Q9UNX9 (IRK14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-sensitive inward rectifier potassium channel 14

Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name=IRK-4
Potassium channel, inwardly rectifying subfamily J member 14

Gene names

Name:	KCNJ14
Synonyms:	IRK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed preferentially in retina. Ref.1
Sequence similarities	Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	dendrite Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara voltage-gated potassium channel complex Traceable author statement PubMed 9592090. Source: ProtInc
Molecular_function	inward rectifier potassium channel activity Traceable author statement PubMed 9592090. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	ATP-sensitive inward rectifier potassium channel 14		PRO_0000154968
Regions
	Topological domain	1 – 86	86	Cytoplasmic By similarity
	Transmembrane	87 – 111	25	Helical; Name=M1; By similarity
	Topological domain	112 – 133	22	Extracellular By similarity
	Intramembrane	134 – 145	12	Helical; Pore-forming; Name=H5; By similarity
	Intramembrane	146 – 152	7	Pore-forming; By similarity
	Topological domain	153 – 161	9	Extracellular By similarity
	Transmembrane	162 – 183	22	Helical; Name=M2; By similarity
	Topological domain	184 – 436	253	Cytoplasmic By similarity
	Motif	147 – 152	6	Selectivity filter By similarity
Natural variations
	Natural variant	289	1	R → C. Corresponds to variant rs3745725 [ dbSNP | Ensembl ].		VAR_034019

Sequences

	Sequence		Length	Mass (Da)
	Q9UNX9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9442E664007D1B7C	FASTA	436	47,846
	10 20 30 40 50 60 MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN 70 80 90 100 110 120 VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA 130 140 150 160 170 180 PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV 190 200 210 220 230 240 VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR 250 260 270 280 290 300 VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV 310 320 330 340 350 360 VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV 370 380 390 400 410 420 CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA 430 ASPRVLTPTL ALTLPP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional expression of human retinal Kir2.4, a pH-sensitive inwardly rectifying K+ channel." Hughes B.A., Kumar G., Yuan Y., Swaminathan A., Yan D., Sharma A., Plumley L., Yang-Feng T.L., Swaroop A. Am. J. Physiol. 279:C771-C784(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
[2]	"Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)." Toepert C., Doring F., Derst C., Daut J., Grzeschik K.H., Karschin A. Mamm. Genome 11:247-249(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081466 mRNA. Translation: AAD51376.1. AF181988 Genomic DNA. Translation: AAF97619.1. BC035918 mRNA. Translation: AAH35918.1.
IPI	IPI00002524.
RefSeq	NP_037480.1. NM_013348.3. NP_733838.1. NM_170720.1.
UniGene	Hs.590945. Hs.736972.
3D structure databases
ProteinModelPortal	Q9UNX9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341479.
Polymorphism databases
DMDM	54036159.
Proteomic databases
PaxDb	Q9UNX9.
PRIDE	Q9UNX9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342291; ENSP00000341479; ENSG00000182324. ENST00000391884; ENSP00000375756; ENSG00000182324.
GeneID	3770.
KEGG	hsa:3770.
UCSC	uc002pje.1. human.
Organism-specific databases
CTD	3770.
GeneCards	GC19P048958.
HGNC	HGNC:6260. KCNJ14.
MIM	603953. gene.
neXtProt	NX_Q9UNX9.
PharmGKB	PA30045.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG251076.
HOGENOM	HOG000237325.
HOVERGEN	HBG006178.
InParanoid	Q9UNX9.
KO	K05007.
OMA	PCFSQVA.
OrthoDB	EOG48GW3C.
PhylomeDB	Q9UNX9.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q9UNX9.
CleanEx	HS_KCNJ14.
Genevestigator	Q9UNX9.
GermOnline	ENSG00000182324. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.1400. 1 hit.
InterPro	IPR014756. Ig_E-set. IPR016449. K_chnl_inward-rec_Kir. IPR013518. K_chnl_inward-rec_Kir_cyto. [Graphical view]
PANTHER	PTHR11767. PTHR11767. 1 hit.
Pfam	PF01007. IRK. 1 hit. [Graphical view]
PIRSF	PIRSF005465. GIRK_kir. 1 hit.
PRINTS	PR01320. KIRCHANNEL.
SUPFAM	SSF81296. Ig_E-set. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	3770.
NextBio	14785.
SOURCE	Search...

Entry information

Entry name

IRK14_HUMAN

Accession

Primary (citable) accession number: Q9UNX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.