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Protein

Rab-like protein 2B

Gene

RABL2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 35GTPBy similarity8
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-like protein 2B
Gene namesi
Name:RABL2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:9800. RABL2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000079974.
PharmGKBiPA34160.

Polymorphism and mutation databases

BioMutaiRABL2B.
DMDMi12229940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212641 – 228Rab-like protein 2BAdd BLAST228

Proteomic databases

PaxDbiQ9UNT1.
PeptideAtlasiQ9UNT1.
PRIDEiQ9UNT1.

PTM databases

iPTMnetiQ9UNT1.
PhosphoSitePlusiQ9UNT1.

Expressioni

Tissue specificityi

Expressed in the testis.1 Publication

Gene expression databases

BgeeiENSG00000079974.
CleanExiHS_RABL2B.
ExpressionAtlasiQ9UNT1. baseline and differential.
GenevisibleiQ9UNT1. HS.

Organism-specific databases

HPAiHPA042642.
HPA042700.
HPA042765.
HPA044007.

Interactioni

Protein-protein interaction databases

BioGridi116329. 4 interactors.
IntActiQ9UNT1. 1 interactor.
STRINGi9606.ENSP00000376871.

Structurei

3D structure databases

ProteinModelPortaliQ9UNT1.
SMRiQ9UNT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000233971.
HOVERGENiHBG106536.
InParanoidiQ9UNT1.
KOiK07931.
OMAiHPSYYHK.
OrthoDBiEOG091G0Q2L.
PhylomeDBiQ9UNT1.
TreeFamiTF329398.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDKTKPSE LDQGKYDADD NVKIICLGDS AVGKSKLMER FLMDGFQPQQ
60 70 80 90 100
LSTYALTLYK HTATVDGRTI LVDFWDTAGQ ERFQSMHASY YHKAHACIMV
110 120 130 140 150
FDVQRKVTYR NLSTWYTELR EFRPEIPCIV VANKIDDINV TQKSFNFAKK
160 170 180 190 200
FSLPLYFVSA ADGTNVVKLF NDAIRLAVSY KQNSQDFMDE IFQELENFSL
210 220
EQEEEDVPDQ EQSSSIETPS EEAASPHS
Length:228
Mass (Da):26,101
Last modified:May 1, 2000 - v1
Checksum:iC2F4335FA0AAFD61
GO
Isoform 2 (identifier: Q9UNT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-136: D → DA

Show »
Length:229
Mass (Da):26,172
Checksum:i5DB0EDAD132F5923
GO
Isoform 3 (identifier: Q9UNT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-168: K → KVWLTAEVASK

Show »
Length:238
Mass (Da):27,186
Checksum:iAB1B867A6F2347B3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005532136D → DA in isoform 2. 2 Publications1
Alternative sequenceiVSP_041061168K → KVWLTAEVASK in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095352 mRNA. Translation: AAD51379.1.
BT020037 mRNA. Translation: AAV38840.1.
AC002055 Genomic DNA. No translation available.
BC014879 mRNA. Translation: AAH14879.1.
BC024281 mRNA. Translation: AAH24281.1.
BC075856 mRNA. No translation available.
CCDSiCCDS14102.1. [Q9UNT1-1]
CCDS33683.1. [Q9UNT1-2]
CCDS46738.1. [Q9UNT1-3]
RefSeqiNP_001003789.1. NM_001003789.1. [Q9UNT1-2]
NP_001124391.1. NM_001130919.1. [Q9UNT1-2]
NP_001124392.1. NM_001130920.1. [Q9UNT1-2]
NP_001124393.1. NM_001130921.1. [Q9UNT1-2]
NP_001124394.1. NM_001130922.1. [Q9UNT1-1]
NP_001124395.1. NM_001130923.1. [Q9UNT1-3]
NP_009012.1. NM_007081.2. [Q9UNT1-1]
XP_005261956.1. XM_005261899.2. [Q9UNT1-3]
XP_011528977.1. XM_011530675.1. [Q9UNT1-1]
XP_016884036.1. XM_017028547.1. [Q9UNT1-3]
XP_016884037.1. XM_017028548.1. [Q9UNT1-3]
XP_016884038.1. XM_017028549.1. [Q9UNT1-3]
XP_016884041.1. XM_017028552.1. [Q9UNT1-2]
XP_016884042.1. XM_017028553.1. [Q9UNT1-2]
XP_016884043.1. XM_017028554.1. [Q9UNT1-2]
XP_016884044.1. XM_017028555.1. [Q9UNT1-2]
XP_016884045.1. XM_017028556.1. [Q9UNT1-1]
XP_016884046.1. XM_017028557.1. [Q9UNT1-1]
XP_016884047.1. XM_017028558.1. [Q9UNT1-1]
UniGeneiHs.584862.

Genome annotation databases

EnsembliENST00000354869; ENSP00000346940; ENSG00000079974. [Q9UNT1-2]
ENST00000395593; ENSP00000378958; ENSG00000079974. [Q9UNT1-3]
ENST00000395595; ENSP00000378960; ENSG00000079974. [Q9UNT1-2]
ENST00000395598; ENSP00000378962; ENSG00000079974. [Q9UNT1-1]
ENST00000435118; ENSP00000401906; ENSG00000079974. [Q9UNT1-1]
GeneIDi11158.
KEGGihsa:11158.
UCSCiuc003bnk.2. human. [Q9UNT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095352 mRNA. Translation: AAD51379.1.
BT020037 mRNA. Translation: AAV38840.1.
AC002055 Genomic DNA. No translation available.
BC014879 mRNA. Translation: AAH14879.1.
BC024281 mRNA. Translation: AAH24281.1.
BC075856 mRNA. No translation available.
CCDSiCCDS14102.1. [Q9UNT1-1]
CCDS33683.1. [Q9UNT1-2]
CCDS46738.1. [Q9UNT1-3]
RefSeqiNP_001003789.1. NM_001003789.1. [Q9UNT1-2]
NP_001124391.1. NM_001130919.1. [Q9UNT1-2]
NP_001124392.1. NM_001130920.1. [Q9UNT1-2]
NP_001124393.1. NM_001130921.1. [Q9UNT1-2]
NP_001124394.1. NM_001130922.1. [Q9UNT1-1]
NP_001124395.1. NM_001130923.1. [Q9UNT1-3]
NP_009012.1. NM_007081.2. [Q9UNT1-1]
XP_005261956.1. XM_005261899.2. [Q9UNT1-3]
XP_011528977.1. XM_011530675.1. [Q9UNT1-1]
XP_016884036.1. XM_017028547.1. [Q9UNT1-3]
XP_016884037.1. XM_017028548.1. [Q9UNT1-3]
XP_016884038.1. XM_017028549.1. [Q9UNT1-3]
XP_016884041.1. XM_017028552.1. [Q9UNT1-2]
XP_016884042.1. XM_017028553.1. [Q9UNT1-2]
XP_016884043.1. XM_017028554.1. [Q9UNT1-2]
XP_016884044.1. XM_017028555.1. [Q9UNT1-2]
XP_016884045.1. XM_017028556.1. [Q9UNT1-1]
XP_016884046.1. XM_017028557.1. [Q9UNT1-1]
XP_016884047.1. XM_017028558.1. [Q9UNT1-1]
UniGeneiHs.584862.

3D structure databases

ProteinModelPortaliQ9UNT1.
SMRiQ9UNT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116329. 4 interactors.
IntActiQ9UNT1. 1 interactor.
STRINGi9606.ENSP00000376871.

PTM databases

iPTMnetiQ9UNT1.
PhosphoSitePlusiQ9UNT1.

Polymorphism and mutation databases

BioMutaiRABL2B.
DMDMi12229940.

Proteomic databases

PaxDbiQ9UNT1.
PeptideAtlasiQ9UNT1.
PRIDEiQ9UNT1.

Protocols and materials databases

DNASUi11158.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354869; ENSP00000346940; ENSG00000079974. [Q9UNT1-2]
ENST00000395593; ENSP00000378958; ENSG00000079974. [Q9UNT1-3]
ENST00000395595; ENSP00000378960; ENSG00000079974. [Q9UNT1-2]
ENST00000395598; ENSP00000378962; ENSG00000079974. [Q9UNT1-1]
ENST00000435118; ENSP00000401906; ENSG00000079974. [Q9UNT1-1]
GeneIDi11158.
KEGGihsa:11158.
UCSCiuc003bnk.2. human. [Q9UNT1-1]

Organism-specific databases

CTDi11158.
GeneCardsiRABL2B.
HGNCiHGNC:9800. RABL2B.
HPAiHPA042642.
HPA042700.
HPA042765.
HPA044007.
MIMi605413. gene.
neXtProtiNX_Q9UNT1.
OpenTargetsiENSG00000079974.
PharmGKBiPA34160.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000233971.
HOVERGENiHBG106536.
InParanoidiQ9UNT1.
KOiK07931.
OMAiHPSYYHK.
OrthoDBiEOG091G0Q2L.
PhylomeDBiQ9UNT1.
TreeFamiTF329398.

Miscellaneous databases

GenomeRNAii11158.
PROiQ9UNT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079974.
CleanExiHS_RABL2B.
ExpressionAtlasiQ9UNT1. baseline and differential.
GenevisibleiQ9UNT1. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBL2B_HUMAN
AccessioniPrimary (citable) accession number: Q9UNT1
Secondary accession number(s): Q5TZT8, Q96C33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.