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Protein

Gamma-aminobutyric acid receptor subunit theta

Gene

GABRQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB-KW
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: InterPro
  • neurotransmitter transporter activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • ion transmembrane transport Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-HSA-112314. Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell.
R-HSA-975298. Ligand-gated ion channel transport.
R-HSA-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit theta
Alternative name(s):
GABA(A) receptor subunit theta
Gene namesi
Name:GABRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14454. GABRQ.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 268247ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei612 – 63221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • chloride channel complex Source: UniProtKB-KW
  • GABA-A receptor complex Source: GO_Central
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: UniProtKB-SubCell
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28504.

Chemistry

ChEMBLiCHEMBL2093872.
DrugBankiDB00659. Acamprosate.
DB00404. Alprazolam.
DB00543. Amoxapine.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB00475. Chlordiazepoxide.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01205. Flumazenil.
DB00690. Flurazepam.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB01028. Methoxyflurane.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB00273. Topiramate.
DB00897. Triazolam.

Polymorphism and mutation databases

DMDMi13959382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 632611Gamma-aminobutyric acid receptor subunit thetaPRO_0000000495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi183 ↔ 197By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UN88.
PeptideAtlasiQ9UN88.
PRIDEiQ9UN88.

PTM databases

iPTMnetiQ9UN88.
PhosphoSiteiQ9UN88.

Expressioni

Gene expression databases

BgeeiENSG00000147402.
CleanExiHS_GABRQ.
GenevisibleiQ9UN88. HS.

Organism-specific databases

HPAiHPA002063.

Interactioni

Subunit structurei

Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.

Protein-protein interaction databases

STRINGi9606.ENSP00000359329.

Structurei

3D structure databases

ProteinModelPortaliQ9UN88.
SMRiQ9UN88. Positions 54-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000049189.
HOVERGENiHBG051708.
InParanoidiQ9UN88.
KOiK05192.
OrthoDBiEOG091G0805.
PhylomeDBiQ9UN88.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UN88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIRGMLRAA VILLLIRTWL AEGNYPSPIP KFHFEFSSAV PEVVLNLFNC
60 70 80 90 100
KNCANEAVVQ KILDRVLSRY DVRLRPNFGG APVPVRISIY VTSIEQISEM
110 120 130 140 150
NMDYTITMFF HQTWKDSRLA YYETTLNLTL DYRMHEKLWV PDCYFLNSKD
160 170 180 190 200
AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT AACSLDLHKF PMDKQACNLV
210 220 230 240 250
VESYGYTVED IILFWDDNGN AIHMTEELHI PQFTFLGRTI TSKEVYFYTG
260 270 280 290 300
SYIRLILKFQ VQREVNSYLV QVYWPTVLTT ITSWISFWMN YDSSAARVTI
310 320 330 340 350
GLTSMLILTT IDSHLRDKLP NISCIKAIDI YILVCLFFVF LSLLEYVYIN
360 370 380 390 400
YLFYSRGPRR QPRRHRRPRR VIARYRYQQV VVGNVQDGLI NVEDGVSSLP
410 420 430 440 450
ITPAQAPLAS PESLGSLTST SEQAQLATSE SLSPLTSLSG QAPLATGESL
460 470 480 490 500
SDLPSTSEQA RHSYGVRFNG FQADDSIFPT EIRNRVEAHG HGVTHDHEDS
510 520 530 540 550
NESLSSDERH GHGPSGKPML HHGEKGVQEA GWDLDDNNDK SDCLAIKEQF
560 570 580 590 600
KCDTNSTWGL NDDELMAHGQ EKDSSSESED SCPPSPGCSF TEGFSFDLFN
610 620 630
PDYVPKVDKW SRFLFPLAFG LFNIVYWVYH MY
Length:632
Mass (Da):72,022
Last modified:May 4, 2001 - v2
Checksum:iC13267AC9212118B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → I.
Corresponds to variant rs4996045 [ dbSNP | Ensembl ].
VAR_030761
Natural varianti478 – 4781F → I.2 Publications
Corresponds to variant rs3810651 [ dbSNP | Ensembl ].
VAR_030762

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189259 mRNA. Translation: AAF70380.1.
AF002997 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99424.1.
BC109210 mRNA. Translation: AAI09211.1.
BC109211 mRNA. Translation: AAI09212.1.
AF144648 mRNA. Translation: AAD51172.1.
CCDSiCCDS14707.1.
RefSeqiNP_061028.3. NM_018558.3.
UniGeneiHs.283081.

Genome annotation databases

EnsembliENST00000598523; ENSP00000469332; ENSG00000268089.
GeneIDi55879.
KEGGihsa:55879.
UCSCiuc004ffp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189259 mRNA. Translation: AAF70380.1.
AF002997 Genomic DNA. No translation available.
CH471169 Genomic DNA. Translation: EAW99424.1.
BC109210 mRNA. Translation: AAI09211.1.
BC109211 mRNA. Translation: AAI09212.1.
AF144648 mRNA. Translation: AAD51172.1.
CCDSiCCDS14707.1.
RefSeqiNP_061028.3. NM_018558.3.
UniGeneiHs.283081.

3D structure databases

ProteinModelPortaliQ9UN88.
SMRiQ9UN88. Positions 54-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359329.

Chemistry

ChEMBLiCHEMBL2093872.
DrugBankiDB00659. Acamprosate.
DB00404. Alprazolam.
DB00543. Amoxapine.
DB01558. Bromazepam.
DB00237. Butabarbital.
DB00241. Butalbital.
DB00475. Chlordiazepoxide.
DB00349. Clobazam.
DB01068. Clonazepam.
DB00628. Clorazepate.
DB01189. Desflurane.
DB00829. Diazepam.
DB00228. Enflurane.
DB01049. Ergoloid mesylate.
DB01215. Estazolam.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00189. Ethchlorvynol.
DB00292. Etomidate.
DB01205. Flumazenil.
DB00690. Flurazepam.
DB01437. Glutethimide.
DB00801. Halazepam.
DB01159. Halothane.
DB00753. Isoflurane.
DB00186. Lorazepam.
DB00371. Meprobamate.
DB01028. Methoxyflurane.
DB01107. Methyprylon.
DB00683. Midazolam.
DB01595. Nitrazepam.
DB00334. Olanzapine.
DB00842. Oxazepam.
DB00312. Pentobarbital.
DB01588. Prazepam.
DB00794. Primidone.
DB00818. Propofol.
DB01589. Quazepam.
DB01236. Sevoflurane.
DB00306. Talbutal.
DB00231. Temazepam.
DB00273. Topiramate.
DB00897. Triazolam.

PTM databases

iPTMnetiQ9UN88.
PhosphoSiteiQ9UN88.

Polymorphism and mutation databases

DMDMi13959382.

Proteomic databases

PaxDbiQ9UN88.
PeptideAtlasiQ9UN88.
PRIDEiQ9UN88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598523; ENSP00000469332; ENSG00000268089.
GeneIDi55879.
KEGGihsa:55879.
UCSCiuc004ffp.2. human.

Organism-specific databases

CTDi55879.
GeneCardsiGABRQ.
H-InvDBHIX0056145.
HGNCiHGNC:14454. GABRQ.
HPAiHPA002063.
MIMi300349. gene.
neXtProtiNX_Q9UN88.
PharmGKBiPA28504.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
HOGENOMiHOG000049189.
HOVERGENiHBG051708.
InParanoidiQ9UN88.
KOiK05192.
OrthoDBiEOG091G0805.
PhylomeDBiQ9UN88.
TreeFamiTF315453.

Enzyme and pathway databases

ReactomeiR-HSA-112314. Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell.
R-HSA-975298. Ligand-gated ion channel transport.
R-HSA-977441. GABA A receptor activation.

Miscellaneous databases

GeneWikiiGABRQ.
GenomeRNAii55879.
PROiQ9UN88.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147402.
CleanExiHS_GABRQ.
GenevisibleiQ9UN88. HS.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008101. GABAAt_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 3 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01725. GABAARTHETA.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 2 hits.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRT_HUMAN
AccessioniPrimary (citable) accession number: Q9UN88
Secondary accession number(s): A6NFN1, Q32MB4, Q9NZK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.