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Protein

TFIIA-alpha and beta-like factor

Gene

GTF2A1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription coactivator activity Source: ProtInc

GO - Biological processi

  • cognition Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription by RNA polymerase II Source: ProtInc
  • transcription initiation from RNA polymerase II promoter Source: InterPro

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ9UNN4

Names & Taxonomyi

Protein namesi
Recommended name:
TFIIA-alpha and beta-like factor
Alternative name(s):
General transcription factor II A, 1-like factor
Gene namesi
Name:GTF2A1L
Synonyms:ALF, GTF2A1LF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000242441.7
HGNCiHGNC:30727 GTF2A1L
MIMi605358 gene
neXtProtiNX_Q9UNN4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11036
OpenTargetsiENSG00000242441
PharmGKBiPA162390383

Polymorphism and mutation databases

BioMutaiGTF2A1L
DMDMi327478545

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724951 – 478TFIIA-alpha and beta-like factorAdd BLAST478

Proteomic databases

PaxDbiQ9UNN4
PeptideAtlasiQ9UNN4
PRIDEiQ9UNN4

PTM databases

iPTMnetiQ9UNN4
PhosphoSitePlusiQ9UNN4

Expressioni

Tissue specificityi

Testis specific. Detected in adult testis mostly in round and elongating spermatids (at protein level). Detected in testis.2 Publications

Inductioni

Down-regulated in Sertoli cell-only syndrome (SCOS) patients.1 Publication

Gene expression databases

BgeeiENSG00000242441
CleanExiHS_GTF2A1L
ExpressionAtlasiQ9UNN4 baseline and differential
GenevisibleiQ9UNN4 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GAB1Q134803EBI-10229384,EBI-517684

Protein-protein interaction databases

BioGridi116225, 19 interactors
IntActiQ9UNN4, 1 interactor
STRINGi9606.ENSP00000384597

Structurei

3D structure databases

ProteinModelPortaliQ9UNN4
SMRiQ9UNN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 1 family.Curated

Phylogenomic databases

eggNOGiENOG410IPCE Eukaryota
ENOG410Y126 LUCA
GeneTreeiENSGT00900000141022
HOGENOMiHOG000015236
HOVERGENiHBG052771
InParanoidiQ9UNN4
KOiK03122
OrthoDBiEOG091G0GC2
PhylomeDBiQ9UNN4
TreeFamiTF350445

Family and domain databases

CDDicd07976 TFIIA_alpha_beta_like, 2 hits
Gene3Di2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR004855 TFIIA_asu/bsu
IPR009088 TFIIA_b-brl
PfamiView protein in Pfam
PF03153 TFIIA, 1 hit
SMARTiView protein in SMART
SM01371 TFIIA, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLNPVPKL YRSVIEDVIE GVRNLFAEEG IEEQVLKDLK QLWETKVLQS
60 70 80 90 100
KATEDFFRNS IQSPLFTLQL PHSLHQTLQS STASLVIPAG RTLPSFTTAE
110 120 130 140 150
LGTSNSSANF TFPGYPIHVP AGVTLQTVSG HLYKVNVPIM VTETSGRAGI
160 170 180 190 200
LQHPIQQVFQ QLGQPSVIQT SVPQLNPWSL QATTEKSQRI ETVLQQPAIL
210 220 230 240 250
PSGPVDRKHL ENATSDILVS PGNEHKIVPE ALLCHQESSH YISLPGVVFS
260 270 280 290 300
PQVSQTNSNV ESVLSGSASM AQNLHDESLS TSPHGALHQH VTDIQLHILK
310 320 330 340 350
NRMYGCDSVK QPRNIEEPSN IPVSEKDSNS QVDLSIRVTD DDIGEIIQVD
360 370 380 390 400
GSGDTSSNEE IGSTRDADEN EFLGNIDGGD LKVPEEEADS ISNEDSATNS
410 420 430 440 450
SDNEDPQVNI VEEDPLNSGD DVSEQDVPDL FDTDNVIVCQ YDKIHRSKNK
460 470
WKFYLKDGVM CFGGRDYVFA KAIGDAEW
Length:478
Mass (Da):52,444
Last modified:April 5, 2011 - v2
Checksum:iE63E9E4DD8DF9C59
GO
Isoform 2 (identifier: Q9UNN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-41: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):48,504
Checksum:i7C858FF7AFD5344E
GO

Sequence cautioni

The sequence AAD39617 differs from that shown. Chimeric cDNA. The in vivo relevance of this transcript of the STON1 (AC Q9Y6Q2) and GTF2A1L genes creating a chimeric protein of 1182 residues is uncertain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97T → A in BAD97070 (Ref. 2) Curated1
Sequence conflicti259N → D in AAD39634 (PubMed:10364255).Curated1
Sequence conflicti259N → D in AAH64585 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0409358 – 41Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026169 mRNA Translation: AAD39617.1 Sequence problems.
AF106857 mRNA Translation: AAD39634.1
AK223350 mRNA Translation: BAD97070.1
AK302220 mRNA Translation: BAG63576.1
BC025991 mRNA Translation: AAH25991.1
BC064585 mRNA Translation: AAH64585.1
CCDSiCCDS46281.1 [Q9UNN4-1]
CCDS54359.1 [Q9UNN4-2]
RefSeqiNP_001180416.1, NM_001193487.2 [Q9UNN4-2]
NP_006863.2, NM_006872.4 [Q9UNN4-1]
UniGeneiHs.732016

Genome annotation databases

EnsembliENST00000403751; ENSP00000384597; ENSG00000242441 [Q9UNN4-1]
ENST00000430487; ENSP00000387896; ENSG00000242441 [Q9UNN4-2]
GeneIDi11036
KEGGihsa:11036
UCSCiuc002rws.4 human [Q9UNN4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTF2AY_HUMAN
AccessioniPrimary (citable) accession number: Q9UNN4
Secondary accession number(s): B4DY14, Q53FD9, Q5D050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health