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Protein

ATP-binding cassette sub-family G member 2

Gene

ABCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 87ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: ProtInc
  • ATP binding Source: ProtInc
  • heme transporter activity Source: Reactome
  • protein homodimerization activity Source: BHF-UCL
  • transporter activity Source: ProtInc
  • xenobiotic-transporting ATPase activity Source: ProtInc

GO - Biological processi

  • cellular iron ion homeostasis Source: Reactome
  • response to drug Source: ProtInc
  • transport Source: ProtInc
  • urate metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118777-MONOMER.
ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-917937. Iron uptake and transport.

Protein family/group databases

TCDBi3.A.1.204.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 2
Alternative name(s):
Breast cancer resistance protein
CDw338
Mitoxantrone resistance-associated protein
Placenta-specific ATP-binding cassette transporter
Urate exporter
CD_antigen: CD338
Gene namesi
Name:ABCG2
Synonyms:ABCP, BCRP, BCRP1, MXR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:74. ABCG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 395CytoplasmicSequence analysisAdd BLAST395
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 428ExtracellularSequence analysisAdd BLAST12
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 477CytoplasmicSequence analysisAdd BLAST28
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Topological domaini499 – 506ExtracellularSequence analysis8
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Topological domaini528 – 535CytoplasmicSequence analysis8
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 630ExtracellularSequence analysisAdd BLAST74
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 655CytoplasmicSequence analysis4

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • mitochondrial membrane Source: UniProtKB-SubCell
  • nucleus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86K → M: Inactive and altered subcellular location. 1 Publication1
Mutagenesisi418N → Q: No effect. 1 Publication1
Mutagenesisi482R → D: Decreases ATPase activity. 1 Publication1
Mutagenesisi482R → G, N, S or T: Increases ATPase activity. 1 Publication1
Mutagenesisi482R → K, I, M or Y: No change in ATPase activity. 1 Publication1
Mutagenesisi482R → T or Y: Decreases transport activity. 1 Publication1
Mutagenesisi557N → Q: No effect. 1 Publication1
Mutagenesisi583H → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi596N → Q: Loss of glycosylation. 1 Publication1
Mutagenesisi603C → A: Strongly reduced binding to hemin but not to PPIX. 1 Publication1
Mutagenesisi605Y → A: No effect on hemin binding. 1 Publication1

Organism-specific databases

DisGeNETi9429.
MIMi138900. phenotype.
614490. phenotype.
OpenTargetsiENSG00000118777.
PharmGKBiPA390.

Chemistry databases

ChEMBLiCHEMBL5393.
DrugBankiDB08916. Afatinib.
DB11363. Alectinib.
DB06605. Apixaban.
DB00921. Buprenorphine.
DB06772. Cabazitaxel.
DB00958. Carboplatin.
DB00515. Cisplatin.
DB00242. Cladribine.
DB00631. Clofarabine.
DB09065. Cobicistat.
DB05239. Cobimetinib.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB00970. Dactinomycin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00470. Dronabinol.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00655. Estrone.
DB00773. Etoposide.
DB00973. Ezetimibe.
DB00544. Fluorouracil.
DB00158. Folic Acid.
DB00317. Gefitinib.
DB01016. Glyburide.
DB01094. Hesperetin.
DB00741. Hydrocortisone.
DB09054. Idelalisib.
DB00619. Imatinib.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB09078. Lenvatinib.
DB00563. Methotrexate.
DB01204. Mitoxantrone.
DB00688. Mycophenolate mofetil.
DB00220. Nelfinavir.
DB04868. Nilotinib.
DB00698. Nitrofurantoin.
DB01051. Novobiocin.
DB00338. Omeprazole.
DB09330. Osimertinib.
DB00526. Oxaliplatin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB06589. Pazopanib.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00457. Prazosin.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB08864. Rilpivirine.
DB00740. Riluzole.
DB08931. Riociguat.
DB00503. Ritonavir.
DB09291. Rolapitant.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB08934. Sofosbuvir.
DB00398. Sorafenib.
DB00795. Sulfasalazine.
DB00669. Sumatriptan.
DB01268. Sunitinib.
DB00675. Tamoxifen.
DB00966. Telmisartan.
DB00444. Teniposide.
DB08880. Teriflunomide.
DB00624. Testosterone.
DB01030. Topotecan.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB00541. Vincristine.
DB08828. Vismodegib.
DB00549. Zafirlukast.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi792.

