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Protein

Zinc finger protein 232

Gene

ZNF232

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167840-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 232
Alternative name(s):
Zinc finger and SCAN domain-containing protein 11
Gene namesi
Name:ZNF232
Synonyms:ZSCAN11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:13026. ZNF232.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37604.

Polymorphism and mutation databases

DMDMi11136137.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474721 – 417Zinc finger protein 232Add BLAST417

Proteomic databases

PaxDbiQ9UNY5.
PeptideAtlasiQ9UNY5.
PRIDEiQ9UNY5.

PTM databases

iPTMnetiQ9UNY5.
PhosphoSitePlusiQ9UNY5.

Expressioni

Tissue specificityi

Ubiquitous. Higher expression seen in the liver, testis and ovary.

Gene expression databases

BgeeiENSG00000167840.
CleanExiHS_ZNF232.
ExpressionAtlasiQ9UNY5. baseline and differential.
GenevisibleiQ9UNY5. HS.

Organism-specific databases

HPAiHPA027309.
HPA028611.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EMDP504023EBI-749023,EBI-489887
MTUS2Q5JR593EBI-749023,EBI-742948
PPCDCQ96CD25EBI-749023,EBI-724333
ZNF446A0A087WUM84EBI-749023,EBI-11955977
ZNF446Q96AF54EBI-749023,EBI-740232

Protein-protein interaction databases

BioGridi113557. 46 interactors.
IntActiQ9UNY5. 7 interactors.
MINTiMINT-1483756.
STRINGi9606.ENSP00000250076.

Structurei

3D structure databases

ProteinModelPortaliQ9UNY5.
SMRiQ9UNY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Met4

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri276 – 298C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri304 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 410C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9UNY5.
KOiK09230.
OrthoDBiEOG091G09O3.
PhylomeDBiQ9UNY5.
TreeFamiTF338304.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9UNY5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVSLTAAET LALQGTQGQE KMMMMGPKEE EQSCEYETRL PGNHSTSQEI
60 70 80 90 100
FRQRFRHLRY QETPGPREAL SQLRVLCCEW LRPEKHTKEQ ILEFLVLEQF
110 120 130 140 150
LTILPEELQS WVRGHHPKSG EEAVTVLEDL EKGLEPEPQV PGPAHGPAQE
160 170 180 190 200
EPWEKKESLG AAQEALSIQL QPKETQPFPK SEQVYLHFLS VVTEDGPEPK
210 220 230 240 250
DKGSLPQPPI TEVESQVFSE KLATDTSTFE ATSEGTLELQ QRNPKAERLR
260 270 280 290 300
WSPAQEESFR QMVVIHKEIP TGKKDHECSE CGKTFIYNSH LVVHQRVHSG
310 320 330 340 350
EKPYKCSDCG KTFKQSSNLG QHQRIHTGEK PFECNECGKA FRWGAHLVQH
360 370 380 390 400
QRIHSGEKPY ECNECGKAFS QSSYLSQHRR IHSGEKPFIC KECGKAYGWC
410
SELIRHRRVH ARKEPSH
Length:417
Mass (Da):47,688
Last modified:May 1, 2000 - v1
Checksum:i6FF80EFAB3AF8AE9
GO
Isoform Short (identifier: Q9UNY5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-190: Missing.

Show »
Length:408
Mass (Da):46,570
Checksum:iC2AA3346A3A9B375
GO

Sequence cautioni

The sequence AAH16039 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035573123A → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006906182 – 190Missing in isoform Short. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080171, AF080170 Genomic DNA. Translation: AAD46135.1.
Y15067 mRNA. Translation: CAB95963.1.
AC012146 Genomic DNA. No translation available.
BC016039 mRNA. Translation: AAH16039.2. Different initiation.
RefSeqiNP_001307882.1. NM_001320953.1. [Q9UNY5-1]
NP_001307883.1. NM_001320954.1. [Q9UNY5-1]
NP_055334.2. NM_014519.3.
XP_016880510.1. XM_017025021.1.
UniGeneiHs.279914.

Genome annotation databases

EnsembliENST00000250076; ENSP00000250076; ENSG00000167840.
GeneIDi7775.
KEGGihsa:7775.
UCSCiuc002gat.4. human. [Q9UNY5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080171, AF080170 Genomic DNA. Translation: AAD46135.1.
Y15067 mRNA. Translation: CAB95963.1.
AC012146 Genomic DNA. No translation available.
BC016039 mRNA. Translation: AAH16039.2. Different initiation.
RefSeqiNP_001307882.1. NM_001320953.1. [Q9UNY5-1]
NP_001307883.1. NM_001320954.1. [Q9UNY5-1]
NP_055334.2. NM_014519.3.
XP_016880510.1. XM_017025021.1.
UniGeneiHs.279914.

3D structure databases

ProteinModelPortaliQ9UNY5.
SMRiQ9UNY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113557. 46 interactors.
IntActiQ9UNY5. 7 interactors.
MINTiMINT-1483756.
STRINGi9606.ENSP00000250076.

PTM databases

iPTMnetiQ9UNY5.
PhosphoSitePlusiQ9UNY5.

Polymorphism and mutation databases

DMDMi11136137.

Proteomic databases

PaxDbiQ9UNY5.
PeptideAtlasiQ9UNY5.
PRIDEiQ9UNY5.

Protocols and materials databases

DNASUi7775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250076; ENSP00000250076; ENSG00000167840.
GeneIDi7775.
KEGGihsa:7775.
UCSCiuc002gat.4. human. [Q9UNY5-1]

Organism-specific databases

CTDi7775.
GeneCardsiZNF232.
HGNCiHGNC:13026. ZNF232.
HPAiHPA027309.
HPA028611.
MIMi616463. gene.
neXtProtiNX_Q9UNY5.
PharmGKBiPA37604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9UNY5.
KOiK09230.
OrthoDBiEOG091G09O3.
PhylomeDBiQ9UNY5.
TreeFamiTF338304.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167840-MONOMER.

Miscellaneous databases

ChiTaRSiZNF232. human.
GenomeRNAii7775.
PROiQ9UNY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167840.
CleanExiHS_ZNF232.
ExpressionAtlasiQ9UNY5. baseline and differential.
GenevisibleiQ9UNY5. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN232_HUMAN
AccessioniPrimary (citable) accession number: Q9UNY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.