Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity protein phosphatase 12

Gene

DUSP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro) (By similarity). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates (PubMed:10446167, PubMed:24531476).By similarity2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.By similarity

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • phosphatase activity Source: UniProtKB
  • protein tyrosine/serine/threonine phosphatase activity Source: Ensembl
  • protein tyrosine phosphatase activity Source: ProtInc
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • dephosphorylation Source: UniProtKB
  • positive regulation of glucokinase activity Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 12 (EC:3.1.3.16By similarity, EC:3.1.3.48By similarity)
Alternative name(s):
Dual specificity tyrosine phosphatase YVH1
Gene namesi
Name:DUSP12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000081721.11
HGNCiHGNC:3067 DUSP12
MIMi604835 gene
neXtProtiNX_Q9UNI6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11266
OpenTargetsiENSG00000081721
PharmGKBiPA27522

Polymorphism and mutation databases

BioMutaiDUSP12
DMDMi9973073

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948181 – 340Dual specificity protein phosphatase 12Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei335PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UNI6
MaxQBiQ9UNI6
PaxDbiQ9UNI6
PeptideAtlasiQ9UNI6
PRIDEiQ9UNI6

PTM databases

DEPODiQ9UNI6
iPTMnetiQ9UNI6
PhosphoSitePlusiQ9UNI6

Expressioni

Tissue specificityi

Ubiquitous, highest expression in spleen, testis, ovary, and peripheral blood leukocytes and lower expression in liver and lung.

Gene expression databases

BgeeiENSG00000081721
CleanExiHS_DUSP12
ExpressionAtlasiQ9UNI6 baseline and differential
GenevisibleiQ9UNI6 HS

Organism-specific databases

HPAiHPA008840

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116424, 45 interactors
IntActiQ9UNI6, 12 interactors
MINTiQ9UNI6
STRINGi9606.ENSP00000356920

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 31Combined sources4
Beta strandi34 – 37Combined sources4
Helixi39 – 43Combined sources5
Helixi45 – 51Combined sources7
Beta strandi53 – 62Combined sources10
Beta strandi76 – 81Combined sources6
Helixi91 – 93Combined sources3
Helixi94 – 106Combined sources13
Beta strandi110 – 114Combined sources5
Beta strandi116 – 120Combined sources5
Helixi121 – 134Combined sources14
Helixi138 – 148Combined sources11
Helixi156 – 167Combined sources12
Helixi177 – 186Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JNBX-ray3.00A27-193[»]
4KI9X-ray2.00A27-189[»]
ProteinModelPortaliQ9UNI6
SMRiQ9UNI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 160Tyrosine-protein phosphataseAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 121Substrate bindingCombined sources1 Publication6

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118853
HOGENOMiHOG000243638
HOVERGENiHBG051421
InParanoidiQ9UNI6
KOiK14819
OMAiQGRLYCP
OrthoDBiEOG091G0QP2
PhylomeDBiQ9UNI6
TreeFamiTF105123

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR016278 DUSP12
IPR029021 Prot-tyrosine_phosphatase-like
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
IPR013087 Znf_C2H2_type
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PIRSFiPIRSF000941 DUSP12, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UNI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEAPGPSDG CELSNPSASR VSCAGQMLEV QPGLYFGGAA AVAEPDHLRE
60 70 80 90 100
AGITAVLTVD SEEPSFKAGP GVEDLWRLFV PALDKPETDL LSHLDRCVAF
110 120 130 140 150
IGQARAEGRA VLVHCHAGVS RSVAIITAFL MKTDQLPFEK AYEKLQILKP
160 170 180 190 200
EAKMNEGFEW QLKLYQAMGY EVDTSSAIYK QYRLQKVTEK YPELQNLPQE
210 220 230 240 250
LFAVDPTTVS QGLKDEVLYK CRKCRRSLFR SSSILDHREG SGPIAFAHKR
260 270 280 290 300
MTPSSMLTTG RQAQCTSYFI EPVQWMESAL LGVMDGQLLC PKCSAKLGSF
310 320 330 340
NWYGEQCSCG RWITPAFQIH KNRVDEMKIL PVLGSQTGKI
Length:340
Mass (Da):37,687
Last modified:May 1, 2000 - v1
Checksum:i56B52192B42C73EB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03389951A → E. Corresponds to variant dbSNP:rs35106830Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119226 mRNA Translation: AAD51134.1
BT006633 mRNA Translation: AAP35279.1
AL359541 Genomic DNA No translation available.
BC006286 mRNA Translation: AAH06286.1
CCDSiCCDS1234.1
RefSeqiNP_009171.1, NM_007240.2
UniGeneiHs.416216

Genome annotation databases

EnsembliENST00000367943; ENSP00000356920; ENSG00000081721
GeneIDi11266
KEGGihsa:11266
UCSCiuc001gbo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDUS12_HUMAN
AccessioniPrimary (citable) accession number: Q9UNI6
Secondary accession number(s): Q5VXA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health