Polymorphism and mutation databases

BioMutaiABCG2.
DMDMi67462103.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933861 – 655ATP-binding cassette sub-family G member 2Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi592 ↔ 6081 Publication
Glycosylationi596N-linked (GlcNAc...)1 Publication1
Disulfide bondi603Interchain1 Publication

Post-translational modificationi

Glycosylation-deficient ABCG2 is normally expressed and functional.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei418Not glycosylated1
Sitei557Not glycosylated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UNQ0.
PeptideAtlasiQ9UNQ0.
PRIDEiQ9UNQ0.

PTM databases

iPTMnetiQ9UNQ0.
PhosphoSitePlusiQ9UNQ0.

Expressioni

Tissue specificityi

Highly expressed in placenta. Low expression in small intestine, liver and colon.2 Publications

Inductioni

Up-regulated in brain tumors.

Gene expression databases

BgeeiENSG00000118777.
ExpressionAtlasiQ9UNQ0. baseline and differential.
GenevisibleiQ9UNQ0. HS.

Organism-specific databases

HPAiCAB037299.
HPA054719.

Interactioni

Subunit structurei

Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PIM1P11309-19EBI-1569435,EBI-1018629
UBCP0CG482EBI-1569435,EBI-3390054

GO - Molecular functioni

  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi114821. 17 interactors.
DIPiDIP-29162N.
IntActiQ9UNQ0. 19 interactors.
MINTiMINT-2840423.
STRINGi9606.ENSP00000237612.

Chemistry databases

BindingDBiQ9UNQ0.

Structurei

3D structure databases

ProteinModelPortaliQ9UNQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 286ABC transporterPROSITE-ProRule annotationAdd BLAST250
Domaini389 – 651ABC transmembrane type-2Add BLAST263

Domaini

The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.1 Publication

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IN8P. Eukaryota.
COG0842. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG050441.
InParanoidiQ9UNQ0.
KOiK05681.
OMAiVDSSFYK.
OrthoDBiEOG091G08QB.
PhylomeDBiQ9UNQ0.
TreeFamiTF105211.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS
60 70 80 90 100
GFLPCRKPVE KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS
110 120 130 140 150
GLSGDVLING APRPANFKCN SGYVVQDDVV MGTLTVRENL QFSAALRLAT
160 170 180 190 200
TMTNHEKNER INRVIQELGL DKVADSKVGT QFIRGVSGGE RKRTSIGMEL
210 220 230 240 250
ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF SIHQPRYSIF
260 270 280 290 300
KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING
310 320 330 340 350
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH
360 370 380 390 400
QLSGGEKKKK ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII
410 420 430 440 450
VTVVLGLVIG AIYFGLKNDS TGIQNRAGVL FFLTTNQCFS SVSAVELFVV
460 470 480 490 500
EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP MRMLPSIIFT CIVYFMLGLK
510 520 530 540 550
PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL MTICFVFMMI
560 570 580 590 600
FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN
610 620 630 640 650
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF

LKKYS
Length:655
Mass (Da):72,314
Last modified:May 10, 2005 - v3
Checksum:iA8AF66B96034C5A8
GO
Isoform 2 (identifier: Q9UNQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-611: IFSGLLVNLT...PCNYATCTGE → VCWSISQPLH...MQHVLAKNIW
     612-655: Missing.

