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Q9UNK0 (STX8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-8
Gene names
Name:STX8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Subunit structure

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 By similarity. Interacts with HECTD3 By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein By similarity. Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits By similarity.

Tissue specificity

Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Post-translational modification

Ubiquitinated by HECTD3 By similarity.

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Syntaxin-8
PRO_0000210217

Regions

Topological domain1 – 215215Cytoplasmic Potential
Transmembrane216 – 23217Helical; Anchor for type IV membrane protein; Potential
Topological domain233 – 2364Vesicular Potential
Domain145 – 20763t-SNARE coiled-coil homology
Coiled coil42 – 6524 Potential

Amino acid modifications

Modified residue1601Phosphoserine By similarity

Experimental info

Sequence conflict781R → Q in AAD20831. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9UNK0 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 1E64A0DA77584CC4

FASTA23626,907
        10         20         30         40         50         60 
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD 

        70         80         90        100        110        120 
LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA 

       130        140        150        160        170        180 
PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN 

       190        200        210        220        230 
EIIDDLANLV ENTDEKLRNE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN 

« Hide

References

« Hide 'large scale' references
[1]"Three novel proteins of the syntaxin/SNAP-25 family."
Steegmaier M., Yang B., Yoo J.-S., Huang B., Shen M., Yu S., Luo Y., Scheller R.H.
J. Biol. Chem. 273:34171-34179(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)."
Thoreau V., Berges T., Callebaut I., Guillier-Gencik Z., Gressin L., Bernheim A., Karst F., Mornon J.-P., Kitzis A., Chomel J.-C.
Biochem. Biophys. Res. Commun. 257:577-583(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]Subramaniam V.N., Loh E., Hong W.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF115323 mRNA. Translation: AAD20831.1.
AF062077 mRNA. Translation: AAC36466.1.
AF036715 mRNA. Translation: AAC95285.1.
BT007319 mRNA. Translation: AAP35983.1.
CH471108 Genomic DNA. Translation: EAW90029.1.
BC009713 mRNA. Translation: AAH09713.1.
CCDSCCDS32565.1.
RefSeqNP_004844.1. NM_004853.2.
UniGeneHs.431109.

3D structure databases

ProteinModelPortalQ9UNK0.
SMRQ9UNK0. Positions 152-204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114867. 12 interactions.
DIPDIP-47274N.
IntActQ9UNK0. 15 interactions.
MINTMINT-1396123.
STRING9606.ENSP00000305255.

PTM databases

PhosphoSiteQ9UNK0.

Polymorphism databases

DMDM9297054.

Proteomic databases

MaxQBQ9UNK0.
PaxDbQ9UNK0.
PRIDEQ9UNK0.

Protocols and materials databases

DNASU9482.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306357; ENSP00000305255; ENSG00000170310.
GeneID9482.
KEGGhsa:9482.
UCSCuc002glx.3. human.

Organism-specific databases

CTD9482.
GeneCardsGC17M009153.
HGNCHGNC:11443. STX8.
HPAHPA001540.
MIM604203. gene.
neXtProtNX_Q9UNK0.
PharmGKBPA36240.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259218.
HOGENOMHOG000031515.
HOVERGENHBG007572.
InParanoidQ9UNK0.
KOK08501.
OMANQYERNG.
PhylomeDBQ9UNK0.
TreeFamTF323262.

Gene expression databases

ArrayExpressQ9UNK0.
BgeeQ9UNK0.
CleanExHS_STX8.
GenevestigatorQ9UNK0.

Family and domain databases

InterProIPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTX8. human.
GeneWikiSTX8.
GenomeRNAi9482.
NextBio35540.
PROQ9UNK0.
SOURCESearch...

Entry information

Entry nameSTX8_HUMAN
AccessionPrimary (citable) accession number: Q9UNK0
Secondary accession number(s): O60712, Q53XT8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM