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Q9UNA3

- A4GCT_HUMAN

UniProt

Q9UNA3 - A4GCT_HUMAN

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Protein
Alpha-1,4-N-acetylglucosaminyltransferase
Gene
A4GNT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for the synthesis of type III mucin. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans.

Pathwayi

GO - Molecular functioni

  1. acetylglucosaminyltransferase activity Source: MGI
  2. galactosyltransferase activity Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: ProtInc
  2. glycoprotein biosynthetic process Source: MGI
  3. negative regulation of epithelial cell proliferation Source: Ensembl
  4. protein O-linked glycosylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT32. Glycosyltransferase Family 32.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.-)
Short name:
Alpha4GnT
Gene namesi
Name:A4GNT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:17968. A4GNT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Cytoplasmic Reviewed prediction
Transmembranei5 – 2521Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini26 – 340315Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. Golgi stack Source: InterPro
  3. integral component of membrane Source: ProtInc
  4. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134960042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Alpha-1,4-N-acetylglucosaminyltransferase
PRO_0000080583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi251 – 2511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi282 – 2821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9UNA3.
PRIDEiQ9UNA3.

Expressioni

Tissue specificityi

Detected in stomach and pancreas.

Gene expression databases

BgeeiQ9UNA3.
CleanExiHS_A4GNT.
GenevestigatoriQ9UNA3.

Organism-specific databases

HPAiHPA008017.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000236709.

Structurei

3D structure databases

ProteinModelPortaliQ9UNA3.
SMRiQ9UNA3. Positions 124-171.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi167 – 1693DXD motif By similarity

Domaini

The conserved DXD motif is involved in enzyme activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251623.
HOGENOMiHOG000254772.
HOVERGENiHBG106704.
InParanoidiQ9UNA3.
KOiK08251.
OMAiCGFLYQF.
OrthoDBiEOG75MVW8.
PhylomeDBiQ9UNA3.
TreeFamiTF324053.

Family and domain databases

InterProiIPR007652. A1-4-GlycosylTfrase_dom.
IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF04572. Gb3_synth. 1 hit.
PF04488. Gly_transf_sug. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9UNA3-1 [UniParc]FASTAAdd to Basket

« Hide

MRKELQLSLS VTLLLVCGFL YQFTLKSSCL FCLPSFKSHQ GLEALLSHRR    50
GIVFLETSER MEPPHLVSCS VESAAKIYPE WPVVFFMKGL TDSTPMPSNS 100
TYPAFSFLSA IDNVFLFPLD MKRLLEDTPL FSWYNQINAS AERNWLHISS 150
DASRLAIIWK YGGIYMDTDV ISIRPIPEEN FLAAQASRYS SNGIFGFLPH 200
HPFLWECMEN FVEHYNSAIW GNQGPELMTR MLRVWCKLED FQEVSDLRCL 250
NISFLHPQRF YPISYREWRR YYEVWDTEPS FNVSYALHLW NHMNQEGRAV 300
IRGSNTLVEN LYRKHCPRTY RDLIKGPEGS VTGELGPGNK 340
Length:340
Mass (Da):39,497
Last modified:May 1, 2000 - v1
Checksum:i00D667A8394300AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti218 – 2181A → D.1 Publication
Corresponds to variant rs2246945 [ dbSNP | Ensembl ].
VAR_022096

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141315 mRNA. Translation: AAD48406.1.
BC119639 mRNA. Translation: AAI19640.1.
BC119640 mRNA. Translation: AAI19641.1.
CCDSiCCDS3097.1.
RefSeqiNP_057245.1. NM_016161.2.
UniGeneiHs.278960.

Genome annotation databases

EnsembliENST00000236709; ENSP00000236709; ENSG00000118017.
GeneIDi51146.
KEGGihsa:51146.
UCSCiuc003ers.2. human.

Polymorphism databases

DMDMi25452797.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Alpha-1,4-N-acetylglucosaminyltransferase

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF141315 mRNA. Translation: AAD48406.1 .
BC119639 mRNA. Translation: AAI19640.1 .
BC119640 mRNA. Translation: AAI19641.1 .
CCDSi CCDS3097.1.
RefSeqi NP_057245.1. NM_016161.2.
UniGenei Hs.278960.

3D structure databases

ProteinModelPortali Q9UNA3.
SMRi Q9UNA3. Positions 124-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000236709.

Protein family/group databases

CAZyi GT32. Glycosyltransferase Family 32.

Polymorphism databases

DMDMi 25452797.

Proteomic databases

PaxDbi Q9UNA3.
PRIDEi Q9UNA3.

Protocols and materials databases

DNASUi 51146.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000236709 ; ENSP00000236709 ; ENSG00000118017 .
GeneIDi 51146.
KEGGi hsa:51146.
UCSCi uc003ers.2. human.

Organism-specific databases

CTDi 51146.
GeneCardsi GC03M137842.
HGNCi HGNC:17968. A4GNT.
HPAi HPA008017.
neXtProti NX_Q9UNA3.
PharmGKBi PA134960042.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG251623.
HOGENOMi HOG000254772.
HOVERGENi HBG106704.
InParanoidi Q9UNA3.
KOi K08251.
OMAi CGFLYQF.
OrthoDBi EOG75MVW8.
PhylomeDBi Q9UNA3.
TreeFami TF324053.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

GenomeRNAii 51146.
NextBioi 54017.
PROi Q9UNA3.

Gene expression databases

Bgeei Q9UNA3.
CleanExi HS_A4GNT.
Genevestigatori Q9UNA3.

Family and domain databases

InterProi IPR007652. A1-4-GlycosylTfrase_dom.
IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF04572. Gb3_synth. 1 hit.
PF04488. Gly_transf_sug. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin."
    Nakayama J., Yeh J.-C., Misra A.K., Ito S., Katsuyama T., Fukuda M.
    Proc. Natl. Acad. Sci. U.S.A. 96:8991-8996(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-218.

Entry informationi

Entry nameiA4GCT_HUMAN
AccessioniPrimary (citable) accession number: Q9UNA3
Secondary accession number(s): Q0VDK1, Q0VDK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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