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Protein

Protein angel homolog 1

Gene

ANGEL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein angel homolog 1
Gene namesi
Name:ANGEL1
Synonyms:KIAA0759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19961. ANGEL1.

Subcellular locationi

GO - Cellular componenti

  • cis-Golgi network Source: AgBase
  • cytosol Source: AgBase
  • endoplasmic reticulum Source: AgBase
  • nucleus Source: AgBase
  • perinuclear region of cytoplasm Source: AgBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982299.

Polymorphism and mutation databases

BioMutaiANGEL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Protein angel homolog 1PRO_0000218581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771PhosphoserineBy similarity
Modified residuei105 – 1051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UNK9.
MaxQBiQ9UNK9.
PaxDbiQ9UNK9.
PeptideAtlasiQ9UNK9.
PRIDEiQ9UNK9.

PTM databases

iPTMnetiQ9UNK9.
PhosphoSiteiQ9UNK9.

Expressioni

Gene expression databases

BgeeiQ9UNK9.
CleanExiHS_ANGEL1.
ExpressionAtlasiQ9UNK9. baseline and differential.
GenevisibleiQ9UNK9. HS.

Organism-specific databases

HPAiHPA000948.

Interactioni

GO - Molecular functioni

  • eukaryotic initiation factor 4E binding Source: AgBase
  • protein domain specific binding Source: AgBase

Protein-protein interaction databases

BioGridi116938. 10 interactions.
STRINGi9606.ENSP00000251089.

Structurei

3D structure databases

ProteinModelPortaliQ9UNK9.
SMRiQ9UNK9. Positions 235-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CCR4/nocturin family.Curated

Phylogenomic databases

eggNOGiKOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ9UNK9.
KOiK18729.
OMAiEGPMWAA.
OrthoDBiEOG74FF2D.
PhylomeDBiQ9UNK9.
TreeFamiTF316126.

Family and domain databases

Gene3Di3.60.10.10. 3 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9UNK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR
60 70 80 90 100
GPEQEECEGL LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE
110 120 130 140 150
ENAASEDRWS SRQLSDLRAA ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI
160 170 180 190 200
PMQSEPQYAD CAALPVGALA TEQWEEDPAV LAWSIAPEPV PQEEASIWPF
210 220 230 240 250
EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG PQFQFTLMSY
260 270 280 290 300
NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ
310 320 330 340 350
EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE
360 370 380 390 400
YFRPGLELLN RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG
410 420 430 440 450
DVKLAQMAIL LAEVDKVARL SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE
460 470 480 490 500
LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL WPSSLGITDC CQYVTSCHPK
510 520 530 540 550
RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE RPAGWAESVL
560 570 580 590 600
EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT
610 620 630 640 650
VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP
660 670
FCSSDHLCLL ASFGMEVTAP
Length:670
Mass (Da):75,276
Last modified:May 1, 2000 - v1
Checksum:i3D40E26813E27D83
GO

Sequence cautioni

The sequence BAA34479.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG63079.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti415 – 4151D → G in AAH28714 (PubMed:15489334).Curated
Sequence conflicti441 – 4411P → T in BAG63079 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti141 – 1411G → W.
Corresponds to variant rs34270005 [ dbSNP | Ensembl ].
VAR_056239
Natural varianti383 – 3831V → L.
Corresponds to variant rs45499197 [ dbSNP | Ensembl ].
VAR_061374
Natural varianti515 – 5151F → C.
Corresponds to variant rs2075773 [ dbSNP | Ensembl ].
VAR_056240

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018302 mRNA. Translation: BAA34479.1. Different initiation.
AL137268 mRNA. Translation: CAB70667.2.
AF111169 Genomic DNA. Translation: AAD44362.1.
BC028714 mRNA. Translation: AAH28714.1.
AK301589 mRNA. Translation: BAG63079.1. Different initiation.
CCDSiCCDS9852.1.
RefSeqiNP_056120.2. NM_015305.3.
UniGeneiHs.497448.

Genome annotation databases

EnsembliENST00000251089; ENSP00000251089; ENSG00000013523.
GeneIDi23357.
KEGGihsa:23357.
UCSCiuc001xsv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018302 mRNA. Translation: BAA34479.1. Different initiation.
AL137268 mRNA. Translation: CAB70667.2.
AF111169 Genomic DNA. Translation: AAD44362.1.
BC028714 mRNA. Translation: AAH28714.1.
AK301589 mRNA. Translation: BAG63079.1. Different initiation.
CCDSiCCDS9852.1.
RefSeqiNP_056120.2. NM_015305.3.
UniGeneiHs.497448.

3D structure databases

ProteinModelPortaliQ9UNK9.
SMRiQ9UNK9. Positions 235-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116938. 10 interactions.
STRINGi9606.ENSP00000251089.

PTM databases

iPTMnetiQ9UNK9.
PhosphoSiteiQ9UNK9.

Polymorphism and mutation databases

BioMutaiANGEL1.

Proteomic databases

EPDiQ9UNK9.
MaxQBiQ9UNK9.
PaxDbiQ9UNK9.
PeptideAtlasiQ9UNK9.
PRIDEiQ9UNK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251089; ENSP00000251089; ENSG00000013523.
GeneIDi23357.
KEGGihsa:23357.
UCSCiuc001xsv.4. human.

Organism-specific databases

CTDi23357.
GeneCardsiANGEL1.
HGNCiHGNC:19961. ANGEL1.
HPAiHPA000948.
neXtProtiNX_Q9UNK9.
PharmGKBiPA134982299.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2338. Eukaryota.
COG5239. LUCA.
GeneTreeiENSGT00550000074364.
HOGENOMiHOG000033940.
HOVERGENiHBG057379.
InParanoidiQ9UNK9.
KOiK18729.
OMAiEGPMWAA.
OrthoDBiEOG74FF2D.
PhylomeDBiQ9UNK9.
TreeFamiTF316126.

Miscellaneous databases

GenomeRNAii23357.
PROiQ9UNK9.

Gene expression databases

BgeeiQ9UNK9.
CleanExiHS_ANGEL1.
ExpressionAtlasiQ9UNK9. baseline and differential.
GenevisibleiQ9UNK9. HS.

Family and domain databases

Gene3Di3.60.10.10. 3 hits.
InterProiIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-670.
    Tissue: Mammary tumor.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiANGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK9
Secondary accession number(s): B4DWL7, O94859, Q8NCS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.