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Protein

60S ribosomal protein L26-like 1

Gene

RPL26L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-like 1
Alternative name(s):
Large ribosomal subunit protein uL24-like 1
Gene namesi
Name:RPL26L1
Synonyms:RPL26P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000037241.7.
HGNCiHGNC:17050. RPL26L1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000037241.
PharmGKBiPA34706.

Chemistry databases

DrugBankiDB02494. Alpha-Hydroxy-Beta-Phenyl-Propionic Acid.
DB07374. Anisomycin.
DB08437. Puromycin.

Polymorphism and mutation databases

BioMutaiRPL26L1.
DMDMi23396835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001307911 – 14560S ribosomal protein L26-like 1Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9UNX3.
MaxQBiQ9UNX3.
PaxDbiQ9UNX3.
PeptideAtlasiQ9UNX3.
PRIDEiQ9UNX3.
TopDownProteomicsiQ9UNX3.

PTM databases

iPTMnetiQ9UNX3.
PhosphoSitePlusiQ9UNX3.

Expressioni

Gene expression databases

BgeeiENSG00000037241.
ExpressionAtlasiQ9UNX3. baseline and differential.
GenevisibleiQ9UNX3. HS.

Organism-specific databases

HPAiHPA030449.

Interactioni

Protein-protein interaction databases

BioGridi119308. 176 interactors.
IntActiQ9UNX3. 20 interactors.
MINTiMINT-4831911.
STRINGi9606.ENSP00000265100.

Structurei

3D structure databases

ProteinModelPortaliQ9UNX3.
SMRiQ9UNX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3401. Eukaryota.
COG0198. LUCA.
GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
HOVERGENiHBG017293.
InParanoidiQ9UNX3.
KOiK02898.
OMAiKICVEGI.
OrthoDBiEOG091G0TZX.
PhylomeDBiQ9UNX3.
TreeFamiTF300236.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_A. Ribosomal_L24_A. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiView protein in PROSITE
PS01108. RIBOSOMAL_L24. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UNX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFNPFVTSD RSKNRKRHFN APSHVRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIH
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEELI EKMQE
Length:145
Mass (Da):17,256
Last modified:May 1, 2000 - v1
Checksum:i090D4CAB4E3F4F36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083248 mRNA. Translation: AAD39846.1.
AK128872 mRNA. Translation: BAG54744.1.
CH471062 Genomic DNA. Translation: EAW61420.1.
CH471062 Genomic DNA. Translation: EAW61421.1.
BC017360 mRNA. Translation: AAH17360.1.
BC070192 mRNA. Translation: AAH70192.1.
CCDSiCCDS4382.1.
RefSeqiNP_001304909.1. NM_001317980.1.
NP_001304910.1. NM_001317981.1.
NP_001304911.1. NM_001317982.1.
NP_057177.1. NM_016093.3.
XP_011532867.1. XM_011534565.2.
XP_016865008.1. XM_017009519.1.
XP_016865009.1. XM_017009520.1.
UniGeneiHs.546390.

Genome annotation databases

EnsembliENST00000265100; ENSP00000265100; ENSG00000037241.
ENST00000519239; ENSP00000430147; ENSG00000037241.
ENST00000519974; ENSP00000428177; ENSG00000037241.
ENST00000521476; ENSP00000428223; ENSG00000037241.
GeneIDi51121.
KEGGihsa:51121.
UCSCiuc003mcc.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL26L_HUMAN
AccessioniPrimary (citable) accession number: Q9UNX3
Secondary accession number(s): B3KY82, D3DQM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families