Q9UP52 (TFR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transferrin receptor protein 2
Short name=TfR2

Gene names

Name:

TFR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	801 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation.
Subunit structure	Homodimer.
Subcellular location	Cell membrane; Single-pass type II membrane protein. Isoform Beta: Cytoplasm Probable. Note: Lacks the transmembrane domain. Probably intracellular.
Tissue specificity	Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.
Involvement in disease	Hemochromatosis 3 (HFE3) [MIM:604250]: A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.9 Ref.10 Ref.12
Miscellaneous	The variant Lys-172 found in hereditary hemochromatosis type III affects the putative initiation codon of the beta isoform thus preventing its translation.
Sequence similarities	Belongs to the peptidase M28 family. M28B subfamily.
Sequence caution	The sequence BAA91153.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Traceable author statement PubMed 15319276. Source: UniProtKB iron ion transport Non-traceable author statement Ref.1. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	peptidase activity Inferred from electronic annotation. Source: InterPro transferrin receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q9UP52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q9UP52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Isoform Gamma (identifier: Q9UP52-3)

The sequence of this isoform differs from the canonical sequence as follows:
     343-369: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 801	801	Transferrin receptor protein 2		PRO_0000174136
Regions
	Topological domain	1 – 83	83	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	105 – 801	697	Extracellular Potential
	Motif	23 – 26	4	Endocytosis signal Potential
Amino acid modifications
	Glycosylation	240	1	N-linked (GlcNAc...) Potential
	Glycosylation	339	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	540	1	N-linked (GlcNAc...) Potential
	Glycosylation	754	1	N-linked (GlcNAc...) Ref.8
	Disulfide bond	108		Interchain Potential
	Disulfide bond	111		Interchain Potential
Natural variations
	Alternative sequence	1 – 171	171	Missing in isoform Beta.		VSP_005354
	Alternative sequence	343 – 369	27	Missing in isoform Gamma.		VSP_005355
	Natural variant	22	1	V → I in HFE3. Ref.12		VAR_042515
	Natural variant	172	1	M → K in HFE3. Ref.9		VAR_012738
	Natural variant	230	1	D → E. Corresponds to variant rs41303465 [ dbSNP | Ensembl ].		VAR_034122
	Natural variant	238	1	I → M. Corresponds to variant rs34242818 [ dbSNP | Ensembl ].		VAR_034123
	Natural variant	455	1	R → Q Hereditary hemochromatosis modifier. Ref.11 Corresponds to variant rs41303501 [ dbSNP | Ensembl ].		VAR_042516
	Natural variant	690	1	Q → P in HFE3. Ref.10		VAR_042517
	Natural variant	752	1	R → H. Corresponds to variant rs41295942 [ dbSNP | Ensembl ].		VAR_034124
Experimental info
	Sequence conflict	712	1	R → RIPLSAQV Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D3D3082BA835413A	FASTA	801	88,755
	10 20 30 40 50 60 MERLWGLFQR AQQLSPRSSQ TVYQRVEGPR KGHLEEEEED GEEGAETLAH FCPMELRGPE 70 80 90 100 110 120 PLGSRPRQPN LIPWAAAGRR AAPYLVLTAL LIFTGAFLLG YVAFRGSCQA CGDSVLVVSE 130 140 150 160 170 180 DVNYEPDLDF HQGRLYWSDL QAMFLQFLGE GRLEDTIRQT SLRERVAGSA GMAALTQDIR 190 200 210 220 230 240 AALSRQKLDH VWTDTHYVGL QFPDPAHPNT LHWVDEAGKV GEQLPLEDPD VYCPYSAIGN 250 260 270 280 290 300 VTGELVYAHY GRPEDLQDLR ARGVDPVGRL LLVRVGVISF AQKVTNAQDF GAQGVLIYPE 310 320 330 340 350 360 PADFSQDPPK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS 370 380 390 400 410 420 ADIASRLLRK LKGPVAPQEW QGSLLGSPYH LGPGPRLRLV VNNHRTSTPI NNIFGCIEGR 430 440 450 460 470 480 SEPDHYVVIG AQRDAWGPGA AKSAVGTAIL LELVRTFSSM VSNGFRPRRS LLFISWDGGD 490 500 510 520 530 540 FGSVGSTEWL EGYLSVLHLK AVVYVSLDNA VLGDDKFHAK TSPLLTSLIE SVLKQVDSPN 550 560 570 580 590 600 HSGQTLYEQV VFTNPSWDAE VIRPLPMDSS AYSFTAFVGV PAVEFSFMED DQAYPFLHTK 610 620 630 640 650 660 EDTYENLHKV LQGRLPAVAQ AVAQLAGQLL IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF 670 680 690 700 710 720 SGDLKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLTRMYNVRI MRVEFYFLSQ 730 740 750 760 770 780 YVSPADSPFR HIFMGRGDHT LGALLDHLRL LRSNSSGTPG ATSSTGFQES RFRRQLALLT 790 800 WTLQGAANAL SGDVWNIDNN F
	Isoform Beta [UniParc]. Checksum: 267F164C1D1DEEAE	FASTA	630	69,618
	10 20 30 40 50 60 MAALTQDIRA ALSRQKLDHV WTDTHYVGLQ FPDPAHPNTL HWVDEAGKVG EQLPLEDPDV 70 80 90 100 110 120 YCPYSAIGNV TGELVYAHYG RPEDLQDLRA RGVDPVGRLL LVRVGVISFA QKVTNAQDFG 130 140 150 160 170 180 AQGVLIYPEP ADFSQDPPKP SLSSQQAVYG HVHLGTGDPY TPGFPSFNQT QFPPVASSGL 190 200 210 220 230 240 PSIPAQPISA DIASRLLRKL KGPVAPQEWQ GSLLGSPYHL GPGPRLRLVV NNHRTSTPIN 250 260 270 280 290 300 NIFGCIEGRS EPDHYVVIGA QRDAWGPGAA KSAVGTAILL ELVRTFSSMV SNGFRPRRSL 310 320 330 340 350 360 LFISWDGGDF GSVGSTEWLE GYLSVLHLKA VVYVSLDNAV LGDDKFHAKT SPLLTSLIES 370 380 390 400 410 420 VLKQVDSPNH SGQTLYEQVV FTNPSWDAEV IRPLPMDSSA YSFTAFVGVP AVEFSFMEDD 430 440 450 460 470 480 QAYPFLHTKE DTYENLHKVL QGRLPAVAQA VAQLAGQLLI RLSHDRLLPL DFGRYGDVVL 490 500 510 520 530 540 RHIGNLNEFS GDLKARGLTL QWVYSARGDY IRAAEKLRQE IYSSEERDER LTRMYNVRIM 550 560 570 580 590 600 RVEFYFLSQY VSPADSPFRH IFMGRGDHTL GALLDHLRLL RSNSSGTPGA TSSTGFQESR 610 620 630 FRRQLALLTW TLQGAANALS GDVWNIDNNF
	Isoform Gamma [UniParc]. Checksum: 09A2662EFC77C9A0	FASTA	774	86,012
	10 20 30 40 50 60 MERLWGLFQR AQQLSPRSSQ TVYQRVEGPR KGHLEEEEED GEEGAETLAH FCPMELRGPE 70 80 90 100 110 120 PLGSRPRQPN LIPWAAAGRR AAPYLVLTAL LIFTGAFLLG YVAFRGSCQA CGDSVLVVSE 130 140 150 160 170 180 DVNYEPDLDF HQGRLYWSDL QAMFLQFLGE GRLEDTIRQT SLRERVAGSA GMAALTQDIR 190 200 210 220 230 240 AALSRQKLDH VWTDTHYVGL QFPDPAHPNT LHWVDEAGKV GEQLPLEDPD VYCPYSAIGN 250 260 270 280 290 300 VTGELVYAHY GRPEDLQDLR ARGVDPVGRL LLVRVGVISF AQKVTNAQDF GAQGVLIYPE 310 320 330 340 350 360 PADFSQDPPK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQKLKGPVAP QEWQGSLLGS 370 380 390 400 410 420 PYHLGPGPRL RLVVNNHRTS TPINNIFGCI EGRSEPDHYV VIGAQRDAWG PGAAKSAVGT 430 440 450 460 470 480 AILLELVRTF SSMVSNGFRP RRSLLFISWD GGDFGSVGST EWLEGYLSVL HLKAVVYVSL 490 500 510 520 530 540 DNAVLGDDKF HAKTSPLLTS LIESVLKQVD SPNHSGQTLY EQVVFTNPSW DAEVIRPLPM 550 560 570 580 590 600 DSSAYSFTAF VGVPAVEFSF MEDDQAYPFL HTKEDTYENL HKVLQGRLPA VAQAVAQLAG 610 620 630 640 650 660 QLLIRLSHDR LLPLDFGRYG DVVLRHIGNL NEFSGDLKAR GLTLQWVYSA RGDYIRAAEK 670 680 690 700 710 720 LRQEIYSSEE RDERLTRMYN VRIMRVEFYF LSQYVSPADS PFRHIFMGRG DHTLGALLDH 730 740 750 760 770 LRLLRSNSSG TPGATSSTGF QESRFRRQLA LLTWTLQGAA NALSGDVWNI DNNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family." Kawabata H., Yang R., Hirama T., Vuong P.T., Kawano S., Gombart A.F., Koeffler H.P. J. Biol. Chem. 274:20826-20832(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). Tissue: Erythroleukemia and Myeloid leukemia cell.
[2]	"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes." Gloeckner G., Scherer S., Schattevoy R., Boright A.P., Weber J., Tsui L.-C., Rosenthal A. Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM GAMMA).
[3]	NHLBI resequencing and genotyping service (RS&G) Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-158 AND 370-801. Tissue: Carcinoma and Embryo.
[7]	"The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22." Camaschella C., Roetto A., Cali A., De Gobbi M., Garozzo G., Carella M., Majorano N., Totaro A., Gasparini P. Nat. Genet. 25:14-15(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DISEASE.
[8]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-339 AND ASN-754, MASS SPECTROMETRY. Tissue: Liver.
[9]	"New mutations inactivating transferrin 2 in hemochromatosis type 3." Roetto A., Totaro A., Piperno A., Piga A., Longo F., Garozzo G., Cali A., De Gobbi M., Gasparini P., Camaschella C. Blood 97:2555-2560(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HFE3 LYS-172.
[10]	"Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation." Mattman A., Huntsman D., Lockitch G., Langlois S., Buskard N., Ralston D., Butterfield Y., Rodrigues P., Jones S., Porto G., Marra M., De Sousa M., Vatcher G. Blood 100:1075-1077(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HFE3 PRO-690.
[11]	"Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis." Hofmann W.-K., Tong X.-J., Ajioka R.S., Kushner J.P., Koeffler H.P. Blood 100:1099-1100(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT GLN-455.
[12]	"Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload." Biasiotto G., Belloli S., Ruggeri G., Zanella I., Gerardi G., Corrado M., Gobbi E., Albertini A., Arosio P. Clin. Chem. 49:1981-1988(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HFE3 ILE-22.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067864 mRNA. Translation: AAD45561.1. AF053356 Genomic DNA. Translation: AAC78796.1. DQ496110 Genomic DNA. Translation: ABF47099.1. AC099394 Genomic DNA. No translation available. BC142630 mRNA. Translation: AAI42631.1. AK022002 mRNA. Translation: BAB13951.1. AK000421 mRNA. Translation: BAA91153.1. Different initiation.
IPI	IPI00215612. IPI00219900. IPI00219901.
RefSeq	NP_001193784.1. NM_001206855.1. NP_003218.2. NM_003227.3.
UniGene	Hs.544932.
3D structure databases
ProteinModelPortal	Q9UP52.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UP52. 1 interaction.
STRING	9606.ENSP00000223051.
Protein family/group databases
MEROPS	M28.973.
PTM databases
PhosphoSite	Q9UP52.
Polymorphism databases
DMDM	20140912.
Proteomic databases
PaxDb	Q9UP52.
PRIDE	Q9UP52.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000223051; ENSP00000223051; ENSG00000106327. ENST00000462107; ENSP00000420525; ENSG00000106327. ENST00000544242; ENSP00000443656; ENSG00000106327.
GeneID	7036.
KEGG	hsa:7036.
UCSC	uc003uvu.1. human. uc010lhc.1. human.
Organism-specific databases
CTD	7036.
GeneCards	GC07M100218.
HGNC	HGNC:11762. TFR2.
HPA	CAB016255. HPA011937.
MIM	604250. phenotype. 604720. gene.
neXtProt	NX_Q9UP52.
Orphanet	225123. Hemochromatosis type 3.
PharmGKB	PA36477.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG74799.
HOGENOM	HOG000124067.
HOVERGEN	HBG023177.
InParanoid	Q9UP52.
OMA	LEGYLSV.
OrthoDB	EOG41RPTM.
Gene expression databases
ArrayExpress	Q9UP52.
Bgee	Q9UP52.
CleanEx	HS_TFR2.
Genevestigator	Q9UP52.
GermOnline	ENSG00000106327. Homo sapiens.
Family and domain databases
Gene3D	1.20.930.40. 1 hit.
InterPro	IPR007484. Peptidase_M28. IPR003137. Protease-assoc_domain. IPR007365. TFR-like_dimer_dom. [Graphical view]
Pfam	PF02225. PA. 1 hit. PF04389. Peptidase_M28. 1 hit. PF04253. TFR_dimer. 1 hit. [Graphical view]
SUPFAM	SSF47672. Transferrin_rcpt-like_dimerise. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	7036.
NextBio	27489.
SOURCE	Search...

Entry information

Entry name

TFR2_HUMAN

Accession

Primary (citable) accession number: Q9UP52
Secondary accession number(s): A6NGM7 , O75422, Q1HE13, Q9HA99, Q9NX67

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.