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Q9UP65

- PA24C_HUMAN

UniProt

Q9UP65 - PA24C_HUMAN

Protein

Cytosolic phospholipase A2 gamma

Gene

PLA2G4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.1 Publication

    Catalytic activityi

    Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Not regulated by calcium.

    Kineticsi

      Vmax=218 pmol/min/mg enzyme1 Publication

      Sites

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Active sitei82 – 821NucleophileBy similarity
      Active sitei385 – 3851Proton acceptorBy similarity

      GO - Molecular functioni

      1. calcium-independent phospholipase A2 activity Source: UniProtKB
      2. phospholipid binding Source: UniProtKB

      GO - Biological processi

      1. arachidonic acid metabolic process Source: UniProtKB
      2. glycerophospholipid biosynthetic process Source: Reactome
      3. glycerophospholipid catabolic process Source: UniProtKB
      4. inflammatory response Source: UniProtKB
      5. intracellular signal transduction Source: UniProtKB
      6. parturition Source: UniProtKB
      7. phosphatidylcholine acyl-chain remodeling Source: Reactome
      8. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
      9. phosphatidylinositol acyl-chain remodeling Source: Reactome
      10. phospholipid metabolic process Source: UniProtKB
      11. small molecule metabolic process Source: Reactome

      Keywords - Molecular functioni

      Hydrolase

      Keywords - Biological processi

      Lipid degradation, Lipid metabolism

      Enzyme and pathway databases

      ReactomeiREACT_120722. Acyl chain remodelling of PI.
      REACT_120785. Hydrolysis of LPE.
      REACT_120829. Acyl chain remodelling of PC.
      REACT_120977. Hydrolysis of LPC.
      REACT_121369. Acyl chain remodelling of PE.

      Names & Taxonomyi

      Protein namesi
      Recommended name:
      Cytosolic phospholipase A2 gamma (EC:3.1.1.4)
      Short name:
      cPLA2-gamma
      Alternative name(s):
      Phospholipase A2 group IVC
      Gene namesi
      Name:PLA2G4C
      OrganismiHomo sapiens (Human)
      Taxonomic identifieri9606 [NCBI]
      Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      ProteomesiUP000005640: Chromosome 19

      Organism-specific databases

      HGNCiHGNC:9037. PLA2G4C.

      Subcellular locationi

      Membrane 1 Publication; Lipid-anchor 1 Publication

      GO - Cellular componenti

      1. cell cortex Source: Ensembl
      2. cytosol Source: UniProtKB
      3. endoplasmic reticulum membrane Source: Reactome
      4. membrane Source: UniProtKB
      5. nuclear envelope Source: Ensembl
      6. nucleoplasm Source: Ensembl

      Keywords - Cellular componenti

      Membrane

      Pathology & Biotechi

      Mutagenesis

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Mutagenesisi54 – 541R → A: Abolishes enzyme activity. 1 Publication
      Mutagenesisi82 – 821S → A: Abolishes enzyme activity. 1 Publication
      Mutagenesisi385 – 3851D → A: Abolishes enzyme activity. 1 Publication
      Mutagenesisi402 – 4021R → A: Abolishes enzyme activity. 1 Publication

      Organism-specific databases

      PharmGKBiPA33365.

      PTM / Processingi

      Molecule processing

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Chaini1 – 538538Cytosolic phospholipase A2 gammaPRO_0000022995Add
      BLAST
      Propeptidei539 – 5413Removed in mature formPRO_0000022996

      Amino acid modifications

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Modified residuei538 – 5381Cysteine methyl ester1 Publication
      Lipidationi538 – 5381S-farnesyl cysteine1 Publication

      Keywords - PTMi

      Lipoprotein, Methylation, Prenylation

      Proteomic databases

      PaxDbiQ9UP65.
      PRIDEiQ9UP65.

      PTM databases

      PhosphoSiteiQ9UP65.

      Expressioni

      Tissue specificityi

      Highly expressed in heart and skeletal muscle.2 Publications

      Gene expression databases

      ArrayExpressiQ9UP65.
      BgeeiQ9UP65.
      CleanExiHS_PLA2G4C.
      GenevestigatoriQ9UP65.

      Organism-specific databases

      HPAiHPA043083.

      Interactioni

      Protein-protein interaction databases

      BioGridi114165. 2 interactions.
      STRINGi9606.ENSP00000346228.

      Structurei

      3D structure databases

      ProteinModelPortaliQ9UP65.
      SMRiQ9UP65. Positions 3-527.
      ModBaseiSearch...
      MobiDBiSearch...

      Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Domaini1 – 541541PLA2cPROSITE-ProRule annotationAdd
      BLAST

      Sequence similaritiesi

      Contains 1 PLA2c domain.PROSITE-ProRule annotation

      Phylogenomic databases

      eggNOGiNOG278787.
      HOVERGENiHBG058910.
      InParanoidiQ9UP65.
      KOiK16342.
      OMAiKDSARSC.
      OrthoDBiEOG78SQJS.
      PhylomeDBiQ9UP65.
      TreeFamiTF325228.

      Family and domain databases

      InterProiIPR016035. Acyl_Trfase/lysoPLipase.
      IPR002642. LysoPLipase_cat_dom.
      [Graphical view]
      PfamiPF01735. PLA2_B. 1 hit.
      [Graphical view]
      SMARTiSM00022. PLAc. 1 hit.
      [Graphical view]
      SUPFAMiSSF52151. SSF52151. 1 hit.
      PROSITEiPS51210. PLA2C. 1 hit.
      [Graphical view]

      Sequences (3)i

      Sequence statusi: Complete.

      Sequence processingi: The displayed sequence is further processed into a mature form.

      This entry describes 3 isoformsi produced by alternative splicing. Align

      Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to Basket

      This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

      « Hide

      MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG    50
      GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA 100
      LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL 150
      PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA 200
      GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR 250
      EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED 300
      EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI 350
      CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP 400
      TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP 450
      ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV 500
      VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A 541
      Length:541
      Mass (Da):60,939
      Last modified:February 8, 2011 - v2
      Checksum:iA114B2A614EA4632
      GO
      Isoform 2 (identifier: Q9UP65-2) [UniParc]FASTAAdd to Basket

      The sequence of this isoform differs from the canonical sequence as follows:
           528-541: Missing.

      Show »
      Length:527
      Mass (Da):59,367
      Checksum:i4F4C4884DE7EAD3A
      GO
      Isoform 3 (identifier: Q9UP65-3) [UniParc]FASTAAdd to Basket

      The sequence of this isoform differs from the canonical sequence as follows:
           1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK

      Show »
      Length:551
      Mass (Da):62,451
      Checksum:iD9A68B760776F943
      GO

      Experimental Info

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Sequence conflicti24 – 241R → G in BAG58352. (PubMed:14702039)Curated
      Sequence conflicti465 – 4651M → I in AAC32823. (PubMed:9705332)Curated
      Sequence conflicti480 – 4801E → G in CAG33097. 1 PublicationCurated

      Natural variant

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Natural varianti21 – 211E → K.1 Publication
      Corresponds to variant rs11564522 [ dbSNP | Ensembl ].
      VAR_018761
      Natural varianti38 – 381A → P.1 Publication
      Corresponds to variant rs2307279 [ dbSNP | Ensembl ].
      VAR_018420
      Natural varianti127 – 1271A → V.1 Publication
      Corresponds to variant rs11564532 [ dbSNP | Ensembl ].
      VAR_018762
      Natural varianti142 – 1421V → F.1 Publication
      Corresponds to variant rs11564534 [ dbSNP | Ensembl ].
      VAR_018763
      Natural varianti143 – 1431I → V.2 Publications
      Corresponds to variant rs2303744 [ dbSNP | Ensembl ].
      VAR_018421
      Natural varianti148 – 1481R → G.1 Publication
      Corresponds to variant rs2307282 [ dbSNP | Ensembl ].
      VAR_018764
      Natural varianti151 – 1511P → L.1 Publication
      Corresponds to variant rs11564538 [ dbSNP | Ensembl ].
      VAR_018765
      Natural varianti203 – 2031S → P.4 Publications
      Corresponds to variant rs156631 [ dbSNP | Ensembl ].
      VAR_018422
      Natural varianti226 – 2261T → S.1 Publication
      Corresponds to variant rs11564541 [ dbSNP | Ensembl ].
      VAR_018766
      Natural varianti360 – 3601T → P.1 Publication
      Corresponds to variant rs11564620 [ dbSNP | Ensembl ].
      VAR_018767
      Natural varianti411 – 4111D → N.1 Publication
      Corresponds to variant rs11564638 [ dbSNP | Ensembl ].
      VAR_018768
      Natural varianti430 – 4301R → C.1 Publication
      Corresponds to variant rs191276960 [ dbSNP | Ensembl ].
      VAR_018423

      Alternative sequence

      Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
      Alternative sequencei1 – 1313MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationVSP_045849Add
      BLAST
      Alternative sequencei528 – 54114Missing in isoform 2. CuratedVSP_045850Add
      BLAST

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      AF058921 mRNA. Translation: AAC32823.1.
      AF065214 mRNA. Translation: AAC78835.1.
      AY485310 Genomic DNA. Translation: AAR25453.1.
      AK295400 mRNA. Translation: BAG58352.1.
      AK314524 mRNA. Translation: BAG37118.1.
      CR456816 mRNA. Translation: CAG33097.1.
      AC010458 Genomic DNA. No translation available.
      AC011466 Genomic DNA. No translation available.
      CH471177 Genomic DNA. Translation: EAW52314.1.
      BC063416 mRNA. Translation: AAH63416.1.
      AB105807 Genomic DNA. Translation: BAC87745.1.
      AL050193 mRNA. Translation: CAB43312.3.
      CCDSiCCDS12710.1. [Q9UP65-1]
      CCDS54286.1. [Q9UP65-2]
      CCDS59403.1. [Q9UP65-3]
      PIRiT13162.
      RefSeqiNP_001152794.1. NM_001159322.1. [Q9UP65-3]
      NP_001152795.1. NM_001159323.1. [Q9UP65-2]
      NP_003697.2. NM_003706.2. [Q9UP65-1]
      UniGeneiHs.631562.

      Genome annotation databases

      EnsembliENST00000354276; ENSP00000346228; ENSG00000105499. [Q9UP65-2]
      ENST00000599111; ENSP00000472546; ENSG00000105499. [Q9UP65-3]
      ENST00000599921; ENSP00000469473; ENSG00000105499. [Q9UP65-1]
      GeneIDi8605.
      KEGGihsa:8605.
      UCSCiuc002phw.3. human. [Q9UP65-1]

      Polymorphism databases

      DMDMi322510066.

      Keywords - Coding sequence diversityi

      Alternative splicing, Polymorphism

      Cross-referencesi

      Web resourcesi

      NIEHS-SNPs

      Sequence databases

      Select the link destinations:
      EMBL
      GenBank
      DDBJ
      Links Updated
      AF058921 mRNA. Translation: AAC32823.1 .
      AF065214 mRNA. Translation: AAC78835.1 .
      AY485310 Genomic DNA. Translation: AAR25453.1 .
      AK295400 mRNA. Translation: BAG58352.1 .
      AK314524 mRNA. Translation: BAG37118.1 .
      CR456816 mRNA. Translation: CAG33097.1 .
      AC010458 Genomic DNA. No translation available.
      AC011466 Genomic DNA. No translation available.
      CH471177 Genomic DNA. Translation: EAW52314.1 .
      BC063416 mRNA. Translation: AAH63416.1 .
      AB105807 Genomic DNA. Translation: BAC87745.1 .
      AL050193 mRNA. Translation: CAB43312.3 .
      CCDSi CCDS12710.1. [Q9UP65-1 ]
      CCDS54286.1. [Q9UP65-2 ]
      CCDS59403.1. [Q9UP65-3 ]
      PIRi T13162.
      RefSeqi NP_001152794.1. NM_001159322.1. [Q9UP65-3 ]
      NP_001152795.1. NM_001159323.1. [Q9UP65-2 ]
      NP_003697.2. NM_003706.2. [Q9UP65-1 ]
      UniGenei Hs.631562.

      3D structure databases

      ProteinModelPortali Q9UP65.
      SMRi Q9UP65. Positions 3-527.
      ModBasei Search...
      MobiDBi Search...

      Protein-protein interaction databases

      BioGridi 114165. 2 interactions.
      STRINGi 9606.ENSP00000346228.

      Chemistry

      BindingDBi Q9UP65.
      ChEMBLi CHEMBL4834.

      PTM databases

      PhosphoSitei Q9UP65.

      Polymorphism databases

      DMDMi 322510066.

      Proteomic databases

      PaxDbi Q9UP65.
      PRIDEi Q9UP65.

      Protocols and materials databases

      Structural Biology Knowledgebase Search...

      Genome annotation databases

      Ensembli ENST00000354276 ; ENSP00000346228 ; ENSG00000105499 . [Q9UP65-2 ]
      ENST00000599111 ; ENSP00000472546 ; ENSG00000105499 . [Q9UP65-3 ]
      ENST00000599921 ; ENSP00000469473 ; ENSG00000105499 . [Q9UP65-1 ]
      GeneIDi 8605.
      KEGGi hsa:8605.
      UCSCi uc002phw.3. human. [Q9UP65-1 ]

      Organism-specific databases

      CTDi 8605.
      GeneCardsi GC19M048551.
      HGNCi HGNC:9037. PLA2G4C.
      HPAi HPA043083.
      MIMi 603602. gene.
      neXtProti NX_Q9UP65.
      PharmGKBi PA33365.
      GenAtlasi Search...

      Phylogenomic databases

      eggNOGi NOG278787.
      HOVERGENi HBG058910.
      InParanoidi Q9UP65.
      KOi K16342.
      OMAi KDSARSC.
      OrthoDBi EOG78SQJS.
      PhylomeDBi Q9UP65.
      TreeFami TF325228.

      Enzyme and pathway databases

      Reactomei REACT_120722. Acyl chain remodelling of PI.
      REACT_120785. Hydrolysis of LPE.
      REACT_120829. Acyl chain remodelling of PC.
      REACT_120977. Hydrolysis of LPC.
      REACT_121369. Acyl chain remodelling of PE.

      Miscellaneous databases

      GeneWikii PLA2G4C.
      GenomeRNAii 8605.
      NextBioi 32245.
      PROi Q9UP65.
      SOURCEi Search...

      Gene expression databases

      ArrayExpressi Q9UP65.
      Bgeei Q9UP65.
      CleanExi HS_PLA2G4C.
      Genevestigatori Q9UP65.

      Family and domain databases

      InterProi IPR016035. Acyl_Trfase/lysoPLipase.
      IPR002642. LysoPLipase_cat_dom.
      [Graphical view ]
      Pfami PF01735. PLA2_B. 1 hit.
      [Graphical view ]
      SMARTi SM00022. PLAc. 1 hit.
      [Graphical view ]
      SUPFAMi SSF52151. SSF52151. 1 hit.
      PROSITEi PS51210. PLA2C. 1 hit.
      [Graphical view ]
      ProtoNeti Search...

      Publicationsi

      1. "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
        Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
        J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
        Tissue: Skeletal muscle.
      2. "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
        Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
        J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203.
      3. NIEHS SNPs program
        Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
        Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-21; PRO-38; VAL-127; PHE-142; VAL-143; GLY-148; LEU-151; PRO-203; SER-226; PRO-360 AND ASN-411.
      4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
        Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
        , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
        Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS VAL-143 AND PRO-203.
        Tissue: Corpus callosum and Tongue.
      5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
        Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
        Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-203.
      6. "The DNA sequence and biology of human chromosome 19."
        Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
        , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
        Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
        The MGC Project Team
        Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
        Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
        Tissue: Pancreas.
      9. "SNP search of PLA2G4C gene."
        Koyama K.S., Kimura T., Imai T.
        Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
        Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 420-476, VARIANT CYS-430.
      10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-541 (ISOFORM 1).
        Tissue: Uterus.
      11. "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
        Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
        Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]
        Cited for: ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
      12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
        Tissue: Platelet.

      Entry informationi

      Entry nameiPA24C_HUMAN
      AccessioniPrimary (citable) accession number: Q9UP65
      Secondary accession number(s): B2RB71
      , B4DI40, O75457, Q6IBI8, Q9UG68
      Entry historyi
      Integrated into UniProtKB/Swiss-Prot: May 10, 2004
      Last sequence update: February 8, 2011
      Last modified: October 1, 2014
      This is version 109 of the entry and version 2 of the sequence. [Complete history]
      Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. Human chromosome 19
        Human chromosome 19: entries, gene names and cross-references to MIM
      2. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
      3. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      4. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      5. SIMILARITY comments
        Index of protein domains and families

      External Data

      Dasty 3