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Protein

Transcription factor SOX-13

Gene

SOX13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi424 – 492HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SignaLinkiQ9UN79

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-13
Alternative name(s):
Islet cell antigen 12
SRY (Sex determining region Y)-box 13
Type 1 diabetes autoantigen ICA12
Gene namesi
Name:SOX13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143842.14
HGNCiHGNC:11192 SOX13
MIMi604748 gene
neXtProtiNX_Q9UN79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9580
OpenTargetsiENSG00000143842
PharmGKBiPA36029

Polymorphism and mutation databases

BioMutaiSOX13
DMDMi288558840

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487561 – 622Transcription factor SOX-13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei335PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UN79
MaxQBiQ9UN79
PaxDbiQ9UN79
PeptideAtlasiQ9UN79
PRIDEiQ9UN79

PTM databases

iPTMnetiQ9UN79
PhosphoSitePlusiQ9UN79

Expressioni

Tissue specificityi

Highly expressed in kidney, lung, and liver and low expression in thymus, brain, spleen, and muscle.

Gene expression databases

BgeeiENSG00000143842
CleanExiHS_SOX13
ExpressionAtlasiQ9UN79 baseline and differential
GenevisibleiQ9UN79 HS

Organism-specific databases

HPAiHPA051790
HPA054843

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565452EBI-3928516,EBI-741533

Protein-protein interaction databases

BioGridi114948, 10 interactors
IntActiQ9UN79, 10 interactors
MINTiQ9UN79
STRINGi9606.ENSP00000356172

Structurei

3D structure databases

ProteinModelPortaliQ9UN79
SMRiQ9UN79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 221Gln-richAdd BLAST38
Compositional biasi225 – 340Pro-richAdd BLAST116

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
GeneTreeiENSGT00760000119274
HOVERGENiHBG003915
InParanoidiQ9UN79
KOiK09269
OMAiCDVDGSR
OrthoDBiEOG091G04EH
PhylomeDBiQ9UN79
TreeFamiTF320471

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR029547 SOX-13
PANTHERiPTHR10270:SF233 PTHR10270:SF233, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9UN79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMRSPISAQ LALDGVGTMV NCTIKSEEKK EPCHEAPQGS ATAAEPQPGD
60 70 80 90 100
PARASQDSAD PQAPAQGNFR GSWDCSSPEG NGSPEPKRPG VSEAASGSQE
110 120 130 140 150
KLDFNRNLKE VVPAIEKLLS SDWKERFLGR NSMEAKDVKG TQESLAEKEL
160 170 180 190 200
QLLVMIHQLS TLRDQLLTAH SEQKNMAAML FEKQQQQMEL ARQQQEQIAK
210 220 230 240 250
QQQQLIQQQH KINLLQQQIQ QVNMPYVMIP AFPPSHQPLP VTPDSQLALP
260 270 280 290 300
IQPIPCKPVE YPLQLLHSPP APVVKRPGAM ATHHPLQEPS QPLNLTAKPK
310 320 330 340 350
APELPNTSSS PSLKMSSCVP RPPSHGGPTR DLQSSPPSLP LGFLGEGDAV
360 370 380 390 400
TKAIQDARQL LHSHSGALDG SPNTPFRKDL ISLDSSPAKE RLEDGCVHPL
410 420 430 440 450
EEAMLSCDMD GSRHFPESRN SSHIKRPMNA FMVWAKDERR KILQAFPDMH
460 470 480 490 500
NSSISKILGS RWKSMTNQEK QPYYEEQARL SRQHLEKYPD YKYKPRPKRT
510 520 530 540 550
CIVEGKRLRV GEYKALMRTR RQDARQSYVI PPQAGQVQMS SSDVLYPRAA
560 570 580 590 600
GMPLAQPLVE HYVPRSLDPN MPVIVNTCSL REEGEGTDDR HSVADGEMYR
610 620
YSEDEDSEGE EKSDGELVVL TD
Length:622
Mass (Da):69,228
Last modified:February 9, 2010 - v3
Checksum:iF8C102AF63128C06
GO

Sequence cautioni

The sequence AAC83687 differs from that shown. Several frameshifts.Curated
The sequence AAF23875 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG65072 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI16596 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91V → A in AAD16237 (Ref. 2) Curated1
Sequence conflicti259V → G in AAD50120 (Ref. 4) Curated1
Sequence conflicti270P → L in AAD50120 (Ref. 4) Curated1
Sequence conflicti491Y → C in AAD50120 (Ref. 4) Curated1
Sequence conflicti515A → G in AAD50120 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062671532P → S. Corresponds to variant dbSNP:rs34758764Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083105 mRNA Translation: AAC83687.1 Sequence problems.
AF098915 mRNA Translation: AAD16237.1
AF116571 mRNA Translation: AAF23875.1 Different initiation.
AK304192 mRNA Translation: BAG65072.1 Different initiation.
AF149301 Genomic DNA Translation: AAD50120.1
AL592146 Genomic DNA Translation: CAI16596.1 Different initiation.
CH471067 Genomic DNA Translation: EAW91500.1
BC106038 mRNA Translation: AAI06039.1
CCDSiCCDS44299.1
RefSeqiNP_005677.2, NM_005686.2
UniGeneiHs.201671

Genome annotation databases

EnsembliENST00000367204; ENSP00000356172; ENSG00000143842
ENST00000618875; ENSP00000478239; ENSG00000143842
GeneIDi9580
KEGGihsa:9580
UCSCiuc001ham.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSOX13_HUMAN
AccessioniPrimary (citable) accession number: Q9UN79
Secondary accession number(s): B4E2B0
, O95275, O95826, Q3KQV7, Q5SXX1, Q9UHW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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