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Q9UNA3

- A4GCT_HUMAN

UniProt

Q9UNA3 - A4GCT_HUMAN

Protein

Alpha-1,4-N-acetylglucosaminyltransferase

Gene

A4GNT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

    Pathwayi

    GO - Molecular functioni

    1. acetylglucosaminyltransferase activity Source: MGI
    2. galactosyltransferase activity Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: ProtInc
    2. glycoprotein biosynthetic process Source: MGI
    3. negative regulation of epithelial cell proliferation Source: Ensembl
    4. protein O-linked glycosylation Source: ProtInc

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT32. Glycosyltransferase Family 32.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.-)
    Short name:
    Alpha4GnT
    Gene namesi
    Name:A4GNT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:17968. A4GNT.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi stack Source: InterPro
    3. integral component of membrane Source: ProtInc
    4. membrane Source: ProtInc

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134960042.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Alpha-1,4-N-acetylglucosaminyltransferasePRO_0000080583Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9UNA3.
    PRIDEiQ9UNA3.

    Expressioni

    Tissue specificityi

    Detected in stomach and pancreas.

    Gene expression databases

    BgeeiQ9UNA3.
    CleanExiHS_A4GNT.
    GenevestigatoriQ9UNA3.

    Organism-specific databases

    HPAiHPA008017.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000236709.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UNA3.
    SMRiQ9UNA3. Positions 124-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 44CytoplasmicSequence Analysis
    Topological domaini26 – 340315LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi167 – 1693DXD motifBy similarity

    Domaini

    The conserved DXD motif is involved in enzyme activity.By similarity

    Sequence similaritiesi

    Belongs to the glycosyltransferase 32 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251623.
    HOGENOMiHOG000254772.
    HOVERGENiHBG106704.
    InParanoidiQ9UNA3.
    KOiK08251.
    OMAiCGFLYQF.
    OrthoDBiEOG75MVW8.
    PhylomeDBiQ9UNA3.
    TreeFamiTF324053.

    Family and domain databases

    InterProiIPR007652. A1-4-GlycosylTfrase_dom.
    IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF04572. Gb3_synth. 1 hit.
    PF04488. Gly_transf_sug. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9UNA3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKELQLSLS VTLLLVCGFL YQFTLKSSCL FCLPSFKSHQ GLEALLSHRR    50
    GIVFLETSER MEPPHLVSCS VESAAKIYPE WPVVFFMKGL TDSTPMPSNS 100
    TYPAFSFLSA IDNVFLFPLD MKRLLEDTPL FSWYNQINAS AERNWLHISS 150
    DASRLAIIWK YGGIYMDTDV ISIRPIPEEN FLAAQASRYS SNGIFGFLPH 200
    HPFLWECMEN FVEHYNSAIW GNQGPELMTR MLRVWCKLED FQEVSDLRCL 250
    NISFLHPQRF YPISYREWRR YYEVWDTEPS FNVSYALHLW NHMNQEGRAV 300
    IRGSNTLVEN LYRKHCPRTY RDLIKGPEGS VTGELGPGNK 340
    Length:340
    Mass (Da):39,497
    Last modified:May 1, 2000 - v1
    Checksum:i00D667A8394300AB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti218 – 2181A → D.1 Publication
    Corresponds to variant rs2246945 [ dbSNP | Ensembl ].
    VAR_022096

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF141315 mRNA. Translation: AAD48406.1.
    BC119639 mRNA. Translation: AAI19640.1.
    BC119640 mRNA. Translation: AAI19641.1.
    CCDSiCCDS3097.1.
    RefSeqiNP_057245.1. NM_016161.2.
    UniGeneiHs.278960.

    Genome annotation databases

    EnsembliENST00000236709; ENSP00000236709; ENSG00000118017.
    GeneIDi51146.
    KEGGihsa:51146.
    UCSCiuc003ers.2. human.

    Polymorphism databases

    DMDMi25452797.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Alpha-1,4-N-acetylglucosaminyltransferase

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF141315 mRNA. Translation: AAD48406.1 .
    BC119639 mRNA. Translation: AAI19640.1 .
    BC119640 mRNA. Translation: AAI19641.1 .
    CCDSi CCDS3097.1.
    RefSeqi NP_057245.1. NM_016161.2.
    UniGenei Hs.278960.

    3D structure databases

    ProteinModelPortali Q9UNA3.
    SMRi Q9UNA3. Positions 124-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000236709.

    Protein family/group databases

    CAZyi GT32. Glycosyltransferase Family 32.

    Polymorphism databases

    DMDMi 25452797.

    Proteomic databases

    PaxDbi Q9UNA3.
    PRIDEi Q9UNA3.

    Protocols and materials databases

    DNASUi 51146.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236709 ; ENSP00000236709 ; ENSG00000118017 .
    GeneIDi 51146.
    KEGGi hsa:51146.
    UCSCi uc003ers.2. human.

    Organism-specific databases

    CTDi 51146.
    GeneCardsi GC03M137842.
    HGNCi HGNC:17968. A4GNT.
    HPAi HPA008017.
    neXtProti NX_Q9UNA3.
    PharmGKBi PA134960042.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG251623.
    HOGENOMi HOG000254772.
    HOVERGENi HBG106704.
    InParanoidi Q9UNA3.
    KOi K08251.
    OMAi CGFLYQF.
    OrthoDBi EOG75MVW8.
    PhylomeDBi Q9UNA3.
    TreeFami TF324053.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    GenomeRNAii 51146.
    NextBioi 54017.
    PROi Q9UNA3.

    Gene expression databases

    Bgeei Q9UNA3.
    CleanExi HS_A4GNT.
    Genevestigatori Q9UNA3.

    Family and domain databases

    InterProi IPR007652. A1-4-GlycosylTfrase_dom.
    IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF04572. Gb3_synth. 1 hit.
    PF04488. Gly_transf_sug. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin."
      Nakayama J., Yeh J.-C., Misra A.K., Ito S., Katsuyama T., Fukuda M.
      Proc. Natl. Acad. Sci. U.S.A. 96:8991-8996(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-218.

    Entry informationi

    Entry nameiA4GCT_HUMAN
    AccessioniPrimary (citable) accession number: Q9UNA3
    Secondary accession number(s): Q0VDK1, Q0VDK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3