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Q9UNP4

- SIAT9_HUMAN

UniProt

Q9UNP4 - SIAT9_HUMAN

Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 4 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).1 Publication

    Catalytic activityi

    CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    GO - Molecular functioni

    1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB
    2. neolactotetraosylceramide alpha-2,3-sialyltransferase activity Source: ProtInc
    3. sialyltransferase activity Source: ProtInc

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. ganglioside biosynthetic process Source: UniProtKB
    3. glycosphingolipid biosynthetic process Source: ProtInc
    4. protein glycosylation Source: InterPro
    5. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.99.9. 2681.
    ReactomeiREACT_200874. Sialic acid metabolism.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
    Alternative name(s):
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    Ganglioside GM3 synthase
    ST3Gal V
    Short name:
    ST3GalV
    Sialyltransferase 9
    Gene namesi
    Name:ST3GAL5
    Synonyms:SIAT9
    ORF Names:UNQ2510/PRO5998
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:10872. ST3GAL5.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB
    2. integral component of Golgi membrane Source: InterPro
    3. integral component of membrane Source: ProtInc
    4. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Amish infantile epilepsy syndrome (AIES) [MIM:609056]: An autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Epilepsy

    Organism-specific databases

    MIMi609056. phenotype.
    Orphaneti171714. Amish infantile epilepsy syndrome.
    370938. Salt-and-pepper syndrome.
    PharmGKBiPA35773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 418418Lactosylceramide alpha-2,3-sialyltransferasePRO_0000149302Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi195 ↔ 353By similarity
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9UNP4.
    PaxDbiQ9UNP4.
    PRIDEiQ9UNP4.

    PTM databases

    PhosphoSiteiQ9UNP4.

    Expressioni

    Tissue specificityi

    Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis.

    Gene expression databases

    ArrayExpressiQ9UNP4.
    BgeeiQ9UNP4.
    CleanExiHS_ST3GAL5.
    GenevestigatoriQ9UNP4.

    Organism-specific databases

    HPAiHPA034708.
    HPA040425.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366549.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNP4.
    SMRiQ9UNP4. Positions 191-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 418336LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei62 – 8221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257001.
    HOVERGENiHBG056676.
    InParanoidiQ9UNP4.
    KOiK03370.
    OMAiFFWKQVA.
    PhylomeDBiQ9UNP4.
    TreeFamiTF352819.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UNP4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTKAAGCAE RRPLQPRTEA AAAPAGRAMP SEYTYVKLRS DCSRPSLQWY    50
    TRAQSKMRRP SLLLKDILKC TLLVFGVWIL YILKLNYTTE ECDMKKMHYV 100
    DPDHVKRAQK YAQQVLQKEC RPKFAKTSMA LLFEHRYSVD LLPFVQKAPK 150
    DSEAESKYDP PFGFRKFSSK VQTLLELLPE HDLPEHLKAK TCRRCVVIGS 200
    GGILHGLELG HTLNQFDVVI RLNSAPVEGY SEHVGNKTTI RMTYPEGAPL 250
    SDLEYYSNDL FVAVLFKSVD FNWLQAMVKK ETLPFWVRLF FWKQVAEKIP 300
    LQPKHFRILN PVIIKETAFD ILQYSEPQSR FWGRDKNVPT IGVIAVVLAT 350
    HLCDEVSLAG FGYDLNQPRT PLHYFDSQCM AAMNFQTMHN VTTETKFLLK 400
    LVKEGVVKDL SGGIDREF 418
    Length:418
    Mass (Da):47,990
    Last modified:May 20, 2008 - v4
    Checksum:iB423540B31C27A8A
    GO
    Isoform 2 (identifier: Q9UNP4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: Missing.

    Show »
    Length:390
    Mass (Da):45,099
    Checksum:i30EC0B46B4C29DBF
    GO
    Isoform 3 (identifier: Q9UNP4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: Missing.
         24-28: PAGRA → MASVP

    Show »
    Length:395
    Mass (Da):45,585
    Checksum:i961126EE86517F66
    GO

    Sequence cautioni

    The sequence AAD14634.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAF66146.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAQ89463.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA33950.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAY24147.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041H → R.3 Publications
    Corresponds to variant rs3731824 [ dbSNP | Ensembl ].
    VAR_025510

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2828Missing in isoform 2. 1 PublicationVSP_033686Add
    BLAST
    Alternative sequencei1 – 2323Missing in isoform 3. 1 PublicationVSP_033687Add
    BLAST
    Alternative sequencei24 – 285PAGRA → MASVP in isoform 3. 1 PublicationVSP_033688

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018356 mRNA. Translation: BAA33950.1. Different initiation.
    AF119415 mRNA. Translation: AAF66146.1. Different initiation.
    AY152815 mRNA. Translation: AAO16866.2.
    AF105026 mRNA. Translation: AAD14634.1. Different initiation.
    AK001340 mRNA. Translation: BAG50894.1.
    AC105053 Genomic DNA. Translation: AAY24147.1. Sequence problems.
    CH471053 Genomic DNA. Translation: EAW99475.1.
    CH471053 Genomic DNA. Translation: EAW99479.1.
    BC065936 mRNA. Translation: AAH65936.2.
    AY359105 mRNA. Translation: AAQ89463.1. Different initiation.
    CCDSiCCDS1986.2. [Q9UNP4-1]
    CCDS42705.1. [Q9UNP4-3]
    RefSeqiNP_001035902.1. NM_001042437.1. [Q9UNP4-3]
    NP_003887.3. NM_003896.3. [Q9UNP4-1]
    UniGeneiHs.415117.

