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Protein

Rab effector Noc2

Gene

RPH3AL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Rab effector Noc2
Alternative name(s):
No C2 domains protein
Rabphilin-3A-like protein
Gene namesi
Name:RPH3AL
Synonyms:NOC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000181031.15.
HGNCiHGNC:10296. RPH3AL.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9501.
OpenTargetsiENSG00000181031.
PharmGKBiPA34658.

Polymorphism and mutation databases

BioMutaiRPH3AL.
DMDMi74735140.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782631 – 315Rab effector Noc2Add BLAST315

Proteomic databases

PaxDbiQ9UNE2.
PeptideAtlasiQ9UNE2.
PRIDEiQ9UNE2.

PTM databases

PhosphoSitePlusiQ9UNE2.

Expressioni

Tissue specificityi

Moderate to high levels of expression in thyroid, ovary, stomach, heart, pancreas, skeletal muscle, kidney and liver. Also detected in epithelial cells.2 Publications

Gene expression databases

BgeeiENSG00000181031.
CleanExiHS_RPH3AL.
ExpressionAtlasiQ9UNE2. baseline and differential.
GenevisibleiQ9UNE2. HS.

Organism-specific databases

HPAiHPA024311.

Interactioni

Subunit structurei

Recruited to dense-core vesicles through specific interaction with RAB27A in endocrine cells. Interacts with RAB3A, RAB3B, RAB3C and RAB3D. Interacts with ZYX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MID2Q9UJV3-23EBI-2855824,EBI-10172526

GO - Molecular functioni

  • cytoskeletal protein binding Source: ProtInc
  • LIM domain binding Source: Ensembl
  • Rab GTPase binding Source: InterPro

Protein-protein interaction databases

BioGridi114880. 5 interactors.
IntActiQ9UNE2. 8 interactors.
STRINGi9606.ENSP00000328977.

Structurei

3D structure databases

ProteinModelPortaliQ9UNE2.
SMRiQ9UNE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 158RabBDPROSITE-ProRule annotationAdd BLAST118

Domaini

The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri89 – 146FYVE-typePROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1013. Eukaryota.
ENOG410XQXA. LUCA.
GeneTreeiENSGT00440000034248.
HOGENOMiHOG000126816.
HOVERGENiHBG052990.
InParanoidiQ9UNE2.
KOiK19939.
OMAiEAPRMGF.
OrthoDBiEOG091G0FPP.
PhylomeDBiQ9UNE2.
TreeFamiTF342971.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR010911. Rab_BD.
IPR030538. Rab_effect_Noc2.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR10024:SF311. PTHR10024:SF311. 1 hit.
PfamiView protein in Pfam
PF02318. FYVE_2. 1 hit.
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiView protein in PROSITE
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UNE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA
60 70 80 90 100
EVEAILQVIQ RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE
110 120 130 140 150
VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR
160 170 180 190 200
SGAWFYKGLP KYILPLKTPG RADDPHFRPL PTEPAEREPR SSETSRIYTW
210 220 230 240 250
ARGRVVSSDS DSDSDLSSSS LEDRLPSTGV RDRKGDKPWK ESGGSVEAPR
260 270 280 290 300
MGFTHPPGHL SGCQSSLASG ETGTGSADPP GGPRPGLTRR APVKDTPGRA
310
PAADAAPAGP SSCLG
Length:315
Mass (Da):34,464
Last modified:May 1, 2000 - v1
Checksum:iFDDB315E0BBC7C23
GO
Isoform 2 (identifier: Q9UNE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-146: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):31,190
Checksum:iE208E7BF9A361BC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85R → Q in AAH05153 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023244118 – 146Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129812 mRNA. Translation: AAD45582.1.
AK000469 mRNA. Translation: BAA91186.1.
CH471108 Genomic DNA. Translation: EAW90670.1.
CH471108 Genomic DNA. Translation: EAW90671.1.
BC005153 mRNA. Translation: AAH05153.1.
BC093776 mRNA. Translation: AAH93776.1.
BC113413 mRNA. Translation: AAI13414.1.
CCDSiCCDS10994.1. [Q9UNE2-1]
CCDS54059.1. [Q9UNE2-2]
RefSeqiNP_001177340.1. NM_001190411.1. [Q9UNE2-1]
NP_001177341.1. NM_001190412.1. [Q9UNE2-2]
NP_001177342.1. NM_001190413.1. [Q9UNE2-2]
NP_008918.1. NM_006987.3. [Q9UNE2-1]
XP_011533669.1. XM_011535367.2. [Q9UNE2-1]
XP_011533670.1. XM_011535368.2. [Q9UNE2-2]
UniGeneiHs.651925.

Genome annotation databases

EnsembliENST00000323434; ENSP00000319210; ENSG00000181031. [Q9UNE2-2]
ENST00000331302; ENSP00000328977; ENSG00000181031. [Q9UNE2-1]
ENST00000536489; ENSP00000438224; ENSG00000181031. [Q9UNE2-2]
ENST00000608278; ENSP00000483035; ENSG00000262334. [Q9UNE2-1]
ENST00000608519; ENSP00000476394; ENSG00000262334. [Q9UNE2-2]
ENST00000618002; ENSP00000479485; ENSG00000181031. [Q9UNE2-1]
ENST00000632000; ENSP00000487689; ENSG00000262334. [Q9UNE2-2]
ENST00000632545; ENSP00000487851; ENSG00000262334. [Q9UNE2-2]
ENST00000632616; ENSP00000487649; ENSG00000262334. [Q9UNE2-1]
GeneIDi9501.
KEGGihsa:9501.
UCSCiuc002fre.3. human. [Q9UNE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPH3L_HUMAN
AccessioniPrimary (citable) accession number: Q9UNE2
Secondary accession number(s): D3DTG7, Q9BSB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot