Reviewed,
UniProtKB/Swiss-Prot Q9UP79 (ATS8_HUMAN)
Last modified
December 15, 2009.
Version 95.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: A disintegrin and metalloproteinase with thrombospondin motifs 8 Short name=ADAMTS-8 Short name=ADAM-TS 8 Short name=ADAM-TS8 EC=3.4.24.- Alternative name(s): METH-2 METH-8 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 890 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has anti-angiogenic properties. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subcellular location | Secreted › extracellular space › extracellular matrix By similarity. |
| Tissue specificity | Highly expressed in adult and fetal lung, lower expression in brain, placenta, heart, stomach and fetal brain and kidney. |
| Domain | The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. |
| Post-translational modification | The precursor is cleaved by a furin endopeptidase By similarity. |
| Sequence similarities | Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 2 TSP type-1 domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 27 | 27 | Potential | ||||||||
| Propeptide | 28 – 214 | 187 | By similarity | PRO_0000029178 | |||||||
| Chain | 215 – 890 | 676 | A disintegrin and metalloproteinase with thrombospondin motifs 8 | PRO_0000029179 | |||||||
Regions | |||||||||||
| Domain | 220 – 430 | 211 | Peptidase M12B | ||||||||
| Domain | 439 – 526 | 88 | Disintegrin | ||||||||
| Domain | 527 – 582 | 56 | TSP type-1 1 | ||||||||
| Domain | 834 – 889 | 56 | TSP type-1 2 | ||||||||
| Region | 691 – 832 | 142 | Spacer | ||||||||
| Compositional bias | 202 – 205 | 4 | Poly-Pro | ||||||||
| Compositional bias | 584 – 690 | 107 | Cys-rich | ||||||||
Sites | |||||||||||
| Active site | 365 | 1 | By similarity | ||||||||
| Metal binding | 364 | 1 | Zinc; catalytic By similarity | ||||||||
| Metal binding | 368 | 1 | Zinc; catalytic By similarity | ||||||||
| Metal binding | 374 | 1 | Zinc; catalytic By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 255 | 1 | Phosphotyrosine Ref.3 | ||||||||
| Modified residue | 259 | 1 | Phosphoserine Ref.3 | ||||||||
| Glycosylation | 345 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 401 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 466 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 491 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 600 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 342 ↔ 425 | By similarity | |||||||||
| Disulfide bond | 380 ↔ 409 | By similarity | |||||||||
| Disulfide bond | 539 ↔ 576 | By similarity | |||||||||
| Disulfide bond | 543 ↔ 581 | By similarity | |||||||||
| Disulfide bond | 554 ↔ 566 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 195 | 1 | E → R in AAF25806. Ref.2 | ||||||||
| Sequence conflict | 413 – 440 | 28 | YLTEL…LPTGL → FSGCHLQGWIHFKYLCKCVS ELKCDLMP in AAF25806. Ref.2 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity." Vazquez F., Hastings G., Ortega M.-A., Lane T.F., Oikemus S., Lombardo M., Iruela-Arispe M.L. J. Biol. Chem. 274:23349-23357(1999) [PubMed: 10438512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. |
| [2] | "ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11." Georgiadis K.E., Hirohata S., Seldin M.F., Apte S.S. Genomics 62:312-315(1999) [PubMed: 10610729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 195-440. |
| [3] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-255 AND SER-259, MASS SPECTROMETRY. Tissue: Epithelium. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF060153 mRNA. Translation: AAD48081.1. AF175283 mRNA. Translation: AAF25806.1. | |
| IPI | IPI00298650. |
| UniGene | Hs.271605 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9UP79. |
Proteomic databases | |
| PRIDE | Q9UP79. |
Genome annotation databases | |
| Ensembl | ENST00000257359; ENSP00000257359; ENSG00000134917; Homo sapiens. [Genome view] |
| UCSC | uc001qgg.2. human. |
Organism-specific databases | |
| GeneCards | GC11M129780. |
| H-InvDB | HIX0026131. |
| HGNC | HGNC:224. ADAMTS8. |
| MIM | 605175. gene. |
| PharmGKB | PA24552. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9UP79. |
| InParanoid | Q9UP79. |
Gene expression databases | |
| ArrayExpress | Q9UP79. |
| Bgee | Q9UP79. |
| CleanEx | HS_ADAMTS8. |
| Genevestigator | Q9UP79. |
Family and domain databases | |
| InterPro | IPR010294. ADAM_spacer1. IPR013277. Pept_M12B_ADAM-TS8. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR000884. Thrombospondin_1_rpt. [Graphical view] |
| Pfam | PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 2 hits. [Graphical view] |
| PRINTS | PR01861. ADAMTS8. PR01857. ADAMTSFAMILY. |
| SMART | SM00209. TSP1. 2 hits. [Graphical view] |
| PROSITE | PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS50092. TSP1. 2 hits. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ATS8_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UP79 Secondary accession number(s): Q9NZS0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


