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Reviewed, UniProtKB/Swiss-Prot Q9UNQ0 (ABCG2_HUMAN)

Last modified June 16, 2009. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    ATP-binding cassette sub-family G member 2
Alternative name(s):
    Placenta-specific ATP-binding cassette transporter
    Breast cancer resistance protein
    Mitoxantrone resistance-associated protein
    CDw338
    CD_antigen=CD338
Gene names
Name: ABCG2
Synonyms: ABCP, BCRP, BCRP1, MXR
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. Ref.7

Subunit structure

Monomer or homodimer; disulfide-linked. Ref.17 Ref.18

Subcellular location

Cell membrane; Multi-pass membrane protein. Ref.17 Ref.15

Tissue specificity

Highly expressed in placenta. Low expression in small intestine, liver and colon. Ref.1 Ref.2

Induction

Up-regulated in brain tumors.

Post-translational modification

Glycosylation-deficient ABCG2 is normally expressed and functional.

Sequence similarities

Belongs to the ABC transporter family. ABCG (White) subfamily.

Contains 1 ABC transmembrane type-2 domain.

Contains 1 ABC transporter domain.

Sequence caution

The sequence AF093771 differs from that shown. Reason: Frameshift at positions 486 and 586.

The sequence AF093772 differs from that shown. Reason: Frameshift at positions 386, 502 and 586.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological processresponse to drug Ref.2

Traceable author statement. Source: ProtInc

transport Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintegral to membrane Ref.1

Traceable author statement. Source: ProtInc

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding Ref.1

Traceable author statement. Source: ProtInc

protein homodimerization activity

Inferred from direct assay. Source: UniProtKB

xenobiotic-transporting ATPase activity Ref.2

Traceable author statement. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PIM1P11309-17EBI-1569435,EBI-1018629

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9UNQ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9UNQ0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     550-611: IFSGLLVNLT...PCNYATCTGE → VCWSISQPLH...MQHVLAKNIW
     612-655: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 655655ATP-binding cassette sub-family G member 2
PRO_0000093386

Regions

Topological domain1 – 395395Cytoplasmic Potential
Transmembrane396 – 41621 Potential
Topological domain417 – 42812Extracellular Potential
Transmembrane429 – 44921 Potential
Topological domain450 – 47728Cytoplasmic Potential
Transmembrane478 – 49821 Potential
Topological domain499 – 5068Extracellular Potential
Transmembrane507 – 52721 Potential
Topological domain528 – 5358Cytoplasmic Potential
Transmembrane536 – 55621 Potential
Topological domain557 – 63074Extracellular Potential
Transmembrane631 – 65121 Potential
Topological domain652 – 6554Cytoplasmic Potential
Domain37 – 286250ABC transporter
Domain389 – 651263ABC transmembrane type-2
Nucleotide binding80 – 878ATP Potential

Sites

Site4181Not glycosylated
Site5571Not glycosylated

Amino acid modifications

Glycosylation5961N-linked (GlcNAc...) Ref.15
Disulfide bond592 ↔ 608 Ref.18
Disulfide bond603Interchain Ref.18

Natural variations

Alternative sequence550 – 61162IFSGL…TCTGE → VCWSISQPLHLGCHGFSTSA FHDMDLRLCSIMNFWDKTSA QDSMQQETILVTMQHVLAKN IW in isoform 2.
VSP_014232
Alternative sequence612 – 65544Missing in isoform 2.
VSP_014233
Natural variant121V → M: dbSNP rs2231137. Ref.11 Ref.19 Ref.21 Ref.22
VAR_020779
Natural variant1411Q → K Lower transport efficiency. dbSNP rs2231142. Ref.11 Ref.19 Ref.21 Ref.22 Ref.8 Ref.12
VAR_020780
Natural variant1661Q → E: dbSNP rs1061017. Ref.7 Ref.1
VAR_022704
Natural variant2061I → L Ref.21
VAR_022705
Natural variant2081F → S: dbSNP rs1061018. Ref.7 Ref.1
VAR_022706
Natural variant2481S → P: dbSNP rs3116448.
VAR_022707
Natural variant2961D → H Ref.11
VAR_030357
Natural variant3161T → P Ref.9
VAR_022443
Natural variant4311F → L Ref.20
VAR_018349
Natural variant4891F → L Ref.20
VAR_018350
Natural variant5281A → T Ref.11
VAR_030358
Natural variant5711F → I: dbSNP rs9282571.
VAR_022708
Natural variant5901N → Y Ref.21
VAR_035355
Natural variant6201D → N Ref.22
VAR_022709

Experimental info

Mutagenesis861K → M: Inactive and altered subcellular location. Ref.17
Mutagenesis4181N → Q: No effect. Ref.15
Mutagenesis4821R → D: Decreases ATPase activity. Ref.16
Mutagenesis4821R → G, N, S or T: Increases ATPase activity. Ref.16
Mutagenesis4821R → K, I, M or Y: No change in ATPase activity. Ref.16
Mutagenesis4821R → T or Y: Decreases transport activity. Ref.16
Mutagenesis5571N → Q: No effect. Ref.15
Mutagenesis5961N → Q: Loss of glycosylation. Ref.15
Sequence conflict241A → V in AAD09188. Ref.1
Sequence conflict241A → V in AAP44087. Ref.7
Sequence conflict315 – 3162Missing in BAA92050. Ref.10
Sequence conflict3901G → V in AAH92408. Ref.12
Sequence conflict4821R → G in AF093771. Ref.13
Sequence conflict4821R → G in AF093772. Ref.13
Sequence conflict4821R → T in AAC97367. Ref.2
Sequence conflict484 – 4852LP → FT in AF093772. Ref.13
Sequence conflict5011P → A in AAG52982. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 10, 2005. Version 3.
Checksum: A8AF66B96034C5A8

FASTA65572,314
        10         20         30         40         50         60 
MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS GFLPCRKPVE 

        70         80         90        100        110        120 
KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS GLSGDVLING APRPANFKCN 

       130        140        150        160        170        180 
SGYVVQDDVV MGTLTVRENL QFSAALRLAT TMTNHEKNER INRVIQELGL DKVADSKVGT 

       190        200        210        220        230        240 
QFIRGVSGGE RKRTSIGMEL ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF 

       250        260        270        280        290        300 
SIHQPRYSIF KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING 

       310        320        330        340        350        360 
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH QLSGGEKKKK 

       370        380        390        400        410        420 
ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII VTVVLGLVIG AIYFGLKNDS 

       430        440        450        460        470        480 
TGIQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP 

       490        500        510        520        530        540 
MRMLPSIIFT CIVYFMLGLK PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL 

       550        560        570        580        590        600 
MTICFVFMMI FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN 

       610        620        630        640        650 
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF LKKYS 

« Hide

Isoform 2.

Checksum: 9F831226192A2D39
Show »

FASTA61167,453

References

« Hide 'large scale' references
[1]"A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance."
Allikmets R., Schriml L.M., Hutchinson A., Romano-Spica V., Dean M.
Cancer Res. 58:5337-5339(1998) [PubMed: 9850061] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-166 AND SER-208, TISSUE SPECIFICITY.
Tissue: Placenta.
[2]"A multidrug resistance transporter from human MCF-7 breast cancer cells."
Doyle L.A., Yang W., Abruzzo L.V., Krogmann T., Gao Y., Rishi A.K., Ross D.D.
Proc. Natl. Acad. Sci. U.S.A. 95:15665-15670(1998) [PubMed: 9861027] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Mammary cancer.
[3]Erratum
Doyle L.A., Yang W., Abruzzo L.V., Krogmann T., Gao Y., Rishi A.K., Ross D.D.
Proc. Natl. Acad. Sci. U.S.A. 96:2569-2569(1999)
[4]"Breast cancer resistance protein constitutes a 140-kDa complex as a homodimer."
Kage K., Tsukahara S., Sugiyama T., Asada S., Ishikawa E., Tsuruo T., Sugimoto Y.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure."
Komatani H., Kotani H., Hara Y., Nakagawa R., Matsumoto M., Arakawa H., Nishimura S.
Cancer Res. 61:2827-2832(2001) [PubMed: 11306452] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[6]"The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."
Zhou S., Schuetz J.D., Bunting K.D., Colapietro A.M., Sampath J., Morris J.J., Lagutina I., Grosveld G.C., Osawa M., Nakauchi H., Sorrentino B.P.
Nat. Med. 7:1028-1034(2001) [PubMed: 11533706] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[7]"The expression and functional characterization of ABCG2 in brain endothelial cells and vessels."
Zhang W., Mojsilovic-Petrovic J., Andrade M.F., Zhang H., Ball M., Stanimirovic D.B.
FASEB J. 17:2085-2087(2003) [PubMed: 12958161] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANTS GLU-166 AND SER-208.
Tissue: Brain endothelium.
[8]Yoshikawa M., Yabuuchi H., Ikegami Y., Ishikawa T.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT LYS-141.
[9]"Cell line K562 resistant to Hoechst 33342."
Sudarikov A., Makarik T., Andreeff M.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-316.
[10]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hippocampus and Placenta.
[11]SeattleSNPs variation discovery resource
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-12; LYS-141; HIS-296 AND THR-528.
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-141.
Tissue: Pancreas and PNS.
[13]"Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes."
Miyake K., Mickley L., Litman T., Zhan Z., Robey R.W., Cristensen B., Brangi M., Greenberger L., Dean M., Fojo T., Bates S.E.
Cancer Res. 59:8-13(1999) [PubMed: 9892175] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-655 (ISOFORM 1).
[14]"Role of ABCG1 and other ABCG family members in lipid metabolism."
Schmitz G., Langmann T., Heimerl S.
J. Lipid Res. 42:1513-1520(2001) [PubMed: 11590207] [Abstract]
Cited for: REVIEW.
[15]"N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane."
Diop N.K., Hrycyna C.A.
Biochemistry 44:5420-5429(2005) [PubMed: 15807535] [Abstract]
Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-596, MUTAGENESIS OF ASN-418; ASN-557 AND ASN-596.
[16]"Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition."
Oezvegy-Laczka C., Koebloes G., Sarkadi B., Varadi A.
Biochim. Biophys. Acta 1668:53-63(2005) [PubMed: 15670731] [Abstract]
Cited for: MUTAGENESIS OF ARG-482.
[17]"Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2."
Henriksen U., Gether U., Litman T.
J. Cell Sci. 118:1417-1426(2005) [PubMed: 15769853] [Abstract]
Cited for: MUTAGENESIS OF LYS-86, SUBCELLULAR LOCATION, HOMODIMERIZATION.
[18]"Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein."
Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T.
J. Biol. Chem. 282:27841-27846(2007) [PubMed: 17686774] [Abstract]
Cited for: SUBUNIT, DISULFIDE BONDS.
[19]"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
Iida A., Saito S., Sekine A., Mishima C., Kitamura Y., Kondo K., Harigae S., Osawa S., Nakamura Y.
J. Hum. Genet. 47:285-310(2002) [PubMed: 12111378] [Abstract]
Cited for: VARIANTS MET-12 AND LYS-141.
[20]"Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan."
Itoda M., Saito Y., Shirao K., Minami H., Ohtsu A., Yoshida T., Saijo N., Suzuki H., Sugiyama Y., Ozawa S., Sawada J.
Drug Metab. Pharmacokinet. 18:212-217(2003) [PubMed: 15618737] [Abstract]
Cited for: VARIANTS LEU-431 AND LEU-489.
[21]"Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine."
Zamber C.P., Lamba J.K., Yasuda K., Farnum J., Thummel K., Schuetz J.D., Schuetz E.G.
Pharmacogenetics 13:19-28(2003) [PubMed: 12544509] [Abstract]
Cited for: VARIANTS MET-12; LYS-141; LEU-206 AND TYR-590.
[22]"Single nucleotide polymorphisms modify the transporter activity of ABCG2."
Morisaki K., Robey R.W., Oezvegy-Laczka C., Honjo Y., Polgar O., Steadman K., Sarkadi B., Bates S.E.
Cancer Chemother. Pharmacol. 56:161-172(2005) [PubMed: 15838659] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS MET-12; LYS-141 AND ASN-620.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

