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Q9UNU2

- Q9UNU2_HUMAN

UniProt

Q9UNU2 - Q9UNU2_HUMAN

Protein
Submitted name:

Complement protein C4B frameshift mutant

Gene

C4B

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Complement protein C4B frameshift mutantImported
    Gene namesi
    Name:C4BImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9UNU2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di1.50.10.20. 1 hit.
    InterProiIPR011626. A2M_comp.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF07678. A2M_comp. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 1 hit.
    PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9UNU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    HRGRTLDIPG NSDPNMIPDG DFNSYVRVTA SDPLDTLGSE GALSPGGVAS    50
    LLRLPRGCGE QTMIYLAPTL AASRYLDKTE QWSTLPPETK DHAVDLIQKG 100
    YMRIQQFRKA DGSYAAWLSR DSSTWLTAFV LKVLSLAQEQ VGGSPEKLQE 150
    TSNWLLSQQQ ADGSFQDLSP VIHRSMQGGL VGNDETVALT AFVTIALHHG 200
    LAVFQDEGAE PLKQRVEASI SKASSFLGEK ASAGLLGAHA AAITAYALTL 250
    TKAPADLRGV AHNNLMAMAQ ETGDNLYWGS QSLVLRAMPC RPPRLLATHP 300
    TPCPRPQPCG LKPQPTPCCT SCFTRAKQRW QTRLRPGSPV RAASKGDSAV 350
    PKTR 354
    Length:354
    Mass (Da):38,138
    Last modified:May 1, 2000 - v1
    Checksum:iDA3AAC7D85708237
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092085 Genomic DNA. Translation: AAC98380.1.
    PIRiI55584.
    UniGeneiHs.534847.
    Hs.720022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092085 Genomic DNA. Translation: AAC98380.1 .
    PIRi I55584.
    UniGenei Hs.534847.
    Hs.720022.

    3D structure databases

    ProteinModelPortali Q9UNU2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9UNU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.50.10.20. 1 hit.
    InterProi IPR011626. A2M_comp.
    IPR019742. MacrogloblnA2_CS.
    IPR019565. MacrogloblnA2_thiol-ester-bond.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF07678. A2M_comp. 1 hit.
    PF10569. Thiol-ester_cl. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 1 hit.
    PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression."
      Barba G., Rittner C., Schneider P.M.
      J. Clin. Invest. 91:1681-1686(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Deficiency of Complement Protein C4 Due to Identical Frameshift Mutations in the C4A and C4B Genes."
      Lokki M.-L., Circolo A., Ahokas P., Rupert K.L., Yu C.Y., Colten H.R.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9UNU2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNU2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.