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Protein

Leydig cell tumor 10 kDa protein homolog

Gene

C19orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May have a potential role in hypercalcemia of malignancy.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leydig cell tumor 10 kDa protein homolog
Gene namesi
ORF Names:HSPC023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24991. C19orf53.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104979.
PharmGKBiPA147358407.

Polymorphism and mutation databases

BioMutaiC19orf53.
DMDMi17369716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843431 – 99Leydig cell tumor 10 kDa protein homologAdd BLAST99

Proteomic databases

EPDiQ9UNZ5.
MaxQBiQ9UNZ5.
PaxDbiQ9UNZ5.
PeptideAtlasiQ9UNZ5.
PRIDEiQ9UNZ5.
TopDownProteomicsiQ9UNZ5.

PTM databases

iPTMnetiQ9UNZ5.
PhosphoSitePlusiQ9UNZ5.

Expressioni

Gene expression databases

BgeeiENSG00000104979.
CleanExiHS_C19orf53.
ExpressionAtlasiQ9UNZ5. baseline and differential.
GenevisibleiQ9UNZ5. HS.

Organism-specific databases

HPAiHPA059928.
HPA061291.

Interactioni

Protein-protein interaction databases

BioGridi118798. 4 interactors.
DIPiDIP-61980N.
IntActiQ9UNZ5. 3 interactors.
MINTiMINT-4541839.
STRINGi9606.ENSP00000465432.

Structurei

3D structure databases

ProteinModelPortaliQ9UNZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0390 family.Curated

Phylogenomic databases

eggNOGiENOG410J3AY. Eukaryota.
ENOG4112C7F. LUCA.
GeneTreeiENSGT00390000011740.
HOGENOMiHOG000059528.
HOVERGENiHBG006239.
InParanoidiQ9UNZ5.
OMAiFQARKPG.
OrthoDBiEOG091G18TZ.
PhylomeDBiQ9UNZ5.

Family and domain databases

InterProiView protein in InterPro
IPR019034. UPF0390.
PfamiView protein in Pfam
PF09495. DUF2462. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK
60 70 80 90
KNLEVGIRKK IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPS
Length:99
Mass (Da):10,577
Last modified:May 1, 2000 - v1
Checksum:iA5FDF26764BED659
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05378339K → R. Corresponds to variant dbSNP:rs10104Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA. Translation: AAD44484.1.
AK311855 mRNA. Translation: BAG34796.1.
CH471106 Genomic DNA. Translation: EAW84372.1.
BC015465 mRNA. Translation: AAH15465.1.
CCDSiCCDS12298.1.
RefSeqiNP_054766.1. NM_014047.2.
UniGeneiHs.231616.

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979.
GeneIDi28974.
KEGGihsa:28974.
UCSCiuc002mxg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiL10K_HUMAN
AccessioniPrimary (citable) accession number: Q9UNZ5
Secondary accession number(s): B2R4J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: March 15, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries