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Q9UNS1 (TIM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein timeless homolog

Short name=hTIM
Gene names
Name:TIMELESS
Synonyms:TIM, TIM1, TIMELESS1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1208 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. Ref.2 Ref.11 Ref.12

Subunit structure

Homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2 and PER3; the interaction with PER2 is via its second PAS domain. Interacts with CRY1, CRY2, CHEK1, ATR and ATRIP. Interacts with CLSPN and TIPIN. Ref.6 Ref.9 Ref.10 Ref.11 Ref.12

Subcellular location

Nucleus Ref.11.

Tissue specificity

Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis. Ref.1 Ref.2

Induction

Regulated by the cell cycle. High levels in S, G2 and M phases, with highest level in S phase. Low expression in G0 and G1 phases. Ref.6

Sequence similarities

Belongs to the timeless family.

Sequence caution

The sequence AAH39842.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
   Biological processBiological rhythms
Cell cycle
Cell division
DNA damage
Mitosis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbranching morphogenesis of an epithelial tube

Inferred from electronic annotation. Source: Ensembl

cell cycle phase transition

Inferred from mutant phenotype Ref.10. Source: BHF-UCL

cellular response to DNA damage stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

circadian rhythm

Inferred from sequence or structural similarity. Source: UniProtKB

detection of abiotic stimulus

Traceable author statement PubMed 9856466. Source: ProtInc

embryo development

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from electronic annotation. Source: Ensembl

mitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

morphogenesis of an epithelium

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from direct assay Ref.2. Source: UniProtKB

response to abiotic stimulus

Traceable author statement Ref.1. Source: ProtInc

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnuclear chromatin

Inferred from direct assay Ref.10. Source: HGNC

nucleus

Inferred by curator Ref.2. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.6. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CHEK1O147572EBI-2212315,EBI-974488

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 Ref.2 (identifier: Q9UNS1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 (identifier: Q9UNS1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12081208Protein timeless homolog
PRO_0000072538

Regions

Compositional bias661 – 68828Glu-rich

Amino acid modifications

Modified residue11491Phosphoserine Ref.15 Ref.16 Ref.18
Modified residue11731Phosphoserine Ref.7 Ref.8 Ref.15 Ref.16 Ref.18

Natural variations

Alternative sequence1771Missing in isoform 2. Ref.2
VSP_051693
Natural variant1291A → S. Ref.3
Corresponds to variant rs72478986 [ dbSNP | Ensembl ].
VAR_047879
Natural variant4291A → D in a breast cancer sample; somatic mutation. Ref.19
VAR_036435
Natural variant4551I → L. Ref.1 Ref.2 Ref.3
Corresponds to variant rs774027 [ dbSNP | Ensembl ].
VAR_021483
Natural variant4711N → S. Ref.3
Corresponds to variant rs72478993 [ dbSNP | Ensembl ].
VAR_047880
Natural variant8311R → Q. Ref.2 Ref.3 Ref.5
Corresponds to variant rs774047 [ dbSNP | Ensembl ].
VAR_021484
Natural variant8701M → V. Ref.3
Corresponds to variant rs61733875 [ dbSNP | Ensembl ].
VAR_047881
Natural variant9221R → H. Ref.3
Corresponds to variant rs72478999 [ dbSNP | Ensembl ].
VAR_047882
Natural variant9241R → W. Ref.3
Corresponds to variant rs72479000 [ dbSNP | Ensembl ].
VAR_047883
Natural variant10081Q → E in a breast cancer sample; somatic mutation. Ref.19
VAR_036436
Natural variant10171I → T. Ref.3
Corresponds to variant rs61376834 [ dbSNP | Ensembl ].
VAR_047884
Natural variant10181P → L. Ref.3 Ref.5
Corresponds to variant rs2291739 [ dbSNP | Ensembl ].
VAR_021485

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 16C6C07DDC6D2701

FASTA1,208138,658
        10         20         30         40         50         60 
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI 

        70         80         90        100        110        120 
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY 

       130        140        150        160        170        180 
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID 

       190        200        210        220        230        240 
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG 

       250        260        270        280        290        300 
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG 

       310        320        330        340        350        360 
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS 

       370        380        390        400        410        420 
VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE 

       430        440        450        460        470        480 
MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE 

       490        500        510        520        530        540 
LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL 

       550        560        570        580        590        600 
DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM 

       610        620        630        640        650        660 
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL SAPLPRQQGP 

       670        680        690        700        710        720 
EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC STVVRAYVLL LRSYQQNSAH 

       730        740        750        760        770        780 
TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL FNRLLSDPAA GAYKELVTFA KYILGKFFAL 

       790        800        810        820        830        840 
AAVNQKAFVE LLFWKNTAVV REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV 

       850        860        870        880        890        900 
EGQDVVEAIL AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL 

       910        920        930        940        950        960 
FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK LASSILPNGA 

       970        980        990       1000       1010       1020 
ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV LSNENLGQSL HQEGFSIPLL 

      1030       1040       1050       1060       1070       1080 
WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE NEEAMENEQF QQLLRKLGVR PPASGQETFW 

      1090       1100       1110       1120       1130       1140 
RIPAKLSPTQ LRRAAASLSQ PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA 

      1150       1160       1170       1180       1190       1200 
HKKKAGLASP EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY 


QIEDDEDD 

« Hide

Isoform 2 [UniParc].

Checksum: C116D7FF6F29B326
Show »

FASTA1,207138,530

References

« Hide 'large scale' references
[1]"Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1."
Koike N., Hida A., Numano R., Hirose M., Sakaki Y., Tei H.
FEBS Lett. 441:427-431(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LEU-455.
Tissue: Brain.
[2]"Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."
Sangoram A.M., Saez L., Antoch M.P., Gekakis N., Staknis D., Whiteley A., Fruechte E.M., Vitaterna M.H., Shimomura K., King D.P., Young M.W., Weitz C.J., Takahashi J.S.
Neuron 21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANTS LEU-455 AND GLN-831.
Tissue: Placenta.
[3]NIEHS SNPs program
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-129; LEU-455; SER-471; GLN-831; VAL-870; HIS-922; TRP-924; THR-1017 AND LEU-1018.
[4]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-831 AND LEU-1018.
Tissue: Duodenum and Skin.
[6]"Coupling of human circadian and cell cycles by the timeless protein."
Uensal-Kacmaz K., Mullen T.E., Kaufmann W.K., Sancar A.
Mol. Cell. Biol. 25:3109-3116(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATR; ATRIP; CHEK1 AND CRY2, INDUCTION.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function."
Chou D.M., Elledge S.J.
Proc. Natl. Acad. Sci. U.S.A. 103:18143-18147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TIPIN.
[10]"Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint."
Yoshizawa-Sugata N., Masai H.
J. Biol. Chem. 282:2729-2740(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TIPIN.
[11]"Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors."
Gotter A.L., Suppa C., Emanuel B.S.
J. Mol. Biol. 366:36-52(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CLSPN, FUNCTION.
[12]"The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement."
Uensal-Kacmaz K., Chastain P.D., Qu P.-P., Minoo P., Cordeiro-Stone M., Sancar A., Kaufmann W.K.
Mol. Cell. Biol. 27:3131-3142(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TIPIN, FUNCTION.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[16]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[17]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-429 AND GLU-1008.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB015597 mRNA. Translation: BAA36499.1.
AF098162 mRNA. Translation: AAC80011.1.
EU627094 Genomic DNA. Translation: ACD11488.1.
AC024884 Genomic DNA. No translation available.
BC039842 mRNA. Translation: AAH39842.1. Sequence problems.
BC050557 mRNA. Translation: AAH50557.1.
CCDSCCDS8918.1. [Q9UNS1-1]
RefSeqNP_003911.2. NM_003920.3. [Q9UNS1-1]
UniGeneHs.118631.

3D structure databases

ProteinModelPortalQ9UNS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114428. 22 interactions.
IntActQ9UNS1. 7 interactions.
STRING9606.ENSP00000229201.

PTM databases

PhosphoSiteQ9UNS1.

Polymorphism databases

DMDM296452931.

Proteomic databases

MaxQBQ9UNS1.
PaxDbQ9UNS1.
PRIDEQ9UNS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229201; ENSP00000229201; ENSG00000111602. [Q9UNS1-2]
ENST00000553532; ENSP00000450607; ENSG00000111602. [Q9UNS1-1]
GeneID8914.
KEGGhsa:8914.
UCSCuc001slf.2. human. [Q9UNS1-1]

Organism-specific databases

CTD8914.
GeneCardsGC12M056810.
H-InvDBHIX0010725.
HGNCHGNC:11813. TIMELESS.
HPAHPA060655.
MIM603887. gene.
neXtProtNX_Q9UNS1.
PharmGKBPA36520.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG328380.
HOGENOMHOG000133002.
HOVERGENHBG079258.
InParanoidQ9UNS1.
KOK03155.
OMARKGTQIV.
PhylomeDBQ9UNS1.
TreeFamTF312802.

Gene expression databases

ArrayExpressQ9UNS1.
BgeeQ9UNS1.
CleanExHS_TIMELESS.
GenevestigatorQ9UNS1.

Family and domain databases

InterProIPR006906. Timeless.
IPR007725. TIMELESS_C.
[Graphical view]
PfamPF04821. TIMELESS. 1 hit.
PF05029. TIMELESS_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8914.
NextBio33532.
PROQ9UNS1.
SOURCESearch...

Entry information

Entry nameTIM_HUMAN
AccessionPrimary (citable) accession number: Q9UNS1
Secondary accession number(s): B2ZAV0 expand/collapse secondary AC list , O94802, Q86VM1, Q8IWH3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM