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Protein

Conserved oligomeric Golgi complex subunit 5

Gene

COG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal Golgi function.By similarity

Caution

It is uncertain whether Met-1 or Met-32 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 5
Short name:
COG complex subunit 5
Alternative name(s):
13S Golgi transport complex 90 kDa subunit
Short name:
GTC-90
Component of oligomeric Golgi complex 5
Golgi transport complex 1
Gene namesi
Name:COG5
Synonyms:GOLTC1, GTC90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164597.13
HGNCiHGNC:14857 COG5
MIMi606821 gene
neXtProtiNX_Q9UP83

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 2I (CDG2I)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Congenital disorder of glycosylation type 2I is characterized by mild neurological impairments.
See also OMIM:613612

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNETi10466
GeneReviewsiCOG5
MalaCardsiCOG5
MIMi613612 phenotype
OpenTargetsiENSG00000164597
Orphaneti263487 COG5-CDG
PharmGKBiPA26698

Polymorphism and mutation databases

BioMutaiCOG5
DMDMi296439390

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002135101 – 839Conserved oligomeric Golgi complex subunit 5Add BLAST839

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei197PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UP83
PaxDbiQ9UP83
PeptideAtlasiQ9UP83
PRIDEiQ9UP83

PTM databases

iPTMnetiQ9UP83
PhosphoSitePlusiQ9UP83

Expressioni

Gene expression databases

BgeeiENSG00000164597
CleanExiHS_COG5
ExpressionAtlasiQ9UP83 baseline and differential
GenevisibleiQ9UP83 HS

Organism-specific databases

HPAiHPA020300
HPA041583

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115729, 41 interactors
CORUMiQ9UP83
IntActiQ9UP83, 14 interactors
MINTiQ9UP83
STRINGi9606.ENSP00000297135

Structurei

3D structure databases

ProteinModelPortaliQ9UP83
SMRiQ9UP83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG5 family.Curated

Phylogenomic databases

eggNOGiKOG2211 Eukaryota
ENOG410XWH0 LUCA
GeneTreeiENSGT00390000004586
HOGENOMiHOG000170357
HOVERGENiHBG051063
InParanoidiQ9UP83
KOiK20292
OMAiKDSLQPY
OrthoDBiEOG091G048P
PhylomeDBiQ9UP83
TreeFamiTF313139

Family and domain databases

InterProiView protein in InterPro
IPR019465 Cog5
PANTHERiPTHR13228 PTHR13228, 1 hit
PfamiView protein in Pfam
PF10392 COG5, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UP83-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG
60 70 80 90 100
AAAATVRELL QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS
110 120 130 140 150
QLDRELHLQV VARHEDLLAQ ATGIESLEGV LQMMQTRIGA LQGAVDRIKA
160 170 180 190 200
KIVEPYNKIV ARTAQLARLQ VACDLLRRII RILNLSKRLQ GQLQGGSREI
210 220 230 240 250
TKAAQSLNEL DYLSQGIDLS GIEVIENDLL FIARARLEVE NQAKRLLEQG
260 270 280 290 300
LETQNPTQVG TALQVFYNLG TLKDTITSVV DGYCATLEEN INSALDIKVL
310 320 330 340 350
TQPSQSAVRG GPGRSTMPTP GNTAALRASF WTNMEKLMDH IYAVCGQVQH
360 370 380 390 400
LQKVLAKKRD PVSHICFIEE IVKDGQPEIF YTFWNSVTQA LSSQFHMATN
410 420 430 440 450
SSMFLKQAFE GEYPKLLRLY NDLWKRLQQY SQHIQGNFNA SGTTDLYVDL
460 470 480 490 500
QHMEDDAQDI FIPKKPDYDP EKALKDSLQP YEAAYLSKSL SRLFDPINLV
510 520 530 540 550
FPPGGRNPPS SDELDGIIKT IASELNVAAV DTNLTLAVSK NVAKTIQLYS
560 570 580 590 600
VKSEQLLSTQ GDASQVIGPL TEGQRRNVAV VNSLYKLHQS VTKAIHALME
610 620 630 640 650
NAVQPLLTSV GDAIEAIIIT MHQEDFSGSL SSSGKPDVPC SLYMKELQGF
660 670 680 690 700
IARVMSDYFK HFECLDFVFD NTEAIAQRAV ELFIRHASLI RPLGEGGKMR
710 720 730 740 750
LAADFAQMEL AVGPFCRRVS DLGKSYRMLR SFRPLLFQAS EHVASSPALG
760 770 780 790 800
DVIPFSIIIQ FLFTRAPAEL KSPFQRAEWS HTRFSQWLDD HPSEKDRLLL
810 820 830
IRGALEAYVQ SVRSREGKEF APVYPIMVQL LQKAMSALQ
Length:839
Mass (Da):92,743
Last modified:May 18, 2010 - v3
Checksum:i95BD2E254A0C3FF7
GO
Isoform 2 (identifier: Q9UP83-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     593-593: K → KVVSSQSSFPLAAEQTIISALK

Show »
Length:860
Mass (Da):94,901
Checksum:iCE98BD7F82CB7D82
GO
Isoform 3 (identifier: Q9UP83-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     593-593: K → KVVSSQSSFPLAAEQTIISALK
     803-839: Missing.

Note: No experimental confirmation available.
Show »
Length:823
Mass (Da):90,810
Checksum:i6E8DA2EC605D40D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112A → V in AAC69276 (PubMed:9792665).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039142330F → L2 PublicationsCorresponds to variant dbSNP:rs2269970Ensembl.1
Natural variantiVAR_039182365I → V. Corresponds to variant dbSNP:rs34087251Ensembl.1
Natural variantiVAR_055664452H → R. Corresponds to variant dbSNP:rs35393416Ensembl.1
Natural variantiVAR_039143558S → P1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031610593K → KVVSSQSSFPLAAEQTIISA LK in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_031611803 – 839Missing in isoform 3. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF058718 mRNA Translation: AAC69276.1
AC002381 Genomic DNA Translation: AAB63816.2
AC004855 Genomic DNA Translation: AAC83406.1
CH236947 Genomic DNA Translation: EAL24392.1
CH236947 Genomic DNA Translation: EAL24393.1
CH471070 Genomic DNA Translation: EAW83395.1
CH471070 Genomic DNA Translation: EAW83396.1
BC068540 mRNA Translation: AAH68540.1
CCDSiCCDS55152.1 [Q9UP83-3]
CCDS5742.1 [Q9UP83-2]
CCDS5743.1 [Q9UP83-1]
RefSeqiNP_001154992.1, NM_001161520.1 [Q9UP83-3]
NP_006339.3, NM_006348.3 [Q9UP83-2]
NP_859422.2, NM_181733.2 [Q9UP83-1]
UniGeneiHs.239631

Genome annotation databases

EnsembliENST00000297135; ENSP00000297135; ENSG00000164597 [Q9UP83-2]
ENST00000347053; ENSP00000334703; ENSG00000164597 [Q9UP83-1]
ENST00000393603; ENSP00000377228; ENSG00000164597 [Q9UP83-3]
GeneIDi10466
KEGGihsa:10466
UCSCiuc003vec.3 human [Q9UP83-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOG5_HUMAN
AccessioniPrimary (citable) accession number: Q9UP83
Secondary accession number(s): A4D0R6
, A4D0R7, O14555, O95008, Q6NUL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health