Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-8

Gene

STX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

GO - Molecular functioni

  • chloride channel inhibitor activity Source: UniProtKB
  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • early endosome to late endosome transport Source: UniProtKB
  • endosome to lysosome transport Source: Ensembl
  • intracellular protein transport Source: GO_Central
  • regulation of protein localization to plasma membrane Source: UniProtKB
  • transport Source: ProtInc
  • vesicle docking Source: GO_Central
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Gene namesi
Name:STX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11443. STX8.

Subcellular locationi

  • Membrane By similarity; Single-pass type IV membrane protein By similarity

  • Note: Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 215CytoplasmicSequence analysisAdd BLAST215
Transmembranei216 – 232Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST17
Topological domaini233 – 236VesicularSequence analysis4

GO - Cellular componenti

  • cytosol Source: GOC
  • early endosome Source: UniProtKB
  • endoplasmic reticulum Source: ProtInc
  • endosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • late endosome Source: UniProtKB
  • late endosome membrane Source: Ensembl
  • lysosomal membrane Source: Ensembl
  • perinuclear region of cytoplasm Source: UniProtKB
  • recycling endosome Source: UniProtKB
  • SNARE complex Source: GO_Central
  • trans-Golgi network Source: UniProtKB
  • vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9482.
OpenTargetsiENSG00000170310.
PharmGKBiPA36240.

Polymorphism and mutation databases

BioMutaiSTX8.
DMDMi9297054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102171 – 236Syntaxin-8Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by HECTD3.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UNK0.
MaxQBiQ9UNK0.
PaxDbiQ9UNK0.
PeptideAtlasiQ9UNK0.
PRIDEiQ9UNK0.

PTM databases

iPTMnetiQ9UNK0.
PhosphoSitePlusiQ9UNK0.
SwissPalmiQ9UNK0.

Expressioni

Tissue specificityi

Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Gene expression databases

BgeeiENSG00000170310.
CleanExiHS_STX8.
ExpressionAtlasiQ9UNK0. baseline and differential.
GenevisibleiQ9UNK0. HS.

Organism-specific databases

HPAiHPA001540.

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
STX4Q128465EBI-727240,EBI-744942
VTI1BQ9UEU06EBI-727240,EBI-723716

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114867. 45 interactors.
DIPiDIP-47274N.
IntActiQ9UNK0. 29 interactors.
MINTiMINT-1396123.
STRINGi9606.ENSP00000305255.

Structurei

3D structure databases

ProteinModelPortaliQ9UNK0.
SMRiQ9UNK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 207t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 65Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiQ9UNK0.
KOiK08501.
OMAiNQYERNG.
OrthoDBiEOG091G0KM1.
PhylomeDBiQ9UNK0.
TreeFamiTF323262.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UNK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN
60 70 80 90 100
LKEKIALLKD LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE
110 120 130 140 150
GAEPDLIRSS LMSEEAKRGA PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE
160 170 180 190 200
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRNE
210 220 230
TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
Length:236
Mass (Da):26,907
Last modified:December 1, 2000 - v2
Checksum:i1E64A0DA77584CC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78R → Q in AAD20831 (PubMed:9852078).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115323 mRNA. Translation: AAD20831.1.
AF062077 mRNA. Translation: AAC36466.1.
AF036715 mRNA. Translation: AAC95285.1.
BT007319 mRNA. Translation: AAP35983.1.
CH471108 Genomic DNA. Translation: EAW90029.1.
BC009713 mRNA. Translation: AAH09713.1.
CCDSiCCDS32565.1.
RefSeqiNP_004844.1. NM_004853.2.
UniGeneiHs.431109.

Genome annotation databases

EnsembliENST00000306357; ENSP00000305255; ENSG00000170310.
GeneIDi9482.
KEGGihsa:9482.
UCSCiuc002glx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115323 mRNA. Translation: AAD20831.1.
AF062077 mRNA. Translation: AAC36466.1.
AF036715 mRNA. Translation: AAC95285.1.
BT007319 mRNA. Translation: AAP35983.1.
CH471108 Genomic DNA. Translation: EAW90029.1.
BC009713 mRNA. Translation: AAH09713.1.
CCDSiCCDS32565.1.
RefSeqiNP_004844.1. NM_004853.2.
UniGeneiHs.431109.

3D structure databases

ProteinModelPortaliQ9UNK0.
SMRiQ9UNK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114867. 45 interactors.
DIPiDIP-47274N.
IntActiQ9UNK0. 29 interactors.
MINTiMINT-1396123.
STRINGi9606.ENSP00000305255.

PTM databases

iPTMnetiQ9UNK0.
PhosphoSitePlusiQ9UNK0.
SwissPalmiQ9UNK0.

Polymorphism and mutation databases

BioMutaiSTX8.
DMDMi9297054.

Proteomic databases

EPDiQ9UNK0.
MaxQBiQ9UNK0.
PaxDbiQ9UNK0.
PeptideAtlasiQ9UNK0.
PRIDEiQ9UNK0.

Protocols and materials databases

DNASUi9482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306357; ENSP00000305255; ENSG00000170310.
GeneIDi9482.
KEGGihsa:9482.
UCSCiuc002glx.4. human.

Organism-specific databases

CTDi9482.
DisGeNETi9482.
GeneCardsiSTX8.
HGNCiHGNC:11443. STX8.
HPAiHPA001540.
MIMi604203. gene.
neXtProtiNX_Q9UNK0.
OpenTargetsiENSG00000170310.
PharmGKBiPA36240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3202. Eukaryota.
ENOG410ZZA3. LUCA.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiQ9UNK0.
KOiK08501.
OMAiNQYERNG.
OrthoDBiEOG091G0KM1.
PhylomeDBiQ9UNK0.
TreeFamiTF323262.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170310-MONOMER.

Miscellaneous databases

ChiTaRSiSTX8. human.
GeneWikiiSTX8.
GenomeRNAii9482.
PROiQ9UNK0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170310.
CleanExiHS_STX8.
ExpressionAtlasiQ9UNK0. baseline and differential.
GenevisibleiQ9UNK0. HS.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTX8_HUMAN
AccessioniPrimary (citable) accession number: Q9UNK0
Secondary accession number(s): O60712, Q53XT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.