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Reviewed, UniProtKB/Swiss-Prot Q9UNK9 (ANGE1_HUMAN)

Last modified December 15, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein angel homolog 1
Gene names
Name: ANGEL1
Synonyms: KIAA0759
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the CCR4/nocturin family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Protein angel homolog 1
PRO_0000218581

Amino acid modifications

Modified residue3471Phosphoserine Ref.6
Modified residue3511Phosphotyrosine Ref.6

Natural variations

Natural variant1411G → W: dbSNP rs34270005.
VAR_056239
Natural variant3831V → L: dbSNP rs45499197.
VAR_061374
Natural variant5151F → C: dbSNP rs2075773.
VAR_056240

Experimental info

Sequence conflict4151D → G in AAH28714. Ref.4
Sequence conflict4411P → T in BAG63079. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9UNK9-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 3D40E26813E27D83

FASTA67075,276
        10         20         30         40         50         60 
MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR GPEQEECEGL 

        70         80         90        100        110        120 
LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE ENAASEDRWS SRQLSDLRAA 

       130        140        150        160        170        180 
ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI PMQSEPQYAD CAALPVGALA TEQWEEDPAV 

       190        200        210        220        230        240 
LAWSIAPEPV PQEEASIWPF EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG 

       250        260        270        280        290        300 
PQFQFTLMSY NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ 

       310        320        330        340        350        360 
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE YFRPGLELLN 

       370        380        390        400        410        420 
RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG DVKLAQMAIL LAEVDKVARL 

       430        440        450        460        470        480 
SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL 

       490        500        510        520        530        540 
WPSSLGITDC CQYVTSCHPK RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE 

       550        560        570        580        590        600 
RPAGWAESVL EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT 

       610        620        630        640        650        660 
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP FCSSDHLCLL 

       670 
ASFGMEVTAP 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed: 12508121] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-670.
Tissue: Mammary tumor.
[6]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND TYR-351, MASS SPECTROMETRY.
Tissue: Epithelium.

Cross-references

Sequence databases

AB018302 mRNA. Translation: BAA34479.1. Different initiation.
AL137268 mRNA. Translation: CAB70667.2.
AF111169 Genomic DNA. Translation: AAD44362.1.
BC028714 mRNA. Translation: AAH28714.1.
AK301589 mRNA. Translation: BAG63079.1. Different initiation.
IPIIPI00298147.
RefSeqNP_056120.2.
UniGeneHs.497448

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9UNK9.

PTM databases

PhosphoSiteQ9UNK9.

Proteomic databases

PRIDEQ9UNK9.

Genome annotation databases

EnsemblENST00000251089; ENSP00000251089; ENSG00000013523; Homo sapiens. [Genome view]
GeneID23357.
KEGGhsa:23357.
UCSCuc001xsv.1. human.

Organism-specific databases

CTD23357.
GeneCardsGC14M076324.
H-InvDBHIX0011837.
HGNCHGNC:19961. ANGEL1.
HPAHPA000948.
PharmGKBPA134982299.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG444702.
HOVERGENQ9UNK9.
InParanoidQ9UNK9.
OMAPYHEILW.
OrthoDBEOG9P2SMQ.

Gene expression databases

ArrayExpressQ9UNK9.
BgeeQ9UNK9.
CleanExHS_ANGEL1.
GenevestigatorQ9UNK9.
GermOnlineENSG00000013523. Homo sapiens.

Family and domain databases

InterProIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameANGE1_HUMAN
AccessionPrimary (citable) accession number: Q9UNK9
Secondary accession number(s): B4DWL7, O94859, Q8NCS9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: December 15, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents