Reviewed,
UniProtKB/Swiss-Prot Q9UNM6 (PSD13_HUMAN)
Last modified
May 26, 2009.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 26S proteasome non-ATPase regulatory subunit 13 Alternative name(s): 26S proteasome regulatory subunit S11 26S proteasome regulatory subunit p40.5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 376 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. |
| Subunit structure | Component of the PA700 complex. |
| Sequence similarities | Belongs to the proteasome subunit S11 family. Contains 1 PCI domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Proteasome |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleInferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleInferred from Experiment. Source: Reactome |
| Cellular component | cytosol Inferred from electronic annotation. Source: UniProtKB-KW proteasome regulatory particle Ref.1Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| PSMC4 | P43686 | 1 | EBI-356070,EBI-743997 | |
| PSMD6 | Q15008 | 1 | EBI-356070,EBI-359701 | |
| VHL | P40337 | 1 | EBI-356070,EBI-301246 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 376 | 376 | 26S proteasome non-ATPase regulatory subunit 13 | PRO_0000173867 | |||||
Regions | |||||||||
| Domain | 239 – 335 | 97 | PCI | ||||||
Amino acid modifications | |||||||||
| Modified residue | 106 | 1 | Phosphoserine Ref.5 | ||||||
Natural variations | |||||||||
| Natural variant | 13 | 1 | S → N: dbSNP rs1045288. Ref.1 | VAR_024591 | |||||
| Natural variant | 150 | 1 | S → L: dbSNP rs28927679. | VAR_057050 | |||||
| Natural variant | 204 | 1 | G → E: dbSNP rs1794108. | VAR_031094 | |||||
| Natural variant | 205 | 1 | L → F: dbSNP rs1794109. | VAR_031095 | |||||
Experimental info | |||||||||
| Sequence conflict | 253 | 1 | T → I in AAC64104. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome." Hori T., Kato S., Saeki M., DeMartino G.N., Slaughter C.A., Takeuchi J., Toh-e A., Tanaka K. Gene 216:113-122(1998) [PubMed: 9714768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-13. |
| [2] | "Cloning of the human 26S proteasome subunit p40.5." Ting M.C., Chang L.Y. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
| [3] | "Identification, molecular cloning, and characterization of subunit 11 of the human 26S proteasome." Hoffman L., Gorbea C., Rechsteiner M. FEBS Lett. 449:88-92(1999) [PubMed: 10225435] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Lung. |
| [5] | "Mass spectrometric characterization of the affinity-purified human 26S proteasome complex." Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L. Biochemistry 46:3553-3565(2007) [PubMed: 17323924] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, MASS SPECTROMETRY. |
| [6] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AB009398 mRNA. Translation: BAA33214.1. AF107837 mRNA. Translation: AAD43442.1. AF086708 mRNA. Translation: AAC64104.1. BC001100 mRNA. Translation: AAH01100.1. BC001747 mRNA. Translation: AAH01747.1. | |
| IPI | IPI00549672. |
| RefSeq | NP_002808.3. |
| UniGene | Hs.134688 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:27576N. |
| IntAct | Q9UNM6. 12 interactions. |
PTM databases | |
| PhosphoSite | Q9UNM6. |
Proteomic databases | |
| PRIDE | Q9UNM6. |
Genome annotation databases | |
| Ensembl | ENSG00000185627. Homo sapiens. [Contig view] |
| GeneID | 5719. |
| KEGG | hsa:5719. |
Organism-specific databases | |
| GeneCards | GC11P000226. |
| H-InvDB | HIX0009340. |
| HGNC | HGNC:9558. PSMD13. |
| MIM | 603481. gene. |
| PharmGKB | PA33904. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9UNM6. |
Enzyme and pathway databases | |
| Reactome | REACT_11045. Signaling by Wnt. REACT_13. Metabolism of amino acids. REACT_13635. Regulation of activated PAK-2p34 by proteasome mediated degradation. REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_383. DNA Replication. REACT_578. Apoptosis. REACT_6185. HIV Infection. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2. |
Gene expression databases | |
| ArrayExpress | Q9UNM6. |
| Bgee | Q9UNM6. |
| CleanEx | HS_PSMD13. |
| GermOnline | ENSG00000185627. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000717. PCI. [Graphical view] |
| Pfam | PF01399. PCI. 1 hit. [Graphical view] |
| SMART | SM00088. PINT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 22226. |
| SOURCE | Search... |
Entry information
| Entry name | PSD13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UNM6 Secondary accession number(s): O75831, Q9UNV3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


