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Protein

Rab-like protein 2B

Gene

RABL2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 358GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi133 – 1364GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 2B
Gene namesi
Name:RABL2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9800. RABL2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34160.

Polymorphism and mutation databases

BioMutaiRABL2B.
DMDMi12229940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Rab-like protein 2BPRO_0000121264Add
BLAST

Proteomic databases

EPDiQ9UNT1.
MaxQBiQ9UNT1.
PaxDbiQ9UNT1.
PRIDEiQ9UNT1.

PTM databases

iPTMnetiQ9UNT1.
PhosphoSiteiQ9UNT1.

Expressioni

Tissue specificityi

Expressed in the testis.1 Publication

Gene expression databases

BgeeiQ9UNT1.
CleanExiHS_RABL2B.
ExpressionAtlasiQ9UNT1. baseline and differential.
GenevisibleiQ9UNT1. HS.

Organism-specific databases

HPAiHPA042642.
HPA042700.
HPA042765.
HPA044007.

Interactioni

Protein-protein interaction databases

BioGridi116329. 4 interactions.
IntActiQ9UNT1. 1 interaction.
STRINGi9606.ENSP00000376871.

Structurei

3D structure databases

ProteinModelPortaliQ9UNT1.
SMRiQ9UNT1. Positions 17-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000233971.
HOVERGENiHBG106536.
InParanoidiQ9UNT1.
KOiK07931.
OMAiHPSYYHK.
PhylomeDBiQ9UNT1.
TreeFamiTF329398.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ
60 70 80 90 100
LSTYALTLYK HTATVDGRTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV
110 120 130 140 150
FDVQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK
160 170 180 190 200
FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL
210 220
EQEEEDVPDQ EQSSSIETPS EEAASPHS
Length:228
Mass (Da):26,101
Last modified:May 1, 2000 - v1
Checksum:iC2F4335FA0AAFD61
GO
Isoform 2 (identifier: Q9UNT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: D → DA

Show »
Length:229
Mass (Da):26,172
Checksum:i5DB0EDAD132F5923
GO
Isoform 3 (identifier: Q9UNT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-168: K → KVWLTAEVASK

Show »
Length:238
Mass (Da):27,186
Checksum:iAB1B867A6F2347B3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei136 – 1361D → DA in isoform 2. 2 PublicationsVSP_005532
Alternative sequencei168 – 1681K → KVWLTAEVASK in isoform 3. 1 PublicationVSP_041061

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095352 mRNA. Translation: AAD51379.1.
BT020037 mRNA. Translation: AAV38840.1.
AC002055 Genomic DNA. No translation available.
BC014879 mRNA. Translation: AAH14879.1.
BC024281 mRNA. Translation: AAH24281.1.
BC075856 mRNA. No translation available.
CCDSiCCDS14102.1. [Q9UNT1-1]
CCDS33683.1. [Q9UNT1-2]
CCDS46738.1. [Q9UNT1-3]
RefSeqiNP_001003789.1. NM_001003789.1. [Q9UNT1-2]
NP_001124391.1. NM_001130919.1. [Q9UNT1-2]
NP_001124392.1. NM_001130920.1. [Q9UNT1-2]
NP_001124393.1. NM_001130921.1. [Q9UNT1-2]
NP_001124394.1. NM_001130922.1. [Q9UNT1-1]
NP_001124395.1. NM_001130923.1. [Q9UNT1-3]
NP_009012.1. NM_007081.2. [Q9UNT1-1]
XP_005261956.1. XM_005261899.2. [Q9UNT1-3]
XP_011528977.1. XM_011530675.1. [Q9UNT1-1]
UniGeneiHs.584862.

Genome annotation databases

EnsembliENST00000354869; ENSP00000346940; ENSG00000079974. [Q9UNT1-2]
ENST00000395593; ENSP00000378958; ENSG00000079974. [Q9UNT1-3]
ENST00000395595; ENSP00000378960; ENSG00000079974. [Q9UNT1-2]
ENST00000395598; ENSP00000378962; ENSG00000079974. [Q9UNT1-1]
ENST00000435118; ENSP00000401906; ENSG00000079974. [Q9UNT1-1]
GeneIDi11158.
KEGGihsa:11158.
UCSCiuc003bnk.2. human. [Q9UNT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095352 mRNA. Translation: AAD51379.1.
BT020037 mRNA. Translation: AAV38840.1.
AC002055 Genomic DNA. No translation available.
BC014879 mRNA. Translation: AAH14879.1.
BC024281 mRNA. Translation: AAH24281.1.
BC075856 mRNA. No translation available.
CCDSiCCDS14102.1. [Q9UNT1-1]
CCDS33683.1. [Q9UNT1-2]
CCDS46738.1. [Q9UNT1-3]
RefSeqiNP_001003789.1. NM_001003789.1. [Q9UNT1-2]
NP_001124391.1. NM_001130919.1. [Q9UNT1-2]
NP_001124392.1. NM_001130920.1. [Q9UNT1-2]
NP_001124393.1. NM_001130921.1. [Q9UNT1-2]
NP_001124394.1. NM_001130922.1. [Q9UNT1-1]
NP_001124395.1. NM_001130923.1. [Q9UNT1-3]
NP_009012.1. NM_007081.2. [Q9UNT1-1]
XP_005261956.1. XM_005261899.2. [Q9UNT1-3]
XP_011528977.1. XM_011530675.1. [Q9UNT1-1]
UniGeneiHs.584862.

3D structure databases

ProteinModelPortaliQ9UNT1.
SMRiQ9UNT1. Positions 17-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116329. 4 interactions.
IntActiQ9UNT1. 1 interaction.
STRINGi9606.ENSP00000376871.

PTM databases

iPTMnetiQ9UNT1.
PhosphoSiteiQ9UNT1.

Polymorphism and mutation databases

BioMutaiRABL2B.
DMDMi12229940.

Proteomic databases

EPDiQ9UNT1.
MaxQBiQ9UNT1.
PaxDbiQ9UNT1.
PRIDEiQ9UNT1.

Protocols and materials databases

DNASUi11158.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354869; ENSP00000346940; ENSG00000079974. [Q9UNT1-2]
ENST00000395593; ENSP00000378958; ENSG00000079974. [Q9UNT1-3]
ENST00000395595; ENSP00000378960; ENSG00000079974. [Q9UNT1-2]
ENST00000395598; ENSP00000378962; ENSG00000079974. [Q9UNT1-1]
ENST00000435118; ENSP00000401906; ENSG00000079974. [Q9UNT1-1]
GeneIDi11158.
KEGGihsa:11158.
UCSCiuc003bnk.2. human. [Q9UNT1-1]

Organism-specific databases

CTDi11158.
GeneCardsiRABL2B.
HGNCiHGNC:9800. RABL2B.
HPAiHPA042642.
HPA042700.
HPA042765.
HPA044007.
MIMi605413. gene.
neXtProtiNX_Q9UNT1.
PharmGKBiPA34160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000233971.
HOVERGENiHBG106536.
InParanoidiQ9UNT1.
KOiK07931.
OMAiHPSYYHK.
PhylomeDBiQ9UNT1.
TreeFamiTF329398.

Miscellaneous databases

GenomeRNAii11158.
PROiQ9UNT1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9UNT1.
CleanExiHS_RABL2B.
ExpressionAtlasiQ9UNT1. baseline and differential.
GenevisibleiQ9UNT1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13."
    Wong A.C., Shkolny D., Dorman A., Willingham D., Roe B.A., McDermid H.E.
    Genomics 59:326-334(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye and Uterus.
  5. "RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly."
    Lo J.C., Jamsai D., O'Connor A.E., Borg C., Clark B.J., Whisstock J.C., Field M.C., Adams V., Ishikawa T., Aitken R.J., Whittle B., Goodnow C.C., Ormandy C.J., O'Bryan M.K.
    PLoS Genet. 8:E1002969-E1002969(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRBL2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UNT1
Secondary accession number(s): Q5TZT8, Q96C33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.