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Protein

RNA-binding protein Nova-2

Gene

NOVA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Nova-2
Alternative name(s):
Astrocytic NOVA1-like RNA-binding protein
Neuro-oncological ventral antigen 2
Gene namesi
Name:NOVA2
Synonyms:ANOVA, NOVA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7887. NOVA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31689.

Polymorphism and mutation databases

BioMutaiNOVA2.
DMDMi33516944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492RNA-binding protein Nova-2PRO_0000050119Add
BLAST

Proteomic databases

EPDiQ9UNW9.
MaxQBiQ9UNW9.
PaxDbiQ9UNW9.
PeptideAtlasiQ9UNW9.
PRIDEiQ9UNW9.

PTM databases

iPTMnetiQ9UNW9.
PhosphoSiteiQ9UNW9.

Expressioni

Tissue specificityi

Brain. Expression restricted to astrocytes.

Gene expression databases

BgeeiQ9UNW9.
CleanExiHS_NOVA2.
ExpressionAtlasiQ9UNW9. baseline and differential.
GenevisibleiQ9UNW9. HS.

Organism-specific databases

HPAiHPA045607.

Interactioni

Subunit structurei

Interacts with PTBP2; the interaction is direct.By similarity

Protein-protein interaction databases

BioGridi110920. 3 interactions.
IntActiQ9UNW9. 2 interactions.
STRINGi9606.ENSP00000263257.

Structurei

Secondary structure

1
492
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi407 – 4148Combined sources
Turni415 – 4173Combined sources
Helixi418 – 4225Combined sources
Helixi424 – 4263Combined sources
Helixi427 – 43610Combined sources
Beta strandi439 – 4424Combined sources
Beta strandi454 – 4629Combined sources
Helixi463 – 47614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DTJX-ray2.00A/B/C/D406-480[»]
1EC6X-ray2.40A/B406-491[»]
ProteinModelPortaliQ9UNW9.
SMRiQ9UNW9. Positions 32-251, 406-491.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNW9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 9968KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 19667KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini406 – 47368KH 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi10 – 2617Bipartite nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 405174Ala-richAdd
BLAST
Compositional biasi332 – 39362Gly-richAdd
BLAST

Domaini

The third KH domain (KH3) recognizes specifically 5'-UCAY-3'.

Sequence similaritiesi

Contains 3 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiQ9UNW9.
KOiK14944.
OMAiPPMESEA.
OrthoDBiEOG7NSB2Z.
PhylomeDBiQ9UNW9.
TreeFamiTF316981.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033087. Nova-2.
[Graphical view]
PANTHERiPTHR10288:SF162. PTHR10288:SF162. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEAPDSRK RPLETPPEVV CTKRSNTGEE GEYFLKVLIP SYAAGSIIGK
60 70 80 90 100
GGQTIVQLQK ETGATIKLSK SKDFYPGTTE RVCLVQGTAE ALNAVHSFIA
110 120 130 140 150
EKVREIPQAM TKPEVVNILQ PQTTMNPDRA KQAKLIVPNS TAGLIIGKGG
160 170 180 190 200
ATVKAVMEQS GAWVQLSQKP EGINLQERVV TVSGEPEQVH KAVSAIVQKV
210 220 230 240 250
QEDPQSSSCL NISYANVAGP VANSNPTGSP YASPADVLPA AAAASAAAAS
260 270 280 290 300
GLLGPAGLAG VGAFPAALPA FSGTDLLAIS TALNTLASYG YNTNSLGLGL
310 320 330 340 350
NSAAASGVLA AVAAGANPAA AAAANLLASY AGEAGAGPAG GAAPPPPPPP
360 370 380 390 400
GALGSFALAA AANGYLGAGA GGGAGGGGGP LVAAAAAAGA AGGFLTAEKL
410 420 430 440 450
AAESAKELVE IAVPENLVGA ILGKGGKTLV EYQELTGARI QISKKGEFLP
460 470 480 490
GTRNRRVTIT GSPAATQAAQ YLISQRVTYE QGVRASNPQK VG
Length:492
Mass (Da):49,009
Last modified:May 1, 2000 - v1
Checksum:i41B63EAF6899256B
GO

Sequence cautioni

The sequence AAB88661.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti247 – 2471A → R in AAB88661 (PubMed:10735272).Curated
Sequence conflicti265 – 2673PAA → TAT in AAB88661 (PubMed:10735272).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70477 mRNA. Translation: AAB88661.1. Different initiation.
AF083898 mRNA. Translation: AAC72355.1.
AC006540 Genomic DNA. Translation: AAD13116.1.
CCDSiCCDS12679.1.
RefSeqiNP_002507.1. NM_002516.3.
UniGeneiHs.375439.

