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Q9UNH7

- SNX6_HUMAN

UniProt

Q9UNH7 - SNX6_HUMAN

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Protein

Sorting nexin-6

Gene

SNX6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation.By similarity3 Publications

GO - Molecular functioni

  1. phosphatidylinositol binding Source: RefGenome
  2. protein homodimerization activity Source: HGNC

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
  2. negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
  3. negative regulation of transcription, DNA-templated Source: UniProtKB
  4. negative regulation of transforming growth factor beta receptor signaling pathway Source: HGNC
  5. retrograde transport, endosome to Golgi Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

SignaLinkiQ9UNH7.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-6
Alternative name(s):
TRAF4-associated factor 2
Cleaved into the following chain:
Gene namesi
Name:SNX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14970. SNX6.

Subcellular locationi

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus
Note: Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. early endosome membrane Source: UniProtKB
  4. intracellular Source: UniProtKB
  5. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi68 – 681R → A: Reduces interaction with SNX1. Abolishes location at endosome membranes. 1 Publication
Mutagenesisi69 – 691Q → A: No effect on subcellular location. 1 Publication
Mutagenesisi97 – 971R → A: No effect on subcellular location. 1 Publication

Organism-specific databases

PharmGKBiPA37946.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Sorting nexin-6PRO_0000423277Add
BLAST
Initiator methioninei1 – 11Removed; alternate1 Publication
Chaini2 – 406405Sorting nexin-6, N-terminally processedPRO_0000213846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei2 – 21N-acetylmethionine; in Sorting nexin-6, N-terminally processed2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9UNH7.
PaxDbiQ9UNH7.
PRIDEiQ9UNH7.

2D gel databases

OGPiQ9UNH7.
REPRODUCTION-2DPAGEIPI00298111.

PTM databases

PhosphoSiteiQ9UNH7.

Expressioni

Gene expression databases

BgeeiQ9UNH7.
CleanExiHS_SNX6.
ExpressionAtlasiQ9UNH7. baseline and differential.
GenevestigatoriQ9UNH7.

Organism-specific databases

HPAiHPA049374.

Interactioni

Subunit structurei

Interacts with CDKN1B (By similarity). Interacts with TGFB receptors. Interacts with dynactin subunit DCTN1. Interacts with SNX1 and SNX2. Interacts with BACE1 and BRMS1.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
OPTNQ96CV92EBI-949294,EBI-748974

Protein-protein interaction databases

BioGridi121852. 50 interactions.
DIPiDIP-37549N.
IntActiQ9UNH7. 15 interactions.
MINTiMINT-2634416.
STRINGi9606.ENSP00000355217.

Structurei

3D structure databases

ProteinModelPortaliQ9UNH7.
SMRiQ9UNH7. Positions 21-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 173148PXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 477Phosphatidylinositol bisphosphate bindingBy similarity
Regioni100 – 1067Phosphatidylinositol bisphosphate bindingBy similarity
Regioni114 – 1174Phosphatidylinositol bisphosphate bindingBy similarity

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG255198.
GeneTreeiENSGT00760000119259.
HOGENOMiHOG000231691.
HOVERGENiHBG000716.
InParanoidiQ9UNH7.
KOiK17920.
OrthoDBiEOG7X0VH4.
PhylomeDBiQ9UNH7.
TreeFamiTF313698.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR001683. Phox.
IPR014637. SNX5/SNX6/SNX32.
IPR028657. SNX6.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF120. PTHR10555:SF120. 1 hit.
PfamiPF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
PIRSFiPIRSF036924. Snx5_Snx6. 1 hit.
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9UNH7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEGLDDGPD FLSEEDRGLK AINVDLQSDA ALQVDISDAL SERDKVKFTV
60 70 80 90 100
HTKSSLPNFK QNEFSVVRQH EEFIWLHDSF VENEDYAGYI IPPAPPRPDF
110 120 130 140 150
DASREKLQKL GEGEGSMTKE EFTKMKQELE AEYLAIFKKT VAMHEVFLCR
160 170 180 190 200
VAAHPILRRD LNFHVFLEYN QDLSVRGKNK KEKLEDFFKN MVKSADGVIV
210 220 230 240 250
SGVKDVDDFF EHERTFLLEY HNRVKDASAK SDRMTRSHKS AADDYNRIGS
260 270 280 290 300
SLYALGTQDS TDICKFFLKV SELFDKTRKI EARVSADEDL KLSDLLKYYL
310 320 330 340 350
RESQAAKDLL YRRSRSLVDY ENANKALDKA RAKNKDVLQA ETSQQLCCQK
360 370 380 390 400
FEKISESAKQ ELIDFKTRRV AAFRKNLVEL AELELKHAKG NLQLLQNCLA

VLNGDT
Length:406
Mass (Da):46,649
Last modified:May 1, 2000 - v1
Checksum:iE3659DB19C59E1BB
GO
Isoform 2 (identifier: Q9UNH7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Note: No experimental confirmation available.

Show »
Length:290
Mass (Da):33,570
Checksum:iC12EC83110C71CA8
GO

Sequence cautioni

The sequence AAD24202.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 116116Missing in isoform 2. 1 PublicationVSP_044824Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121856 mRNA. Translation: AAD27829.1.
U83194 mRNA. Translation: AAD24202.1. Different initiation.
AL445363 Genomic DNA. No translation available.
AL445883 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65913.1.
CH471078 Genomic DNA. Translation: EAW65915.1.
BC001798 mRNA. Translation: AAH01798.1.
CCDSiCCDS9648.1. [Q9UNH7-2]
RefSeqiNP_067072.3. NM_021249.3. [Q9UNH7-2]
NP_689419.2. NM_152233.2.
UniGeneiHs.356647.

Genome annotation databases

EnsembliENST00000396526; ENSP00000379779; ENSG00000129515. [Q9UNH7-2]
GeneIDi58533.
KEGGihsa:58533.
UCSCiuc001wse.1. human. [Q9UNH7-1]

Polymorphism databases

DMDMi10720285.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121856 mRNA. Translation: AAD27829.1 .
U83194 mRNA. Translation: AAD24202.1 . Different initiation.
AL445363 Genomic DNA. No translation available.
AL445883 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65913.1 .
CH471078 Genomic DNA. Translation: EAW65915.1 .
BC001798 mRNA. Translation: AAH01798.1 .
CCDSi CCDS9648.1. [Q9UNH7-2 ]
RefSeqi NP_067072.3. NM_021249.3. [Q9UNH7-2 ]
NP_689419.2. NM_152233.2.
UniGenei Hs.356647.

3D structure databases

ProteinModelPortali Q9UNH7.
SMRi Q9UNH7. Positions 21-175.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121852. 50 interactions.
DIPi DIP-37549N.
IntActi Q9UNH7. 15 interactions.
MINTi MINT-2634416.
STRINGi 9606.ENSP00000355217.

PTM databases

PhosphoSitei Q9UNH7.

Polymorphism databases

DMDMi 10720285.

2D gel databases

OGPi Q9UNH7.
REPRODUCTION-2DPAGE IPI00298111.

Proteomic databases

MaxQBi Q9UNH7.
PaxDbi Q9UNH7.
PRIDEi Q9UNH7.

Protocols and materials databases

DNASUi 58533.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396526 ; ENSP00000379779 ; ENSG00000129515 . [Q9UNH7-2 ]
GeneIDi 58533.
KEGGi hsa:58533.
UCSCi uc001wse.1. human. [Q9UNH7-1 ]

Organism-specific databases

CTDi 58533.
GeneCardsi GC14M035030.
H-InvDB HIX0011592.
HGNCi HGNC:14970. SNX6.
HPAi HPA049374.
MIMi 606098. gene.
neXtProti NX_Q9UNH7.
PharmGKBi PA37946.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255198.
GeneTreei ENSGT00760000119259.
HOGENOMi HOG000231691.
HOVERGENi HBG000716.
InParanoidi Q9UNH7.
KOi K17920.
OrthoDBi EOG7X0VH4.
PhylomeDBi Q9UNH7.
TreeFami TF313698.

Enzyme and pathway databases

SignaLinki Q9UNH7.

Miscellaneous databases

ChiTaRSi SNX6. human.
GenomeRNAii 58533.
NextBioi 65116.
PROi Q9UNH7.
SOURCEi Search...

Gene expression databases

Bgeei Q9UNH7.
CleanExi HS_SNX6.
ExpressionAtlasi Q9UNH7. baseline and differential.
Genevestigatori Q9UNH7.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
3.30.1520.10. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR001683. Phox.
IPR014637. SNX5/SNX6/SNX32.
IPR028657. SNX6.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF120. PTHR10555:SF120. 1 hit.
Pfami PF00787. PX. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
PIRSFi PIRSF036924. Snx5_Snx6. 1 hit.
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of endosome-localized proteins related to sorting nexin 1."
    Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
    Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. Toji S., Yano M., Kobayasi A., Tamai K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  6. "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases."
    Parks W.T., Frank D.B., Huff C., Haft C.R., Martin J., Meng X., de Caestecker M.P., McNally J.G., Reddi A., Taylor S.I., Roberts A.B., Wang T., Lechleider R.J.
    J. Biol. Chem. 276:19332-19339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, SUBUNIT.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND MET-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."
    Hong Z., Yang Y., Zhang C., Niu Y., Li K., Zhao X., Liu J.J.
    Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DCTN1; SNX1 AND SNX2, MUTAGENESIS OF ARG-68; GLN-69 AND ARG-97, SUBCELLULAR LOCATION.
  9. "Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing."
    Okada H., Zhang W., Peterhoff C., Hwang J.C., Nixon R.A., Ryu S.H., Kim T.W.
    FASEB J. 24:2783-2794(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BACE1.
  10. "Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression."
    Rivera J., Megias D., Bravo J.
    J. Cell. Biochem. 111:1464-1472(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BRMS1.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND MET-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX6_HUMAN
AccessioniPrimary (citable) accession number: Q9UNH7
Secondary accession number(s): C0H5W9, Q9Y449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3