Note: No experimental confirmation available.
Show »
Length:611
Mass (Da):67,453
Checksum:i9F831226192A2D39
GO

Sequence cautioni

The sequence AF093771 differs from that shown. Reason: Frameshift at positions 486 and 586.Curated
The sequence AF093772 differs from that shown. Reason: Frameshift at positions 386, 502 and 586.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → V in AAD09188 (PubMed:9850061).Curated1
Sequence conflicti24A → V in AAP44087 (PubMed:12958161).Curated1
Sequence conflicti315 – 316Missing in BAA92050 (PubMed:14702039).Curated2
Sequence conflicti390G → V in AAH92408 (PubMed:15489334).Curated1
Sequence conflicti482R → G in AF093771 (PubMed:9892175).Curated1
Sequence conflicti482R → G in AF093772 (PubMed:9892175).Curated1
Sequence conflicti482R → T in AAC97367 (PubMed:9861027).Curated1
Sequence conflicti484 – 485LP → FT in AF093772 (PubMed:9892175).Curated2
Sequence conflicti501P → A in AAG52982 (PubMed:11533706).Curated1

Polymorphismi

Genetic variations in ABCG2 define the blood group Junior system (JR) [MIMi:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait.2 Publications
Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIMi:138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed:18834626, PubMed:19506252, PubMed:20368174).3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02077912V → M Found in Jr(a-) blood group phenotype. 6 PublicationsCorresponds to variant rs2231137dbSNPEnsembl.1
Natural variantiVAR_06736313S → L.1 Publication1
Natural variantiVAR_020780141Q → K Polymorphism associated with high serum levels of uric acid and increased risk of gout; results in lower urate transport rates compared to wild-type. 8 PublicationsCorresponds to variant rs2231142dbSNPEnsembl.1
Natural variantiVAR_067364160R → Q.1 PublicationCorresponds to variant rs528655917dbSNPEnsembl.1
Natural variantiVAR_022704166Q → E.2 PublicationsCorresponds to variant rs1061017dbSNPEnsembl.1
Natural variantiVAR_022705206I → L.1 PublicationCorresponds to variant rs12721643dbSNPEnsembl.1
Natural variantiVAR_022706208F → S.2 PublicationsCorresponds to variant rs1061018dbSNPEnsembl.1
Natural variantiVAR_022707248S → P.Corresponds to variant rs3116448dbSNPEnsembl.1
Natural variantiVAR_030357296D → H.1 PublicationCorresponds to variant rs41282401dbSNPEnsembl.1
Natural variantiVAR_022443316T → P.1 Publication1
Natural variantiVAR_067365354G → R.1 PublicationCorresponds to variant rs138606116dbSNPEnsembl.1
Natural variantiVAR_018349431F → L.2 Publications1
Natural variantiVAR_067366441S → N.1 Publication1
Natural variantiVAR_018350489F → L.2 PublicationsCorresponds to variant rs192169063dbSNPEnsembl.1
Natural variantiVAR_030358528A → T.1 PublicationCorresponds to variant rs45605536dbSNPEnsembl.1
Natural variantiVAR_022708571F → I.Corresponds to variant rs9282571dbSNPEnsembl.1
Natural variantiVAR_035355590N → Y.1 PublicationCorresponds to variant rs34264773dbSNPEnsembl.1
Natural variantiVAR_022709620D → N.1 PublicationCorresponds to variant rs34783571dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014232550 – 611IFSGL…TCTGE → VCWSISQPLHLGCHGFSTSA FHDMDLRLCSIMNFWDKTSA QDSMQQETILVTMQHVLAKN IW in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_014233612 – 655Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103796 mRNA. Translation: AAD09188.1.
AF098951 mRNA. Translation: AAC97367.1.
AB056867 mRNA. Translation: BAB39212.1.
AB051855 mRNA. Translation: BAB46933.1.
AY017168 mRNA. Translation: AAG52982.1.
AY289766 mRNA. Translation: AAP44087.1.
AY288307 mRNA. Translation: AAP31310.1.
AF463519 mRNA. Translation: AAO14617.1.
AY333755 mRNA. Translation: AAQ92941.1.
AY333756 mRNA. Translation: AAQ92942.1.
AK002040 mRNA. Translation: BAA92050.1.
AK290000 mRNA. Translation: BAF82689.1.
DQ996467 Genomic DNA. Translation: ABI97388.1.
AC084732 Genomic DNA. No translation available.
AC097484 Genomic DNA. Translation: AAY40902.1.
BC021281 mRNA. Translation: AAH21281.1.
BC092408 mRNA. Translation: AAH92408.1.
AF093771 mRNA. No translation available.
AF093772 mRNA. No translation available.
CCDSiCCDS3628.1. [Q9UNQ0-1]
CCDS58910.1. [Q9UNQ0-2]
RefSeqiNP_001244315.1. NM_001257386.1. [Q9UNQ0-2]
NP_004818.2. NM_004827.2. [Q9UNQ0-1]
XP_005263411.1. XM_005263354.3. [Q9UNQ0-1]
XP_005263412.1. XM_005263355.3. [Q9UNQ0-1]
XP_011530722.1. XM_011532420.2. [Q9UNQ0-1]
XP_016864342.1. XM_017008853.1. [Q9UNQ0-1]
UniGeneiHs.480218.

Genome annotation databases

EnsembliENST00000237612; ENSP00000237612; ENSG00000118777. [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777. [Q9UNQ0-2]
GeneIDi9429.
KEGGihsa:9429.
UCSCiuc003hrg.4. human. [Q9UNQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF103796 mRNA. Translation: AAD09188.1.
AF098951 mRNA. Translation: AAC97367.1.
AB056867 mRNA. Translation: BAB39212.1.
AB051855 mRNA. Translation: BAB46933.1.
AY017168 mRNA. Translation: AAG52982.1.
AY289766 mRNA. Translation: AAP44087.1.
AY288307 mRNA. Translation: AAP31310.1.
AF463519 mRNA. Translation: AAO14617.1.
AY333755 mRNA. Translation: AAQ92941.1.
AY333756 mRNA. Translation: AAQ92942.1.
AK002040 mRNA. Translation: BAA92050.1.
AK290000 mRNA. Translation: BAF82689.1.
DQ996467 Genomic DNA. Translation: ABI97388.1.
AC084732 Genomic DNA. No translation available.
AC097484 Genomic DNA. Translation: AAY40902.1.
BC021281 mRNA. Translation: AAH21281.1.
BC092408 mRNA. Translation: AAH92408.1.
AF093771 mRNA. No translation available.
AF093772 mRNA. No translation available.
CCDSiCCDS3628.1. [Q9UNQ0-1]
CCDS58910.1. [Q9UNQ0-2]
RefSeqiNP_001244315.1. NM_001257386.1. [Q9UNQ0-2]
NP_004818.2. NM_004827.2. [Q9UNQ0-1]
XP_005263411.1. XM_005263354.3. [Q9UNQ0-1]
XP_005263412.1. XM_005263355.3. [Q9UNQ0-1]
XP_011530722.1. XM_011532420.2. [Q9UNQ0-1]
XP_016864342.1. XM_017008853.1. [Q9UNQ0-1]
UniGeneiHs.480218.

3D structure databases

ProteinModelPortaliQ9UNQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114821. 17 interactors.
DIPiDIP-29162N.
IntActiQ9UNQ0. 19 interactors.
MINTiMINT-2840423.
STRINGi9606.ENSP00000237612.

Chemistry databases

BindingDBiQ9UNQ0.
ChEMBLiCHEMBL5393.
DrugBankiDB08916. Afatinib.
DB11363. Alectinib.
DB06605. Apixaban.
DB00921. Buprenorphine.
DB06772. Cabazitaxel.
DB00958. Carboplatin.
DB00515. Cisplatin.
DB00242. Cladribine.
DB00631. Clofarabine.
DB09065. Cobicistat.
DB05239. Cobimetinib.
DB00286. Conjugated Estrogens.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB00970. Dactinomycin.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB01234. Dexamethasone.
DB00255. Diethylstilbestrol.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00470. Dronabinol.
DB00530. Erlotinib.
DB00783. Estradiol.
DB00655. Estrone.
DB00773. Etoposide.
DB00973. Ezetimibe.
DB00544. Fluorouracil.
DB00158. Folic Acid.
DB00317. Gefitinib.
DB01016. Glyburide.
DB01094. Hesperetin.
DB00741. Hydrocortisone.
DB09054. Idelalisib.
DB00619. Imatinib.
DB00762. Irinotecan.
DB00602. Ivermectin.
DB00709. Lamivudine.
DB00448. Lansoprazole.
DB01097. Leflunomide.
DB09078. Lenvatinib.
DB00563. Methotrexate.
DB01204. Mitoxantrone.
DB00688. Mycophenolate mofetil.
DB00220. Nelfinavir.
DB04868. Nilotinib.
DB00698. Nitrofurantoin.
DB01051. Novobiocin.
DB00338. Omeprazole.
DB09330. Osimertinib.
DB00526. Oxaliplatin.
DB01229. Paclitaxel.
DB00213. Pantoprazole.
DB06589. Pazopanib.
DB08860. Pitavastatin.
DB08901. Ponatinib.
DB00175. Pravastatin.
DB00457. Prazosin.
DB01129. Rabeprazole.
DB08896. Regorafenib.
DB08864. Rilpivirine.
DB00740. Riluzole.
DB08931. Riociguat.
DB00503. Ritonavir.
DB09291. Rolapitant.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB08934. Sofosbuvir.
DB00398. Sorafenib.
DB00795. Sulfasalazine.
DB00669. Sumatriptan.
DB01268. Sunitinib.
DB00675. Tamoxifen.
DB00966. Telmisartan.
DB00444. Teniposide.
DB08880. Teriflunomide.
DB00624. Testosterone.
DB01030. Topotecan.
DB05294. Vandetanib.
DB08881. Vemurafenib.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB00541. Vincristine.
DB08828. Vismodegib.
DB00549. Zafirlukast.
DB00495. Zidovudine.
GuidetoPHARMACOLOGYi792.

Protein family/group databases

TCDBi3.A.1.204.2. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ9UNQ0.
PhosphoSitePlusiQ9UNQ0.

Polymorphism and mutation databases

BioMutaiABCG2.
DMDMi67462103.

Proteomic databases

PaxDbiQ9UNQ0.
PeptideAtlasiQ9UNQ0.
PRIDEiQ9UNQ0.

Protocols and materials databases

DNASUi9429.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237612; ENSP00000237612; ENSG00000118777. [Q9UNQ0-1]
ENST00000515655; ENSP00000426917; ENSG00000118777. [Q9UNQ0-2]
GeneIDi9429.
KEGGihsa:9429.
UCSCiuc003hrg.4. human. [Q9UNQ0-1]

Organism-specific databases

CTDi9429.
DisGeNETi9429.
GeneCardsiABCG2.
HGNCiHGNC:74. ABCG2.
HPAiCAB037299.
HPA054719.
MIMi138900. phenotype.
603756. gene.
614490. phenotype.
neXtProtiNX_Q9UNQ0.
OpenTargetsiENSG00000118777.
PharmGKBiPA390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN8P. Eukaryota.
COG0842. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG050441.
InParanoidiQ9UNQ0.
KOiK05681.
OMAiVDSSFYK.
OrthoDBiEOG091G08QB.
PhylomeDBiQ9UNQ0.
TreeFamiTF105211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118777-MONOMER.
ReactomeiR-HSA-2161517. Abacavir transmembrane transport.
R-HSA-917937. Iron uptake and transport.

Miscellaneous databases

ChiTaRSiABCG2. human.
GeneWikiiABCG2.
GenomeRNAii9429.
PROiQ9UNQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118777.
ExpressionAtlasiQ9UNQ0. baseline and differential.
GenevisibleiQ9UNQ0. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCG2_HUMAN
AccessioniPrimary (citable) accession number: Q9UNQ0
Secondary accession number(s): A0A1W3
, A8K1T5, O95374, Q4W5I3, Q53ZQ1, Q569L4, Q5YLG4, Q86V64, Q8IX16, Q96LD6, Q96TA8, Q9BY73, Q9NUS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.