WD repeat-containing protein 3 - Homo sapiens (Human)

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Q9UNX4 (WDR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 3

Gene names

Name:

WDR3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	943 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Nucleus › nucleolus Ref.2.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the WD repeat WDR3/UTP12 family.

Contains 13 WD repeats.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nuclear membrane Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 943

943

WD repeat-containing protein 3

PRO_0000051347

Regions

Repeat

21 – 60

WD 1

Repeat

63 – 102

WD 2

Repeat

105 – 144

WD 3

Repeat

147 – 186

WD 4

Repeat

189 – 228

WD 5

Repeat

277 – 316

WD 6

Repeat

413 – 451

WD 7

Repeat

453 – 493

WD 8

Repeat

494 – 533

WD 9

Repeat

547 – 586

WD 10

Repeat

589 – 630

WD 11

Repeat

631 – 670

WD 12

Repeat

673 – 712

WD 13

Amino acid modifications

Modified residue

240

Phosphoserine Ref.4

Modified residue

241

Phosphoserine Ref.4

Natural variations

Natural variant

234

P → A.
Corresponds to variant rs3738420 [ dbSNP | Ensembl ].

VAR_033809

Sequences

Sequence

Length

Mass (Da)

Tools

Q9UNX4 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 316A151738D91AD7
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FASTA

943

106,099

        10         20         30         40         50         60 
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI 

        70         80         90        100        110        120 
LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAI TTLKYDQLGG 

       130        140        150        160        170        180 
RLASGSKDTD IIVWDVINES GLYRLKGHKD AITQALFLRE KNLLVTSGKD TMVKWWDLDT 

       190        200        210        220        230        240 
QHCFKTMVGH RTEVWGLVLL SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS 

       250        260        270        280        290        300 
SPGIQDTLEA EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD 

       310        320        330        340        350        360 
SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ DEIQRVTNIK 

       370        380        390        400        410        420 
TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT PQPVRTSRIT IGGHRSDVRT 

       430        440        450        460        470        480 
LSFSSDNIAV LSAAADSIKI WNRSTLQCIR TMTCEYALCS FFVPGDRQVV IGTKTGKLQL 

       490        500        510        520        530        540 
YDLASGNLLE TIDAHDGALW SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV 

       550        560        570        580        590        600 
KQTRTLQLDE DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS 

       610        620        630        640        650        660 
HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT AGKDHKIKQW 

       670        680        690        700        710        720 
DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR LWERTREPLI LEEEREMERE 

       730        740        750        760        770        780 
AEYEESVAKE DQPAVPGETQ GDSYFTGKKT IETVKAAERI MEAIELYREE TAKMKEHKAI 

       790        800        810        820        830        840 
CKAAGKEVPL PSNPILMAYG SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN 

       850        860        870        880        890        900 
EFIQLGSDVE LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA 

       910        920        930        940 
GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13." Claudio J.O., Liew C.-C., Ma J., Heng H.H.Q., Stewart A.K., Hawley R.G. Genomics 59:85-89(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240 AND SER-241, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[6]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF083217 mRNA. Translation: AAD45865.1.
IPI	IPI00009471.
RefSeq	NP_006775.1. NM_006784.2.
UniGene	Hs.310809.
3D structure databases
ProteinModelPortal	Q9UNX4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UNX4. 3 interactions.
MINT	MINT-1401247.
STRING	9606.ENSP00000308179.
PTM databases
PhosphoSite	Q9UNX4.
Polymorphism databases
DMDM	12230773.
2D gel databases
SWISS-2DPAGE	Q9UNX4.
Proteomic databases
PaxDb	Q9UNX4.
PeptideAtlas	Q9UNX4.
PRIDE	Q9UNX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349139; ENSP00000308179; ENSG00000065183.
GeneID	10885.
KEGG	hsa:10885.
UCSC	uc010oxe.1. human.
Organism-specific databases
CTD	10885.
GeneCards	GC01P118472.
HGNC	HGNC:12755. WDR3.
HPA	HPA027509.
MIM	604737. gene.
neXtProt	NX_Q9UNX4.
PharmGKB	PA37359.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2319.
HOGENOM	HOG000212524.
HOVERGEN	HBG013192.
InParanoid	Q9UNX4.
KO	K14556.
OMA	SIFAHDD.
OrthoDB	EOG412M4S.
PhylomeDB	Q9UNX4.
Gene expression databases
ArrayExpress	Q9UNX4.
Bgee	Q9UNX4.
CleanEx	HS_WDR3.
Genevestigator	Q9UNX4.
GermOnline	ENSG00000065183. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 4 hits.
InterPro	IPR020472. G-protein_beta_WD-40_rep. IPR007148. SSU_processome_Utp12. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF04003. Utp12. 1 hit. PF00400. WD40. 10 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 11 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 9 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	WDR3. human.
GenomeRNAi	10885.
NextBio	41331.
SOURCE	Search...

Entry information

Entry name

WDR3_HUMAN

Accession

Primary (citable) accession number: Q9UNX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents