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Q9UN79

- SOX13_HUMAN

UniProt

Q9UN79 - SOX13_HUMAN

Protein

Transcription factor SOX-13

Gene

SOX13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Binds to the sequence 5'-AACAAT-3'.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi424 – 49269HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ9UN79.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-13
    Alternative name(s):
    Islet cell antigen 12
    SRY (Sex determining region Y)-box 13
    Type 1 diabetes autoantigen ICA12
    Gene namesi
    Name:SOX13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11192. SOX13.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36029.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 622622Transcription factor SOX-13PRO_0000048756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei335 – 3351Phosphoserine1 Publication
    Modified residuei382 – 3821Phosphoserine1 Publication
    Modified residuei386 – 3861Phosphoserine2 Publications
    Modified residuei613 – 6131Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9UN79.
    PaxDbiQ9UN79.
    PRIDEiQ9UN79.

    PTM databases

    PhosphoSiteiQ9UN79.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, lung, and liver and low expression in thymus, brain, spleen, and muscle.

    Gene expression databases

    ArrayExpressiQ9UN79.
    BgeeiQ9UN79.
    CleanExiHS_SOX13.
    GenevestigatoriQ9UN79.

    Organism-specific databases

    HPAiHPA051790.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTBP2P565452EBI-3928516,EBI-741533

    Protein-protein interaction databases

    BioGridi114948. 4 interactions.
    IntActiQ9UN79. 3 interactions.
    MINTiMINT-1179847.
    STRINGi9606.ENSP00000272193.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9UN79.
    SMRiQ9UN79. Positions 423-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi184 – 22138Gln-richAdd
    BLAST
    Compositional biasi225 – 340116Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG275089.
    HOVERGENiHBG003915.
    InParanoidiQ9UN79.
    KOiK09269.
    OMAiCDVDGSR.
    OrthoDBiEOG7R56S9.
    PhylomeDBiQ9UN79.
    TreeFamiTF320471.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR029547. SOX-13.
    [Graphical view]
    PANTHERiPTHR10270:SF109. PTHR10270:SF109. 1 hit.
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9UN79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMRSPISAQ LALDGVGTMV NCTIKSEEKK EPCHEAPQGS ATAAEPQPGD    50
    PARASQDSAD PQAPAQGNFR GSWDCSSPEG NGSPEPKRPG VSEAASGSQE 100
    KLDFNRNLKE VVPAIEKLLS SDWKERFLGR NSMEAKDVKG TQESLAEKEL 150
    QLLVMIHQLS TLRDQLLTAH SEQKNMAAML FEKQQQQMEL ARQQQEQIAK 200
    QQQQLIQQQH KINLLQQQIQ QVNMPYVMIP AFPPSHQPLP VTPDSQLALP 250
    IQPIPCKPVE YPLQLLHSPP APVVKRPGAM ATHHPLQEPS QPLNLTAKPK 300
    APELPNTSSS PSLKMSSCVP RPPSHGGPTR DLQSSPPSLP LGFLGEGDAV 350
    TKAIQDARQL LHSHSGALDG SPNTPFRKDL ISLDSSPAKE RLEDGCVHPL 400
    EEAMLSCDMD GSRHFPESRN SSHIKRPMNA FMVWAKDERR KILQAFPDMH 450
    NSSISKILGS RWKSMTNQEK QPYYEEQARL SRQHLEKYPD YKYKPRPKRT 500
    CIVEGKRLRV GEYKALMRTR RQDARQSYVI PPQAGQVQMS SSDVLYPRAA 550
    GMPLAQPLVE HYVPRSLDPN MPVIVNTCSL REEGEGTDDR HSVADGEMYR 600
    YSEDEDSEGE EKSDGELVVL TD 622
    Length:622
    Mass (Da):69,228
    Last modified:February 9, 2010 - v3
    Checksum:iF8C102AF63128C06
    GO

    Sequence cautioni

    The sequence AAC83687.1 differs from that shown. Reason: Several frameshifts.
    The sequence AAF23875.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG65072.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI16596.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911V → A in AAD16237. 1 PublicationCurated
    Sequence conflicti259 – 2591V → G in AAD50120. 1 PublicationCurated
    Sequence conflicti270 – 2701P → L in AAD50120. 1 PublicationCurated
    Sequence conflicti491 – 4911Y → C in AAD50120. 1 PublicationCurated
    Sequence conflicti515 – 5151A → G in AAD50120. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti532 – 5321P → S.
    Corresponds to variant rs34758764 [ dbSNP | Ensembl ].
    VAR_062671

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083105 mRNA. Translation: AAC83687.1. Sequence problems.
    AF098915 mRNA. Translation: AAD16237.1.
    AF116571 mRNA. Translation: AAF23875.1. Different initiation.
    AK304192 mRNA. Translation: BAG65072.1. Different initiation.
    AF149301 Genomic DNA. Translation: AAD50120.1.
    AL592146 Genomic DNA. Translation: CAI16596.1. Different initiation.
    CH471067 Genomic DNA. Translation: EAW91500.1.
    BC106038 mRNA. Translation: AAI06039.1.
    CCDSiCCDS44299.1.
    RefSeqiNP_005677.2. NM_005686.2.
    UniGeneiHs.201671.

    Genome annotation databases

    EnsembliENST00000367204; ENSP00000356172; ENSG00000143842.
    GeneIDi9580.
    KEGGihsa:9580.
    UCSCiuc001ham.3. human.

    Polymorphism databases

    DMDMi288558840.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083105 mRNA. Translation: AAC83687.1 . Sequence problems.
    AF098915 mRNA. Translation: AAD16237.1 .
    AF116571 mRNA. Translation: AAF23875.1 . Different initiation.
    AK304192 mRNA. Translation: BAG65072.1 . Different initiation.
    AF149301 Genomic DNA. Translation: AAD50120.1 .
    AL592146 Genomic DNA. Translation: CAI16596.1 . Different initiation.
    CH471067 Genomic DNA. Translation: EAW91500.1 .
    BC106038 mRNA. Translation: AAI06039.1 .
    CCDSi CCDS44299.1.
    RefSeqi NP_005677.2. NM_005686.2.
    UniGenei Hs.201671.

    3D structure databases

    ProteinModelPortali Q9UN79.
    SMRi Q9UN79. Positions 423-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114948. 4 interactions.
    IntActi Q9UN79. 3 interactions.
    MINTi MINT-1179847.
    STRINGi 9606.ENSP00000272193.

    PTM databases

    PhosphoSitei Q9UN79.

    Polymorphism databases

    DMDMi 288558840.

    Proteomic databases

    MaxQBi Q9UN79.
    PaxDbi Q9UN79.
    PRIDEi Q9UN79.

    Protocols and materials databases

    DNASUi 9580.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367204 ; ENSP00000356172 ; ENSG00000143842 .
    GeneIDi 9580.
    KEGGi hsa:9580.
    UCSCi uc001ham.3. human.

    Organism-specific databases

    CTDi 9580.
    GeneCardsi GC01P204043.
    HGNCi HGNC:11192. SOX13.
    HPAi HPA051790.
    MIMi 604748. gene.
    neXtProti NX_Q9UN79.
    PharmGKBi PA36029.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275089.
    HOVERGENi HBG003915.
    InParanoidi Q9UN79.
    KOi K09269.
    OMAi CDVDGSR.
    OrthoDBi EOG7R56S9.
    PhylomeDBi Q9UN79.
    TreeFami TF320471.

    Enzyme and pathway databases

    SignaLinki Q9UN79.

    Miscellaneous databases

    GeneWikii SOX13.
    GenomeRNAii 9580.
    NextBioi 35933.
    PROi Q9UN79.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9UN79.
    Bgeei Q9UN79.
    CleanExi HS_SOX13.
    Genevestigatori Q9UN79.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR029547. SOX-13.
    [Graphical view ]
    PANTHERi PTHR10270:SF109. PTHR10270:SF109. 1 hit.
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High expression of the HMG box factor sox-13 in arterial walls during embryonic development."
      Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M., Lamers W., Clevers H.
      Nucleic Acids Res. 26:469-476(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "ICA12: a novel autoantigen in type I diabetes."
      LaGasse J.M., Gleason S., Rabin D.U., Michaels D., Kletter G., Pihoker K., Mahoney P., Valle T., Nguyen C., Hagopian W.A.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreatic islet.
    3. "SOX13 encodes an autoimmune antigen in type 1 diabetes."
      Kasimiotis H., Myers M.A., Mertin S., Argentaro A., Fida S., Ferro T., Olsson J.E., Rowley M.J., Harley V.R.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas and Placenta.
    4. "Genomic structure and precise chromosomal localization of human SOX13."
      Argentaro A., Olsson J., Critcher R., McDowall S.G., Harley V.R.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSOX13_HUMAN
    AccessioniPrimary (citable) accession number: Q9UN79
    Secondary accession number(s): B4E2B0
    , O95275, O95826, Q3KQV7, Q5SXX1, Q9UHW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3