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Protein

Protein angel homolog 1

Gene

ANGEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013523-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein angel homolog 1
Gene namesi
Name:ANGEL1
Synonyms:KIAA0759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19961. ANGEL1.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: AgBase
  • cytosol Source: AgBase
  • endoplasmic reticulum Source: AgBase
  • nucleus Source: AgBase
  • perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi23357.
OpenTargetsiENSG00000013523.
PharmGKBiPA134982299.

Polymorphism and mutation databases

BioMutaiANGEL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185811 – 670Protein angel homolog 1Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNK9.
MaxQBiQ9UNK9.
PaxDbiQ9UNK9.
PeptideAtlasiQ9UNK9.
PRIDEiQ9UNK9.

PTM databases

iPTMnetiQ9UNK9.
PhosphoSitePlusiQ9UNK9.

Expressioni

Gene expression databases

BgeeiENSG00000013523.
CleanExiHS_ANGEL1.
ExpressionAtlasiQ9UNK9. baseline and differential.
GenevisibleiQ9UNK9. HS.

Organism-specific databases

HPAiHPA000948.

Interactioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase

Protein-protein interaction databases

BioGridi116938. 10 interactors.
STRINGi9606.ENSP00000251089.

Structurei

3D structure databases

ProteinModelPortaliQ9UNK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiKOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ9UNK9.
KOiK18729.
OMAiEGPMWAA.
OrthoDBiEOG091G0BJF.
PhylomeDBiQ9UNK9.
TreeFamiTF316126.

Family and domain databases

Gene3Di3.60.10.10. 3 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UNK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR
60 70 80 90 100
GPEQEECEGL LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE
110 120 130 140 150
ENAASEDRWS SRQLSDLRAA ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI
160 170 180 190 200
PMQSEPQYAD CAALPVGALA TEQWEEDPAV LAWSIAPEPV PQEEASIWPF
210 220 230 240 250
EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG PQFQFTLMSY
260 270 280 290 300
NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ
310 320 330 340 350
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE
360 370 380 390 400
YFRPGLELLN RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG
410 420 430 440 450
DVKLAQMAIL LAEVDKVARL SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE
460 470 480 490 500
LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL WPSSLGITDC CQYVTSCHPK
510 520 530 540 550
RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE RPAGWAESVL
560 570 580 590 600
EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT
610 620 630 640 650
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP
660 670
FCSSDHLCLL ASFGMEVTAP
Length:670
Mass (Da):75,276
Last modified:May 1, 2000 - v1
Checksum:i3D40E26813E27D83
GO

Sequence cautioni

The sequence BAA34479 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG63079 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti415D → G in AAH28714 (PubMed:15489334).Curated1
Sequence conflicti441P → T in BAG63079 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056239141G → W.Corresponds to variant rs34270005dbSNPEnsembl.1
Natural variantiVAR_061374383V → L.Corresponds to variant rs45499197dbSNPEnsembl.1
Natural variantiVAR_056240515F → C.Corresponds to variant rs2075773dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018302 mRNA. Translation: BAA34479.1. Different initiation.
AL137268 mRNA. Translation: CAB70667.2.
AF111169 Genomic DNA. Translation: AAD44362.1.
BC028714 mRNA. Translation: AAH28714.1.
AK301589 mRNA. Translation: BAG63079.1. Different initiation.
CCDSiCCDS9852.1.
RefSeqiNP_056120.2. NM_015305.3.
UniGeneiHs.497448.

Genome annotation databases

EnsembliENST00000251089; ENSP00000251089; ENSG00000013523.
GeneIDi23357.
KEGGihsa:23357.
UCSCiuc001xsv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018302 mRNA. Translation: BAA34479.1. Different initiation.
AL137268 mRNA. Translation: CAB70667.2.
AF111169 Genomic DNA. Translation: AAD44362.1.
BC028714 mRNA. Translation: AAH28714.1.
AK301589 mRNA. Translation: BAG63079.1. Different initiation.
CCDSiCCDS9852.1.
RefSeqiNP_056120.2. NM_015305.3.
UniGeneiHs.497448.

3D structure databases

ProteinModelPortaliQ9UNK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116938. 10 interactors.
STRINGi9606.ENSP00000251089.

PTM databases

iPTMnetiQ9UNK9.
PhosphoSitePlusiQ9UNK9.

Polymorphism and mutation databases

BioMutaiANGEL1.

Proteomic databases

EPDiQ9UNK9.
MaxQBiQ9UNK9.
PaxDbiQ9UNK9.
PeptideAtlasiQ9UNK9.
PRIDEiQ9UNK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251089; ENSP00000251089; ENSG00000013523.
GeneIDi23357.
KEGGihsa:23357.
UCSCiuc001xsv.4. human.

Organism-specific databases

CTDi23357.
DisGeNETi23357.
GeneCardsiANGEL1.
HGNCiHGNC:19961. ANGEL1.
HPAiHPA000948.
neXtProtiNX_Q9UNK9.
OpenTargetsiENSG00000013523.
PharmGKBiPA134982299.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ9UNK9.
KOiK18729.
OMAiEGPMWAA.
OrthoDBiEOG091G0BJF.
PhylomeDBiQ9UNK9.
TreeFamiTF316126.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013523-MONOMER.

Miscellaneous databases

GenomeRNAii23357.
PROiQ9UNK9.

Gene expression databases

BgeeiENSG00000013523.
CleanExiHS_ANGEL1.
ExpressionAtlasiQ9UNK9. baseline and differential.
GenevisibleiQ9UNK9. HS.

Family and domain databases

Gene3Di3.60.10.10. 3 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiANGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK9
Secondary accession number(s): B4DWL7, O94859, Q8NCS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.