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Q9UP65

- PA24C_HUMAN

UniProt

Q9UP65 - PA24C_HUMAN

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Protein

Cytosolic phospholipase A2 gamma

Gene

PLA2G4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Enzyme regulationi

Not regulated by calcium.

Kineticsi

    Vmax=218 pmol/min/mg enzyme1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei82 – 821NucleophileBy similarity
    Active sitei385 – 3851Proton acceptorBy similarity

    GO - Molecular functioni

    1. calcium-independent phospholipase A2 activity Source: UniProtKB
    2. phospholipid binding Source: UniProtKB

    GO - Biological processi

    1. arachidonic acid metabolic process Source: UniProtKB
    2. glycerophospholipid biosynthetic process Source: Reactome
    3. glycerophospholipid catabolic process Source: UniProtKB
    4. inflammatory response Source: UniProtKB
    5. intracellular signal transduction Source: UniProtKB
    6. parturition Source: UniProtKB
    7. phosphatidylcholine acyl-chain remodeling Source: Reactome
    8. phosphatidylethanolamine acyl-chain remodeling Source: Reactome
    9. phosphatidylinositol acyl-chain remodeling Source: Reactome
    10. phospholipid metabolic process Source: UniProtKB
    11. small molecule metabolic process Source: Reactome
    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_120722. Acyl chain remodelling of PI.
    REACT_120785. Hydrolysis of LPE.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120977. Hydrolysis of LPC.
    REACT_121369. Acyl chain remodelling of PE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 gamma (EC:3.1.1.4)
    Short name:
    cPLA2-gamma
    Alternative name(s):
    Phospholipase A2 group IVC
    Gene namesi
    Name:PLA2G4C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9037. PLA2G4C.

    Subcellular locationi

    Membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cytosol Source: UniProtKB
    3. endoplasmic reticulum membrane Source: Reactome
    4. membrane Source: UniProtKB
    5. nuclear envelope Source: Ensembl
    6. nucleoplasm Source: Ensembl
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi54 – 541R → A: Abolishes enzyme activity. 1 Publication
    Mutagenesisi82 – 821S → A: Abolishes enzyme activity. 1 Publication
    Mutagenesisi385 – 3851D → A: Abolishes enzyme activity. 1 Publication
    Mutagenesisi402 – 4021R → A: Abolishes enzyme activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA33365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Cytosolic phospholipase A2 gammaPRO_0000022995Add
    BLAST
    Propeptidei539 – 5413Removed in mature formPRO_0000022996

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei538 – 5381Cysteine methyl ester1 Publication
    Lipidationi538 – 5381S-farnesyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ9UP65.
    PRIDEiQ9UP65.

    PTM databases

    PhosphoSiteiQ9UP65.

    Expressioni

    Tissue specificityi

    Highly expressed in heart and skeletal muscle.2 Publications

    Gene expression databases

    BgeeiQ9UP65.
    CleanExiHS_PLA2G4C.
    ExpressionAtlasiQ9UP65. baseline and differential.
    GenevestigatoriQ9UP65.

    Organism-specific databases

    HPAiHPA043083.

    Interactioni

    Protein-protein interaction databases

    BioGridi114165. 2 interactions.
    STRINGi9606.ENSP00000346228.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UP65.
    SMRiQ9UP65. Positions 3-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 541541PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278787.
    GeneTreeiENSGT00550000074489.
    HOVERGENiHBG058910.
    InParanoidiQ9UP65.
    KOiK16342.
    OMAiKDSARSC.
    OrthoDBiEOG78SQJS.
    PhylomeDBiQ9UP65.
    TreeFamiTF325228.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UP65-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MGSSEVSIIP GLQKEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG
    60 70 80 90 100
    GGLRAHIACL GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA
    110 120 130 140 150
    LEADLKHRFT RQEWDLAKSL QKTIQAARSE NYSLTDFWAY MVISKQTREL
    160 170 180 190 200
    PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ PSWQEARAPE TWFEFTPHHA
    210 220 230 240 250
    GFSALGAFVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG SALGNTEVIR
    260 270 280 290 300
    EYIFDQLRNL TLKGLWRRAV ANAKSIGHLI FARLLRLQES SQGEHPPPED
    310 320 330 340 350
    EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGSLSN LMDFVKKTGI
    360 370 380 390 400
    CASKWEWGTT HNFLYKHGGI RDKIMSSRKH LHLVDAGLAI NTPFPLVLPP
    410 420 430 440 450
    TREVHLILSF DFSAGDPFET IRATTDYCRR HKIPFPQVEE AELDLWSKAP
    460 470 480 490 500
    ASCYILKGET GPVVMHFPLF NIDACGGDIE AWSDTYDTFK LADTYTLDVV
    510 520 530 540
    VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL A
    Length:541
    Mass (Da):60,939
    Last modified:February 8, 2011 - v2
    Checksum:iA114B2A614EA4632
    GO
    Isoform 2 (identifier: Q9UP65-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-541: Missing.

