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Protein

Chymotrypsin-like elastase family member 1

Gene

CELA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Catalytic activityi

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay systemBy similarity1
Metal bindingi77CalciumBy similarity1
Metal bindingi82Calcium; via carbonyl oxygenBy similarity1
Metal bindingi87CalciumBy similarity1
Active sitei111Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS06634-MONOMER.
BRENDAi3.4.21.36. 2681.

Protein family/group databases

MEROPSiS01.153.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)
Alternative name(s):
Elastase-1
Pancreatic elastase 1
Gene namesi
Name:CELA1
Synonyms:ELA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:3308. CELA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1990.
OpenTargetsiENSG00000139610.
PharmGKBiPA27734.

Chemistry databases

ChEMBLiCHEMBL3000.
GuidetoPHARMACOLOGYi2338.

Polymorphism and mutation databases

BioMutaiCELA1.
DMDMi62298049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 8By similarity8
PropeptideiPRO_00000276779 – 18Activation peptide10
ChainiPRO_000002767819 – 258Chymotrypsin-like elastase family member 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 212PROSITE-ProRule annotation
Disulfide bondi176 ↔ 192PROSITE-ProRule annotation
Disulfide bondi202 ↔ 232PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9UNI1.
PeptideAtlasiQ9UNI1.
PRIDEiQ9UNI1.

Miscellaneous databases

PMAP-CutDBQ9UNI1.

Expressioni

Tissue specificityi

Basal layers of epidermis (at protein level). Not expressed in the pancreas.1 Publication

Gene expression databases

BgeeiENSG00000139610.
CleanExiHS_ELA1.
GenevisibleiQ9UNI1. HS.

Interactioni

Protein-protein interaction databases

BioGridi108305. 16 interactors.
STRINGi9606.ENSP00000293636.

Chemistry databases

BindingDBiQ9UNI1.

Structurei

3D structure databases

ProteinModelPortaliQ9UNI1.
SMRiQ9UNI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 256Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiQ9UNI1.
KOiK01326.
OMAiDYAICSS.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UNI1.
TreeFamiTF330455.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UNI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLYGHSTQ DLPETNARVV GGTEAGRNSW PSQISLQYRS GGSRYHTCGG
60 70 80 90 100
TLIRQNWVMT AAHCVDYQKT FRVVAGDHNL SQNDGTEQYV SVQKIVVHPY
110 120 130 140 150
WNSDNVAAGY DIALLRLAQS VTLNSYVQLG VLPQEGAILA NNSPCYITGW
160 170 180 190 200
GKTKTNGQLA QTLQQAYLPS VDYAICSSSS YWGSTVKNTM VCAGGDGVRS
210 220 230 240 250
GCQGDSGGPL HCLVNGKYSV HGVTSFVSSR GCNVSRKPTV FTQVSAYISW

INNVIASN
Length:258
Mass (Da):27,798
Last modified:March 29, 2005 - v2
Checksum:i684EDE8F1F011F8D
GO

Sequence cautioni

The sequence AAV88109 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220V → L in AAD28441 (PubMed:10620133).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03364510Q → H.Corresponds to variant rs17860287dbSNPEnsembl.1
Natural variantiVAR_03364644R → W.Corresponds to variant rs17860299dbSNPEnsembl.1
Natural variantiVAR_03364759M → V.Corresponds to variant rs17860300dbSNPEnsembl.1
Natural variantiVAR_03629576G → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033648243Q → R.Corresponds to variant rs17860364dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120493 mRNA. Translation: AAD28441.1.
AC046135 Genomic DNA. No translation available.
BC069454 mRNA. Translation: AAH69454.1.
BC075091 mRNA. Translation: AAH75091.2.
AY740424 Genomic DNA. Translation: AAV88109.1. Sequence problems.
CCDSiCCDS8812.1.
RefSeqiNP_001962.3. NM_001971.5.
UniGeneiHs.348395.

Genome annotation databases

EnsembliENST00000293636; ENSP00000293636; ENSG00000139610.
GeneIDi1990.
KEGGihsa:1990.
UCSCiuc001ryi.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Elastase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120493 mRNA. Translation: AAD28441.1.
AC046135 Genomic DNA. No translation available.
BC069454 mRNA. Translation: AAH69454.1.
BC075091 mRNA. Translation: AAH75091.2.
AY740424 Genomic DNA. Translation: AAV88109.1. Sequence problems.
CCDSiCCDS8812.1.
RefSeqiNP_001962.3. NM_001971.5.
UniGeneiHs.348395.

3D structure databases

ProteinModelPortaliQ9UNI1.
SMRiQ9UNI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108305. 16 interactors.
STRINGi9606.ENSP00000293636.

Chemistry databases

BindingDBiQ9UNI1.
ChEMBLiCHEMBL3000.
GuidetoPHARMACOLOGYi2338.

Protein family/group databases

MEROPSiS01.153.

Polymorphism and mutation databases

BioMutaiCELA1.
DMDMi62298049.

Proteomic databases

PaxDbiQ9UNI1.
PeptideAtlasiQ9UNI1.
PRIDEiQ9UNI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293636; ENSP00000293636; ENSG00000139610.
GeneIDi1990.
KEGGihsa:1990.
UCSCiuc001ryi.1. human.

Organism-specific databases

CTDi1990.
DisGeNETi1990.
GeneCardsiCELA1.
HGNCiHGNC:3308. CELA1.
MIMi130120. gene.
neXtProtiNX_Q9UNI1.
OpenTargetsiENSG00000139610.
PharmGKBiPA27734.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119027.
HOGENOMiHOG000251820.
InParanoidiQ9UNI1.
KOiK01326.
OMAiDYAICSS.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9UNI1.
TreeFamiTF330455.

Enzyme and pathway databases

BioCyciZFISH:HS06634-MONOMER.
BRENDAi3.4.21.36. 2681.

Miscellaneous databases

GeneWikiiCELA1.
GenomeRNAii1990.
PMAP-CutDBQ9UNI1.
PROiQ9UNI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139610.
CleanExiHS_ELA1.
GenevisibleiQ9UNI1. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCELA1_HUMAN
AccessioniPrimary (citable) accession number: Q9UNI1
Secondary accession number(s): Q5MLF0, Q6DJT0, Q6ISM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.