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Protein

Gamma-aminobutyric acid receptor subunit theta

Gene

GABRQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: InterPro
  • neurotransmitter transporter activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • signal transduction Source: ProtInc

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene namesi
Name:GABRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000268089.2
HGNCiHGNC:14454 GABRQ
MIMi300349 gene
neXtProtiNX_Q9UN88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 268ExtracellularSequence analysisAdd BLAST247
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei612 – 632HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi55879
PharmGKBiPA28504

Chemistry databases

ChEMBLiCHEMBL2093872
DrugBankiDB00659 Acamprosate
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01205 Flumazenil
DB00690 Flurazepam
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

Polymorphism and mutation databases

DMDMi13959382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000049522 – 632Gamma-aminobutyric acid receptor subunit thetaAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 197By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UN88
PeptideAtlasiQ9UN88
PRIDEiQ9UN88

PTM databases

iPTMnetiQ9UN88
PhosphoSitePlusiQ9UN88

Expressioni

Gene expression databases

BgeeiENSG00000268089
CleanExiHS_GABRQ
GenevisibleiQ9UN88 HS

Organism-specific databases

HPAiHPA002063

Interactioni

Subunit structurei

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Protein-protein interaction databases

IntActiQ9UN88, 1 interactor
STRINGi9606.ENSP00000359329

Structurei

3D structure databases

ProteinModelPortaliQ9UN88
SMRiQ9UN88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
HOGENOMiHOG000049189
HOVERGENiHBG051708
InParanoidiQ9UN88
KOiK05192
OrthoDBiEOG091G0805
PhylomeDBiQ9UN88
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008101 GABAAt_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01725 GABAARTHETA
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 2 hits
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIRGMLRAA VILLLIRTWL AEGNYPSPIP KFHFEFSSAV PEVVLNLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSRY DVRLRPNFGG APVPVRISIY VTSIEQISEM
110 120 130 140 150
NMDYTITMFF HQTWKDSRLA YYETTLNLTL DYRMHEKLWV PDCYFLNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLHKF PMDKQACNLV
210 220 230 240 250
VESYGYTVED IILFWDDNGN AIHMTEELHI PQFTFLGRTI TSKEVYFYTG
260 270 280 290 300
SYIRLILKFQ VQREVNSYLV QVYWPTVLTT ITSWISFWMN YDSSAARVTI
310 320 330 340 350
GLTSMLILTT IDSHLRDKLP NISCIKAIDI YILVCLFFVF LSLLEYVYIN
360 370 380 390 400
YLFYSRGPRR QPRRHRRPRR VIARYRYQQV VVGNVQDGLI NVEDGVSSLP
410 420 430 440 450
ITPAQAPLAS PESLGSLTST SEQAQLATSE SLSPLTSLSG QAPLATGESL
460 470 480 490 500
SDLPSTSEQA RHSYGVRFNG FQADDSIFPT EIRNRVEAHG HGVTHDHEDS
510 520 530 540 550
NESLSSDERH GHGPSGKPML HHGEKGVQEA GWDLDDNNDK SDCLAIKEQF
560 570 580 590 600
KCDTNSTWGL NDDELMAHGQ EKDSSSESED SCPPSPGCSF TEGFSFDLFN
610 620 630
PDYVPKVDKW SRFLFPLAFG LFNIVYWVYH MY
Length:632
Mass (Da):72,022
Last modified:May 4, 2001 - v2
Checksum:iC13267AC9212118B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03076115L → I. Corresponds to variant dbSNP:rs4996045Ensembl.1
Natural variantiVAR_030762478F → I2 PublicationsCorresponds to variant dbSNP:rs3810651Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189259 mRNA Translation: AAF70380.1
AF002997 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99424.1
BC109210 mRNA Translation: AAI09211.1
BC109211 mRNA Translation: AAI09212.1
AF144648 mRNA Translation: AAD51172.1
CCDSiCCDS14707.1
RefSeqiNP_061028.3, NM_018558.3
UniGeneiHs.283081

Genome annotation databases

EnsembliENST00000598523; ENSP00000469332; ENSG00000268089
GeneIDi55879
KEGGihsa:55879
UCSCiuc004ffp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGBRT_HUMAN
AccessioniPrimary (citable) accession number: Q9UN88
Secondary accession number(s): A6NFN1, Q32MB4, Q9NZK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: February 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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