Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Squalene epoxidase

Gene

ERG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Squalene epoxidaseImported (EC:1.14.99.7Imported)
Submitted name:
cDNA, FLJ93917, highly similar to Homo sapiens squalene epoxidase (SQLE), mRNAImported
Gene namesi
Name:ERG1Imported
Synonyms:SQLEImported
ORF Names:hCG_14874Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei63 – 81HelicalSequence analysisAdd BLAST19
Transmembranei517 – 535HelicalSequence analysisAdd BLAST19
Transmembranei547 – 566HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36108.

Expressioni

Gene expression databases

BgeeiENSG00000104549.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265896.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 548SEInterPro annotationAdd BLAST272

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1298. Eukaryota.
COG0654. LUCA.
HOVERGENiHBG005603.
KOiK00511.
OMAiQNSFYRS.
OrthoDBiEOG091G03XY.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR013698. Squalene_epoxidase.
PfamiView protein in Pfam
PF08491. SE. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UNR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN
60 70 80 90 100
GGLLGRQQSG SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK
110 120 130 140 150
GTNISETSLI GTAACTSTSS QNDPEVIIVG AGVLGSALAA VLSRDGRKVT
160 170 180 190 200
VIERDLKEPD RIVGEFLQPG GYHVLKDLGL GDTVEGLDAQ VVNGYMIHDQ
210 220 230 240 250
ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE PNAKFIEGVV
260 270 280 290 300
LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV
310 320 330 340 350
SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG
360 370 380 390 400
EMPRNLREYM VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK
410 420 430 440 450
RGVLLLGDAY NMRHPLTGGG MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA
460 470 480 490 500
KKSFYWARKT SHSFVVNILA QALYELFSAT DDSLHQLRKA CFLYFKLGGE
510 520 530 540 550
CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW ITKPRALLSS
560 570
GAVLYKACSV IFPLIYSEMK YMVH
Length:574
Mass (Da):63,923
Last modified:May 1, 2000 - v1
Checksum:i6957F5CF1F1624C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098865 mRNA. Translation: AAD10823.1.
BC017033 mRNA. Translation: AAH17033.1.
AK313384 mRNA. Translation: BAG36182.1.
CH471060 Genomic DNA. Translation: EAW92079.1.
RefSeqiNP_003120.2. NM_003129.3.
UniGeneiHs.71465.

Genome annotation databases

GeneIDi6713.
KEGGihsa:6713.
UCSCiuc011liq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098865 mRNA. Translation: AAD10823.1.
BC017033 mRNA. Translation: AAH17033.1.
AK313384 mRNA. Translation: BAG36182.1.
CH471060 Genomic DNA. Translation: EAW92079.1.
RefSeqiNP_003120.2. NM_003129.3.
UniGeneiHs.71465.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265896.

Protocols and materials databases

DNASUi6713.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6713.
KEGGihsa:6713.
UCSCiuc011liq.3. human.

Organism-specific databases

CTDi6713.
PharmGKBiPA36108.

Phylogenomic databases

eggNOGiKOG1298. Eukaryota.
COG0654. LUCA.
HOVERGENiHBG005603.
KOiK00511.
OMAiQNSFYRS.
OrthoDBiEOG091G03XY.

Miscellaneous databases

ChiTaRSiKCNH2. human.
GenomeRNAii6713.

Gene expression databases

BgeeiENSG00000104549.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR013698. Squalene_epoxidase.
PfamiView protein in Pfam
PF08491. SE. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9UNR6_HUMAN
AccessioniPrimary (citable) accession number: Q9UNR6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.