    Show »
    Length:527
    Mass (Da):59,367
    Checksum:i4F4C4884DE7EAD3A
    GO
    Isoform 3 (identifier: Q9UP65-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MGSSEVSIIPGLQ → MRTRPRPRLRRTENFLTAVHHGK

    Show »
    Length:551
    Mass (Da):62,451
    Checksum:iD9A68B760776F943
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241R → G in BAG58352. (PubMed:14702039)Curated
    Sequence conflicti465 – 4651M → I in AAC32823. (PubMed:9705332)Curated
    Sequence conflicti480 – 4801E → G in CAG33097. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211E → K.1 Publication
    Corresponds to variant rs11564522 [ dbSNP | Ensembl ].
    VAR_018761
    Natural varianti38 – 381A → P.1 Publication
    Corresponds to variant rs2307279 [ dbSNP | Ensembl ].
    VAR_018420
    Natural varianti127 – 1271A → V.1 Publication
    Corresponds to variant rs11564532 [ dbSNP | Ensembl ].
    VAR_018762
    Natural varianti142 – 1421V → F.1 Publication
    Corresponds to variant rs11564534 [ dbSNP | Ensembl ].
    VAR_018763
    Natural varianti143 – 1431I → V.2 Publications
    Corresponds to variant rs2303744 [ dbSNP | Ensembl ].
    VAR_018421
    Natural varianti148 – 1481R → G.1 Publication
    Corresponds to variant rs2307282 [ dbSNP | Ensembl ].
    VAR_018764
    Natural varianti151 – 1511P → L.1 Publication
    Corresponds to variant rs11564538 [ dbSNP | Ensembl ].
    VAR_018765
    Natural varianti203 – 2031S → P.4 Publications
    Corresponds to variant rs156631 [ dbSNP | Ensembl ].
    VAR_018422
    Natural varianti226 – 2261T → S.1 Publication
    Corresponds to variant rs11564541 [ dbSNP | Ensembl ].
    VAR_018766
    Natural varianti360 – 3601T → P.1 Publication
    Corresponds to variant rs11564620 [ dbSNP | Ensembl ].
    VAR_018767
    Natural varianti411 – 4111D → N.1 Publication
    Corresponds to variant rs11564638 [ dbSNP | Ensembl ].
    VAR_018768
    Natural varianti430 – 4301R → C.1 Publication
    Corresponds to variant rs191276960 [ dbSNP | Ensembl ].
    VAR_018423

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313MGSSE…IPGLQ → MRTRPRPRLRRTENFLTAVH HGK in isoform 3. 1 PublicationVSP_045849Add
    BLAST
    Alternative sequencei528 – 54114Missing in isoform 2. CuratedVSP_045850Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058921 mRNA. Translation: AAC32823.1.
    AF065214 mRNA. Translation: AAC78835.1.
    AY485310 Genomic DNA. Translation: AAR25453.1.
    AK295400 mRNA. Translation: BAG58352.1.
    AK314524 mRNA. Translation: BAG37118.1.
    CR456816 mRNA. Translation: CAG33097.1.
    AC010458 Genomic DNA. No translation available.
    AC011466 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52314.1.
    BC063416 mRNA. Translation: AAH63416.1.
    AB105807 Genomic DNA. Translation: BAC87745.1.
    AL050193 mRNA. Translation: CAB43312.3.
    CCDSiCCDS12710.1. [Q9UP65-1]
    CCDS54286.1. [Q9UP65-2]
    CCDS59403.1. [Q9UP65-3]
    PIRiT13162.
    RefSeqiNP_001152794.1. NM_001159322.1. [Q9UP65-3]
    NP_001152795.1. NM_001159323.1. [Q9UP65-2]
    NP_003697.2. NM_003706.2. [Q9UP65-1]
    UniGeneiHs.631562.

    Genome annotation databases

    EnsembliENST00000354276; ENSP00000346228; ENSG00000105499. [Q9UP65-2]
    ENST00000599111; ENSP00000472546; ENSG00000105499. [Q9UP65-3]
    ENST00000599921; ENSP00000469473; ENSG00000105499. [Q9UP65-1]
    GeneIDi8605.
    KEGGihsa:8605.
    UCSCiuc002phw.3. human. [Q9UP65-1]

