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UniProtKB - Q9UN86 (G3BP2_HUMAN)

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Protein

Ras GTPase-activating protein-binding protein 2

Gene

G3BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable scaffold protein that may be involved in mRNA transport.Curated

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • receptor signaling complex scaffold activity Source: UniProtKB
  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • cytoplasmic sequestering of NF-kappaB Source: UniProtKB
  • mRNA transport Source: UniProtKB-KW
  • Ras protein signal transduction Source: UniProtKB
  • stress granule assembly Source: InterPro
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein-binding protein 2
Short name:
G3BP-2
Alternative name(s):
GAP SH3 domain-binding protein 2
Gene namesi
Name:G3BP2
Synonyms:KIAA0660
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138757.14
HGNCiHGNC:30291 G3BP2
neXtProtiNX_Q9UN86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9908
OpenTargetsiENSG00000138757
PharmGKBiPA162389134

Polymorphism and mutation databases

BioMutaiG3BP2
DMDMi116242482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001948002 – 482Ras GTPase-activating protein-binding protein 2Add BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei227PhosphothreonineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392N6-succinyllysineBy similarity1
Modified residuei457Omega-N-methylarginineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei468Omega-N-methylarginineCombined sources1
Isoform B (identifier: Q9UN86-2)
Modified residuei227PhosphothreonineCombined sources1
Modified residuei235PhosphoserineCombined sources1

Post-translational modificationi

Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UN86
PaxDbiQ9UN86
PeptideAtlasiQ9UN86
PRIDEiQ9UN86

PTM databases

iPTMnetiQ9UN86
PhosphoSitePlusiQ9UN86

Expressioni

Gene expression databases

BgeeiENSG00000138757
CleanExiHS_G3BP2
ExpressionAtlasiQ9UN86 baseline and differential
GenevisibleiQ9UN86 HS

Organism-specific databases

HPAiHPA018304
HPA018425

Interactioni

Subunit structurei

Binds to the N-terminal domain of I-kappa-B-alpha.

Binary interactionsi

Show more details

GO - Molecular functioni

  • receptor signaling complex scaffold activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi11523768 interactors.
DIPiDIP-50299N
ELMiQ9UN86
IntActiQ9UN86 38 interactors.
MINTiQ9UN86
STRINGi9606.ENSP00000352738

Structurei

Secondary structure

1482
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi8 – 25Combined sources18
Helixi27 – 33Combined sources7
Beta strandi34 – 43Combined sources10
Helixi58 – 66Combined sources9
Beta strandi74 – 84Combined sources11
Helixi86 – 88Combined sources3
Beta strandi90 – 99Combined sources10
Beta strandi106 – 116Combined sources11
Beta strandi118 – 133Combined sources16
Helixi134 – 137Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DRVX-ray2.75A1-139[»]
ProteinModelPortaliQ9UN86
SMRiQ9UN86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 133NTF2PROSITE-ProRule annotationAdd BLAST123
Domaini331 – 409RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi134 – 223Glu-richAdd BLAST90
Compositional biasi419 – 479Gly-richAdd BLAST61

Phylogenomic databases

eggNOGiKOG0116 Eukaryota
ENOG410YV57 LUCA
GeneTreeiENSGT00390000011365
HOGENOMiHOG000220838
HOVERGENiHBG007211
InParanoidiQ9UN86
OMAiGEFNYRS
OrthoDBiEOG091G0GAN
PhylomeDBiQ9UN86
TreeFamiTF325464

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd12464 RRM_G3BP2, 1 hit
Gene3Di3.30.70.3301 hit
InterProiView protein in InterPro
IPR034377 G3BP2
IPR034376 G3BP2_RRM
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR10693:SF10 PTHR10693:SF10, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q9UN86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMEKPSPLL VGREFVRQYY TLLNKAPEYL HRFYGRNSSY VHGGVDASGK 
        60         70         80         90        100
PQEAVYGQND IHHKVLSLNF SECHTKIRHV DAHATLSDGV VVQVMGLLSN 
       110        120        130        140        150
SGQPERKFMQ TFVLAPEGSV PNKFYVHNDM FRYEDEVFGD SEPELDEESE 
       160        170        180        190        200
DEVEEEQEER QPSPEPVQEN ANSGYYEAHP VTNGIEEPLE ESSHEPEPEP 
       210        220        230        240        250
ESETKTEELK PQVEEKNLEE LEEKSTTPPP AEPVSLPQEP PKAFSWASVT 
       260        270        280        290        300
SKNLPPSGTV SSSGIPPHVK APVSQPRVEA KPEVQSQPPR VREQRPRERP 
       310        320        330        340        350
GFPPRGPRPG RGDMEQNDSD NRRIIRYPDS HQLFVGNLPH DIDENELKEF 
       360        370        380        390        400
FMSFGNVVEL RINTKGVGGK LPNFGFVVFD DSEPVQRILI AKPIMFRGEV 
       410        420        430        440        450
RLNVEEKKTR AARERETRGG GDDRRDIRRN DRGPGGPRGI VGGGMMRDRD 
       460        470        480 
GRGPPPRGGM AQKLGSGRGT GQMEGRFTGQ RR
Length:482
Mass (Da):54,121
Last modified:October 17, 2006 - v2
Checksum:i74B8EA43C0560229
GO
Isoform B (identifier: Q9UN86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-275: Missing.

Show »
Length:449
Mass (Da):50,817
Checksum:i1B0F021C138992E0
GO

Sequence cautioni

The sequence BAA31635 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267P → S in AAD51932 (Ref. 1) Curated1
Sequence conflicti359E → V in AAC15705 (Ref. 3) Curated1
Sequence conflicti460M → I in AAC15705 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036128434P → L in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003605243 – 275Missing in isoform B. 4 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145284 mRNA Translation: AAD51932.1
AB014560 mRNA Translation: BAA31635.2 Different initiation.
AF051311 mRNA Translation: AAC15705.1
AF053535 mRNA Translation: AAC95292.1
AK291786 mRNA Translation: BAF84475.1
CH471057 Genomic DNA Translation: EAX05742.1
BC011731 mRNA Translation: AAH11731.1
CCDSiCCDS3571.1 [Q9UN86-1]
CCDS3572.1 [Q9UN86-2]
RefSeqiNP_036429.2, NM_012297.4 [Q9UN86-1]
NP_987100.1, NM_203504.2 [Q9UN86-2]
NP_987101.1, NM_203505.2 [Q9UN86-1]
XP_005263439.1, XM_005263382.2 [Q9UN86-1]
XP_005263440.1, XM_005263383.3 [Q9UN86-1]
XP_011530743.1, XM_011532441.2 [Q9UN86-1]
XP_016864365.1, XM_017008876.1 [Q9UN86-1]
XP_016864366.1, XM_017008877.1 [Q9UN86-1]
XP_016864367.1, XM_017008878.1 [Q9UN86-2]
XP_016864368.1, XM_017008879.1 [Q9UN86-2]
UniGeneiHs.303676
Hs.613996

Genome annotation databases

EnsembliENST00000357854; ENSP00000350518; ENSG00000138757 [Q9UN86-2]
ENST00000359707; ENSP00000352738; ENSG00000138757 [Q9UN86-1]
ENST00000395719; ENSP00000379069; ENSG00000138757 [Q9UN86-1]
GeneIDi9908
KEGGihsa:9908
UCSCiuc003hir.4 human [Q9UN86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiG3BP2_HUMAN
AccessioniPrimary (citable) accession number: Q9UN86
Secondary accession number(s): A8K6X1
, O60606, O75149, Q9UPA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome