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Q9UNK0

- STX8_HUMAN

UniProt

Q9UNK0 - STX8_HUMAN

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Protein

Syntaxin-8

Gene

STX8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome

GO - Biological processi

  1. endosome to lysosome transport Source: Ensembl
  2. intracellular protein transport Source: RefGenome
  3. transport Source: ProtInc
  4. vesicle fusion Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Gene namesi
Name:STX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:11443. STX8.

Subcellular locationi

Membrane By similarity; Single-pass type IV membrane protein By similarity
Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity).By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: ProtInc
  2. integral component of plasma membrane Source: ProtInc
  3. late endosome membrane Source: Ensembl
  4. lysosomal membrane Source: Ensembl
  5. SNARE complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Syntaxin-8PRO_0000210217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by HECTD3.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9UNK0.
PaxDbiQ9UNK0.
PRIDEiQ9UNK0.

PTM databases

PhosphoSiteiQ9UNK0.

Expressioni

Tissue specificityi

Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Gene expression databases

BgeeiQ9UNK0.
CleanExiHS_STX8.
ExpressionAtlasiQ9UNK0. baseline and differential.
GenevestigatoriQ9UNK0.

Organism-specific databases

HPAiHPA001540.

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi114867. 24 interactions.
DIPiDIP-47274N.
IntActiQ9UNK0. 17 interactions.
MINTiMINT-1396123.
STRINGi9606.ENSP00000305255.

Structurei

3D structure databases

ProteinModelPortaliQ9UNK0.
SMRiQ9UNK0. Positions 152-204.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 215215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini233 – 2364VesicularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei216 – 23217Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili42 – 6524Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259218.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiQ9UNK0.
KOiK08501.
OMAiNQYERNG.
PhylomeDBiQ9UNK0.
TreeFamiTF323262.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNK0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN
60 70 80 90 100
LKEKIALLKD LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GAEPDLIRSS LMSEEAKRGA PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRNE
210 220 230
TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,907
Last modified:December 1, 2000 - v2
Checksum:i1E64A0DA77584CC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781R → Q in AAD20831. (PubMed:9852078)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115323 mRNA. Translation: AAD20831.1.
AF062077 mRNA. Translation: AAC36466.1.
AF036715 mRNA. Translation: AAC95285.1.
BT007319 mRNA. Translation: AAP35983.1.
CH471108 Genomic DNA. Translation: EAW90029.1.
BC009713 mRNA. Translation: AAH09713.1.
CCDSiCCDS32565.1.
RefSeqiNP_004844.1. NM_004853.2.
UniGeneiHs.431109.

Genome annotation databases

EnsembliENST00000306357; ENSP00000305255; ENSG00000170310.
GeneIDi9482.
KEGGihsa:9482.
UCSCiuc002glx.3. human.

Polymorphism databases

DMDMi9297054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF115323 mRNA. Translation: AAD20831.1 .
AF062077 mRNA. Translation: AAC36466.1 .
AF036715 mRNA. Translation: AAC95285.1 .
BT007319 mRNA. Translation: AAP35983.1 .
CH471108 Genomic DNA. Translation: EAW90029.1 .
BC009713 mRNA. Translation: AAH09713.1 .
CCDSi CCDS32565.1.
RefSeqi NP_004844.1. NM_004853.2.
UniGenei Hs.431109.

3D structure databases

ProteinModelPortali Q9UNK0.
SMRi Q9UNK0. Positions 152-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114867. 24 interactions.
DIPi DIP-47274N.
IntActi Q9UNK0. 17 interactions.
MINTi MINT-1396123.
STRINGi 9606.ENSP00000305255.

PTM databases

PhosphoSitei Q9UNK0.

Polymorphism databases

DMDMi 9297054.

Proteomic databases

MaxQBi Q9UNK0.
PaxDbi Q9UNK0.
PRIDEi Q9UNK0.

Protocols and materials databases

DNASUi 9482.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306357 ; ENSP00000305255 ; ENSG00000170310 .
GeneIDi 9482.
KEGGi hsa:9482.
UCSCi uc002glx.3. human.

Organism-specific databases

CTDi 9482.
GeneCardsi GC17M009153.
HGNCi HGNC:11443. STX8.
HPAi HPA001540.
MIMi 604203. gene.
neXtProti NX_Q9UNK0.
PharmGKBi PA36240.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259218.
GeneTreei ENSGT00390000007779.
HOGENOMi HOG000031515.
HOVERGENi HBG007572.
InParanoidi Q9UNK0.
KOi K08501.
OMAi NQYERNG.
PhylomeDBi Q9UNK0.
TreeFami TF323262.

Miscellaneous databases

ChiTaRSi STX8. human.
GeneWikii STX8.
GenomeRNAii 9482.
NextBioi 35540.
PROi Q9UNK0.
SOURCEi Search...

Gene expression databases

Bgeei Q9UNK0.
CleanExi HS_STX8.
ExpressionAtlasi Q9UNK0. baseline and differential.
Genevestigatori Q9UNK0.

Family and domain databases

InterProi IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)."
    Thoreau V., Berges T., Callebaut I., Guillier-Gencik Z., Gressin L., Bernheim A., Karst F., Mornon J.-P., Kitzis A., Chomel J.-C.
    Biochem. Biophys. Res. Commun. 257:577-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. Subramaniam V.N., Loh E., Hong W.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX8_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK0
Secondary accession number(s): O60712, Q53XT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3