UniProtKB - Q9UN86 (G3BP2_HUMAN)
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Protein
Ras GTPase-activating protein-binding protein 2
Gene
G3BP2
Organism
Homo sapiens (Human)
Status
Functioni
Probable scaffold protein that may be involved in mRNA transport.Curated
GO - Molecular functioni
- mRNA binding Source: GO_Central
- receptor signaling complex scaffold activity Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- cytoplasmic sequestering of NF-kappaB Source: UniProtKB
- mRNA transport Source: UniProtKB-KW
- Ras protein signal transduction Source: UniProtKB
- stress granule assembly Source: InterPro
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Ras GTPase-activating protein-binding protein 2Short name: G3BP-2 Alternative name(s): GAP SH3 domain-binding protein 2 |
Gene namesi | Name:G3BP2 Synonyms:KIAA0660 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138757.14 |
HGNCi | HGNC:30291 G3BP2 |
neXtProti | NX_Q9UN86 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9908 |
OpenTargetsi | ENSG00000138757 |
PharmGKBi | PA162389134 |
Polymorphism and mutation databases
BioMutai | G3BP2 |
DMDMi | 116242482 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000194800 | 2 – 482 | Ras GTPase-activating protein-binding protein 2Add BLAST | 481 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 141 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 149 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 225 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 227 | PhosphothreonineCombined sources | 1 | ||
Cross-linki | 281 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 392 | N6-succinyllysineBy similarity | 1 | ||
Modified residuei | 457 | Omega-N-methylarginineCombined sources | 1 | ||
Modified residuei | 466 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 468 | Omega-N-methylarginineCombined sources | 1 | ||
Isoform B (identifier: Q9UN86-2) | |||||
Modified residuei | 227 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 235 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UN86 |
PaxDbi | Q9UN86 |
PeptideAtlasi | Q9UN86 |
PRIDEi | Q9UN86 |
PTM databases
iPTMneti | Q9UN86 |
PhosphoSitePlusi | Q9UN86 |
Expressioni
Gene expression databases
Bgeei | ENSG00000138757 |
CleanExi | HS_G3BP2 |
ExpressionAtlasi | Q9UN86 baseline and differential |
Genevisiblei | Q9UN86 HS |
Organism-specific databases
HPAi | HPA018304 HPA018425 |
Interactioni
Subunit structurei
Binds to the N-terminal domain of I-kappa-B-alpha.
Binary interactionsi
GO - Molecular functioni
- receptor signaling complex scaffold activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 11523768 interactors. |
DIPi | DIP-50299N |
ELMi | Q9UN86 |
IntActi | Q9UN86 38 interactors. |
MINTi | Q9UN86 |
STRINGi | 9606.ENSP00000352738 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 3 – 5 | Combined sources | 3 | |
Helixi | 8 – 25 | Combined sources | 18 | |
Helixi | 27 – 33 | Combined sources | 7 | |
Beta strandi | 34 – 43 | Combined sources | 10 | |
Helixi | 58 – 66 | Combined sources | 9 | |
Beta strandi | 74 – 84 | Combined sources | 11 | |
Helixi | 86 – 88 | Combined sources | 3 | |
Beta strandi | 90 – 99 | Combined sources | 10 | |
Beta strandi | 106 – 116 | Combined sources | 11 | |
Beta strandi | 118 – 133 | Combined sources | 16 | |
Helixi | 134 – 137 | Combined sources | 4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5DRV | X-ray | 2.75 | A | 1-139 | [»] | |
ProteinModelPortali | Q9UN86 | |||||
SMRi | Q9UN86 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 133 | NTF2PROSITE-ProRule annotationAdd BLAST | 123 | |
Domaini | 331 – 409 | RRMPROSITE-ProRule annotationAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 134 – 223 | Glu-richAdd BLAST | 90 | |
Compositional biasi | 419 – 479 | Gly-richAdd BLAST | 61 |
Phylogenomic databases
eggNOGi | KOG0116 Eukaryota ENOG410YV57 LUCA |
GeneTreei | ENSGT00390000011365 |
HOGENOMi | HOG000220838 |
HOVERGENi | HBG007211 |
InParanoidi | Q9UN86 |
OMAi | GEFNYRS |
OrthoDBi | EOG091G0GAN |
PhylomeDBi | Q9UN86 |
TreeFami | TF325464 |
Family and domain databases
CDDi | cd00780 NTF2, 1 hit cd12464 RRM_G3BP2, 1 hit |
Gene3Di | 3.30.70.3301 hit |
InterProi | View protein in InterPro IPR034377 G3BP2 IPR034376 G3BP2_RRM IPR002075 NTF2 IPR032710 NTF2-like_dom_sf IPR018222 Nuclear_transport_factor_2_euk IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom |
PANTHERi | PTHR10693:SF10 PTHR10693:SF10, 1 hit |
Pfami | View protein in Pfam PF02136 NTF2, 1 hit PF00076 RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360 RRM, 1 hit |
SUPFAMi | SSF54427 SSF54427, 1 hit SSF54928 SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50177 NTF2_DOMAIN, 1 hit PS50102 RRM, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform A (identifier: Q9UN86-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK
60 70 80 90 100
PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN
110 120 130 140 150
SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE
160 170 180 190 200
DEVEEEQEER QPSPEPVQEN ANSGYYEAHP VTNGIEEPLE ESSHEPEPEP
210 220 230 240 250
ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP PKAFSWASVT
260 270 280 290 300
SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP
310 320 330 340 350
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF
360 370 380 390 400
FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV
410 420 430 440 450
RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD
460 470 480
GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ RR
Sequence cautioni
The sequence BAA31635 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 267 | P → S in AAD51932 (Ref. 1) Curated | 1 | |
Sequence conflicti | 359 | E → V in AAC15705 (Ref. 3) Curated | 1 | |
Sequence conflicti | 460 | M → I in AAC15705 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036128 | 434 | P → L in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003605 | 243 – 275 | Missing in isoform B. 4 PublicationsAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145284 mRNA Translation: AAD51932.1 AB014560 mRNA Translation: BAA31635.2 Different initiation. AF051311 mRNA Translation: AAC15705.1 AF053535 mRNA Translation: AAC95292.1 AK291786 mRNA Translation: BAF84475.1 CH471057 Genomic DNA Translation: EAX05742.1 BC011731 mRNA Translation: AAH11731.1 |
CCDSi | CCDS3571.1 [Q9UN86-1] CCDS3572.1 [Q9UN86-2] |
RefSeqi | NP_036429.2, NM_012297.4 [Q9UN86-1] NP_987100.1, NM_203504.2 [Q9UN86-2] NP_987101.1, NM_203505.2 [Q9UN86-1] XP_005263439.1, XM_005263382.2 [Q9UN86-1] XP_005263440.1, XM_005263383.3 [Q9UN86-1] XP_011530743.1, XM_011532441.2 [Q9UN86-1] XP_016864365.1, XM_017008876.1 [Q9UN86-1] XP_016864366.1, XM_017008877.1 [Q9UN86-1] XP_016864367.1, XM_017008878.1 [Q9UN86-2] XP_016864368.1, XM_017008879.1 [Q9UN86-2] |
UniGenei | Hs.303676 Hs.613996 |
Genome annotation databases
Ensembli | ENST00000357854; ENSP00000350518; ENSG00000138757 [Q9UN86-2] ENST00000359707; ENSP00000352738; ENSG00000138757 [Q9UN86-1] ENST00000395719; ENSP00000379069; ENSG00000138757 [Q9UN86-1] |
GeneIDi | 9908 |
KEGGi | hsa:9908 |
UCSCi | uc003hir.4 human [Q9UN86-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | G3BP2_HUMAN | |
Accessioni | Q9UN86Primary (citable) accession number: Q9UN86 Secondary accession number(s): A8K6X1 Q9UPA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2001 |
Last sequence update: | October 17, 2006 | |
Last modified: | March 28, 2018 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |