ID   Q9UNU2_HUMAN            Unreviewed;       354 AA.
AC   Q9UNU2;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   28-JUN-2023, entry version 68.
DE   SubName: Full=Complement protein C4B frameshift mutant {ECO:0000313|EMBL:AAC98380.1};
DE   Flags: Fragment;
GN   Name=C4B {ECO:0000313|EMBL:AAC98380.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAC98380.1};
RN   [1] {ECO:0000313|EMBL:AAC98380.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lokki M.-L., Circolo A., Ahokas P., Rupert K.L., Yu C.Y., Colten H.R.;
RT   "Deficiency of Complement Protein C4 Due to Identical Frameshift Mutations
RT   in the C4A and C4B Genes.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF092085; AAC98380.1; -; Genomic_DNA.
DR   PIR; I55584; I55584.
DR   AlphaFoldDB; Q9UNU2; -.
DR   MEROPS; I39.951; -.
DR   PeptideAtlas; Q9UNU2; -.
DR   ChiTaRS; C4B; human.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   CDD; cd02896; complement_C3_C4_C5; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
FT   DOMAIN          32..282
FT                   /note="Alpha-macroglobulin-like TED"
FT                   /evidence="ECO:0000259|Pfam:PF07678"
FT   REGION          333..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAC98380.1"
SQ   SEQUENCE   354 AA;  38138 MW;  DA3AAC7D85708237 CRC64;
     HRGRTLDIPG NSDPNMIPDG DFNSYVRVTA SDPLDTLGSE GALSPGGVAS LLRLPRGCGE
     QTMIYLAPTL AASRYLDKTE QWSTLPPETK DHAVDLIQKG YMRIQQFRKA DGSYAAWLSR
     DSSTWLTAFV LKVLSLAQEQ VGGSPEKLQE TSNWLLSQQQ ADGSFQDLSP VIHRSMQGGL
     VGNDETVALT AFVTIALHHG LAVFQDEGAE PLKQRVEASI SKASSFLGEK ASAGLLGAHA
     AAITAYALTL TKAPADLRGV AHNNLMAMAQ ETGDNLYWGS QSLVLRAMPC RPPRLLATHP
     TPCPRPQPCG LKPQPTPCCT SCFTRAKQRW QTRLRPGSPV RAASKGDSAV PKTR
//