AF103796 mRNA. Translation: AAD09188.1.
AF098951 mRNA. Translation: AAC97367.1.
AB056867 mRNA. Translation: BAB39212.1.
AB051855 mRNA. Translation: BAB46933.1.
AY017168 mRNA. Translation: AAG52982.1.
AY289766 mRNA. Translation: AAP44087.1.
AY288307 mRNA. Translation: AAP31310.1.
AF463519 mRNA. Translation: AAO14617.1.
AY333755 mRNA. Translation: AAQ92941.1.
AY333756 mRNA. Translation: AAQ92942.1.
AK002040 mRNA. Translation: BAA92050.1.
AK290000 mRNA. Translation: BAF82689.1.
DQ996467 Genomic DNA. Translation: ABI97388.1.
BC021281 mRNA. Translation: AAH21281.1.
BC092408 mRNA. Translation: AAH92408.1.
AF093771 mRNA. No translation available.
AF093772 mRNA. No translation available.
IPIIPI00298214.
IPI00607625.
RefSeqNP_004818.2.
UniGeneHs.480218

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:29162N.
IntActQ9UNQ0. 2 interactions.

Protein family/group databases

TCDB3.A.1.204.3. ATP-binding cassette (ABC) superfamily.

PTM databases

PhosphoSiteQ9UNQ0.

Proteomic databases

PRIDEQ9UNQ0.

Genome annotation databases

EnsemblENSG00000118777. Homo sapiens. [Contig view]
GeneID9429.
KEGGhsa:9429.

Organism-specific databases

GeneCardsGC04M089314.
H-InvDBHIX0019250.
HGNCHGNC:74. ABCG2.
MIM603756. gene.
PharmGKBPA390.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9UNQ0.
OMAQ9UNQ0. AQIIVTV.

Enzyme and pathway databases

Pathway_Interaction_DBhif1_tfpathway. HIF-1-alpha transcription factor network.

Gene expression databases

ArrayExpressQ9UNQ0.
BgeeQ9UNQ0.
GermOnlineENSG00000118777. Homo sapiens.

Family and domain databases

InterProIPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
ProDomPD000006. ABC_transporter. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS51012. ABC_TM2. False negative.
PS00211. ABC_TRANSPORTER_1. False negative.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00619. Imatinib.
DB01204. Mitoxantrone.
DB00622. Nicardipine.
DB01054. Nitrendipine.
DB01098. Rosuvastatin.
DB01232. Saquinavir.
DB01030. Topotecan.
NextBio35322.
SOURCESearch...

Entry information

Entry nameABCG2_HUMAN
AccessionPrimary (citable) accession number: Q9UNQ0
Secondary accession number(s): A0A1W3 expand/collapse secondary AC list , A8K1T5, O95374, Q53ZQ1, Q569L4, Q5YLG4, Q86V64, Q8IX16, Q96LD6, Q96TA8, Q9BY73, Q9NUS0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 10, 2005
Last modified: June 16, 2009
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents