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Q9UNX9

- KCJ14_HUMAN

UniProt

Q9UNX9 - KCJ14_HUMAN

Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

KCNJ14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium By similarity.By similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transmembrane transport Source: GOC
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75870. Classical Kir channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 14
    Alternative name(s):
    Inward rectifier K(+) channel Kir2.4
    Short name:
    IRK-4
    Potassium channel, inwardly rectifying subfamily J member 14
    Gene namesi
    Name:KCNJ14
    Synonyms:IRK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6260. KCNJ14.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. neuronal cell body Source: Ensembl
    3. plasma membrane Source: Reactome
    4. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30045.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436ATP-sensitive inward rectifier potassium channel 14PRO_0000154968Add
    BLAST

    Proteomic databases

    PaxDbiQ9UNX9.
    PRIDEiQ9UNX9.

    Expressioni

    Tissue specificityi

    Expressed preferentially in retina.1 Publication

    Gene expression databases

    BgeeiQ9UNX9.
    CleanExiHS_KCNJ14.
    GenevestigatoriQ9UNX9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341479.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNX9.
    SMRiQ9UNX9. Positions 49-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8686CytoplasmicBy similarityAdd
    BLAST
    Topological domaini112 – 13322ExtracellularBy similarityAdd
    BLAST
    Topological domaini153 – 1619ExtracellularBy similarity
    Topological domaini184 – 436253CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei134 – 14512Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei146 – 1527Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei87 – 11125Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei162 – 18322Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi147 – 1526Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251076.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiQ9UNX9.
    KOiK05007.
    OMAiPCFSQVA.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiQ9UNX9.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UNX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG    50
    RFVKKDGHCN VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS 100
    WLLFGLAFWL IASLHGDLAA PPPPAPCFSH VASFLAAFLF ALETQTSIGY 150
    GVRSVTEECP AAVAAVVLQC IAGCVLDAFV VGAVMAKMAK PKKRNETLVF 200
    SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR VTPEGEYIPL 250
    DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV 300
    VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH 350
    RTYEVPGTPV CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ 400
    EEDEDDETEE GNGVETEDGA ASPRVLTPTL ALTLPP 436
    Length:436
    Mass (Da):47,846
    Last modified:May 1, 2000 - v1
    Checksum:i9442E664007D1B7C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti289 – 2891R → C.
    Corresponds to variant rs3745725 [ dbSNP | Ensembl ].
    VAR_034019

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081466 mRNA. Translation: AAD51376.1.
    AF181988 Genomic DNA. Translation: AAF97619.1.
    BC035918 mRNA. Translation: AAH35918.1.
    CCDSiCCDS12721.1.
    RefSeqiNP_037480.1. NM_013348.3.
    UniGeneiHs.144011.
    Hs.736972.
    Hs.745133.

    Genome annotation databases

    EnsembliENST00000342291; ENSP00000341479; ENSG00000182324.
    ENST00000391884; ENSP00000375756; ENSG00000182324.
    GeneIDi3770.
    KEGGihsa:3770.
    UCSCiuc002pje.2. human.

    Polymorphism databases

    DMDMi54036159.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF081466 mRNA. Translation: AAD51376.1 .
    AF181988 Genomic DNA. Translation: AAF97619.1 .
    BC035918 mRNA. Translation: AAH35918.1 .
    CCDSi CCDS12721.1.
    RefSeqi NP_037480.1. NM_013348.3.
    UniGenei Hs.144011.
    Hs.736972.
    Hs.745133.

    3D structure databases

    ProteinModelPortali Q9UNX9.
    SMRi Q9UNX9. Positions 49-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341479.

    Chemistry

    GuidetoPHARMACOLOGYi 433.

    Polymorphism databases

    DMDMi 54036159.

    Proteomic databases

    PaxDbi Q9UNX9.
    PRIDEi Q9UNX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342291 ; ENSP00000341479 ; ENSG00000182324 .
    ENST00000391884 ; ENSP00000375756 ; ENSG00000182324 .
    GeneIDi 3770.
    KEGGi hsa:3770.
    UCSCi uc002pje.2. human.

    Organism-specific databases

    CTDi 3770.
    GeneCardsi GC19P048958.
    HGNCi HGNC:6260. KCNJ14.
    MIMi 603953. gene.
    neXtProti NX_Q9UNX9.
    PharmGKBi PA30045.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251076.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi Q9UNX9.
    KOi K05007.
    OMAi PCFSQVA.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi Q9UNX9.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_75870. Classical Kir channels.

    Miscellaneous databases

    GeneWikii KCNJ14.
    GenomeRNAii 3770.
    NextBioi 14785.
    PROi Q9UNX9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9UNX9.
    CleanExi HS_KCNJ14.
    Genevestigatori Q9UNX9.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of human retinal Kir2.4, a pH-sensitive inwardly rectifying K+ channel."
      Hughes B.A., Kumar G., Yuan Y., Swaminathan A., Yan D., Sharma A., Plumley L., Yang-Feng T.L., Swaroop A.
      Am. J. Physiol. 279:C771-C784(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    2. "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)."
      Toepert C., Doring F., Derst C., Daut J., Grzeschik K.H., Karschin A.
      Mamm. Genome 11:247-249(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiKCJ14_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3