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Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • leukocyte migration Source: Reactome
  • negative regulation of coagulation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101000-MONOMER.
ReactomeiR-HSA-140875. Common Pathway of Fibrin Clot Formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:PROCR
Synonyms:EPCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9452. PROCR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 210ExtracellularSequence analysisAdd BLAST193
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 238CytoplasmicSequence analysis7

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • centrosome Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10544.
OpenTargetsiENSG00000101000.
Orphaneti64738. Non rare thrombophilia.
PharmGKBiPA33800.

Chemistry databases

DrugBankiDB00055. Drotrecogin alfa.

Polymorphism and mutation databases

DMDMi13626550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002119118 – 238Endothelial protein C receptorAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)1 Publication1
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 1861 Publication
Glycosylationi136N-linked (GlcNAc...)1 Publication1
Glycosylationi172N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UNN8.
MaxQBiQ9UNN8.
PaxDbiQ9UNN8.
PeptideAtlasiQ9UNN8.
PRIDEiQ9UNN8.

PTM databases

iPTMnetiQ9UNN8.
PhosphoSitePlusiQ9UNN8.
SwissPalmiQ9UNN8.

Expressioni

Tissue specificityi

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Gene expression databases

BgeeiENSG00000101000.
CleanExiHS_PROCR.
ExpressionAtlasiQ9UNN8. baseline and differential.
GenevisibleiQ9UNN8. HS.

Organism-specific databases

HPAiHPA039461.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
F2RP251163EBI-719705,EBI-2803960

Protein-protein interaction databases

BioGridi115797. 24 interactors.
DIPiDIP-48671N.
IntActiQ9UNN8. 4 interactors.
MINTiMINT-1418215.
STRINGi9606.ENSP00000216968.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 38Combined sources13
Beta strandi41 – 50Combined sources10
Beta strandi53 – 61Combined sources9
Beta strandi66 – 71Combined sources6
Helixi76 – 104Combined sources29
Beta strandi108 – 120Combined sources13
Beta strandi128 – 135Combined sources8
Beta strandi138 – 144Combined sources7
Turni145 – 148Combined sources4
Beta strandi149 – 153Combined sources5
Beta strandi154 – 156Combined sources3
Helixi159 – 168Combined sources10
Turni172 – 175Combined sources4
Helixi176 – 183Combined sources8
Helixi185 – 193Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8.
SMRiQ9UNN8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNN8.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ9UNN8.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ9UNN8.
TreeFamiTF335868.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UNN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL
60 70 80 90 100
GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV
110 120 130 140 150
HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW
160 170 180 190 200
QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK
210 220 230
GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC
Length:238
Mass (Da):26,671
Last modified:May 1, 2000 - v1
Checksum:iEA7F0658CD19695C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6L → P in BAA77249 (PubMed:10570964).Curated1
Sequence conflicti47N → A in BAA77249 (PubMed:10570964).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_012282219S → G.2 PublicationsCorresponds to variant rs867186dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA. Translation: AAA63647.1.
X89079 mRNA. Translation: CAA61450.1.
AF106202 Genomic DNA. Translation: AAD43967.1.
AB026584 Genomic DNA. Translation: BAA77249.2.
CR456948 mRNA. Translation: CAG33229.1.
AF375468 Genomic DNA. Translation: AAK53045.1.
AK314887 mRNA. Translation: BAG37401.1.
AL356652 Genomic DNA. Translation: CAC16283.1.
CH471077 Genomic DNA. Translation: EAW76224.1.
BC014451 mRNA. Translation: AAH14451.1.
CCDSiCCDS13248.1.
PIRiA55365.
RefSeqiNP_006395.2. NM_006404.4.
UniGeneiHs.647450.

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000.
GeneIDi10544.
KEGGihsa:10544.
UCSCiuc002xbt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA. Translation: AAA63647.1.
X89079 mRNA. Translation: CAA61450.1.
AF106202 Genomic DNA. Translation: AAD43967.1.
AB026584 Genomic DNA. Translation: BAA77249.2.
CR456948 mRNA. Translation: CAG33229.1.
AF375468 Genomic DNA. Translation: AAK53045.1.
AK314887 mRNA. Translation: BAG37401.1.
AL356652 Genomic DNA. Translation: CAC16283.1.
CH471077 Genomic DNA. Translation: EAW76224.1.
BC014451 mRNA. Translation: AAH14451.1.
CCDSiCCDS13248.1.
PIRiA55365.
RefSeqiNP_006395.2. NM_006404.4.
UniGeneiHs.647450.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8.
SMRiQ9UNN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115797. 24 interactors.
DIPiDIP-48671N.
IntActiQ9UNN8. 4 interactors.
MINTiMINT-1418215.
STRINGi9606.ENSP00000216968.

Chemistry databases

DrugBankiDB00055. Drotrecogin alfa.

PTM databases

iPTMnetiQ9UNN8.
PhosphoSitePlusiQ9UNN8.
SwissPalmiQ9UNN8.

Polymorphism and mutation databases

DMDMi13626550.

Proteomic databases

EPDiQ9UNN8.
MaxQBiQ9UNN8.
PaxDbiQ9UNN8.
PeptideAtlasiQ9UNN8.
PRIDEiQ9UNN8.

Protocols and materials databases

DNASUi10544.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000.
GeneIDi10544.
KEGGihsa:10544.
UCSCiuc002xbt.5. human.

Organism-specific databases

CTDi10544.
DisGeNETi10544.
GeneCardsiPROCR.
HGNCiHGNC:9452. PROCR.
HPAiHPA039461.
MIMi600646. gene.
neXtProtiNX_Q9UNN8.
OpenTargetsiENSG00000101000.
Orphaneti64738. Non rare thrombophilia.
PharmGKBiPA33800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ9UNN8.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ9UNN8.
TreeFamiTF335868.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101000-MONOMER.
ReactomeiR-HSA-140875. Common Pathway of Fibrin Clot Formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiQ9UNN8.
GeneWikiiEndothelial_protein_C_receptor.
GenomeRNAii10544.
PROiQ9UNN8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101000.
CleanExiHS_PROCR.
ExpressionAtlasiQ9UNN8. baseline and differential.
GenevisibleiQ9UNN8. HS.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPCR_HUMAN
AccessioniPrimary (citable) accession number: Q9UNN8
Secondary accession number(s): B2RC04
, Q14218, Q6IB56, Q96CB3, Q9ULX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.