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Protein

Translocon-associated protein subunit gamma

Gene

SSR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit gamma
Short name:
TRAP-gamma
Alternative name(s):
Signal sequence receptor subunit gamma
Short name:
SSR-gamma
Gene namesi
Name:SSR3
Synonyms:TRAPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11325. SSR3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727LumenalSequence analysisAdd
BLAST
Transmembranei28 – 4821HelicalSequence analysisAdd
BLAST
Topological domaini49 – 546CytoplasmicSequence analysis
Transmembranei55 – 7622HelicalSequence analysisAdd
BLAST
Topological domaini77 – 13559LumenalSequence analysisAdd
BLAST
Transmembranei136 – 15722HelicalSequence analysisAdd
BLAST
Topological domaini158 – 1636CytoplasmicSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36149.

Polymorphism and mutation databases

BioMutaiSSR3.
DMDMi9087205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Translocon-associated protein subunit gammaPRO_0000191690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei11 – 111PhosphoserineCombined sources
Modified residuei105 – 1051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNL2.
MaxQBiQ9UNL2.
PaxDbiQ9UNL2.
PeptideAtlasiQ9UNL2.
PRIDEiQ9UNL2.
TopDownProteomicsiQ9UNL2-1. [Q9UNL2-1]

PTM databases

iPTMnetiQ9UNL2.
PhosphoSiteiQ9UNL2.
SwissPalmiQ9UNL2.

Expressioni

Gene expression databases

BgeeiENSG00000114850.
CleanExiHS_SSR3.
ExpressionAtlasiQ9UNL2. baseline and differential.
GenevisibleiQ9UNL2. HS.

Organism-specific databases

HPAiHPA014906.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

BioGridi112625. 61 interactions.
IntActiQ9UNL2. 14 interactions.
MINTiMINT-1032208.
STRINGi9606.ENSP00000265044.

Structurei

3D structure databases

ProteinModelPortaliQ9UNL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4490. Eukaryota.
ENOG410XR1X. LUCA.
GeneTreeiENSGT00390000000970.
HOGENOMiHOG000007534.
HOVERGENiHBG012424.
InParanoidiQ9UNL2.
KOiK13251.
OMAiKHKIAVK.
OrthoDBiEOG091G0QS4.
PhylomeDBiQ9UNL2.
TreeFamiTF314998.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKGSSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI
60 70 80 90 100
WHMDLIQSAV LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV
110 120 130 140 150
TRKLSEADNR KMSRKEKDER ILWKKNEVAD YEATTFSIFY NNTLFLVVVI
160 170 180
VASFFILKNF NPTVNYILSI SASSGLIALL STGSK
Length:185
Mass (Da):21,080
Last modified:May 1, 2000 - v1
Checksum:iDEE0B14BF524F62A
GO
Isoform 2 (identifier: Q9UNL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-120: R → RFDSCLKYGHHKRG

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,610
Checksum:iC66D0F4D32D36719
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 1201R → RFDSCLKYGHHKRG in isoform 2. 1 PublicationVSP_056195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087907 mRNA. Translation: AAP97205.1.
AF110647 mRNA. Translation: AAD48587.1.
BT006669 mRNA. Translation: AAP35315.1.
AK304364 mRNA. Translation: BAG65204.1.
AK312935 mRNA. Translation: BAG35777.1.
AC092927 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78730.1.
CH471052 Genomic DNA. Translation: EAW78731.1.
BC017203 mRNA. Translation: AAH17203.1.
CCDSiCCDS3176.1. [Q9UNL2-1]
CCDS77846.1. [Q9UNL2-2]
RefSeqiNP_001295126.1. NM_001308197.1. [Q9UNL2-2]
NP_001295133.1. NM_001308204.1.
NP_001295134.1. NM_001308205.1.
NP_009038.1. NM_007107.4. [Q9UNL2-1]
UniGeneiHs.518346.
Hs.660787.

Genome annotation databases

EnsembliENST00000265044; ENSP00000265044; ENSG00000114850. [Q9UNL2-1]
ENST00000467789; ENSP00000420641; ENSG00000114850. [Q9UNL2-2]
GeneIDi6747.
KEGGihsa:6747.
UCSCiuc003fau.3. human. [Q9UNL2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087907 mRNA. Translation: AAP97205.1.
AF110647 mRNA. Translation: AAD48587.1.
BT006669 mRNA. Translation: AAP35315.1.
AK304364 mRNA. Translation: BAG65204.1.
AK312935 mRNA. Translation: BAG35777.1.
AC092927 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78730.1.
CH471052 Genomic DNA. Translation: EAW78731.1.
BC017203 mRNA. Translation: AAH17203.1.
CCDSiCCDS3176.1. [Q9UNL2-1]
CCDS77846.1. [Q9UNL2-2]
RefSeqiNP_001295126.1. NM_001308197.1. [Q9UNL2-2]
NP_001295133.1. NM_001308204.1.
NP_001295134.1. NM_001308205.1.
NP_009038.1. NM_007107.4. [Q9UNL2-1]
UniGeneiHs.518346.
Hs.660787.

3D structure databases

ProteinModelPortaliQ9UNL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112625. 61 interactions.
IntActiQ9UNL2. 14 interactions.
MINTiMINT-1032208.
STRINGi9606.ENSP00000265044.

PTM databases

iPTMnetiQ9UNL2.
PhosphoSiteiQ9UNL2.
SwissPalmiQ9UNL2.

Polymorphism and mutation databases

BioMutaiSSR3.
DMDMi9087205.

Proteomic databases

EPDiQ9UNL2.
MaxQBiQ9UNL2.
PaxDbiQ9UNL2.
PeptideAtlasiQ9UNL2.
PRIDEiQ9UNL2.
TopDownProteomicsiQ9UNL2-1. [Q9UNL2-1]

Protocols and materials databases

DNASUi6747.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265044; ENSP00000265044; ENSG00000114850. [Q9UNL2-1]
ENST00000467789; ENSP00000420641; ENSG00000114850. [Q9UNL2-2]
GeneIDi6747.
KEGGihsa:6747.
UCSCiuc003fau.3. human. [Q9UNL2-1]

Organism-specific databases

CTDi6747.
GeneCardsiSSR3.
HGNCiHGNC:11325. SSR3.
HPAiHPA014906.
MIMi606213. gene.
neXtProtiNX_Q9UNL2.
PharmGKBiPA36149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4490. Eukaryota.
ENOG410XR1X. LUCA.
GeneTreeiENSGT00390000000970.
HOGENOMiHOG000007534.
HOVERGENiHBG012424.
InParanoidiQ9UNL2.
KOiK13251.
OMAiKHKIAVK.
OrthoDBiEOG091G0QS4.
PhylomeDBiQ9UNL2.
TreeFamiTF314998.

Enzyme and pathway databases

ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.

Miscellaneous databases

ChiTaRSiSSR3. human.
GenomeRNAii6747.
PROiQ9UNL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114850.
CleanExiHS_SSR3.
ExpressionAtlasiQ9UNL2. baseline and differential.
GenevisibleiQ9UNL2. HS.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRG_HUMAN
AccessioniPrimary (citable) accession number: Q9UNL2
Secondary accession number(s): B2R7D0
, B4E2P2, D3DNK5, Q549M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.