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Protein

Probable G-protein coupled receptor 132

Gene

GPR132

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 132
Alternative name(s):
G2 accumulation protein
Gene namesi
Name:GPR132
Synonyms:G2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17482. GPR132.

Subcellular locationi

  • Cell membrane Curated; Multi-pass membrane protein Curated

  • Note: Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence analysisAdd
BLAST
Transmembranei46 – 6823Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini69 – 7911CytoplasmicSequence analysisAdd
BLAST
Transmembranei80 – 10223Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini103 – 11614ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15820CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17820Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 19719ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 22023Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 24626CytoplasmicSequence analysisAdd
BLAST
Transmembranei247 – 26923Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini270 – 28819ExtracellularSequence analysisAdd
BLAST
Transmembranei289 – 31123Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini312 – 38069CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi7 – 71K → A: No change in basal activity. 1 Publication
Mutagenesisi31 – 311K → A: Decreased IP1 accumulation at any pH. 1 Publication
Mutagenesisi42 – 421R → A: Decreased basal activity at alkaline pH and loss of proton-sensing activity at low pH. 1 Publication

Organism-specific databases

PharmGKBiPA134940832.

Chemistry

ChEMBLiCHEMBL3085618.
GuidetoPHARMACOLOGYi128.

Polymorphism and mutation databases

DMDMi37537754.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Probable G-protein coupled receptor 132PRO_0000069461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi115 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UNW8.
PRIDEiQ9UNW8.

PTM databases

iPTMnetiQ9UNW8.
PhosphoSiteiQ9UNW8.

Expressioni

Tissue specificityi

Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.1 Publication

Inductioni

By stress and DNA-damaging agents.1 Publication

Gene expression databases

BgeeiQ9UNW8.
CleanExiHS_GPR132.
ExpressionAtlasiQ9UNW8. baseline and differential.
GenevisibleiQ9UNW8. HS.

Organism-specific databases

HPAiHPA029694.
HPA029695.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328818.

Structurei

3D structure databases

ProteinModelPortaliQ9UNW8.
SMRiQ9UNW8. Positions 43-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 1577Poly-Arg

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKDS. Eukaryota.
ENOG4111F3F. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000013146.
HOVERGENiHBG104029.
InParanoidiQ9UNW8.
KOiK08426.
OMAiFFCNIYI.
OrthoDBiEOG76QFJ8.
PhylomeDBiQ9UNW8.
TreeFamiTF331803.

Family and domain databases

InterProiIPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNW8-1) [UniParc]FASTAAdd to basket

Also known as: G2A-a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCPMLLKNGY NGNATPVTTT APWASLGLSA KTCNNVSFEE SRIVLVVVYS
60 70 80 90 100
AVCTLGVPAN CLTAWLALLQ VLQGNVLAVY LLCLALCELL YTGTLPLWVI
110 120 130 140 150
YIRNQHRWTL GLLACKVTAY IFFCNIYVSI LFLCCISCDR FVAVVYALES
160 170 180 190 200
RGRRRRRTAI LISACIFILV GIVHYPVFQT EDKETCFDML QMDSRIAGYY
210 220 230 240 250
YARFTVGFAI PLSIIAFTNH RIFRSIKQSM GLSAAQKAKV KHSAIAVVVI
260 270 280 290 300
FLVCFAPYHL VLLVKAAAFS YYRGDRNAMC GLEERLYTAS VVFLCLSTVN
310 320 330 340 350
GVADPIIYVL ATDHSRQEVS RIHKGWKEWS MKTDVTRLTH SRDTEELQSP
360 370 380
VALADHYTFS RPVHPPGSPC PAKRLIEESC
Length:380
Mass (Da):42,499
Last modified:May 1, 2000 - v1
Checksum:i6DE63D17275ECD74
GO
Isoform 2 (identifier: Q9UNW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-188: Missing.

Show »
Length:192
Mass (Da):21,555
Checksum:i039E1BE113D7CB24
GO
Isoform 3 (identifier: Q9UNW8-3) [UniParc]FASTAAdd to basket

Also known as: G2A-b

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MCPMLLKNGYN → MP

Note: More abundant than isoform 1 in leukocytes by approximately 3-fold.
Show »
Length:371
Mass (Da):41,462
Checksum:i85CF16178275BD91
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 188188Missing in isoform 2. 2 PublicationsVSP_008404Add
BLAST
Alternative sequencei1 – 1111MCPMLLKNGYN → MP in isoform 3. 2 PublicationsVSP_054592Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083955 mRNA. Translation: AAD47380.1.
AB465599 mRNA. Translation: BAG84609.1.
AB465600 mRNA. Translation: BAG84610.1.
EU432121 mRNA. Translation: ABY87920.1.
BT007257 mRNA. Translation: AAP35921.1.
AK292142 mRNA. Translation: BAF84831.1.
AK303654 mRNA. Translation: BAG64656.1.
AL512356 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81898.1.
BC004555 mRNA. No translation available.
BC084546 mRNA. Translation: AAH84546.1.
CCDSiCCDS61567.1. [Q9UNW8-3]
CCDS9997.1. [Q9UNW8-1]
RefSeqiNP_001265623.1. NM_001278694.1. [Q9UNW8-1]
NP_001265624.1. NM_001278695.1. [Q9UNW8-3]
NP_001265625.1. NM_001278696.1. [Q9UNW8-2]
NP_037477.1. NM_013345.3. [Q9UNW8-1]
UniGeneiHs.532504.

Genome annotation databases

EnsembliENST00000329797; ENSP00000328818; ENSG00000183484. [Q9UNW8-1]
ENST00000392585; ENSP00000376364; ENSG00000183484. [Q9UNW8-3]
ENST00000539291; ENSP00000438094; ENSG00000183484. [Q9UNW8-1]
GeneIDi29933.
KEGGihsa:29933.
UCSCiuc001yqd.5. human. [Q9UNW8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083955 mRNA. Translation: AAD47380.1.
AB465599 mRNA. Translation: BAG84609.1.
AB465600 mRNA. Translation: BAG84610.1.
EU432121 mRNA. Translation: ABY87920.1.
BT007257 mRNA. Translation: AAP35921.1.
AK292142 mRNA. Translation: BAF84831.1.
AK303654 mRNA. Translation: BAG64656.1.
AL512356 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81898.1.
BC004555 mRNA. No translation available.
BC084546 mRNA. Translation: AAH84546.1.
CCDSiCCDS61567.1. [Q9UNW8-3]
CCDS9997.1. [Q9UNW8-1]
RefSeqiNP_001265623.1. NM_001278694.1. [Q9UNW8-1]
NP_001265624.1. NM_001278695.1. [Q9UNW8-3]
NP_001265625.1. NM_001278696.1. [Q9UNW8-2]
NP_037477.1. NM_013345.3. [Q9UNW8-1]
UniGeneiHs.532504.

3D structure databases

ProteinModelPortaliQ9UNW8.
SMRiQ9UNW8. Positions 43-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328818.

Chemistry

ChEMBLiCHEMBL3085618.
GuidetoPHARMACOLOGYi128.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9UNW8.
PhosphoSiteiQ9UNW8.

Polymorphism and mutation databases

DMDMi37537754.

Proteomic databases

PaxDbiQ9UNW8.
PRIDEiQ9UNW8.

Protocols and materials databases

DNASUi29933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329797; ENSP00000328818; ENSG00000183484. [Q9UNW8-1]
ENST00000392585; ENSP00000376364; ENSG00000183484. [Q9UNW8-3]
ENST00000539291; ENSP00000438094; ENSG00000183484. [Q9UNW8-1]
GeneIDi29933.
KEGGihsa:29933.
UCSCiuc001yqd.5. human. [Q9UNW8-1]

Organism-specific databases

CTDi29933.
GeneCardsiGPR132.
HGNCiHGNC:17482. GPR132.
HPAiHPA029694.
HPA029695.
MIMi606167. gene.
neXtProtiNX_Q9UNW8.
PharmGKBiPA134940832.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKDS. Eukaryota.
ENOG4111F3F. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000013146.
HOVERGENiHBG104029.
InParanoidiQ9UNW8.
KOiK08426.
OMAiFFCNIYI.
OrthoDBiEOG76QFJ8.
PhylomeDBiQ9UNW8.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-416476. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiGPR132.
GenomeRNAii29933.
PROiQ9UNW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UNW8.
CleanExiHS_GPR132.
ExpressionAtlasiQ9UNW8. baseline and differential.
GenevisibleiQ9UNW8. HS.

Family and domain databases

InterProiIPR005388. G2A_lysphc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01563. G2ARECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION.
    Tissue: Spleen.
  2. "Identification and analysis of two splice variants of human G2A generated by alternative splicing."
    Ogawa A., Obinata H., Hattori T., Kishi M., Tatei K., Ishikawa O., Izumi T.
    J. Pharmacol. Exp. Ther. 332:469-478(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, ALTERNATIVE SPLICING, MUTAGENESIS OF LYS-7; LYS-31 AND ARG-42.
  3. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Synovium and Thymus.
  6. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: B-cell and Brain.
  9. "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A."
    Kabarowski J.H.S., Zhu K., Le L.Q., Witte O.N., Xu Y.
    Science 293:702-705(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY FUNCTION.
  10. Cited for: RETRACTION.
  11. "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques."
    Rikitake Y., Hirata K., Yamashita T., Iwai K., Kobayashi S., Itoh H., Ozaki M., Ejiri J., Shiomi M., Inoue N., Kawashima S., Yokoyama M.
    Arterioscler. Thromb. Vasc. Biol. 22:2049-2053(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  12. "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis."
    Lin P., Ye R.D.
    J. Biol. Chem. 278:14379-14386(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGP132_HUMAN
AccessioniPrimary (citable) accession number: Q9UNW8
Secondary accession number(s): A8K7X7, B4E144, Q9BSU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.