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Q9UNK0

- STX8_HUMAN

UniProt

Q9UNK0 - STX8_HUMAN

Protein

Syntaxin-8

Gene

STX8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

    GO - Molecular functioni

    1. SNAP receptor activity Source: RefGenome

    GO - Biological processi

    1. endosome to lysosome transport Source: Ensembl
    2. intracellular protein transport Source: RefGenome
    3. transport Source: ProtInc
    4. vesicle fusion Source: RefGenome

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-8
    Gene namesi
    Name:STX8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11443. STX8.

    Subcellular locationi

    Membrane By similarity; Single-pass type IV membrane protein By similarity
    Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. integral component of plasma membrane Source: ProtInc
    3. late endosome membrane Source: Ensembl
    4. lysosomal membrane Source: Ensembl
    5. SNARE complex Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36240.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Syntaxin-8PRO_0000210217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei160 – 1601PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated by HECTD3.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9UNK0.
    PaxDbiQ9UNK0.
    PRIDEiQ9UNK0.

    PTM databases

    PhosphoSiteiQ9UNK0.

    Expressioni

    Tissue specificityi

    Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

    Gene expression databases

    ArrayExpressiQ9UNK0.
    BgeeiQ9UNK0.
    CleanExiHS_STX8.
    GenevestigatoriQ9UNK0.

    Organism-specific databases

    HPAiHPA001540.

    Interactioni

    Subunit structurei

    Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 By similarity. Interacts with HECTD3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114867. 12 interactions.
    DIPiDIP-47274N.
    IntActiQ9UNK0. 17 interactions.
    MINTiMINT-1396123.
    STRINGi9606.ENSP00000305255.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNK0.
    SMRiQ9UNK0. Positions 152-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 215215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 2364VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei216 – 23217Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 20763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili42 – 6524Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259218.
    HOGENOMiHOG000031515.
    HOVERGENiHBG007572.
    InParanoidiQ9UNK0.
    KOiK08501.
    OMAiNQYERNG.
    PhylomeDBiQ9UNK0.
    TreeFamiTF323262.

    Family and domain databases

    InterProiIPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    PROSITEiPS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UNK0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN    50
    LKEKIALLKD LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE 100
    GAEPDLIRSS LMSEEAKRGA PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE 150
    QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRNE 200
    TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN 236
    Length:236
    Mass (Da):26,907
    Last modified:December 1, 2000 - v2
    Checksum:i1E64A0DA77584CC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781R → Q in AAD20831. (PubMed:9852078)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115323 mRNA. Translation: AAD20831.1.
    AF062077 mRNA. Translation: AAC36466.1.
    AF036715 mRNA. Translation: AAC95285.1.
    BT007319 mRNA. Translation: AAP35983.1.
    CH471108 Genomic DNA. Translation: EAW90029.1.
    BC009713 mRNA. Translation: AAH09713.1.
    CCDSiCCDS32565.1.
    RefSeqiNP_004844.1. NM_004853.2.
    UniGeneiHs.431109.

    Genome annotation databases

    EnsembliENST00000306357; ENSP00000305255; ENSG00000170310.
    GeneIDi9482.
    KEGGihsa:9482.
    UCSCiuc002glx.3. human.

    Polymorphism databases

    DMDMi9297054.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF115323 mRNA. Translation: AAD20831.1 .
    AF062077 mRNA. Translation: AAC36466.1 .
    AF036715 mRNA. Translation: AAC95285.1 .
    BT007319 mRNA. Translation: AAP35983.1 .
    CH471108 Genomic DNA. Translation: EAW90029.1 .
    BC009713 mRNA. Translation: AAH09713.1 .
    CCDSi CCDS32565.1.
    RefSeqi NP_004844.1. NM_004853.2.
    UniGenei Hs.431109.

    3D structure databases

    ProteinModelPortali Q9UNK0.
    SMRi Q9UNK0. Positions 152-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114867. 12 interactions.
    DIPi DIP-47274N.
    IntActi Q9UNK0. 17 interactions.
    MINTi MINT-1396123.
    STRINGi 9606.ENSP00000305255.

    PTM databases

    PhosphoSitei Q9UNK0.

    Polymorphism databases

    DMDMi 9297054.

    Proteomic databases

    MaxQBi Q9UNK0.
    PaxDbi Q9UNK0.
    PRIDEi Q9UNK0.

    Protocols and materials databases

    DNASUi 9482.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306357 ; ENSP00000305255 ; ENSG00000170310 .
    GeneIDi 9482.
    KEGGi hsa:9482.
    UCSCi uc002glx.3. human.

    Organism-specific databases

    CTDi 9482.
    GeneCardsi GC17M009153.
    HGNCi HGNC:11443. STX8.
    HPAi HPA001540.
    MIMi 604203. gene.
    neXtProti NX_Q9UNK0.
    PharmGKBi PA36240.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259218.
    HOGENOMi HOG000031515.
    HOVERGENi HBG007572.
    InParanoidi Q9UNK0.
    KOi K08501.
    OMAi NQYERNG.
    PhylomeDBi Q9UNK0.
    TreeFami TF323262.

    Miscellaneous databases

    ChiTaRSi STX8. human.
    GeneWikii STX8.
    GenomeRNAii 9482.
    NextBioi 35540.
    PROi Q9UNK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UNK0.
    Bgeei Q9UNK0.
    CleanExi HS_STX8.
    Genevestigatori Q9UNK0.

    Family and domain databases

    InterProi IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    PROSITEi PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8)."
      Thoreau V., Berges T., Callebaut I., Guillier-Gencik Z., Gressin L., Bernheim A., Karst F., Mornon J.-P., Kitzis A., Chomel J.-C.
      Biochem. Biophys. Res. Commun. 257:577-583(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. Subramaniam V.N., Loh E., Hong W.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX8_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNK0
    Secondary accession number(s): O60712, Q53XT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3