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Protein
Submitted name:

Type II interleukin-1 receptor antagonist

Gene

IL-1ra3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Biological processi

  1. carboxylic acid metabolic process Source: Ensembl
  2. cellular response to norepinephrine stimulus Source: Ensembl
  3. chronic inflammatory response to antigenic stimulus Source: Ensembl
  4. female pregnancy Source: Ensembl
  5. fever generation Source: Ensembl
  6. insulin secretion Source: Ensembl
  7. lipid metabolic process Source: Ensembl
  8. memory Source: Ensembl
  9. negative regulation of apoptotic process Source: Ensembl
  10. negative regulation of cell migration Source: Ensembl
  11. negative regulation of glutamate secretion Source: Ensembl
  12. negative regulation of membrane potential Source: Ensembl
  13. positive regulation of JUN kinase activity Source: Ensembl
  14. response to activity Source: Ensembl
  15. response to drug Source: Ensembl
  16. response to interleukin-1 Source: Ensembl
  17. response to interleukin-4 Source: Ensembl
  18. response to lipopolysaccharide Source: Ensembl
  19. response to starvation Source: Ensembl
  20. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Type II interleukin-1 receptor antagonistImported
Gene namesi
Name:IL-1ra3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Ensembl
  2. vesicle Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9UP87.
ExpressionAtlasiQ9UP87. baseline and differential.

Sequencei

Sequence statusi: Fragment.

Q9UP87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
DLYEEGGGGG GEGEDNADSK
Length:20
Mass (Da):1,956
Last modified:May 1, 2000 - v1
Checksum:i47DDD28AE94667D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei20 – 201Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057168 Genomic DNA. Translation: AAC13499.1.
UniGeneiHs.81134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057168 Genomic DNA. Translation: AAC13499.1.
UniGeneiHs.81134.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiIL1RN. human.

Gene expression databases

BgeeiQ9UP87.
ExpressionAtlasiQ9UP87. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Characterization of the type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra without demonstrable intracellular function."
    Muzio M., Polentarutti N., Sironi M., Transidico P., Introna M., Mantovani A.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9UP87_HUMAN
AccessioniPrimary (citable) accession number: Q9UP87
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.