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Protein

Leydig cell tumor 10 kDa protein homolog

Gene

C19orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May have a potential role in hypercalcemia of malignancy.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Leydig cell tumor 10 kDa protein homolog
Gene namesi
ORF Names:HSPC023
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24991. C19orf53.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358407.

Polymorphism and mutation databases

BioMutaiC19orf53.
DMDMi17369716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Leydig cell tumor 10 kDa protein homologPRO_0000084343Add
BLAST

Proteomic databases

EPDiQ9UNZ5.
MaxQBiQ9UNZ5.
PaxDbiQ9UNZ5.
PeptideAtlasiQ9UNZ5.
PRIDEiQ9UNZ5.
TopDownProteomicsiQ9UNZ5.

PTM databases

iPTMnetiQ9UNZ5.
PhosphoSiteiQ9UNZ5.

Expressioni

Gene expression databases

BgeeiQ9UNZ5.
CleanExiHS_C19orf53.
ExpressionAtlasiQ9UNZ5. baseline and differential.
GenevisibleiQ9UNZ5. HS.

Organism-specific databases

HPAiHPA061291.

Interactioni

Protein-protein interaction databases

BioGridi118798. 3 interactions.
IntActiQ9UNZ5. 3 interactions.
MINTiMINT-4541839.
STRINGi9606.ENSP00000465432.

Structurei

3D structure databases

ProteinModelPortaliQ9UNZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0390 family.Curated

Phylogenomic databases

eggNOGiENOG410J3AY. Eukaryota.
ENOG4112C7F. LUCA.
GeneTreeiENSGT00390000011740.
HOGENOMiHOG000059528.
HOVERGENiHBG006239.
InParanoidiQ9UNZ5.
OMAiFQARKPG.
OrthoDBiEOG7992TQ.
PhylomeDBiQ9UNZ5.

Family and domain databases

InterProiIPR019034. UPF0390.
[Graphical view]
PfamiPF09495. DUF2462. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGQRKFQA HKPAKSKTAA AASEKNRGPR KGGRVIAPKK ARVVQQQKLK
60 70 80 90
KNLEVGIRKK IEHDVVMKAS SSLPKKLALL KAPAKKKGAA AATSSKTPS
Length:99
Mass (Da):10,577
Last modified:May 1, 2000 - v1
Checksum:iA5FDF26764BED659
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391K → R.
Corresponds to variant rs10104 [ dbSNP | Ensembl ].
VAR_053783

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA. Translation: AAD44484.1.
AK311855 mRNA. Translation: BAG34796.1.
CH471106 Genomic DNA. Translation: EAW84372.1.
BC015465 mRNA. Translation: AAH15465.1.
CCDSiCCDS12298.1.
RefSeqiNP_054766.1. NM_014047.2.
UniGeneiHs.231616.

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979.
GeneIDi28974.
KEGGihsa:28974.
UCSCiuc002mxg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078852 mRNA. Translation: AAD44484.1.
AK311855 mRNA. Translation: BAG34796.1.
CH471106 Genomic DNA. Translation: EAW84372.1.
BC015465 mRNA. Translation: AAH15465.1.
CCDSiCCDS12298.1.
RefSeqiNP_054766.1. NM_014047.2.
UniGeneiHs.231616.

3D structure databases

ProteinModelPortaliQ9UNZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118798. 3 interactions.
IntActiQ9UNZ5. 3 interactions.
MINTiMINT-4541839.
STRINGi9606.ENSP00000465432.

PTM databases

iPTMnetiQ9UNZ5.
PhosphoSiteiQ9UNZ5.

Polymorphism and mutation databases

BioMutaiC19orf53.
DMDMi17369716.

Proteomic databases

EPDiQ9UNZ5.
MaxQBiQ9UNZ5.
PaxDbiQ9UNZ5.
PeptideAtlasiQ9UNZ5.
PRIDEiQ9UNZ5.
TopDownProteomicsiQ9UNZ5.

Protocols and materials databases

DNASUi28974.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588234; ENSP00000465432; ENSG00000104979.
GeneIDi28974.
KEGGihsa:28974.
UCSCiuc002mxg.4. human.

Organism-specific databases

CTDi28974.
GeneCardsiC19orf53.
HGNCiHGNC:24991. C19orf53.
HPAiHPA061291.
neXtProtiNX_Q9UNZ5.
PharmGKBiPA147358407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3AY. Eukaryota.
ENOG4112C7F. LUCA.
GeneTreeiENSGT00390000011740.
HOGENOMiHOG000059528.
HOVERGENiHBG006239.
InParanoidiQ9UNZ5.
OMAiFQARKPG.
OrthoDBiEOG7992TQ.
PhylomeDBiQ9UNZ5.

Miscellaneous databases

GenomeRNAii28974.
PROiQ9UNZ5.

Gene expression databases

BgeeiQ9UNZ5.
CleanExiHS_C19orf53.
ExpressionAtlasiQ9UNZ5. baseline and differential.
GenevisibleiQ9UNZ5. HS.

Family and domain databases

InterProiIPR019034. UPF0390.
[Graphical view]
PfamiPF09495. DUF2462. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiL10K_HUMAN
AccessioniPrimary (citable) accession number: Q9UNZ5
Secondary accession number(s): B2R4J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.