Q9UNR6 (Q9UNR6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Squalene epoxidase EMBL AAD10823.1
EC=1.14.99.7 EMBL AAD10823.1

Submitted name:
cDNA, FLJ93917, highly similar to Homo sapiens squalene epoxidase (SQLE), mRNA EMBL BAG36182.1

Gene names

Name:	ERG1 EMBL AAD10823.1
Synonyms:	SQLE EMBL AAH17033.1
ORF Names:	hCG_14874 EMBL EAW92079.1

Organism

Homo sapiens (Human) EMBL AAD10823.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL AAD10823.1
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro squalene monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9UNR6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6957F5CF1F1624C8	FASTA	574	63,923
	10 20 30 40 50 60 MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN GGLLGRQQSG 70 80 90 100 110 120 SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK GTNISETSLI GTAACTSTSS 130 140 150 160 170 180 QNDPEVIIVG AGVLGSALAA VLSRDGRKVT VIERDLKEPD RIVGEFLQPG GYHVLKDLGL 190 200 210 220 230 240 GDTVEGLDAQ VVNGYMIHDQ ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE 250 260 270 280 290 300 PNAKFIEGVV LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV 310 320 330 340 350 360 SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG EMPRNLREYM 370 380 390 400 410 420 VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK RGVLLLGDAY NMRHPLTGGG 430 440 450 460 470 480 MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA KKSFYWARKT SHSFVVNILA QALYELFSAT 490 500 510 520 530 540 DDSLHQLRKA CFLYFKLGGE CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW 550 560 570 ITKPRALLSS GAVLYKACSV IFPLIYSEMK YMVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of Human Squalene Epoxidase." Tang Y., Porter T.D. Flavins Flavoproteins 12:97-100(1997) Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAD10823.1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon EMBL AAH17033.1.
[3]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Ovary EMBL BAG36182.1.
[4]	Porter T.D., Tang Y. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAD10823.1.
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098865 mRNA. Translation: AAD10823.1. BC017033 mRNA. Translation: AAH17033.1. AK313384 mRNA. Translation: BAG36182.1. CH471060 Genomic DNA. Translation: EAW92079.1.
IPI	IPI00291544.
RefSeq	NP_003120.2. NM_003129.3.
UniGene	Hs.71465.
3D structure databases
ProteinModelPortal	Q9UNR6.
SMR	Q9UNR6. Positions 117-182.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UNR6.
Proteomic databases
PRIDE	Q9UNR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6713.
KEGG	hsa:6713.
Organism-specific databases
CTD	6713.
Phylogenomic databases
GeneTree	ENSGT00390000011759.
HOVERGEN	HBG005603.
OMA	KSFYWAR.
PhylomeDB	Q9UNR6.
Gene expression databases
ArrayExpress	Q9UNR6.
Bgee	Q9UNR6.
Family and domain databases
InterPro	IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR003042. Rng_hydrolase-like. IPR013698. Squalene_epoxidase. [Graphical view]
KO	K00511.
Pfam	PF00070. Pyr_redox. 1 hit. PF08491. SE. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...
Other
NextBio	26182.

Entry information

Entry name

Q9UNR6_HUMAN

Accession

Primary (citable) accession number: Q9UNR6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.