    Polymorphism databases

    DMDMi322510066.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF058921 mRNA. Translation: AAC32823.1 .
    AF065214 mRNA. Translation: AAC78835.1 .
    AY485310 Genomic DNA. Translation: AAR25453.1 .
    AK295400 mRNA. Translation: BAG58352.1 .
    AK314524 mRNA. Translation: BAG37118.1 .
    CR456816 mRNA. Translation: CAG33097.1 .
    AC010458 Genomic DNA. No translation available.
    AC011466 Genomic DNA. No translation available.
    CH471177 Genomic DNA. Translation: EAW52314.1 .
    BC063416 mRNA. Translation: AAH63416.1 .
    AB105807 Genomic DNA. Translation: BAC87745.1 .
    AL050193 mRNA. Translation: CAB43312.3 .
    CCDSi CCDS12710.1. [Q9UP65-1 ]
    CCDS54286.1. [Q9UP65-2 ]
    CCDS59403.1. [Q9UP65-3 ]
    PIRi T13162.
    RefSeqi NP_001152794.1. NM_001159322.1. [Q9UP65-3 ]
    NP_001152795.1. NM_001159323.1. [Q9UP65-2 ]
    NP_003697.2. NM_003706.2. [Q9UP65-1 ]
    UniGenei Hs.631562.

    3D structure databases

    ProteinModelPortali Q9UP65.
    SMRi Q9UP65. Positions 3-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114165. 2 interactions.
    STRINGi 9606.ENSP00000346228.

    Chemistry

    ChEMBLi CHEMBL4834.

    PTM databases

    PhosphoSitei Q9UP65.

    Polymorphism databases

    DMDMi 322510066.

    Proteomic databases

    PaxDbi Q9UP65.
    PRIDEi Q9UP65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354276 ; ENSP00000346228 ; ENSG00000105499 . [Q9UP65-2 ]
    ENST00000599111 ; ENSP00000472546 ; ENSG00000105499 . [Q9UP65-3 ]
    ENST00000599921 ; ENSP00000469473 ; ENSG00000105499 . [Q9UP65-1 ]
    GeneIDi 8605.
    KEGGi hsa:8605.
    UCSCi uc002phw.3. human. [Q9UP65-1 ]

    Organism-specific databases

    CTDi 8605.
    GeneCardsi GC19M048551.
    HGNCi HGNC:9037. PLA2G4C.
    HPAi HPA043083.
    MIMi 603602. gene.
    neXtProti NX_Q9UP65.
    PharmGKBi PA33365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278787.
    GeneTreei ENSGT00550000074489.
    HOVERGENi HBG058910.
    InParanoidi Q9UP65.
    KOi K16342.
    OMAi KDSARSC.
    OrthoDBi EOG78SQJS.
    PhylomeDBi Q9UP65.
    TreeFami TF325228.

    Enzyme and pathway databases

    Reactomei REACT_120722. Acyl chain remodelling of PI.
    REACT_120785. Hydrolysis of LPE.
    REACT_120829. Acyl chain remodelling of PC.
    REACT_120977. Hydrolysis of LPC.
    REACT_121369. Acyl chain remodelling of PE.

    Miscellaneous databases

    GeneWikii PLA2G4C.
    GenomeRNAii 8605.
    NextBioi 32245.
    PROi Q9UP65.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UP65.
    CleanExi HS_PLA2G4C.
    ExpressionAtlasi Q9UP65. baseline and differential.
    Genevestigatori Q9UP65.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "A novel calcium-independent phospholipase A2, cPLA2-gamma, that is prenylated and contains homology to cPLA2."
      Underwood K.W., Song C., Kriz R.W., Chang X.J., Knopf J.L., Lin L.L.
      J. Biol. Chem. 273:21926-21932(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.
    2. "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2."
      Pickard R.T., Strifler B.A., Kramer R.M., Sharp J.D.
      J. Biol. Chem. 274:8823-8831(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-54; SER-82; ASP-385 AND ARG-402, VARIANT PRO-203.
    3. NIEHS SNPs program
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-21; PRO-38; VAL-127; PHE-142; VAL-143; GLY-148; LEU-151; PRO-203; SER-226; PRO-360 AND ASN-411.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS VAL-143 AND PRO-203.
      Tissue: Corpus callosum and Tongue.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PRO-203.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    9. "SNP search of PLA2G4C gene."
      Koyama K.S., Kimura T., Imai T.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 420-476, VARIANT CYS-430.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 443-541 (ISOFORM 1).
      Tissue: Uterus.
    11. "Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis."
      Jenkins C.M., Han X., Yang J., Mancuso D.J., Sims H.F., Muslin A.J., Gross R.W.
      Biochemistry 42:11798-11807(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-538, METHYLATION AT CYS-538.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.

    Entry informationi

    Entry nameiPA24C_HUMAN
    AccessioniPrimary (citable) accession number: Q9UP65
    Secondary accession number(s): B2RB71
    , B4DI40, O75457, Q6IBI8, Q9UG68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: February 8, 2011
    Last modified: November 26, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3