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Q9UNF1

- MAGD2_HUMAN

UniProt

Q9UNF1 - MAGD2_HUMAN

Protein

Melanoma-associated antigen D2

Gene

MAGED2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Tumor antigen

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen D2
    Alternative name(s):
    11B6
    Breast cancer-associated gene 1 protein
    Short name:
    BCG-1
    Hepatocellular carcinoma-associated protein JCL-1
    MAGE-D2 antigen
    Gene namesi
    Name:MAGED2
    Synonyms:BCG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:16353. MAGED2.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30560.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed6 Publications
    Chaini2 – 606605Melanoma-associated antigen D2PRO_0000156727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine6 Publications
    Modified residuei5 – 51Phosphoserine1 Publication
    Modified residuei72 – 721Phosphothreonine1 Publication
    Modified residuei157 – 1571Phosphoserine1 Publication
    Modified residuei190 – 1901Phosphoserine2 Publications
    Modified residuei191 – 1911Phosphoserine3 Publications
    Modified residuei194 – 1941Phosphoserine3 Publications
    Modified residuei197 – 1971Phosphoserine1 Publication
    Modified residuei244 – 2441Phosphoserine1 Publication
    Modified residuei247 – 2471Phosphoserine7 Publications
    Modified residuei265 – 2651Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9UNF1.
    PaxDbiQ9UNF1.
    PRIDEiQ9UNF1.

    PTM databases

    PhosphoSiteiQ9UNF1.

    Expressioni

    Tissue specificityi

    Widely expressed in normal tissues.

    Gene expression databases

    ArrayExpressiQ9UNF1.
    BgeeiQ9UNF1.
    CleanExiHS_MAGED2.
    GenevestigatoriQ9UNF1.

    Organism-specific databases

    HPAiHPA031572.
    HPA031573.

    Interactioni

    Protein-protein interaction databases

    BioGridi116121. 32 interactions.
    IntActiQ9UNF1. 9 interactions.
    MINTiMINT-1389350.
    STRINGi9606.ENSP00000218439.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNF1.
    SMRiQ9UNF1. Positions 273-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini279 – 478200MAGEPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi215 – 25844Arg-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG292115.
    HOVERGENiHBG003714.
    InParanoidiQ9UNF1.
    OMAiEPTDAGI.
    OrthoDBiEOG75F4GM.
    PhylomeDBiQ9UNF1.
    TreeFamiTF352132.

    Family and domain databases

    InterProiIPR002190. MAGE.
    IPR028810. MAGED2.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PTHR11736:SF11. PTHR11736:SF11. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9UNF1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDTSESGAG LTRFQAEASE KDSSSMMQTL LTVTQNVEVP ETPKASKALE    50
    VSEDVKVSKA SGVSKATEVS KTPEAREAPA TQASSTTQLT DTQVLAAENK 100
    SLAADTKKQN ADPQAVTMPA TETKKVSHVA DTKVNTKAQE TEAAPSQAPA 150
    DEPEPESAAA QSQENQDTRP KVKAKKARKV KHLDGEEDGS SDQSQASGTT 200
    GGRRVSKALM ASMARRASRG PIAFWARRAS RTRLAAWARR ALLSLRSPKA 250
    RRGKARRRAA KLQSSQEPEA PPPRDVALLQ GRANDLVKYL LAKDQTKIPI 300
    KRSDMLKDII KEYTDVYPEI IERAGYSLEK VFGIQLKEID KNDHLYILLS 350
    TLEPTDAGIL GTTKDSPKLG LLMVLLSIIF MNGNRSSEAV IWEVLRKLGL 400
    RPGIHHSLFG DVKKLITDEF VKQKYLDYAR VPNSNPPEYE FFWGLRSYYE 450
    TSKMKVLKFA CKVQKKDPKE WAAQYREAME ADLKAAAEAA AEAKARAEIR 500
    ARMGIGLGSE NAAGPCNWDE ADIGPWAKAR IQAGAEAKAK AQESGSASTG 550
    ASTSTNNSAS ASASTSGGFS AGASLTATLT FGLFAGLGGA GASTSGSSGA 600
    CGFSYK 606
    Length:606
    Mass (Da):64,954
    Last modified:September 26, 2001 - v2
    Checksum:i352FD5BAF5088652
    GO
    Isoform 2 (identifier: Q9UNF1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-62: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:588
    Mass (Da):63,167
    Checksum:iAF568E2B27C5765B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731P → S in AAD00728. 1 PublicationCurated
    Sequence conflicti377 – 3771S → C in BAC03896. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871E → D.
    Corresponds to variant rs12014977 [ dbSNP | Ensembl ].
    VAR_053508
    Natural varianti266 – 2661Q → R.1 Publication
    VAR_011639
    Natural varianti458 – 4581K → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036584

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 6218Missing in isoform 2. 1 PublicationVSP_008030Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128527 mRNA. Translation: AAD33392.1.
    AF128528 mRNA. Translation: AAD33393.1.
    AF126181 mRNA. Translation: AAD28598.1.
    AJ293618 mRNA. Translation: CAC19410.1.
    U92544 mRNA. Translation: AAD00728.1.
    AF320070 mRNA. Translation: AAG35066.2.
    AK092463 mRNA. Translation: BAC03896.1.
    Z98046 Genomic DNA. Translation: CAB10841.1.
    CH471154 Genomic DNA. Translation: EAW93189.1.
    BC000304 mRNA. Translation: AAH00304.1.
    BC091503 mRNA. Translation: AAH91503.1.
    AF148815 mRNA. Translation: AAF73137.1.
    AF320907 mRNA. Translation: AAG38603.1.
    CCDSiCCDS14362.1. [Q9UNF1-1]
    RefSeqiNP_055414.2. NM_014599.5. [Q9UNF1-1]
    NP_803182.1. NM_177433.2. [Q9UNF1-1]
    NP_957516.1. NM_201222.2. [Q9UNF1-1]
    UniGeneiHs.522665.

    Genome annotation databases

    EnsembliENST00000218439; ENSP00000218439; ENSG00000102316. [Q9UNF1-1]
    ENST00000375053; ENSP00000364193; ENSG00000102316. [Q9UNF1-1]
    ENST00000375058; ENSP00000364198; ENSG00000102316. [Q9UNF1-1]
    ENST00000375068; ENSP00000364209; ENSG00000102316. [Q9UNF1-1]
    ENST00000396224; ENSP00000379526; ENSG00000102316. [Q9UNF1-1]
    GeneIDi10916.
    KEGGihsa:10916.
    UCSCiuc004dtk.1. human. [Q9UNF1-1]

    Polymorphism databases

    DMDMi17380153.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF128527 mRNA. Translation: AAD33392.1 .
    AF128528 mRNA. Translation: AAD33393.1 .
    AF126181 mRNA. Translation: AAD28598.1 .
    AJ293618 mRNA. Translation: CAC19410.1 .
    U92544 mRNA. Translation: AAD00728.1 .
    AF320070 mRNA. Translation: AAG35066.2 .
    AK092463 mRNA. Translation: BAC03896.1 .
    Z98046 Genomic DNA. Translation: CAB10841.1 .
    CH471154 Genomic DNA. Translation: EAW93189.1 .
    BC000304 mRNA. Translation: AAH00304.1 .
    BC091503 mRNA. Translation: AAH91503.1 .
    AF148815 mRNA. Translation: AAF73137.1 .
    AF320907 mRNA. Translation: AAG38603.1 .
    CCDSi CCDS14362.1. [Q9UNF1-1 ]
    RefSeqi NP_055414.2. NM_014599.5. [Q9UNF1-1 ]
    NP_803182.1. NM_177433.2. [Q9UNF1-1 ]
    NP_957516.1. NM_201222.2. [Q9UNF1-1 ]
    UniGenei Hs.522665.

    3D structure databases

    ProteinModelPortali Q9UNF1.
    SMRi Q9UNF1. Positions 273-479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116121. 32 interactions.
    IntActi Q9UNF1. 9 interactions.
    MINTi MINT-1389350.
    STRINGi 9606.ENSP00000218439.

    PTM databases

    PhosphoSitei Q9UNF1.

    Polymorphism databases

    DMDMi 17380153.

    Proteomic databases

    MaxQBi Q9UNF1.
    PaxDbi Q9UNF1.
    PRIDEi Q9UNF1.

    Protocols and materials databases

    DNASUi 10916.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218439 ; ENSP00000218439 ; ENSG00000102316 . [Q9UNF1-1 ]
    ENST00000375053 ; ENSP00000364193 ; ENSG00000102316 . [Q9UNF1-1 ]
    ENST00000375058 ; ENSP00000364198 ; ENSG00000102316 . [Q9UNF1-1 ]
    ENST00000375068 ; ENSP00000364209 ; ENSG00000102316 . [Q9UNF1-1 ]
    ENST00000396224 ; ENSP00000379526 ; ENSG00000102316 . [Q9UNF1-1 ]
    GeneIDi 10916.
    KEGGi hsa:10916.
    UCSCi uc004dtk.1. human. [Q9UNF1-1 ]

    Organism-specific databases

    CTDi 10916.
    GeneCardsi GC0XP054834.
    HGNCi HGNC:16353. MAGED2.
    HPAi HPA031572.
    HPA031573.
    MIMi 300470. gene.
    neXtProti NX_Q9UNF1.
    PharmGKBi PA30560.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292115.
    HOVERGENi HBG003714.
    InParanoidi Q9UNF1.
    OMAi EPTDAGI.
    OrthoDBi EOG75F4GM.
    PhylomeDBi Q9UNF1.
    TreeFami TF352132.

    Miscellaneous databases

    ChiTaRSi MAGED2. human.
    GeneWikii MAGED2.
    GenomeRNAii 10916.
    NextBioi 41463.
    PROi Q9UNF1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UNF1.
    Bgeei Q9UNF1.
    CleanExi HS_MAGED2.
    Genevestigatori Q9UNF1.

    Family and domain databases

    InterProi IPR002190. MAGE.
    IPR028810. MAGED2.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    PTHR11736:SF11. PTHR11736:SF11. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of genes overexpressed in freshly isolated breast cancer specimens."
      Kurt R.A., Urba W.J., Schoof D.D.
      Breast Cancer Res. Treat. 59:41-48(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-266.
      Tissue: Fetal lung, Mammary cancer and Mammary gland.
    2. "Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues."
      Langnaese K., Kloos D.U., Wehnert M., Seidel B., Wieacker P.
      Cytogenet. Cell Genet. 94:233-240(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Hepatocellular carcinoma associated gene JCL-1."
      Jin C.L., Wang D.Y., Wan D.F., Gu J.R.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Identification of genes which are differentially expressed in hepatocellular carcinoma by SSH method."
      Dong X.-Y., Chen W.-F.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    6. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Skeletal muscle.
    9. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 77-100; 182-203; 220-227; 262-274; 312-323; 386-397 AND 431-446, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryonic kidney.
    10. "Isolation of genes which are differentially expressed in prostate cancer cells."
      Stubbs A.P., Abel P.D., Lalani E.-N., Stamp G.W.H.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 346-424.
      Tissue: Prostatic carcinoma.
    11. "A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells."
      Lucas S., Brasseur F., Boon T.
      Cancer Res. 59:4100-4103(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 369-503.
      Tissue: Testis.
    12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190; SER-191 AND SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-190; SER-191; SER-194; SER-197; SER-247 AND SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; THR-72; SER-191; SER-244; SER-247 AND SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    23. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    24. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    25. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-458.

    Entry informationi

    Entry nameiMAGD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNF1
    Secondary accession number(s): A6NMX0
    , O76058, Q5BJF3, Q8NAL6, Q9H218, Q9P0U9, Q9UM52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3