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Protein

COP9 signalosome complex subunit 3

Gene

COPS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.5 Publications

Miscellaneous

Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5696394. DNA Damage Recognition in GG-NER.
R-HSA-6781823. Formation of TC-NER Pre-Incision Complex.
R-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8951664. Neddylation.
SignaLinkiQ9UNS2.
SIGNORiQ9UNS2.

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 3
Short name:
SGN3
Short name:
Signalosome subunit 3
Alternative name(s):
JAB1-containing signalosome subunit 3
Gene namesi
Name:COPS3
Synonyms:CSN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000141030.12.
HGNCiHGNC:2239. COPS3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi8533.
OpenTargetsiENSG00000141030.
PharmGKBiPA26755.

Polymorphism and mutation databases

BioMutaiCOPS3.
DMDMi55976621.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00001209782 – 423COP9 signalosome complex subunit 3Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei407PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UNS2.
PaxDbiQ9UNS2.
PeptideAtlasiQ9UNS2.
PRIDEiQ9UNS2.

PTM databases

iPTMnetiQ9UNS2.
PhosphoSitePlusiQ9UNS2.
SwissPalmiQ9UNS2.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high level in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000141030.
CleanExiHS_COPS3.
HS_CSN3.
ExpressionAtlasiQ9UNS2. baseline and differential.
GenevisibleiQ9UNS2. HS.

Organism-specific databases

HPAiHPA021997.
HPA050557.

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS8 and COPS9 isoform 1 (PubMed:18850735, PubMed:26456823). Interacts with CK2 and PKD (PubMed:12628923). Interacts with the translation initiation factor EIF3S6 and IKBKG (PubMed:11418127, PubMed:12220626).5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114103. 96 interactors.
CORUMiQ9UNS2.
DIPiDIP-32478N.
IntActiQ9UNS2. 33 interactors.
MINTiMINT-129190.
STRINGi9606.ENSP00000268717.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D10X-ray3.80C/K1-423[»]
4D18X-ray4.08C/K1-423[»]
4WSNX-ray5.50C/K/S/a/i/q1-423[»]
ProteinModelPortaliQ9UNS2.
SMRiQ9UNS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 365PCIPROSITE-ProRule annotationAdd BLAST169

Sequence similaritiesi

Belongs to the CSN3 family.Curated

Phylogenomic databases

eggNOGiKOG2582. Eukaryota.
ENOG410XRKY. LUCA.
GeneTreeiENSGT00490000043408.
HOGENOMiHOG000030451.
HOVERGENiHBG051135.
InParanoidiQ9UNS2.
KOiK12177.
OMAiNHYHDLV.
OrthoDBiEOG091G07DK.
PhylomeDBiQ9UNS2.
TreeFamiTF101146.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50250. PCI. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD
60 70 80 90 100
VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF
110 120 130 140 150
AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS IHADLCQLCL
160 170 180 190 200
LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER
210 220 230 240 250
ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG
260 270 280 290 300
RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS
310 320 330 340 350
SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS
360 370 380 390 400
INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN
410 420
PQFVQKSMGS QEDDSGNKPS SYS
Length:423
Mass (Da):47,873
Last modified:January 23, 2007 - v3
Checksum:i1D371050C7D7BF8D
GO
Isoform 2 (identifier: Q9UNS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:403
Mass (Da):45,727
Checksum:iC835D56B8A9DFA4A
GO

Sequence cautioni

Q9UNS2: The sequence AAC14197 differs from that shown. Reason: Frameshift at position 5.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442711 – 20Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031647 mRNA. Translation: AAC14197.1. Frameshift.
AF098109 mRNA. Translation: AAD41247.1.
AK312476 mRNA. Translation: BAG35380.1.
AK302304 mRNA. Translation: BAG63643.1.
AK316400 mRNA. Translation: BAH14771.1.
AC055811 Genomic DNA. No translation available.
CH471196 Genomic DNA. Translation: EAW55712.1.
BC001891 mRNA. Translation: AAH01891.1.
CCDSiCCDS11183.1. [Q9UNS2-1]
CCDS56022.1. [Q9UNS2-2]
RefSeqiNP_001186054.1. NM_001199125.1. [Q9UNS2-2]
NP_001303283.1. NM_001316354.1.
NP_001303284.1. NM_001316355.1.
NP_001303285.1. NM_001316356.1.
NP_001303286.1. NM_001316357.1.
NP_001303287.1. NM_001316358.1.
NP_003644.2. NM_003653.3. [Q9UNS2-1]
XP_005256894.1. XM_005256837.4. [Q9UNS2-2]
UniGeneiHs.6076.

Genome annotation databases

EnsembliENST00000268717; ENSP00000268717; ENSG00000141030. [Q9UNS2-1]
ENST00000539941; ENSP00000437606; ENSG00000141030. [Q9UNS2-2]
GeneIDi8533.
KEGGihsa:8533.
UCSCiuc002grd.4. human. [Q9UNS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSN3_HUMAN
AccessioniPrimary (citable) accession number: Q9UNS2
Secondary accession number(s): B2R683
, B4DY81, O43191, Q7LDR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families