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Q9UNX9 (KCJ14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name=IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene names
Name:KCNJ14
Synonyms:IRK4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed preferentially in retina. Ref.1

Sequence similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436ATP-sensitive inward rectifier potassium channel 14
PRO_0000154968

Regions

Topological domain1 – 8686Cytoplasmic By similarity
Transmembrane87 – 11125Helical; Name=M1; By similarity
Topological domain112 – 13322Extracellular By similarity
Intramembrane134 – 14512Helical; Pore-forming; Name=H5; By similarity
Intramembrane146 – 1527Pore-forming; By similarity
Topological domain153 – 1619Extracellular By similarity
Transmembrane162 – 18322Helical; Name=M2; By similarity
Topological domain184 – 436253Cytoplasmic By similarity
Motif147 – 1526Selectivity filter By similarity

Natural variations

Natural variant2891R → C.
Corresponds to variant rs3745725 [ dbSNP | Ensembl ].
VAR_034019

Sequences

Sequence LengthMass (Da)Tools
Q9UNX9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 9442E664007D1B7C

FASTA43647,846
        10         20         30         40         50         60 
MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN 

        70         80         90        100        110        120 
VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA 

       130        140        150        160        170        180 
PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV 

       190        200        210        220        230        240 
VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR 

       250        260        270        280        290        300 
VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV 

       310        320        330        340        350        360 
VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV 

       370        380        390        400        410        420 
CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA 

       430 
ASPRVLTPTL ALTLPP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional expression of human retinal Kir2.4, a pH-sensitive inwardly rectifying K+ channel."
Hughes B.A., Kumar G., Yuan Y., Swaminathan A., Yan D., Sharma A., Plumley L., Yang-Feng T.L., Swaroop A.
Am. J. Physiol. 279:C771-C784(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
[2]"Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)."
Toepert C., Doring F., Derst C., Daut J., Grzeschik K.H., Karschin A.
Mamm. Genome 11:247-249(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF081466 mRNA. Translation: AAD51376.1.
AF181988 Genomic DNA. Translation: AAF97619.1.
BC035918 mRNA. Translation: AAH35918.1.
CCDSCCDS12721.1.
RefSeqNP_037480.1. NM_013348.3.
UniGeneHs.144011.
Hs.736972.
Hs.745133.

3D structure databases

ProteinModelPortalQ9UNX9.
SMRQ9UNX9. Positions 49-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000341479.

Chemistry

GuidetoPHARMACOLOGY433.

Polymorphism databases

DMDM54036159.

Proteomic databases

PaxDbQ9UNX9.
PRIDEQ9UNX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342291; ENSP00000341479; ENSG00000182324.
ENST00000391884; ENSP00000375756; ENSG00000182324.
GeneID3770.
KEGGhsa:3770.
UCSCuc002pje.2. human.

Organism-specific databases

CTD3770.
GeneCardsGC19P048958.
HGNCHGNC:6260. KCNJ14.
MIM603953. gene.
neXtProtNX_Q9UNX9.
PharmGKBPA30045.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251076.
HOGENOMHOG000237325.
HOVERGENHBG006178.
InParanoidQ9UNX9.
KOK05007.
OMAPCFSQVA.
OrthoDBEOG7XPZ5K.
PhylomeDBQ9UNX9.
TreeFamTF313676.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ9UNX9.
CleanExHS_KCNJ14.
GenevestigatorQ9UNX9.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNJ14.
GenomeRNAi3770.
NextBio14785.
PROQ9UNX9.
SOURCESearch...

Entry information

Entry nameKCJ14_HUMAN
AccessionPrimary (citable) accession number: Q9UNX9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM