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Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • immune response Source: InterPro
  • leukocyte migration Source: Reactome
  • negative regulation of coagulation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-HSA-140875. Common Pathway of Fibrin Clot Formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:PROCR
Synonyms:EPCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9452. PROCR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 210193ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST
Topological domaini232 – 2387CytoplasmicSequence analysis

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • centrosome Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • focal adhesion Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti64738. Non rare thrombophilia.
PharmGKBiPA33800.

Chemistry

DrugBankiDB00055. Drotrecogin alfa.

Polymorphism and mutation databases

DMDMi13626550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 238221Endothelial protein C receptorPRO_0000021191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)1 Publication
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi118 ↔ 1861 Publication
Glycosylationi136 – 1361N-linked (GlcNAc...)1 Publication
Glycosylationi172 – 1721N-linked (GlcNAc...)1 Publication

Post-translational modificationi

N-glycosylated.1 Publication
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UNN8.
MaxQBiQ9UNN8.
PaxDbiQ9UNN8.
PeptideAtlasiQ9UNN8.
PRIDEiQ9UNN8.

PTM databases

iPTMnetiQ9UNN8.
PhosphoSiteiQ9UNN8.
SwissPalmiQ9UNN8.

Expressioni

Tissue specificityi

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Gene expression databases

BgeeiENSG00000101000.
CleanExiHS_PROCR.
GenevisibleiQ9UNN8. HS.

Organism-specific databases

HPAiHPA039461.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
F2RP251163EBI-719705,EBI-2803960

Protein-protein interaction databases

BioGridi115797. 24 interactions.
DIPiDIP-48671N.
IntActiQ9UNN8. 4 interactions.
MINTiMINT-1418215.
STRINGi9606.ENSP00000216968.

Structurei

Secondary structure

1
238
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 3813Combined sources
Beta strandi41 – 5010Combined sources
Beta strandi53 – 619Combined sources
Beta strandi66 – 716Combined sources
Helixi76 – 10429Combined sources
Beta strandi108 – 12013Combined sources
Beta strandi128 – 1358Combined sources
Beta strandi138 – 1447Combined sources
Turni145 – 1484Combined sources
Beta strandi149 – 1535Combined sources
Beta strandi154 – 1563Combined sources
Helixi159 – 16810Combined sources
Turni172 – 1754Combined sources
Helixi176 – 1838Combined sources
Helixi185 – 1939Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8.
SMRiQ9UNN8. Positions 25-197.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UNN8.

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ9UNN8.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ9UNN8.
TreeFamiTF335868.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UNN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL
60 70 80 90 100
GGHLTHVLEG PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV
110 120 130 140 150
HQERTLAFPL TIRCFLGCEL PPEGSRAHVF FEVAVNGSSF VSFRPERALW
160 170 180 190 200
QADTQVTSGV VTFTLQQLNA YNRTRYELRE FLEDTCVQYV QKHISAENTK
210 220 230
GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC
Length:238
Mass (Da):26,671
Last modified:May 1, 2000 - v1
Checksum:iEA7F0658CD19695C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61L → P in BAA77249 (PubMed:10570964).Curated
Sequence conflicti47 – 471N → A in BAA77249 (PubMed:10570964).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191S → G.2 Publications
Corresponds to variant rs867186 [ dbSNP | Ensembl ].
VAR_012282

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA. Translation: AAA63647.1.
X89079 mRNA. Translation: CAA61450.1.
AF106202 Genomic DNA. Translation: AAD43967.1.
AB026584 Genomic DNA. Translation: BAA77249.2.
CR456948 mRNA. Translation: CAG33229.1.
AF375468 Genomic DNA. Translation: AAK53045.1.
AK314887 mRNA. Translation: BAG37401.1.
AL356652 Genomic DNA. Translation: CAC16283.1.
CH471077 Genomic DNA. Translation: EAW76224.1.
BC014451 mRNA. Translation: AAH14451.1.
CCDSiCCDS13248.1.
PIRiA55365.
RefSeqiNP_006395.2. NM_006404.4.
UniGeneiHs.647450.

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000.
GeneIDi10544.
KEGGihsa:10544.
UCSCiuc002xbt.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35545 mRNA. Translation: AAA63647.1.
X89079 mRNA. Translation: CAA61450.1.
AF106202 Genomic DNA. Translation: AAD43967.1.
AB026584 Genomic DNA. Translation: BAA77249.2.
CR456948 mRNA. Translation: CAG33229.1.
AF375468 Genomic DNA. Translation: AAK53045.1.
AK314887 mRNA. Translation: BAG37401.1.
AL356652 Genomic DNA. Translation: CAC16283.1.
CH471077 Genomic DNA. Translation: EAW76224.1.
BC014451 mRNA. Translation: AAH14451.1.
CCDSiCCDS13248.1.
PIRiA55365.
RefSeqiNP_006395.2. NM_006404.4.
UniGeneiHs.647450.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L8JX-ray2.00A18-210[»]
1LQVX-ray1.60A/B18-210[»]
3JTCX-ray1.60A/B18-210[»]
4V3DX-ray2.65B/D25-194[»]
4V3EX-ray2.90B25-195[»]
ProteinModelPortaliQ9UNN8.
SMRiQ9UNN8. Positions 25-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115797. 24 interactions.
DIPiDIP-48671N.
IntActiQ9UNN8. 4 interactions.
MINTiMINT-1418215.
STRINGi9606.ENSP00000216968.

Chemistry

DrugBankiDB00055. Drotrecogin alfa.

PTM databases

iPTMnetiQ9UNN8.
PhosphoSiteiQ9UNN8.
SwissPalmiQ9UNN8.

Polymorphism and mutation databases

DMDMi13626550.

Proteomic databases

EPDiQ9UNN8.
MaxQBiQ9UNN8.
PaxDbiQ9UNN8.
PeptideAtlasiQ9UNN8.
PRIDEiQ9UNN8.

Protocols and materials databases

DNASUi10544.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216968; ENSP00000216968; ENSG00000101000.
GeneIDi10544.
KEGGihsa:10544.
UCSCiuc002xbt.5. human.

Organism-specific databases

CTDi10544.
GeneCardsiPROCR.
HGNCiHGNC:9452. PROCR.
HPAiHPA039461.
MIMi600646. gene.
neXtProtiNX_Q9UNN8.
Orphaneti64738. Non rare thrombophilia.
PharmGKBiPA33800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ9UNN8.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG091G0JCK.
PhylomeDBiQ9UNN8.
TreeFamiTF335868.

Enzyme and pathway databases

ReactomeiR-HSA-140875. Common Pathway of Fibrin Clot Formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiQ9UNN8.
GeneWikiiEndothelial_protein_C_receptor.
GenomeRNAii10544.
PROiQ9UNN8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101000.
CleanExiHS_PROCR.
GenevisibleiQ9UNN8. HS.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEPCR_HUMAN
AccessioniPrimary (citable) accession number: Q9UNN8
Secondary accession number(s): B2RC04
, Q14218, Q6IB56, Q96CB3, Q9ULX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.