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145214.
    HOGENOMiHOG000039982.
    HOVERGENiHBG063715.
    InParanoidiQ9UPC5.
    KOiK08383.
    OMAiYHAFRFV.
    OrthoDBiEOG7NGQCP.
    PhylomeDBiQ9UPC5.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UPC5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE    50
    KLLSTVLTTS YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD 100
    LLLIFCLPFR IMYHINQNKW TLGVILCKVV GTLFYMNMYI SIILLGFISL 150
    DRYIKINRSI QQRKAITTKQ SIYVCCIVWM LALGGFLTMI ILTLKKGGHN 200
    STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK IGKNLLRISK 250
    RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY 300
    WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP 350
    SRSESTSEFK PGYSLHDTSV AVKIQSSSKS T 381
    Length:381
    Mass (Da):43,860
    Last modified:January 24, 2001 - v2
    Checksum:i491FC016E5624379
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811L → V in AAD50531. (PubMed:10395919)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039686 mRNA. Translation: AAD50531.1.
    AF118670 Genomic DNA. Translation: AAD17248.1.
    AK027780 mRNA. Translation: BAB55362.1.
    BC020678 mRNA. Translation: AAH20678.1.
    CCDSiCCDS14258.1.
    RefSeqiNP_001091048.1. NM_001097579.1.
    NP_005291.1. NM_005300.3.
    XP_005272654.1. XM_005272597.1.
    UniGeneiHs.495989.

    Genome annotation databases

    EnsembliENST00000378138; ENSP00000367378; ENSG00000171659.
    ENST00000378142; ENSP00000367384; ENSG00000171659.
    GeneIDi2857.
    KEGGihsa:2857.
    UCSCiuc004dfp.4. human.

    Polymorphism databases

    DMDMi12643337.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF039686 mRNA. Translation: AAD50531.1 .
    AF118670 Genomic DNA. Translation: AAD17248.1 .
    AK027780 mRNA. Translation: BAB55362.1 .
    BC020678 mRNA. Translation: AAH20678.1 .
    CCDSi CCDS14258.1.
    RefSeqi NP_001091048.1. NM_001097579.1.
    NP_005291.1. NM_005300.3.
    XP_005272654.1. XM_005272597.1.
    UniGenei Hs.495989.

    3D structure databases

    ProteinModelPortali Q9UPC5.
    SMRi Q9UPC5. Positions 50-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9UPC5. 1 interaction.
    STRINGi 9606.ENSP00000367378.

    Chemistry

    GuidetoPHARMACOLOGYi 101.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9UPC5.

    Polymorphism databases

    DMDMi 12643337.

    Proteomic databases

    PaxDbi Q9UPC5.
    PRIDEi Q9UPC5.

    Protocols and materials databases

    DNASUi 2857.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378138 ; ENSP00000367378 ; ENSG00000171659 .
    ENST00000378142 ; ENSP00000367384 ; ENSG00000171659 .
    GeneIDi 2857.
    KEGGi hsa:2857.
    UCSCi uc004dfp.4. human.

    Organism-specific databases

    CTDi 2857.
    GeneCardsi GC0XP041548.
    HGNCi HGNC:4490. GPR34.
    HPAi CAB025490.
    HPA010668.
    MIMi 300241. gene.
    neXtProti NX_Q9UPC5.
    PharmGKBi PA28878.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145214.
    HOGENOMi HOG000039982.
    HOVERGENi HBG063715.
    InParanoidi Q9UPC5.
    KOi K08383.
    OMAi YHAFRFV.
    OrthoDBi EOG7NGQCP.
    PhylomeDBi Q9UPC5.
    TreeFami TF330969.

    Miscellaneous databases

    GenomeRNAii 2857.
    NextBioi 11267.
    PROi Q9UPC5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UPC5.
    Bgeei Q9UPC5.
    CleanExi HS_GPR34.
    Genevestigatori Q9UPC5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel subgroup of class I G-protein-coupled receptors."
      Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G., Gudermann T.
      Biochim. Biophys. Acta 1446:57-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1."
      Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A., Pusch C.M.
      Hum. Genet. 107:89-91(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiGPR34_HUMAN
    AccessioniPrimary (citable) accession number: Q9UPC5
    Secondary accession number(s): O95853
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3