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Protein

60S ribosomal protein L26-like 1

Gene

RPL26L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-like 1
Gene namesi
Name:RPL26L1
Synonyms:RPL26P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:17050. RPL26L1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: GO_Central
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34706.

Polymorphism and mutation databases

BioMutaiRPL26L1.
DMDMi23396835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14514560S ribosomal protein L26-like 1PRO_0000130791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki136 – 136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UNX3.
MaxQBiQ9UNX3.
PaxDbiQ9UNX3.
PeptideAtlasiQ9UNX3.
PRIDEiQ9UNX3.
TopDownProteomicsiQ9UNX3.

PTM databases

iPTMnetiQ9UNX3.
PhosphoSiteiQ9UNX3.

Expressioni

Gene expression databases

BgeeiENSG00000037241.
ExpressionAtlasiQ9UNX3. baseline and differential.
GenevisibleiQ9UNX3. HS.

Organism-specific databases

HPAiHPA030449.

Interactioni

Protein-protein interaction databases

BioGridi119308. 150 interactions.
IntActiQ9UNX3. 11 interactions.
MINTiMINT-4831911.
STRINGi9606.ENSP00000265100.

Structurei

3D structure databases

ProteinModelPortaliQ9UNX3.
SMRiQ9UNX3. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

eggNOGiKOG3401. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiQ9UNX3.
KOiK02898.
OMAiVRIMRGD.
OrthoDBiEOG091G0TZX.
PhylomeDBiQ9UNX3.
TreeFamiTF300236.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNPFVTSD RSKNRKRHFN APSHVRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEELI EKMQE
Length:145
Mass (Da):17,256
Last modified:May 1, 2000 - v1
Checksum:i090D4CAB4E3F4F36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083248 mRNA. Translation: AAD39846.1.
AK128872 mRNA. Translation: BAG54744.1.
CH471062 Genomic DNA. Translation: EAW61420.1.
CH471062 Genomic DNA. Translation: EAW61421.1.
BC017360 mRNA. Translation: AAH17360.1.
BC070192 mRNA. Translation: AAH70192.1.
CCDSiCCDS4382.1.
RefSeqiNP_001304909.1. NM_001317980.1.
NP_001304910.1. NM_001317981.1.
NP_001304911.1. NM_001317982.1.
NP_057177.1. NM_016093.3.
XP_011532867.1. XM_011534565.2.
UniGeneiHs.546390.

Genome annotation databases

EnsembliENST00000265100; ENSP00000265100; ENSG00000037241.
ENST00000519239; ENSP00000430147; ENSG00000037241.
ENST00000519974; ENSP00000428177; ENSG00000037241.
ENST00000521476; ENSP00000428223; ENSG00000037241.
GeneIDi51121.
KEGGihsa:51121.
UCSCiuc003mcc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083248 mRNA. Translation: AAD39846.1.
AK128872 mRNA. Translation: BAG54744.1.
CH471062 Genomic DNA. Translation: EAW61420.1.
CH471062 Genomic DNA. Translation: EAW61421.1.
BC017360 mRNA. Translation: AAH17360.1.
BC070192 mRNA. Translation: AAH70192.1.
CCDSiCCDS4382.1.
RefSeqiNP_001304909.1. NM_001317980.1.
NP_001304910.1. NM_001317981.1.
NP_001304911.1. NM_001317982.1.
NP_057177.1. NM_016093.3.
XP_011532867.1. XM_011534565.2.
UniGeneiHs.546390.

3D structure databases

ProteinModelPortaliQ9UNX3.
SMRiQ9UNX3. Positions 7-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119308. 150 interactions.
IntActiQ9UNX3. 11 interactions.
MINTiMINT-4831911.
STRINGi9606.ENSP00000265100.

PTM databases

iPTMnetiQ9UNX3.
PhosphoSiteiQ9UNX3.

Polymorphism and mutation databases

BioMutaiRPL26L1.
DMDMi23396835.

Proteomic databases

EPDiQ9UNX3.
MaxQBiQ9UNX3.
PaxDbiQ9UNX3.
PeptideAtlasiQ9UNX3.
PRIDEiQ9UNX3.
TopDownProteomicsiQ9UNX3.

Protocols and materials databases

DNASUi51121.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265100; ENSP00000265100; ENSG00000037241.
ENST00000519239; ENSP00000430147; ENSG00000037241.
ENST00000519974; ENSP00000428177; ENSG00000037241.
ENST00000521476; ENSP00000428223; ENSG00000037241.
GeneIDi51121.
KEGGihsa:51121.
UCSCiuc003mcc.4. human.

Organism-specific databases

CTDi51121.
GeneCardsiRPL26L1.
HGNCiHGNC:17050. RPL26L1.
HPAiHPA030449.
neXtProtiNX_Q9UNX3.
PharmGKBiPA34706.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3401. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiQ9UNX3.
KOiK02898.
OMAiVRIMRGD.
OrthoDBiEOG091G0TZX.
PhylomeDBiQ9UNX3.
TreeFamiTF300236.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GenomeRNAii51121.
PROiQ9UNX3.

Gene expression databases

BgeeiENSG00000037241.
ExpressionAtlasiQ9UNX3. baseline and differential.
GenevisibleiQ9UNX3. HS.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL26L_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX3
Secondary accession number(s): B3KY82, D3DQM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.