Reviewed, UniProtKB/Swiss-Prot Q9UNM6 (PSD13_HUMAN)

Names and origin

Protein names

Recommended name:
    26S proteasome non-ATPase regulatory subunit 13
Alternative name(s):
    26S proteasome regulatory subunit S11
    26S proteasome regulatory subunit p40.5

Gene names

Name:

PSMD13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Subunit structure	Component of the PA700 complex.
Sequence similarities	Belongs to the proteasome subunit S11 family. Contains 1 PCI domain.

Ontologies

Keywords
Cellular component	Proteasome
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-KW proteasome regulatory particle Ref.1 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PSMC4	P43686	1	EBI-356070,EBI-743997
PSMD6	Q15008	1	EBI-356070,EBI-359701
VHL	P40337	1	EBI-356070,EBI-301246

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	26S proteasome non-ATPase regulatory subunit 13		PRO_0000173867
Regions
	Domain	239 – 335	97	PCI
Amino acid modifications
	Modified residue	106	1	Phosphoserine Ref.5
Natural variations
	Natural variant	13	1	S → N: dbSNP rs1045288. Ref.1		VAR_024591
	Natural variant	150	1	S → L: dbSNP rs28927679.		VAR_057050
	Natural variant	204	1	G → E: dbSNP rs1794108.		VAR_031094
	Natural variant	205	1	L → F: dbSNP rs1794109.		VAR_031095
Experimental info
	Sequence conflict	253	1	T → I in AAC64104. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UNM6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 069F965890AC9DD9	FASTA	376	42,918
	10 20 30 40 50 60 MKDVPGFLQQ SQSSGPGQPA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF AQGDGLIKLY 70 80 90 100 110 120 ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT REKVKSSDEA VILCKTAIGA 130 140 150 160 170 180 LKLNIGDLQV TKETIEDVEE MLNNLPGVTS VHSRFYDLSS KYYQTIGNHA SYYKDALRFL 190 200 210 220 230 240 GCVDIKDLPV SEQQERAFTL GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF 250 260 270 280 290 300 NSGNVERFQT LKTAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA 310 320 330 340 350 360 KITVNEVELL VMKALSVGLV KGSIDEVDKR VHMTWVQPRV LDLQQIKGMK DRLEFWCTDV 370 KSMEMLVEHQ AHDILT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome." Hori T., Kato S., Saeki M., DeMartino G.N., Slaughter C.A., Takeuchi J., Toh-e A., Tanaka K. Gene 216:113-122(1998) [PubMed: 9714768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-13.
[2]	"Cloning of the human 26S proteasome subunit p40.5." Ting M.C., Chang L.Y. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[3]	"Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome." Hoffman L., Gorbea C., Rechsteiner M. FEBS Lett. 449:88-92(1999) [PubMed: 10225435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Lung.
[5]	"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB009398 mRNA. Translation: BAA33214.1. AF107837 mRNA. Translation: AAD43442.1. AF086708 mRNA. Translation: AAC64104.1. BC001100 mRNA. Translation: AAH01100.1. BC001747 mRNA. Translation: AAH01747.1.
IPI	IPI00549672.
RefSeq	NP_002808.3.
UniGene	Hs.134688
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:27576N.
IntAct	Q9UNM6. 12 interactions.
PTM databases
PhosphoSite	Q9UNM6.
Proteomic databases
PRIDE	Q9UNM6.
Genome annotation databases
Ensembl	ENSG00000185627. Homo sapiens. [Contig view]
GeneID	5719.
KEGG	hsa:5719.
Organism-specific databases
GeneCards	GC11P000226.
H-InvDB	HIX0009340.
HGNC	HGNC:9558. PSMD13.
MIM	603481. gene.
PharmGKB	PA33904.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9UNM6.
Enzyme and pathway databases
Reactome	REACT_11045. Signaling by Wnt. REACT_13. Metabolism of amino acids. REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.
Gene expression databases
ArrayExpress	Q9UNM6.
Bgee	Q9UNM6.
CleanEx	HS_PSMD13.
GermOnline	ENSG00000185627. Homo sapiens.
Family and domain databases
InterPro	IPR000717. PCI. [Graphical view]
Pfam	PF01399. PCI. 1 hit. [Graphical view]
SMART	SM00088. PINT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	22226.
SOURCE	Search...

Entry information

Entry name

PSD13_HUMAN

Accession

Primary (citable) accession number: Q9UNM6
Secondary accession number(s): O75831, Q9UNV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2002
Last sequence update:	May 1, 2000
Last modified:	May 26, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)