Q9UN88 (GBRT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit theta

Alternative name(s):
GABA(A) receptor subunit theta

Gene names

Name:

GABRQ

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	632 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Traceable author statement. Source: ProtInc postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro chloride channel activity Inferred from electronic annotation. Source: UniProtKB-KW extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro neurotransmitter transporter activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 632	611	Gamma-aminobutyric acid receptor subunit theta		PRO_0000000495
Regions
	Topological domain	22 – 268	247	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Potential
	Transmembrane	327 – 347	21	Helical; Potential
	Transmembrane	612 – 632	21	Helical; Potential
Amino acid modifications
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Disulfide bond	183 ↔ 197		By similarity
Natural variations
	Natural variant	15	1	L → I. Corresponds to variant rs4996045 [ dbSNP | Ensembl ].		VAR_030761
	Natural variant	478	1	F → I. Ref.1 Ref.4 Corresponds to variant rs3810651 [ dbSNP | Ensembl ].		VAR_030762

Sequences

	Sequence		Length	Mass (Da)
	Q9UN88 [UniParc]. Last modified May 4, 2001. Version 2. Checksum: C13267AC9212118B	FASTA	632	72,022
	10 20 30 40 50 60 MGIRGMLRAA VILLLIRTWL AEGNYPSPIP KFHFEFSSAV PEVVLNLFNC KNCANEAVVQ 70 80 90 100 110 120 KILDRVLSRY DVRLRPNFGG APVPVRISIY VTSIEQISEM NMDYTITMFF HQTWKDSRLA 130 140 150 160 170 180 YYETTLNLTL DYRMHEKLWV PDCYFLNSKD AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT 190 200 210 220 230 240 AACSLDLHKF PMDKQACNLV VESYGYTVED IILFWDDNGN AIHMTEELHI PQFTFLGRTI 250 260 270 280 290 300 TSKEVYFYTG SYIRLILKFQ VQREVNSYLV QVYWPTVLTT ITSWISFWMN YDSSAARVTI 310 320 330 340 350 360 GLTSMLILTT IDSHLRDKLP NISCIKAIDI YILVCLFFVF LSLLEYVYIN YLFYSRGPRR 370 380 390 400 410 420 QPRRHRRPRR VIARYRYQQV VVGNVQDGLI NVEDGVSSLP ITPAQAPLAS PESLGSLTST 430 440 450 460 470 480 SEQAQLATSE SLSPLTSLSG QAPLATGESL SDLPSTSEQA RHSYGVRFNG FQADDSIFPT 490 500 510 520 530 540 EIRNRVEAHG HGVTHDHEDS NESLSSDERH GHGPSGKPML HHGEKGVQEA GWDLDDNNDK 550 560 570 580 590 600 SDCLAIKEQF KCDTNSTWGL NDDELMAHGQ EKDSSSESED SCPPSPGCSF TEGFSFDLFN 610 620 630 PDYVPKVDKW SRFLFPLAFG LFNIVYWVYH MY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus." Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R. J. Neurosci. 20:3588-3595(2000) [PubMed: 10804200] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-478.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-478.
[5]	"Theta, a novel gamma-aminobutyric acid type A receptor subunit." Bonnert T.P., McKernan R.M., Farrar S., le Bourdelles B., Heavens R.P., Smith D.W., Hewson L., Rigby M.R., Sirinathsinghji D.J.S., Brown N., Wafford K.A., Whiting P.J. Proc. Natl. Acad. Sci. U.S.A. 96:9891-9896(1999) [PubMed: 10449790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-632.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF189259 mRNA. Translation: AAF70380.1. AF002997 Genomic DNA. No translation available. CH471169 Genomic DNA. Translation: EAW99424.1. BC109210 mRNA. Translation: AAI09211.1. BC109211 mRNA. Translation: AAI09212.1. AF144648 mRNA. Translation: AAD51172.1.
IPI	IPI00297913.
RefSeq	NP_061028.2. NM_018558.2.
UniGene	Hs.283081.
3D structure databases
ProteinModelPortal	Q9UN88.
SMR	Q9UN88. Positions 59-353.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9UN88.
PTM databases
PhosphoSite	Q9UN88.
Polymorphism databases
DMDM	13959382.
Proteomic databases
PRIDE	Q9UN88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370306; ENSP00000359329; ENSG00000147402.
GeneID	55879.
KEGG	hsa:55879.
UCSC	uc004ffp.1. human.
Organism-specific databases
CTD	55879.
GeneCards	GC0XP151806.
HGNC	HGNC:14454. GABRQ.
HPA	HPA002063.
MIM	300349. gene.
neXtProt	NX_Q9UN88.
PharmGKB	PA28504.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000083996.
HOGENOM	HBG127508.
HOVERGEN	HBG051708.
InParanoid	Q9UN88.
OMA	NVQDGLI.
OrthoDB	EOG48SGSN.
PhylomeDB	Q9UN88.
Gene expression databases
ArrayExpress	Q9UN88.
Bgee	Q9UN88.
CleanEx	HS_GABRQ.
Genevestigator	Q9UN88.
GermOnline	ENSG00000147402. Homo sapiens.
Family and domain databases
InterPro	IPR006028. GABAA_rcpt. IPR008101. GABAAt_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
Gene3D	G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.
KO	K05192.
PANTHER	PTHR18945:SF87. GABAAt_rcpt. 1 hit. PTHR18945. Neur_channel. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 1 hit. [Graphical view]
PRINTS	PR00253. GABAARECEPTR. PR01725. GABAARTHETA. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	61204.
SOURCE	Search...

Entry information

Entry name

GBRT_HUMAN

Accession

Primary (citable) accession number: Q9UN88
Secondary accession number(s): A6NFN1, Q32MB4, Q9NZK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	January 25, 2012
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.