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Protein

WD repeat-containing protein 3

Gene

WDR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • snoRNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9UNX4.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 3
Gene namesi
Name:WDR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:12755. WDR3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37359.

Polymorphism and mutation databases

BioMutaiWDR3.
DMDMi12230773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 943943WD repeat-containing protein 3PRO_0000051347Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei240 – 2401PhosphoserineCombined sources
Modified residuei241 – 2411PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNX4.
MaxQBiQ9UNX4.
PaxDbiQ9UNX4.
PeptideAtlasiQ9UNX4.
PRIDEiQ9UNX4.

2D gel databases

SWISS-2DPAGEQ9UNX4.

PTM databases

iPTMnetiQ9UNX4.
PhosphoSiteiQ9UNX4.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9UNX4.
CleanExiHS_WDR3.
ExpressionAtlasiQ9UNX4. baseline and differential.
GenevisibleiQ9UNX4. HS.

Organism-specific databases

HPAiHPA027509.
HPA054354.

Interactioni

Protein-protein interaction databases

BioGridi116092. 35 interactions.
IntActiQ9UNX4. 11 interactions.
MINTiMINT-1401247.
STRINGi9606.ENSP00000308179.

Structurei

3D structure databases

ProteinModelPortaliQ9UNX4.
SMRiQ9UNX4. Positions 12-315, 339-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 6040WD 1Add
BLAST
Repeati63 – 10240WD 2Add
BLAST
Repeati105 – 14440WD 3Add
BLAST
Repeati147 – 18640WD 4Add
BLAST
Repeati189 – 22840WD 5Add
BLAST
Repeati277 – 31640WD 6Add
BLAST
Repeati413 – 45139WD 7Add
BLAST
Repeati453 – 49341WD 8Add
BLAST
Repeati494 – 53340WD 9Add
BLAST
Repeati547 – 58640WD 10Add
BLAST
Repeati589 – 63042WD 11Add
BLAST
Repeati631 – 67040WD 12Add
BLAST
Repeati673 – 71240WD 13Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR3/UTP12 family.Curated
Contains 13 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00830000128374.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ9UNX4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG77DJ54.
PhylomeDBiQ9UNX4.
TreeFamiTF300427.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04003. Utp12. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW
60 70 80 90 100
DLRKGEKILI LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN
110 120 130 140 150
VTFNGHKAAI TTLKYDQLGG RLASGSKDTD IIVWDVINES GLYRLKGHKD
160 170 180 190 200
AITQALFLRE KNLLVTSGKD TMVKWWDLDT QHCFKTMVGH RTEVWGLVLL
210 220 230 240 250
SEEKRLITGA SDSELRVWDI AYLQEIEDPE EPDPKKIKGS SPGIQDTLEA
260 270 280 290 300
EDGAFETDEA PEDRILSCRK AGSIMREGRD RVVNLAVDKT GRILACHGTD
310 320 330 340 350
SVLELFCILS KKEIQKKMDK KMKKARKKAK LHSSKGEEED PEVNVEMSLQ
360 370 380 390 400
DEIQRVTNIK TSAKIKSFDL IHSPHGELKA VFLLQNNLVE LYSLNPSLPT
410 420 430 440 450
PQPVRTSRIT IGGHRSDVRT LSFSSDNIAV LSAAADSIKI WNRSTLQCIR
460 470 480 490 500
TMTCEYALCS FFVPGDRQVV IGTKTGKLQL YDLASGNLLE TIDAHDGALW
510 520 530 540 550
SMSLSPDQRG FVTGGADKSV KFWDFELVKD ENSTQKRLSV KQTRTLQLDE
560 570 580 590 600
DVLCVSYSPN QKLLAVSLLD CTVKIFYVDT LKFFLSLYGH KLPVICMDIS
610 620 630 640 650
HDGALIATGS ADRNVKIWGL DFGDCHKSLF AHDDSVMYLQ FVPKSHLFFT
660 670 680 690 700
AGKDHKIKQW DADKFEHIQT LEGHHQEIWC LAVSPSGDYV VSSSHDKSLR
710 720 730 740 750
LWERTREPLI LEEEREMERE AEYEESVAKE DQPAVPGETQ GDSYFTGKKT
760 770 780 790 800
IETVKAAERI MEAIELYREE TAKMKEHKAI CKAAGKEVPL PSNPILMAYG
810 820 830 840 850
SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN EFIQLGSDVE
860 870 880 890 900
LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVSQ VRDVIGFNMA
910 920 930 940
GLDYLKRECE AKSEVMFFAD ATSHLEEKKR KRKKREKLIL TLT
Length:943
Mass (Da):106,099
Last modified:May 1, 2000 - v1
Checksum:i316A151738D91AD7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341P → A.
Corresponds to variant rs3738420 [ dbSNP | Ensembl ].
VAR_033809

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083217 mRNA. Translation: AAD45865.1.
CCDSiCCDS898.1.
RefSeqiNP_006775.1. NM_006784.2.
UniGeneiHs.310809.

Genome annotation databases

EnsembliENST00000349139; ENSP00000308179; ENSG00000065183.
GeneIDi10885.
KEGGihsa:10885.
UCSCiuc010oxe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083217 mRNA. Translation: AAD45865.1.
CCDSiCCDS898.1.
RefSeqiNP_006775.1. NM_006784.2.
UniGeneiHs.310809.

3D structure databases

ProteinModelPortaliQ9UNX4.
SMRiQ9UNX4. Positions 12-315, 339-718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116092. 35 interactions.
IntActiQ9UNX4. 11 interactions.
MINTiMINT-1401247.
STRINGi9606.ENSP00000308179.

PTM databases

iPTMnetiQ9UNX4.
PhosphoSiteiQ9UNX4.

Polymorphism and mutation databases

BioMutaiWDR3.
DMDMi12230773.

2D gel databases

SWISS-2DPAGEQ9UNX4.

Proteomic databases

EPDiQ9UNX4.
MaxQBiQ9UNX4.
PaxDbiQ9UNX4.
PeptideAtlasiQ9UNX4.
PRIDEiQ9UNX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349139; ENSP00000308179; ENSG00000065183.
GeneIDi10885.
KEGGihsa:10885.
UCSCiuc010oxe.2. human.

Organism-specific databases

CTDi10885.
GeneCardsiWDR3.
HGNCiHGNC:12755. WDR3.
HPAiHPA027509.
HPA054354.
MIMi604737. gene.
neXtProtiNX_Q9UNX4.
PharmGKBiPA37359.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0306. Eukaryota.
ENOG410XR1C. LUCA.
GeneTreeiENSGT00830000128374.
HOGENOMiHOG000212524.
HOVERGENiHBG013192.
InParanoidiQ9UNX4.
KOiK14556.
OMAiSYLKYEH.
OrthoDBiEOG77DJ54.
PhylomeDBiQ9UNX4.
TreeFamiTF300427.

Enzyme and pathway databases

SignaLinkiQ9UNX4.

Miscellaneous databases

ChiTaRSiWDR3. human.
GeneWikiiWDR3.
GenomeRNAii10885.
NextBioi41331.
PROiQ9UNX4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UNX4.
CleanExiHS_WDR3.
ExpressionAtlasiQ9UNX4. baseline and differential.
GenevisibleiQ9UNX4. HS.

Family and domain databases

Gene3Di2.130.10.10. 4 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR007148. SSU_processome_Utp12.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF04003. Utp12. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13."
    Claudio J.O., Liew C.-C., Ma J., Heng H.H.Q., Stewart A.K., Hawley R.G.
    Genomics 59:85-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240 AND SER-241, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR3_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.