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Protein

WD repeat-containing protein 3

Gene

WDR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • snoRNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065183-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ9UNX4.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 3
Gene namesi
Name:WDR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12755. WDR3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10885.
OpenTargetsiENSG00000065183.
PharmGKBiPA37359.

Polymorphism and mutation databases

BioMutaiWDR3.
DMDMi12230773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513471 – 943WD repeat-containing protein 3Add BLAST943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei240PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei726PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNX4.
MaxQBiQ9UNX4.
PaxDbiQ9UNX4.
PeptideAtlasiQ9UNX4.
PRIDEiQ9UNX4.

2D gel databases

SWISS-2DPAGEQ9UNX4.

PTM databases

iPTMnetiQ9UNX4.
PhosphoSitePlusiQ9UNX4.
SwissPalmiQ9UNX4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000065183.
CleanExiHS_WDR3.
ExpressionAtlasiQ9UNX4. baseline and differential.
GenevisibleiQ9UNX4. HS.

Organism-specific databases

HPAiHPA027509.
HPA054354.

Interactioni

Protein-protein interaction databases

BioGridi116092. 35 interactors.
IntActiQ9UNX4. 11 interactors.
MINTiMINT-1401247.
STRINGi9606.ENSP00000308179.

Structurei

3D structure databases

ProteinModelPortaliQ9UNX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 60WD 1Add BLAST40
Repeati63 – 102WD 2Add BLAST40
Repeati105 – 144WD 3Add BLAST40
Repeati147 – 186WD 4Add BLAST40
Repeati189 – 228WD 5Add BLAST40
Repeati277 – 316WD 6Add BLAST40
Repeati413 – 451WD 7Add BLAST39
Repeati453 – 493WD 8Add BLAST41
Repeati494 – 533WD 9Add BLAST40
Repeati547 – 586WD 10Add BLAST40
Repeati589 – 630WD 11Add BLAST42
Repeati631 – 670WD 12Add BLAST40
Repeati673 – 712WD 13Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated
Contains 13 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00860000133855.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ9UNX4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG091G023R.
PhylomeDBiQ9UNX4.
TreeFamiTF300427.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04003. Utp12. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW
60 70 80 90 100
DLRKGEKILI LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN
110 120 130 140 150
VTFNGHKAAI TTLKYDQLGG RLASGSKDTD IIVWDVINES GLYRLKGHKD
160 170 180 190 200
AITQALFLRE KNLLVTSGKD TMVKWWDLDT QHCFKTMVGH RTEVWGLVLL
210 220 230 240 250
SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS SPGIQDTLEA
260 270 280 290 300
EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD
310 320 330 340 350
SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ
360 370 380 390 400
DEIQRVTNIK TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT
410 420 430 440 450
PQPVRTSRIT IGGHRSDVRT LSFSSDNIAV LSAAADSIKI WNRSTLQCIR
460 470 480 490 500
TMTCEYALCS FFVPGDRQVV IGTKTGKLQL YDLASGNLLE TIDAHDGALW
510 520 530 540 550
SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV KQTRTLQLDE
560 570 580 590 600
DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
610 620 630 640 650
HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT
660 670 680 690 700
AGKDHKIKQW DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR
710 720 730 740 750
LWERTREPLI LEEEREMERE AEYEESVAKE DQPAVPGETQ GDSYFTGKKT
760 770 780 790 800
IETVKAAERI MEAIELYREE TAKMKEHKAI CKAAGKEVPL PSNPILMAYG
810 820 830 840 850
SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN EFIQLGSDVE
860 870 880 890 900
LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA
910 920 930 940
GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT
Length:943
Mass (Da):106,099
Last modified:May 1, 2000 - v1
Checksum:i316A151738D91AD7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033809234P → A.Corresponds to variant rs3738420dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083217 mRNA. Translation: AAD45865.1.
CCDSiCCDS898.1.
RefSeqiNP_006775.1. NM_006784.2.
UniGeneiHs.310809.

Genome annotation databases

EnsembliENST00000349139; ENSP00000308179; ENSG00000065183.
GeneIDi10885.
KEGGihsa:10885.
UCSCiuc010oxe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083217 mRNA. Translation: AAD45865.1.
CCDSiCCDS898.1.
RefSeqiNP_006775.1. NM_006784.2.
UniGeneiHs.310809.

3D structure databases

ProteinModelPortaliQ9UNX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116092. 35 interactors.
IntActiQ9UNX4. 11 interactors.
MINTiMINT-1401247.
STRINGi9606.ENSP00000308179.

PTM databases

iPTMnetiQ9UNX4.
PhosphoSitePlusiQ9UNX4.
SwissPalmiQ9UNX4.

Polymorphism and mutation databases

BioMutaiWDR3.
DMDMi12230773.

2D gel databases

SWISS-2DPAGEQ9UNX4.

Proteomic databases

EPDiQ9UNX4.
MaxQBiQ9UNX4.
PaxDbiQ9UNX4.
PeptideAtlasiQ9UNX4.
PRIDEiQ9UNX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349139; ENSP00000308179; ENSG00000065183.
GeneIDi10885.
KEGGihsa:10885.
UCSCiuc010oxe.2. human.

Organism-specific databases

CTDi10885.
DisGeNETi10885.
GeneCardsiWDR3.
HGNCiHGNC:12755. WDR3.
HPAiHPA027509.
HPA054354.
MIMi604737. gene.
neXtProtiNX_Q9UNX4.
OpenTargetsiENSG00000065183.
PharmGKBiPA37359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00860000133855.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ9UNX4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG091G023R.
PhylomeDBiQ9UNX4.
TreeFamiTF300427.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065183-MONOMER.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ9UNX4.

Miscellaneous databases

ChiTaRSiWDR3. human.
GeneWikiiWDR3.
GenomeRNAii10885.
PROiQ9UNX4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065183.
CleanExiHS_WDR3.
ExpressionAtlasiQ9UNX4. baseline and differential.
GenevisibleiQ9UNX4. HS.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04003. Utp12. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.