Reviewed, UniProtKB/Swiss-Prot Q9UNK9 (ANGE1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein angel homolog 1

Gene names

Name:	ANGEL1
Synonyms:	KIAA0759

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the CCR4/nocturin family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 670	670	Protein angel homolog 1		PRO_0000218581
Amino acid modifications
	Modified residue	347	1	Phosphoserine Ref.6
	Modified residue	351	1	Phosphotyrosine Ref.6
Natural variations
	Natural variant	141	1	G → W: dbSNP rs34270005.		VAR_056239
	Natural variant	383	1	V → L: dbSNP rs45499197.		VAR_061374
	Natural variant	515	1	F → C: dbSNP rs2075773.		VAR_056240
Experimental info
	Sequence conflict	415	1	D → G in AAH28714. Ref.4
	Sequence conflict	441	1	P → T in BAG63079. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9UNK9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 3D40E26813E27D83	FASTA	670	75,276
	10 20 30 40 50 60 MIASCLCYLL LPATRLFRAL SDAFFTCRKN VLLANSSSPQ VEGDFAMAPR GPEQEECEGL 70 80 90 100 110 120 LQQWREEGLS QVLSTASEGP LIDKGLAQSS LALLMDNPGE ENAASEDRWS SRQLSDLRAA 130 140 150 160 170 180 ENLDEPFPEM LGEEPLLEVE GVEGSMWAAI PMQSEPQYAD CAALPVGALA TEQWEEDPAV 190 200 210 220 230 240 LAWSIAPEPV PQEEASIWPF EGLGQLQPPA VEIPYHEILW REWEDFSTQP DAQGLKAGDG 250 260 270 280 290 300 PQFQFTLMSY NILAQDLMQQ SSELYLHCHP DILNWNYRFV NLMQEFQHWD PDILCLQEVQ 310 320 330 340 350 360 EDHYWEQLEP SLRMMGFTCF YKRRTGCKTD GCAVCYKPTR FRLLCASPVE YFRPGLELLN 370 380 390 400 410 420 RDNVGLVLLL QPLVPEGLGQ VSVAPLCVAN THILYNPRRG DVKLAQMAIL LAEVDKVARL 430 440 450 460 470 480 SDGSHCPIIL CGDLNSVPDS PLYNFIRDGE LQYHGMPAWK VSGQEDFSHQ LYQRKLQAPL 490 500 510 520 530 540 WPSSLGITDC CQYVTSCHPK RSERRKYGRD FLLRFRFCSI ACQRPVGLVL MEGVTDTKPE 550 560 570 580 590 600 RPAGWAESVL EEDASELEPA FSRTVGTIQH CLHLTSVYTH FLPQRGRPEV TTMPLGLGMT 610 620 630 640 650 660 VDYIFFSAES CENGNRTDHR LYRDGTLKLL GRLSLLSEEI LWAANGLPNP FCSSDHLCLL 670 ASFGMEVTAP

References

[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed: 9872452] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 441-670. Tissue: Mammary tumor.
[6]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347 AND TYR-351, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB018302 mRNA. Translation: BAA34479.1. Different initiation. AL137268 mRNA. Translation: CAB70667.2. AF111169 Genomic DNA. Translation: AAD44362.1. BC028714 mRNA. Translation: AAH28714.1. AK301589 mRNA. Translation: BAG63079.1. Different initiation.
IPI	IPI00298147.
RefSeq	NP_056120.2.
UniGene	Hs.497448
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UNK9.
PTM databases
PhosphoSite	Q9UNK9.
Proteomic databases
PRIDE	Q9UNK9.
Genome annotation databases
Ensembl	ENST00000251089; ENSP00000251089; ENSG00000013523; Homo sapiens. [Genome view]
GeneID	23357.
KEGG	hsa:23357.
UCSC	uc001xsv.1. human.
Organism-specific databases
CTD	23357.
GeneCards	GC14M076324.
H-InvDB	HIX0011837.
HGNC	HGNC:19961. ANGEL1.
HPA	HPA000948.
PharmGKB	PA134982299.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG444702.
HOVERGEN	Q9UNK9.
InParanoid	Q9UNK9.
OMA	PYHEILW.
OrthoDB	EOG9P2SMQ.
Gene expression databases
ArrayExpress	Q9UNK9.
Bgee	Q9UNK9.
CleanEx	HS_ANGEL1.
Genevestigator	Q9UNK9.
GermOnline	ENSG00000013523. Homo sapiens.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANGE1_HUMAN

Accession

Primary (citable) accession number: Q9UNK9
Secondary accession number(s): B4DWL7, O94859, Q8NCS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	May 1, 2000
Last modified:	December 15, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.