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Q9UNS1

- TIM_HUMAN

UniProt

Q9UNS1 - TIM_HUMAN

Protein

Protein timeless homolog

Gene

TIMELESS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. branching morphogenesis of an epithelial tube Source: Ensembl
    2. cell cycle phase transition Source: BHF-UCL
    3. cellular response to DNA damage stimulus Source: UniProtKB
    4. circadian rhythm Source: UniProtKB
    5. detection of abiotic stimulus Source: ProtInc
    6. embryo development Source: Ensembl
    7. lung development Source: Ensembl
    8. mitotic nuclear division Source: UniProtKB-KW
    9. morphogenesis of an epithelium Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of circadian rhythm Source: UniProtKB
    13. response to abiotic stimulus Source: ProtInc
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Biological rhythms, Cell cycle, Cell division, DNA damage, Mitosis, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein timeless homolog
    Short name:
    hTIM
    Gene namesi
    Name:TIMELESSImported
    Synonyms:TIM1 Publication, TIM11 Publication, TIMELESS11 Publication
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:11813. TIMELESS.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nuclear chromatin Source: HGNC
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36520.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12081208Protein timeless homologPRO_0000072538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1149 – 11491Phosphoserine3 Publications
    Modified residuei1173 – 11731Phosphoserine5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UNS1.
    PaxDbiQ9UNS1.
    PRIDEiQ9UNS1.

    PTM databases

    PhosphoSiteiQ9UNS1.

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined including brain, heart, lung, liver, skeletal muscle, kidney, placenta, pancreas, spleen, thymus and testis. Highest levels of expression in placenta, pancreas, thymus and testis.2 Publications

    Inductioni

    Regulated by the cell cycle. High levels in S, G2 and M phases, with highest level in S phase. Low expression in G0 and G1 phases.1 Publication

    Gene expression databases

    ArrayExpressiQ9UNS1.
    BgeeiQ9UNS1.
    CleanExiHS_TIMELESS.
    GenevestigatoriQ9UNS1.

    Organism-specific databases

    HPAiHPA060655.

    Interactioni

    Subunit structurei

    Homodimer or homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2 and PER3; the interaction with PER2 is via its second PAS domain. Interacts with CRY1, CRY2, CHEK1, ATR and ATRIP. Interacts with CLSPN and TIPIN.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHEK1O147572EBI-2212315,EBI-974488

    Protein-protein interaction databases

    BioGridi114428. 22 interactions.
    IntActiQ9UNS1. 7 interactions.
    STRINGi9606.ENSP00000229201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 309309Required for homodimerization and for interaction with CRY1 and CHEK1By similarityAdd
    BLAST
    Regioni1082 – 1208127Required for nuclear localizationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi661 – 68828Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the timeless family.Curated

    Phylogenomic databases

    eggNOGiNOG328380.
    HOGENOMiHOG000133002.
    HOVERGENiHBG079258.
    InParanoidiQ9UNS1.
    KOiK03155.
    OMAiRKGTQIV.
    PhylomeDBiQ9UNS1.
    TreeFamiTF312802.

    Family and domain databases

    InterProiIPR006906. Timeless.
    IPR007725. TIMELESS_C.
    [Graphical view]
    PfamiPF04821. TIMELESS. 1 hit.
    PF05029. TIMELESS_C. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 12 Publications (identifier: Q9UNS1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD     50
    VRQQLGAAQI LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL 100
    PKEPSFRHHF LQVLTYLQAY KEAFASEKAF GVLSETLYEL LQLGWEERQE 150
    EDNLLIERIL LLVRNILHVP ADLDQEKKID DDASAHDQLL WAIHLSGLDD 200
    LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG RLAQERSADF 250
    AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG 300
    LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL 350
    ENCYNRLMGS VKDHLLREKA QQHDETYYMW ALAFFMAFNR AASFRPGLVS 400
    ETLSVRTFHF IEQNLTNYYE MMLTDRKEAA SWARRMHLAL KAYQELLATV 450
    NEMDISPDEA VRESSRIIKN NIFYVMEYRE LFLALFRKFD ERCQPRSFLR 500
    DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL DQAIVSGNVP 550
    SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM 600
    VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDISPE EEIQLLKQIL 650
    SAPLPRQQGP EERGAEEEEE EEEEEEEELQ VVQVSEKEFN FLDYLKRFAC 700
    STVVRAYVLL LRSYQQNSAH TNHCIVKMLH RLAHDLKMEA LLFQLSVFCL 750
    FNRLLSDPAA GAYKELVTFA KYILGKFFAL AAVNQKAFVE LLFWKNTAVV 800
    REMTEGYGSL DDRSSSRRAP TWSPEEEAHL RELYLANKDV EGQDVVEAIL 850
    AHLNTVPRTR KQIIHHLVQM GLADSVKDFQ RKGTHIVLWT GDQELELQRL 900
    FEEFRDSDDV LGHIMKNITA KRSRARIVDK LLALGLVAER RELYKKRQKK 950
    LASSILPNGA ESLKDFCQED LEEEENLPEE DSEEEEEGGS EAEQVQGSLV 1000
    LSNENLGQSL HQEGFSIPLL WLQNCLIRAA DDREEDGCSQ AVPLVPLTEE 1050
    NEEAMENEQF QQLLRKLGVR PPASGQETFW RIPAKLSPTQ LRRAAASLSQ 1100
    PEEEQKLQPE LQPKVPGEQG SDEEHCKEHR AQALRALLLA HKKKAGLASP 1150
    EEEDAVGKEP LKAAPKKRQL LDSDEEQEED EGRNRAPELG APGIQKKKRY 1200
    QIEDDEDD 1208
    Length:1,208
    Mass (Da):138,658
    Last modified:May 18, 2010 - v2
    Checksum:i16C6C07DDC6D2701
    GO
    Isoform 21 Publication (identifier: Q9UNS1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         177-177: Missing.

    Show »
    Length:1,207
    Mass (Da):138,530
    Checksum:iC116D7FF6F29B326
    GO

    Sequence cautioni

    The sequence AAH39842.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291A → S.1 Publication
    Corresponds to variant rs72478986 [ dbSNP | Ensembl ].
    VAR_047879
    Natural varianti429 – 4291A → D in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036435
    Natural varianti455 – 4551I → L.3 Publications
    Corresponds to variant rs774027 [ dbSNP | Ensembl ].
    VAR_021483
    Natural varianti471 – 4711N → S.1 Publication
    Corresponds to variant rs72478993 [ dbSNP | Ensembl ].
    VAR_047880
    Natural varianti831 – 8311R → Q.3 Publications
    Corresponds to variant rs774047 [ dbSNP | Ensembl ].
    VAR_021484
    Natural varianti870 – 8701M → V.1 Publication
    Corresponds to variant rs61733875 [ dbSNP | Ensembl ].
    VAR_047881
    Natural varianti922 – 9221R → H.1 Publication
    Corresponds to variant rs72478999 [ dbSNP | Ensembl ].
    VAR_047882
    Natural varianti924 – 9241R → W.1 Publication
    Corresponds to variant rs72479000 [ dbSNP | Ensembl ].
    VAR_047883
    Natural varianti1008 – 10081Q → E in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036436
    Natural varianti1017 – 10171I → T.1 Publication
    Corresponds to variant rs61376834 [ dbSNP | Ensembl ].
    VAR_047884
    Natural varianti1018 – 10181P → L.2 Publications
    Corresponds to variant rs2291739 [ dbSNP | Ensembl ].
    VAR_021485

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei177 – 1771Missing in isoform 2. 2 PublicationsVSP_051693

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015597 mRNA. Translation: BAA36499.1.
    AF098162 mRNA. Translation: AAC80011.1.
    EU627094 Genomic DNA. Translation: ACD11488.1.
    AC024884 Genomic DNA. No translation available.
    BC039842 mRNA. Translation: AAH39842.1. Sequence problems.
    BC050557 mRNA. Translation: AAH50557.1.
    CCDSiCCDS8918.1. [Q9UNS1-1]
    RefSeqiNP_003911.2. NM_003920.3. [Q9UNS1-1]
    UniGeneiHs.118631.

    Genome annotation databases

    EnsembliENST00000229201; ENSP00000229201; ENSG00000111602. [Q9UNS1-2]
    ENST00000553532; ENSP00000450607; ENSG00000111602. [Q9UNS1-1]
    GeneIDi8914.
    KEGGihsa:8914.
    UCSCiuc001slf.2. human. [Q9UNS1-1]

    Polymorphism databases

    DMDMi296452931.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015597 mRNA. Translation: BAA36499.1 .
    AF098162 mRNA. Translation: AAC80011.1 .
    EU627094 Genomic DNA. Translation: ACD11488.1 .
    AC024884 Genomic DNA. No translation available.
    BC039842 mRNA. Translation: AAH39842.1 . Sequence problems.
    BC050557 mRNA. Translation: AAH50557.1 .
    CCDSi CCDS8918.1. [Q9UNS1-1 ]
    RefSeqi NP_003911.2. NM_003920.3. [Q9UNS1-1 ]
    UniGenei Hs.118631.

    3D structure databases

    ProteinModelPortali Q9UNS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114428. 22 interactions.
    IntActi Q9UNS1. 7 interactions.
    STRINGi 9606.ENSP00000229201.

    PTM databases

    PhosphoSitei Q9UNS1.

    Polymorphism databases

    DMDMi 296452931.

    Proteomic databases

    MaxQBi Q9UNS1.
    PaxDbi Q9UNS1.
    PRIDEi Q9UNS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229201 ; ENSP00000229201 ; ENSG00000111602 . [Q9UNS1-2 ]
    ENST00000553532 ; ENSP00000450607 ; ENSG00000111602 . [Q9UNS1-1 ]
    GeneIDi 8914.
    KEGGi hsa:8914.
    UCSCi uc001slf.2. human. [Q9UNS1-1 ]

    Organism-specific databases

    CTDi 8914.
    GeneCardsi GC12M056810.
    H-InvDB HIX0010725.
    HGNCi HGNC:11813. TIMELESS.
    HPAi HPA060655.
    MIMi 603887. gene.
    neXtProti NX_Q9UNS1.
    PharmGKBi PA36520.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG328380.
    HOGENOMi HOG000133002.
    HOVERGENi HBG079258.
    InParanoidi Q9UNS1.
    KOi K03155.
    OMAi RKGTQIV.
    PhylomeDBi Q9UNS1.
    TreeFami TF312802.

    Miscellaneous databases

    GenomeRNAii 8914.
    NextBioi 33532.
    PROi Q9UNS1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UNS1.
    Bgeei Q9UNS1.
    CleanExi HS_TIMELESS.
    Genevestigatori Q9UNS1.

    Family and domain databases

    InterProi IPR006906. Timeless.
    IPR007725. TIMELESS_C.
    [Graphical view ]
    Pfami PF04821. TIMELESS. 1 hit.
    PF05029. TIMELESS_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1."
      Koike N., Hida A., Numano R., Hirose M., Sakaki Y., Tei H.
      FEBS Lett. 441:427-431(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LEU-455.
      Tissue: BrainImported.
    2. "Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-ARTNL/BMAL1-induced transcription."
      Sangoram A.M., Saez L., Antoch M.P., Gekakis N., Staknis D., Whiteley A., Fruechte E.M., Vitaterna M.H., Shimomura K., King D.P., Young M.W., Weitz C.J., Takahashi J.S.
      Neuron 21:1101-1113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, TISSUE SPECIFICITY, VARIANTS LEU-455 AND GLN-831.
      Tissue: Placenta1 Publication.
    3. NIEHS SNPs program
      Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-129; LEU-455; SER-471; GLN-831; VAL-870; HIS-922; TRP-924; THR-1017 AND LEU-1018.
    4. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-831 AND LEU-1018.
      Tissue: DuodenumImported and SkinImported.
    6. "Coupling of human circadian and cell cycles by the timeless protein."
      Uensal-Kacmaz K., Mullen T.E., Kaufmann W.K., Sancar A.
      Mol. Cell. Biol. 25:3109-3116(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATR; ATRIP; CHEK1 AND CRY2, INDUCTION.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function."
      Chou D.M., Elledge S.J.
      Proc. Natl. Acad. Sci. U.S.A. 103:18143-18147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIPIN.
    10. "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint."
      Yoshizawa-Sugata N., Masai H.
      J. Biol. Chem. 282:2729-2740(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIPIN.
    11. "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors."
      Gotter A.L., Suppa C., Emanuel B.S.
      J. Mol. Biol. 366:36-52(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CLSPN, FUNCTION.
    12. "The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement."
      Uensal-Kacmaz K., Chastain P.D., Qu P.-P., Minoo P., Cordeiro-Stone M., Sancar A., Kaufmann W.K.
      Mol. Cell. Biol. 27:3131-3142(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIPIN, FUNCTION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "The many facets of the Tim-Tipin protein families' roles in chromosome biology."
      McFarlane R.J., Mian S., Dalgaard J.Z.
      Cell Cycle 9:700-705(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Timeless makes some time for itself."
      Diaz-Martinez L.A., Clarke D.J.
      Cell Cycle 10:2254-2254(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1149 AND SER-1173, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. "Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock."
      Engelen E., Janssens R.C., Yagita K., Smits V.A., van der Horst G.T., Tamanini F.
      PLoS ONE 8:E56623-E56623(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    22. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASP-429 AND GLU-1008.

    Entry informationi

    Entry nameiTIM_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNS1
    Secondary accession number(s): B2ZAV0
    , O94802, Q86VM1, Q8IWH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3