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Q9UN79

- SOX13_HUMAN

UniProt

Q9UN79 - SOX13_HUMAN

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Protein

Transcription factor SOX-13

Gene

SOX13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi424 – 49269HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. regulation of gamma-delta T cell differentiation Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ9UN79.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-13
Alternative name(s):
Islet cell antigen 12
SRY (Sex determining region Y)-box 13
Type 1 diabetes autoantigen ICA12
Gene namesi
Name:SOX13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11192. SOX13.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Transcription factor SOX-13PRO_0000048756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei335 – 3351Phosphoserine1 Publication
Modified residuei382 – 3821Phosphoserine1 Publication
Modified residuei386 – 3861Phosphoserine2 Publications
Modified residuei613 – 6131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9UN79.
PaxDbiQ9UN79.
PRIDEiQ9UN79.

PTM databases

PhosphoSiteiQ9UN79.

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, and liver and low expression in thymus, brain, spleen, and muscle.

Gene expression databases

BgeeiQ9UN79.
CleanExiHS_SOX13.
ExpressionAtlasiQ9UN79. baseline and differential.
GenevestigatoriQ9UN79.

Organism-specific databases

HPAiHPA051790.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565452EBI-3928516,EBI-741533

Protein-protein interaction databases

BioGridi114948. 6 interactions.
IntActiQ9UN79. 3 interactions.
MINTiMINT-1179847.
STRINGi9606.ENSP00000272193.

Structurei

3D structure databases

ProteinModelPortaliQ9UN79.
SMRiQ9UN79. Positions 423-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi184 – 22138Gln-richAdd
BLAST
Compositional biasi225 – 340116Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG275089.
GeneTreeiENSGT00760000119274.
HOVERGENiHBG003915.
InParanoidiQ9UN79.
KOiK09269.
OMAiCDVDGSR.
OrthoDBiEOG7R56S9.
PhylomeDBiQ9UN79.
TreeFamiTF320471.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR029547. SOX-13.
[Graphical view]
PANTHERiPTHR10270:SF109. PTHR10270:SF109. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9UN79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMRSPISAQ LALDGVGTMV NCTIKSEEKK EPCHEAPQGS ATAAEPQPGD
60 70 80 90 100
PARASQDSAD PQAPAQGNFR GSWDCSSPEG NGSPEPKRPG VSEAASGSQE
110 120 130 140 150
KLDFNRNLKE VVPAIEKLLS SDWKERFLGR NSMEAKDVKG TQESLAEKEL
160 170 180 190 200
QLLVMIHQLS TLRDQLLTAH SEQKNMAAML FEKQQQQMEL ARQQQEQIAK
210 220 230 240 250
QQQQLIQQQH KINLLQQQIQ QVNMPYVMIP AFPPSHQPLP VTPDSQLALP
260 270 280 290 300
IQPIPCKPVE YPLQLLHSPP APVVKRPGAM ATHHPLQEPS QPLNLTAKPK
310 320 330 340 350
APELPNTSSS PSLKMSSCVP RPPSHGGPTR DLQSSPPSLP LGFLGEGDAV
360 370 380 390 400
TKAIQDARQL LHSHSGALDG SPNTPFRKDL ISLDSSPAKE RLEDGCVHPL
410 420 430 440 450
EEAMLSCDMD GSRHFPESRN SSHIKRPMNA FMVWAKDERR KILQAFPDMH
460 470 480 490 500
NSSISKILGS RWKSMTNQEK QPYYEEQARL SRQHLEKYPD YKYKPRPKRT
510 520 530 540 550
CIVEGKRLRV GEYKALMRTR RQDARQSYVI PPQAGQVQMS SSDVLYPRAA
560 570 580 590 600
GMPLAQPLVE HYVPRSLDPN MPVIVNTCSL REEGEGTDDR HSVADGEMYR
610 620
YSEDEDSEGE EKSDGELVVL TD
Length:622
Mass (Da):69,228
Last modified:February 9, 2010 - v3
Checksum:iF8C102AF63128C06
GO

Sequence cautioni

The sequence AAC83687.1 differs from that shown. Reason: Several frameshifts.Curated
The sequence AAF23875.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG65072.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI16596.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911V → A in AAD16237. 1 PublicationCurated
Sequence conflicti259 – 2591V → G in AAD50120. 1 PublicationCurated
Sequence conflicti270 – 2701P → L in AAD50120. 1 PublicationCurated
Sequence conflicti491 – 4911Y → C in AAD50120. 1 PublicationCurated
Sequence conflicti515 – 5151A → G in AAD50120. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti532 – 5321P → S.
Corresponds to variant rs34758764 [ dbSNP | Ensembl ].
VAR_062671

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083105 mRNA. Translation: AAC83687.1. Sequence problems.
AF098915 mRNA. Translation: AAD16237.1.
AF116571 mRNA. Translation: AAF23875.1. Different initiation.
AK304192 mRNA. Translation: BAG65072.1. Different initiation.
AF149301 Genomic DNA. Translation: AAD50120.1.
AL592146 Genomic DNA. Translation: CAI16596.1. Different initiation.
CH471067 Genomic DNA. Translation: EAW91500.1.
BC106038 mRNA. Translation: AAI06039.1.
CCDSiCCDS44299.1.
RefSeqiNP_005677.2. NM_005686.2.
UniGeneiHs.201671.

Genome annotation databases

EnsembliENST00000367204; ENSP00000356172; ENSG00000143842.
ENST00000618875; ENSP00000478239; ENSG00000143842.
GeneIDi9580.
KEGGihsa:9580.
UCSCiuc001ham.3. human.

Polymorphism databases

DMDMi288558840.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083105 mRNA. Translation: AAC83687.1 . Sequence problems.
AF098915 mRNA. Translation: AAD16237.1 .
AF116571 mRNA. Translation: AAF23875.1 . Different initiation.
AK304192 mRNA. Translation: BAG65072.1 . Different initiation.
AF149301 Genomic DNA. Translation: AAD50120.1 .
AL592146 Genomic DNA. Translation: CAI16596.1 . Different initiation.
CH471067 Genomic DNA. Translation: EAW91500.1 .
BC106038 mRNA. Translation: AAI06039.1 .
CCDSi CCDS44299.1.
RefSeqi NP_005677.2. NM_005686.2.
UniGenei Hs.201671.

3D structure databases

ProteinModelPortali Q9UN79.
SMRi Q9UN79. Positions 423-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114948. 6 interactions.
IntActi Q9UN79. 3 interactions.
MINTi MINT-1179847.
STRINGi 9606.ENSP00000272193.

PTM databases

PhosphoSitei Q9UN79.

Polymorphism databases

DMDMi 288558840.

Proteomic databases

MaxQBi Q9UN79.
PaxDbi Q9UN79.
PRIDEi Q9UN79.

Protocols and materials databases

DNASUi 9580.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367204 ; ENSP00000356172 ; ENSG00000143842 .
ENST00000618875 ; ENSP00000478239 ; ENSG00000143842 .
GeneIDi 9580.
KEGGi hsa:9580.
UCSCi uc001ham.3. human.

Organism-specific databases

CTDi 9580.
GeneCardsi GC01P204043.
HGNCi HGNC:11192. SOX13.
HPAi HPA051790.
MIMi 604748. gene.
neXtProti NX_Q9UN79.
PharmGKBi PA36029.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275089.
GeneTreei ENSGT00760000119274.
HOVERGENi HBG003915.
InParanoidi Q9UN79.
KOi K09269.
OMAi CDVDGSR.
OrthoDBi EOG7R56S9.
PhylomeDBi Q9UN79.
TreeFami TF320471.

Enzyme and pathway databases

SignaLinki Q9UN79.

Miscellaneous databases

ChiTaRSi SOX13. human.
GeneWikii SOX13.
GenomeRNAii 9580.
NextBioi 35933.
PROi Q9UN79.
SOURCEi Search...

Gene expression databases

Bgeei Q9UN79.
CleanExi HS_SOX13.
ExpressionAtlasi Q9UN79. baseline and differential.
Genevestigatori Q9UN79.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
IPR029547. SOX-13.
[Graphical view ]
PANTHERi PTHR10270:SF109. PTHR10270:SF109. 1 hit.
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High expression of the HMG box factor sox-13 in arterial walls during embryonic development."
    Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers W., Clevers H.
    Nucleic Acids Res. 26:469-476(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "ICA12: a novel autoantigen in type I diabetes."
    LaGasse J.M., Gleason S., Rabin D.U., Michaels D., Kletter G., Pihoker K., Mahoney P., Valle T., Nguyen C., Hagopian W.A.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreatic islet.
  3. "SOX13 encodes an autoimmune antigen in type 1 diabetes."
    Kasimiotis H., Myers M.A., Mertin S., Argentaro A., Fida S., Ferro T., Olsson J.E., Rowley M.J., Harley V.R.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas and Placenta.
  4. "Genomic structure and precise chromosomal localization of human SOX13."
    Argentaro A., Olsson J., Critcher R., McDowall S.G., Harley V.R.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSOX13_HUMAN
AccessioniPrimary (citable) accession number: Q9UN79
Secondary accession number(s): B4E2B0
, O95275, O95826, Q3KQV7, Q5SXX1, Q9UHW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 9, 2010
Last modified: November 26, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3