Genome annotation databases

EnsembliENST00000263257; ENSP00000263257; ENSG00000104967.
GeneIDi4858.
KEGGihsa:4858.
UCSCiuc002pdv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70477 mRNA. Translation: AAB88661.1. Different initiation.
AF083898 mRNA. Translation: AAC72355.1.
AC006540 Genomic DNA. Translation: AAD13116.1.
CCDSiCCDS12679.1.
RefSeqiNP_002507.1. NM_002516.3.
UniGeneiHs.375439.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DTJX-ray2.00A/B/C/D406-480[»]
1EC6X-ray2.40A/B406-491[»]
ProteinModelPortaliQ9UNW9.
SMRiQ9UNW9. Positions 32-251, 406-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110920. 3 interactions.
IntActiQ9UNW9. 2 interactions.
STRINGi9606.ENSP00000263257.

PTM databases

iPTMnetiQ9UNW9.
PhosphoSiteiQ9UNW9.

Polymorphism and mutation databases

BioMutaiNOVA2.
DMDMi33516944.

Proteomic databases

EPDiQ9UNW9.
MaxQBiQ9UNW9.
PaxDbiQ9UNW9.
PeptideAtlasiQ9UNW9.
PRIDEiQ9UNW9.

Protocols and materials databases

DNASUi4858.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263257; ENSP00000263257; ENSG00000104967.
GeneIDi4858.
KEGGihsa:4858.
UCSCiuc002pdv.3. human.

Organism-specific databases

CTDi4858.
GeneCardsiNOVA2.
HGNCiHGNC:7887. NOVA2.
HPAiHPA045607.
MIMi601991. gene.
neXtProtiNX_Q9UNW9.
PharmGKBiPA31689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2191. Eukaryota.
ENOG410XRZD. LUCA.
GeneTreeiENSGT00760000119144.
HOGENOMiHOG000007833.
HOVERGENiHBG082048.
InParanoidiQ9UNW9.
KOiK14944.
OMAiPPMESEA.
OrthoDBiEOG7NSB2Z.
PhylomeDBiQ9UNW9.
TreeFamiTF316981.

Miscellaneous databases

EvolutionaryTraceiQ9UNW9.
GenomeRNAii4858.
PROiQ9UNW9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UNW9.
CleanExiHS_NOVA2.
ExpressionAtlasiQ9UNW9. baseline and differential.
GenevisibleiQ9UNW9. HS.

Family and domain databases

Gene3Di3.30.1370.10. 3 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR033087. Nova-2.
[Graphical view]
PANTHERiPTHR10288:SF162. PTHR10288:SF162. 3 hits.
PfamiPF00013. KH_1. 3 hits.
[Graphical view]
SMARTiSM00322. KH. 3 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 3 hits.
PROSITEiPS50084. KH_TYPE_1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ANOVA, a putative astrocytic RNA binding protein gene that maps to chromosome 19q13.3."
    Ueki K., Ramaswamy S., Billings S.J., Mohrenweiser H.W., Louis D.N.
    Neurogenetics 1:31-36(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia."
    Yang Y.Y., Yin G.L., Darnell R.B.
    Proc. Natl. Acad. Sci. U.S.A. 95:13254-13259(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains."
    Lewis H.A., Chen H., Edo C., Buckanovich R.J., Yang Y.Y.-L., Musunuru K., Zhong R., Darnell R.B., Burley S.K.
    Structure 7:191-203(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 405-480.
  5. "Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome."
    Lewis H.A., Musunuru K., Jensen K.B., Edo C., Chen H., Darnell R.B., Burley S.K.
    Cell 100:323-332(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 405-491 IN COMPLEX WITH RNA.

Entry informationi

Entry nameiNOVA2_HUMAN
AccessioniPrimary (citable) accession number: Q9UNW9
Secondary accession number(s): O43267, Q9UEA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.