    Genome annotation databases

    EnsembliENST00000377332; ENSP00000366549; ENSG00000115525. [Q9UNP4-1]
    ENST00000393805; ENSP00000377394; ENSG00000115525. [Q9UNP4-2]
    ENST00000393808; ENSP00000377397; ENSG00000115525. [Q9UNP4-3]
    GeneIDi8869.
    KEGGihsa:8869.
    UCSCiuc002sqp.1. human. [Q9UNP4-3]
    uc002sqq.1. human. [Q9UNP4-1]

    Polymorphism databases

    DMDMi189047140.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    ST3Gal V

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018356 mRNA. Translation: BAA33950.1 . Different initiation.
    AF119415 mRNA. Translation: AAF66146.1 . Different initiation.
    AY152815 mRNA. Translation: AAO16866.2 .
    AF105026 mRNA. Translation: AAD14634.1 . Different initiation.
    AK001340 mRNA. Translation: BAG50894.1 .
    AC105053 Genomic DNA. Translation: AAY24147.1 . Sequence problems.
    CH471053 Genomic DNA. Translation: EAW99475.1 .
    CH471053 Genomic DNA. Translation: EAW99479.1 .
    BC065936 mRNA. Translation: AAH65936.2 .
    AY359105 mRNA. Translation: AAQ89463.1 . Different initiation.
    CCDSi CCDS1986.2. [Q9UNP4-1 ]
    CCDS42705.1. [Q9UNP4-3 ]
    RefSeqi NP_001035902.1. NM_001042437.1. [Q9UNP4-3 ]
    NP_003887.3. NM_003896.3. [Q9UNP4-1 ]
    UniGenei Hs.415117.

    3D structure databases

    ProteinModelPortali Q9UNP4.
    SMRi Q9UNP4. Positions 191-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366549.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    PTM databases

    PhosphoSitei Q9UNP4.

    Polymorphism databases

    DMDMi 189047140.

    Proteomic databases

    MaxQBi Q9UNP4.
    PaxDbi Q9UNP4.
    PRIDEi Q9UNP4.

    Protocols and materials databases

    DNASUi 8869.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377332 ; ENSP00000366549 ; ENSG00000115525 . [Q9UNP4-1 ]
    ENST00000393805 ; ENSP00000377394 ; ENSG00000115525 . [Q9UNP4-2 ]
    ENST00000393808 ; ENSP00000377397 ; ENSG00000115525 . [Q9UNP4-3 ]
    GeneIDi 8869.
    KEGGi hsa:8869.
    UCSCi uc002sqp.1. human. [Q9UNP4-3 ]
    uc002sqq.1. human. [Q9UNP4-1 ]

    Organism-specific databases

    CTDi 8869.
    GeneCardsi GC02M086066.
    HGNCi HGNC:10872. ST3GAL5.
    HPAi HPA034708.
    HPA040425.
    MIMi 604402. gene.
    609056. phenotype.
    neXtProti NX_Q9UNP4.
    Orphaneti 171714. Amish infantile epilepsy syndrome.
    370938. Salt-and-pepper syndrome.
    PharmGKBi PA35773.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257001.
    HOVERGENi HBG056676.
    InParanoidi Q9UNP4.
    KOi K03370.
    OMAi FFWKQVA.
    PhylomeDBi Q9UNP4.
    TreeFami TF352819.

    Enzyme and pathway databases

    BRENDAi 2.4.99.9. 2681.
    Reactomei REACT_200874. Sialic acid metabolism.

    Miscellaneous databases

    GeneWikii ST3GAL5.
    GenomeRNAii 8869.
    NextBioi 33295.
    PROi Q9UNP4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UNP4.
    Bgeei Q9UNP4.
    CleanExi HS_ST3GAL5.
    Genevestigatori Q9UNP4.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase."
      Ishii A., Ohta M., Watanabe Y., Matsuda K., Ishiyama K., Sakoe K., Nakamura M., Inokuchi J., Sanai Y., Saito M.
      J. Biol. Chem. 273:31652-31655(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-104, CHARACTERIZATION.
    2. "Molecular cloning and expression of ceramide galactosyltransferases. Comparison with other glycosyltransferases."
      Kapitonov D.
      Thesis (1999), Medical College of Viriginia, United States
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-104.
      Tissue: Brain.
    3. "Molecular cloning of CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase cDNA from human fetal brain."
      Kim K.-W., Kim K.-S., Do S.-I., Kim C.-H., Lee Y.-C.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal brain.
    4. "Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein."
      Berselli P., Zava S., Sottocornola E., Milani S., Berra B., Colombo I.
      Biochim. Biophys. Acta 1759:348-358(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, GLYCOSYLATION.
      Tissue: Placenta.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-104.
      Tissue: Skin.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-418 (ISOFORM 1).
    10. Cited for: INVOLVEMENT IN AIES.

    Entry informationi

    Entry nameiSIAT9_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNP4
    Secondary accession number(s): B3KM82
    , D6W5L9, O94902, Q53QU1, Q6NZX4, Q6YFL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 121 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3