Q9UP03 (Q9UP03_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Transporter 2 isoform EMBL AAD31384.1

Submitted name:
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), isoform CRA_a EMBL EAX03642.1

Gene names

Name:	TAP2 EMBL AAD31384.1
ORF Names:	hCG_2001583 EMBL EAX03642.1

Organism

Homo sapiens (Human) EMBL AAD31384.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	653 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003299 EMBL EAX03642.1 Nucleotide-binding
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	endoplasmic reticulum Inferred from direct assay. Source: HPA integral to membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro peptide transporter activity Inferred from electronic annotation. Source: InterPro tapasin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9UP03 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: AA79C3E9C6FE31AB	FASTA	653	72,003
	10 20 30 40 50 60 MRLPDLRPWT SLLLVDAALL WLLQGPLGTL LPQGLPGLWL EGTLRLGGLW GLLKLRGLLG 70 80 90 100 110 120 FVGTLLLPLC LATPLTVSLR ALVAGASRAP PARVASAPWS WLLVGYGAAG LSWSLWAVLS 130 140 150 160 170 180 PPGAQEKEQD QVNNKVLMWR LLKLSRPDLP LLVAAFFFLV LAVLGETLIP HYSGRVIDIL 190 200 210 220 230 240 GGDFDPHAFA SAIFFMCLFS FGSSLSAGCR GGCFTYTMSR INLRIREQLF SSLLRQDLGF 250 260 270 280 290 300 FQETKTGELN SRLSSDTTLM SNWLPLNANV LLRSLVKVVG LYGFMLSISP RLTLLSLLHM 310 320 330 340 350 360 PFTIAAEKVY NTRHQEVLRE IQDAVARAGQ VVREAVGGLQ TVRSFGAEEH EVCRYKEALE 370 380 390 400 410 420 QCRQLYWRRD LERALYLLVR RVLHLGVQML MLSCGLQQMQ DGELTQGSLL SFMIYQESVG 430 440 450 460 470 480 SYVQTLVYIY GDMLSNVGAA EKVFSYMDRQ PNLPSPGTLA PTTLQGVVKF QDVSFAYPNR 490 500 510 520 530 540 PDRPVLKGLT FTLRPGEVTA LVGPNGSGKS TVAALLQNLY QPTGGQVLLD EKPISQYEHC 550 560 570 580 590 600 YLHSQVVSVG QEPVLFSGSV RNNIAYGLQS CEDDKVMAAA QAAHADDFIQ EMEHGIYTDV 610 620 630 640 650 GEKGSQLAAG QKQRLAIARA LVRDPRVLIL DEATSALDVQ CEQAKTLWKF MIF

References

[1]	"Isoform of TAP2." Li H.C. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF078671 mRNA. Translation: AAD31384.1. CH471081 Genomic DNA. Translation: EAX03642.1.
IPI	IPI00001382.
RefSeq	NP_061313.2. NM_018833.2.
UniGene	Hs.502.
3D structure databases
HSSP	HSSP built from PDB template 1JJ7 based on UniProtKB Q03518.
ProteinModelPortal	Q9UP03.
SMR	Q9UP03. Positions 136-648.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000364034.
Proteomic databases
PRIDE	Q9UP03.
Protocols and materials databases
DNASU	6891.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6891.
KEGG	hsa:6891.
UCSC	uc003ocb.1. human.
Organism-specific databases
CTD	6891.
PharmGKB	PA35022.
Phylogenomic databases
HOVERGEN	HBG008358.
KO	K05654.
Gene expression databases
ArrayExpress	Q9UP03.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR013306. ABC_B3. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR005293. Ag_transporter2. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
PRINTS	PR01897. TAP2PROTEIN.
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 1 hit.
TIGRFAMs	TIGR00958. 3a01208. 1 hit.
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6891.
NextBio	26929.

Entry information

Entry name

Q9UP03_HUMAN

Accession

Primary (citable) accession number: Q9UP03

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.