Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

KCNJ14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity).By similarity

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75870. Classical Kir channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:KCNJ14
Synonyms:IRK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6260. KCNJ14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicBy similarityAdd
BLAST
Transmembranei87 – 11125Helical; Name=M1By similarityAdd
BLAST
Topological domaini112 – 13322ExtracellularBy similarityAdd
BLAST
Intramembranei134 – 14512Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei146 – 1527Pore-formingBy similarity
Topological domaini153 – 1619ExtracellularBy similarity
Transmembranei162 – 18322Helical; Name=M2By similarityAdd
BLAST
Topological domaini184 – 436253CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30045.

Chemistry

DrugBankiDB01392. Yohimbine.

Polymorphism and mutation databases

DMDMi54036159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436ATP-sensitive inward rectifier potassium channel 14PRO_0000154968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811S-nitrosocysteineBy similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiQ9UNX9.
PRIDEiQ9UNX9.

Expressioni

Tissue specificityi

Expressed preferentially in retina.1 Publication

Gene expression databases

BgeeiQ9UNX9.
CleanExiHS_KCNJ14.
GenevisibleiQ9UNX9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341479.

Structurei

3D structure databases

ProteinModelPortaliQ9UNX9.
SMRiQ9UNX9. Positions 49-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi147 – 1526Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9UNX9.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ9UNX9.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UNX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG
60 70 80 90 100
RFVKKDGHCN VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS
110 120 130 140 150
WLLFGLAFWL IASLHGDLAA PPPPAPCFSH VASFLAAFLF ALETQTSIGY
160 170 180 190 200
GVRSVTEECP AAVAAVVLQC IAGCVLDAFV VGAVMAKMAK PKKRNETLVF
210 220 230 240 250
SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR VTPEGEYIPL
260 270 280 290 300
DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV
310 320 330 340 350
VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH
360 370 380 390 400
RTYEVPGTPV CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ
410 420 430
EEDEDDETEE GNGVETEDGA ASPRVLTPTL ALTLPP
Length:436
Mass (Da):47,846
Last modified:May 1, 2000 - v1
Checksum:i9442E664007D1B7C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti289 – 2891R → C.
Corresponds to variant rs3745725 [ dbSNP | Ensembl ].
VAR_034019

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081466 mRNA. Translation: AAD51376.1.
AF181988 Genomic DNA. Translation: AAF97619.1.
BC035918 mRNA. Translation: AAH35918.1.
CCDSiCCDS12721.1.
RefSeqiNP_037480.1. NM_013348.3.
UniGeneiHs.144011.
Hs.736972.
Hs.745133.

Genome annotation databases

EnsembliENST00000342291; ENSP00000341479; ENSG00000182324.
ENST00000391884; ENSP00000375756; ENSG00000182324.
GeneIDi3770.
KEGGihsa:3770.
UCSCiuc002pje.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081466 mRNA. Translation: AAD51376.1.
AF181988 Genomic DNA. Translation: AAF97619.1.
BC035918 mRNA. Translation: AAH35918.1.
CCDSiCCDS12721.1.
RefSeqiNP_037480.1. NM_013348.3.
UniGeneiHs.144011.
Hs.736972.
Hs.745133.

3D structure databases

ProteinModelPortaliQ9UNX9.
SMRiQ9UNX9. Positions 49-376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341479.

Chemistry

DrugBankiDB01392. Yohimbine.
GuidetoPHARMACOLOGYi433.

Polymorphism and mutation databases

DMDMi54036159.

Proteomic databases

PaxDbiQ9UNX9.
PRIDEiQ9UNX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342291; ENSP00000341479; ENSG00000182324.
ENST00000391884; ENSP00000375756; ENSG00000182324.
GeneIDi3770.
KEGGihsa:3770.
UCSCiuc002pje.2. human.

Organism-specific databases

CTDi3770.
GeneCardsiGC19P048958.
HGNCiHGNC:6260. KCNJ14.
MIMi603953. gene.
neXtProtiNX_Q9UNX9.
PharmGKBiPA30045.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ9UNX9.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ9UNX9.
TreeFamiTF313676.

Enzyme and pathway databases

ReactomeiREACT_75870. Classical Kir channels.

Miscellaneous databases

GeneWikiiKCNJ14.
GenomeRNAii3770.
NextBioi14785.
PROiQ9UNX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UNX9.
CleanExiHS_KCNJ14.
GenevisibleiQ9UNX9. HS.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional expression of human retinal Kir2.4, a pH-sensitive inwardly rectifying K+ channel."
    Hughes B.A., Kumar G., Yuan Y., Swaminathan A., Yan D., Sharma A., Plumley L., Yang-Feng T.L., Swaroop A.
    Am. J. Physiol. 279:C771-C784(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
  2. "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)."
    Toepert C., Doring F., Derst C., Daut J., Grzeschik K.H., Karschin A.
    Mamm. Genome 11:247-249(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiKCJ14_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.